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Saturday, 19 April 2025

Not so fast!

 


The word rendered worship is "proskuneo" and while JEHOVAH  receives absolute proskuneo/worship the bible clearly shows that holy messengers of God both human and superhuman can also lawfully receive a kind relative proskuneo/worship for instance,

Daniel ch.2:46KJV"Then the king Nebuchadnezzar fell upon his face, and WORSHIPPED Daniel, and commanded that they should offer an oblation and sweet odours unto him."

1Chronicles 29:20KJV"And David said to all the congregation, Now bless the LORD your God. And all the congregation blessed the LORD God of their fathers, and bowed down their heads, and WORSHIPPED the LORD, and the king."

Note that king David is worshiped alongside the Lord JEHOVAH

What about this:
Luke ch.4:8KJV"And Jesus answered and said unto him, Get thee behind me, Satan: for it is written, Thou shalt worship the LORD thy God, and him only shalt thou serve."

To help us reason scripturally on this matter lets consider another caution Jesus gave us.

Matthew ch.23:9,10NIV"And do not call anyone on earth ‘father,’ for you have one Father, and he is in heaven.Nor are you to be called instructors, for you have one Instructor, the Messiah."

A careless investigator of God's word might conclude that Paul is in violation of Jesus's command based on such texts as:
  Romans ch.4:1NKJV"What then shall we say that Abraham our father has found according to the flesh?"
1corinthians ch.4:15NIV"Even if you had ten thousand guardians in Christ, you do not have many fathers, for in Christ Jesus I became your father through the gospel."
Clearly our Lord was cautioning against the use of honorific titles especially those that might obscure JEHOVAH'S Unique fatherhood and Christ's unique teaching authority

So JEHOVAH Recieves absolute worship but his divinely appointed and empowered prophet can also lawfully receive relative worship out of regard for the God who selected and empowered him see Daniel ch.2:46 but Luke ch.4:8b uses the Greek word Latreo only the God and Father of Jesus is ever depicted as receiving Latreo in the Holy scriptures and no one else, so it is interesting that Jesus takes pains to spell out that only the Lord JEHOVAH is entitled to this absolutely sacred form of worship.


Using AI to give ourselves superpowers?

 

The king of titans lays the smackdown on all comers.

 

Matthew Henry re: Daniel ch.10:10-21

"10:10-21 Whenever we enter into communion with God, it becomes us to have a due sense of the infinite distance between us and the holy God. How shall we, that are dust and ashes, speak to the Lord of glory? Nothing is more likely, nothing more effectual to revive the drooping spirits of the saints, than to be assured of God's love to them. From the very first day we begin to look toward God in a way of duty, he is ready to meet us in the way of mercy. Thus ready is God to hear prayer. When the angel had told the prophet of the things to come, he was to return, and oppose the decrees of the Persian kings against the Jews. The angels are employed as God's ministering servants, Heb 1:14. Though much was done against the Jews by the kings of Persia, God permitting it, much more mischief would have been done if God had not prevented it. He would now more fully show what were God's purposes, of which the prophecies form an outline; and we are concerned to study what is written in these Scriptures of truth, for they belong to our everlasting peace. While Satan and his angels, and evil counsellors, excite princes to mischief against the church, we may rejoice that Christ our Prince, and all his mighty angels, act against our enemies; but we ought not to expect many to favour us in this evil world. Yet the whole counsel of God shall be established; and let each one pray, Lord Jesus, be our righteousness now, and thou wilt be our everlasting confidence, through life, in death, at the day of judgment, and for evermore."

https://biblehub.com/commentaries/mhcw/daniel/10.htm


John Calvin in his own words on Michael the great prince.

"On Daniel 10:13:
“He adds next, Behold! Michael, one of the chief leaders or princes, came to strengthen me. Some think the word Michael represents Christ, and I do not object to this opinion.”
Criticism of Misinterpretation

 (Daniel 12:1):
“That foul hypocrite, Servetus, has dared to appropriate this passage to himself; for he has inscribed it as a frontispiece on his horrible comments, because he was called Michael! … But this was a proof of his impudence and sacrilegious madness — to adorn himself with this epithet of Christ without blushing, and to elevate himself into Christ’s place, by boasting himself to be Michael, the guardian of the Church, and the mighty prince of the people!

https://www.ccel.org/ccel/calvin/calcom25.vii.i.html
https://ccel.org/ccel/calvin/calcom25/calcom25.v.xiv.html
I found this pair of quotes from protestant reformer John calvin most interesting.

GROK quotes tertullian on the seventy weeks of the book of Daniel.

 Tertullian discusses the seventy weeks prophecy from Daniel 9:24-27, arguing it was fulfilled in the coming of Christ. Here is the relevant quote from Chapter VIII:against the Jews.

"For the prophet Daniel, in the vision of the seventy weeks, speaks thus: 'Seventy weeks are determined upon thy people and upon thy holy city, to finish the transgression, and to seal up sins, and to wipe out iniquities, and to bring in everlasting righteousness, and to seal up the vision and prophecy, and to anoint the Holy of Holies; and thou shalt know and understand, from the going forth of the word to answer and to build Jerusalem, unto Christ the Leader, there shall be seven weeks, and sixty-two weeks.' Now, from the going forth of the word to rebuild Jerusalem, which was given through Cyrus, king of the Persians, unto the advent of Christ, are computed seventy weeks, which make four hundred and ninety years, since each week contains seven years. In these weeks, therefore, Christ came and suffered, and the city was destroyed, and the sacrifices ceased."

This passage reflects Tertullian’s interpretation that the seventy weeks (490 years) prophesied by Daniel were fulfilled with the coming of Christ, His death, and the subsequent destruction of Jerusalem."

Note the use of the day for a year formula in calculating prophetic time.

Friday, 18 April 2025

Ex nihilo = Design?

 Why the “Universe from Nothing” Model Points to Intelligent Design


Did our universe come from nothing, as some physicists have proposed? On a new episode of ID the Future, I critique the audacious claim that our universe popped into existence out of nothing. What is nothing? What isn’t nothing? And how does the universe from nothing claim actually imply the necessity for intelligent design? I share audio from the Science Uprising video series, as well a portion of an interview with Dr. Stephen Meyer, to help answer these questions. 

This episode is built around a suggestion I recently received from an ID the Future listener. Timothy in South Australia wants to know where the theory that the universe was created from nothing came from, how old the idea is, and why some would accept the premise over intelligent design. Says Timothy: “When they say that ‘nothing’ is responsible for the creation of the universe, do they literally mean nothing at all? Or are they referring to something? If so, why do they say that ‘nothing’ created the universe? Doesn’t that phrasing mislead us to believe that ‘nothing’ has creative powers?”

To sort it out, we hear audio from Dr. Stephen Meyer and Dr. Brian Miller as they describe how scientists discovered that the universe had a beginning, and why some scientists have proposed exotic theories to get around the evidence of fine-tuning that has been discovered in recent decades. The “universe from nothing” idea, popularized by physicists like Stephen Hawking and Lawrence Krauss, is one of those exotic ideas. But rather than explain the origin of the universe in materialistic terms, the “universe from nothing” proposal actually bolsters the case for intelligent design, as Dr. Meyer explains. Download the podcast or listen to it here.

Now bird brain for the win?

 High Bird Intelligence Is Consistent with Design, Not Evolution


Editor’s note: Pre-order The Immortal Mind by Michael Egnor and Denyse O’Leary and get a sneak peek exclusive excerpt from the book as well as the full digital book anthology Minding the Brain.

At Quanta, science writer Yasemin Saplakoglu explores the thesis that intelligence evolved at least twice in vertebrate animals. We’ll get to the specifics but first I’d like to focus on the opening paragraph:

Humans tend to put our own intelligence on a pedestal. Our brains can do math, employ logic, explore abstractions and think critically. But we can’t claim a monopoly on thought. Among a variety of nonhuman species known to display intelligent behavior, birds have been shown time and again to have advanced cognitive abilities. Ravens plan for the future, crows count and use tools, cockatoos open and pillage booby-trapped garbage cans, and chickadees keep track of tens of thousands of seeds cached across a landscape. Notably, birds achieve such feats with brains that look completely different from ours: They’re smaller and lack the highly organized structures that scientists associate with mammalian intelligence.

“INTELLIGENCE EVOLVED AT LEAST TWICE IN VERTEBRATE ANIMALS,” APRIL 7, 

Putting Our Intelligence on a Pedestal?

Wait ,How did we lose track of the fact that humans are studying birds, using both abstractions and critical thinking (not to mention sophisticated equipment). Birds get on with their lives by cleverly solving problems. But they are not studying us that way — because they can’t.

A discussion of animal intelligence that refuses to acknowledge human exceptionalism becomes a script for suppressing discussions we need to have about our place in the world.

One of Saplakoglu’s interview subjects harps on the same theme:

The findings emerge in a world enraptured by artificial forms of intelligence, and they could teach us something about how complex circuits in our own brains evolved. Perhaps most importantly, they could help us step “away from the idea that we are the best creatures in the world,” said Niklas Kempynck, a graduate student at KU Leuven who led one of the studies. “We are not this optimal solution to intelligence.” 

“EVOLVED AT LEAST TWICE”

The Evolution of Nonsense

Kempynck is doubtless an intelligent man. But here he is talking nonsense. It is a nonsense imposed on him by the unquestioned philosophical commitments of evolutionary biology. If he started uttering common sense, he would be deplatformed.

He can’t think — let alone say — the obvious. So once again, I will: We are not “this optimal solution to intelligence.” We belong to a different order of intelligence from all other life forms. We fly — by building aircraft. We don’t howl at the moon; we go there.

Whatever the human difference is, it makes a huge difference, one in which all the contributors to “Evolved at Least Twice” participate, without being free to acknowledge it.

Whether we are the “best creatures” on the planet is a logical dead end. If several other species had the capacity for abstract thought and moral choice, we might have (one hopes) a friendly rivalry. Because we are all alone in this regard, we can vote ourselves whatever titles or putdowns we want — the drama changes nothing.

It is ironic that otherwise intelligent people must play the “we’re just another animal” game while demanding the attention to their work that only humans can give.

Leaving Humans Out of the Picture for a Moment…

The  question of whether birds developed intelligence separately from mammals hinges on how the various brain parts currently believed to be associated with intelligence formed. Recent papers delving into the matter offer some useful new insights:

A series of studies published in Science in February 2025 provides the best evidence yet that birds and mammals did not inherit the neural pathways that generate intelligence from a common ancestor, but rather evolved them independently. This suggests that vertebrate intelligence arose not once, but multiple times. Still, their neural complexity didn’t evolve in wildly different directions: Avian and mammalian brains display surprisingly similar circuits, the studies found. 

“EVOLVED AT LEAST TWICE”

As Saplakoglu notes, that pattern is consistent with convergent evolution. It’s also consistent with intelligent design in nature: achieving the same goal using quite different neural structures.

An article at Science introduces the topic, pointing to current papers:

On pages 733, 734, and 732 of this issue, Zaremba et al. (1), Hecker et al. (2), and Rueda-Alaña et al. (3), respectively, provide evidence for the convergent development and evolution of neurons and their connections in the bird and mammalian pallia, highlighting the need for multiple perspectives in brain comparative studies. 

GIACOMO GATTONI, MARIA ANTONIETTA TOSCHES, CONSTRAINED ROADS TO COMPLEX BRAINS. SCIENCE 387,716-717(2025). DOI:10.1126/SCIENCE.ADV2609

Saplakoglu’s article provides a valuable overview of the study of bird intelligence. She covers both the predominant view in the first half of the twentieth century — that birds are not as intelligent as mammals — and the successful challenges to that view. For example,

“A bird with a 10-gram brain is doing pretty much the same as a chimp with a 400-gram brain,” said Onur Güntürkün, who studies brain structures at Ruhr University Bochum in Germany. “How is it possible?” 

“EVOLVED AT LEAST TWICE”

How indeed? It may be time for a rethink of what animal intelligence is.

Thursday, 17 April 2025

Lizard brain for the win(again)

 Get Smart: Recognizing Reptile Intelligence


Editor’s note: Pre-order The Immortal Mind by Michael Egnor and Denyse O’Leary and get a sneak peek exclusive excerpt from the book as well as the full digital book anthology Minding The Brain.

At JStor Daily,Matthew Wills, introducing a recent paper, tells us that reptiles are are smarter than we used to think. One reason that biologists used to think that reptiles are of uniformly low intelligence was a misunderstanding about their behavior in captivity:

Herpetologist Gilles De Meester and evolutionary ecologist Simon Baeckens write that, into the 1970s, researchers were dismissing reptiles as “reflex machines,” “intellectual dwarfs,” and creatures of “very small brain.” The latter description implies much — but those implications turn out to tell us more about researchers than the subjects of their studies.

The few earlier studies that seemed to confirm the dumb reptile stereotype had “inadequate and ecologically irrelevant experimental study designs, such as suboptimal room temperatures or insufficient reinforces,” write De Meester and Baeckens. For instance, food, which works well as a motivation for rodents and birds in cognitive tests, seems to have much less appeal to reptiles because of their low metabolic rate and irregular feeding habits. Snakes, as an example, may not want to eat for months after consuming large prey, so a new food source may not interest them at all.

“THE REPTILIAN RENAISSANCE,” APRIL 11, 2025

Clever Reptiles

It turns out that reptiles observed in the wild can be rather clever:

There’s even some evidence of reptilian tool-use: species of crocodiles and alligators “display sticks and twigs on their snout in order to lure nest-building birds.” This has only been observed in bird-breeding season, when the birds on the lookout for sticks to construct or repair their nests.

Once considered simple and “primitive,” the “reptilian brain is now recognized to govern complex behaviours,” write De Meester and Baeckens. They argue that reptiles show “immense potential” as model species for research into the “mechanisms, the development, and evolution of animal cognition.”

“THE REPTILIAN RENAISSANCE”

In  fairness, the fact that reptiles can afford to be torpid much of the time due to their low energy needs probably means that they don’t need to exercise intelligence as often as energy-burning mammals and birds do. But that’s a separate matter from not having intelligence.

The Reptile Brain

Mammals and birds have different types of brains from each others. But if reptiles can demonstrate intelligence similar to that of, say, mammals or birds, is it because they have similar types of brains to either?

At Neuroscience News, Irina Epstein reports that the Max Planck Institute looked at the question in a 2022 paper. They think that a basic ancestral brain developed 320 million years ago when reptiles, birds, and mammals (all tetrapods) moved to land. But the subsequent development of their brains was quite different:

Neuroscientists at the Max Planck Institute for Brain Research in Frankfurt tackled this question by generating a molecular atlas of the dragon [lizard] brain and comparing it with one from mice.

Their findings suggest that, contrary to popular belief that a mammalian brain consists of an ancient “reptilian” brain supplemented with new mammalian features, both reptilian and mammalian brains evolved their own clade-specific neuron types and circuits, from a common ancestral set. 

“DRAGONS AND BRAIN EVOLUTION,” SEPTEMBER 2, 2022

That suggests that mammals, birds, and reptiles all developed different smart survival strategies on their own. It sounds like convergent evolution or intelligent design.

Complicating the Picture: Evidence for Smart Fish and Invertebrates

The manta ray, which has a rather large brain, also has a reputation for intelligence: From the Daily Mail:

Their large brains are also believed to have engorged regions known to play a role in higher functions, such as intelligence, vision and motor coordination.

In addition, manta rays are known to repeatedly revisit the same feeding areas or so-called ‘cleaning stations’ on coral reefs — where cleaner fish will nibble away any parasitic organisms that have attached themselves to the manta.

This behaviour has led researchers to conclude that mantas are able to creative cognitive maps of their environment to help them navigate back to these preferred locations.

They are also known to be highly curious animals and often initiate play-like behaviour with human divers — a phenomenon otherwise really only seen to such an extent in intelligent social marine mammals like dolphins and whales.

Divers also report that mantas actively solicit help when tangled in lines or injured, rather than the fear response more typical of a vulnerable animal.

“HOW INTELLIGENT ARE MANTA RAYS?” JULY 12, 2019

Other fish can lay claim to intelligence too. So intelligence doesn’t seem to be just a feature of tetrapod evolution.

And then there’s the octopus… Scientists clash over why these invertebrates are smart, as smart as lab rats. And then there are the cuttlefish. And crabs and lobsters too.

But this takes us back be half a billion years. Maybe if we are looking for general principles underlying the development of intelligence, we would be wise to leave evolution out of it for a bit.

Finally earth 2.0?

 

Wednesday, 16 April 2025

Less is more?

 1Timothy ch.6:7,8NIV"For we brought nothing into the world, and we can take nothing out of it. 8But if we have food and clothing, we will be content with that. "

Higher ed. Is higher in name only?

 

Maximum commercialising of the ideological divide?

 

The invincible fortress?

 

Why origin of life science continues to flounder.

 

TERF island indeed.

 

The thinking microbe vs. Darwin.

 A Cell Makes “Decisions” — But if It’s Following a Material Blueprint, How Does It Do That?


Editor’s note: For more on the “immaterial” aspect of the cell’s blueprint, see the new book describing the thought of biologist Richard Sternberg, Plato’s Revenge: The New Science of the Immaterial Genome (Discovery Institute Press), by David Klinghoffer. To be published on April 28, it is available for preorder now.

Watch an entertaining video in a press release from the University of Massachusetts (UMass) called “Rules of Engagement,” set to the Strauss waltz “Voices of Spring.” We see four varieties of enzymes deciding what to do when traveling along DNA strands and running into each other. We sympathize with these molecular actors, envisioning construction workers trying to work past each other in a narrow corridor. Somehow, they figure out the challenge and carry on. 

Later in the video, we zoom out and see that all these interactions blend into a magnificent ballet, resulting in precise folding of DNA into the familiar X-shaped chromosomes. If a cell is merely a “fortuitous concourse of atoms,” how is this possible?

Abiotic matter can self-organize in some circumstances. Tornadoes and hurricanes form spirals. Cooling lava forms hexagonal columns. Elements combine into geometric crystals. In those cases, though, the atoms simply follow physical laws without regard to consequences or function. Life is different. It solves problems for a purpose. It makes decisions.

Decisions to Cooperate

The condensins and cohesins in the video are not drawn into their interactions by gravity or electrostatics. Multiple levels of programming are involved, including: (1) genetic instructions to build the molecular machines, (2) “rules of engagement” to govern their interactions, (3) an overarching design plan to compact DNA into chromosomes, and (4) a need to separate the chromosome pairs into daughter cells in mitosis. To these programs could be added monitoring systems, repair mechanisms, and the astonishingly complex DNA replication process.

Programming makes the difference. Crystals, lava, and tornadoes do not follow a code telling them what to do. Philosophers and theologians may argue about whether the laws are designed and finely tuned for life, but once established, the laws generate predictable outcomes that can be described mathematically. The actions of molecules in the cell are not predictable from the laws, nor are the paths that electrons take in a silicon chip unless directed by a mind with a plan. 

The press release from UMass highlights a new paper in Science by Samejima et al., explaining that the plan for chromosome construction succeeds despite stochastic interactions at lower levels:
                             
Given the dynamic interactions and stochastic nature of binding and loop extrusion processes, mitotic chromosomes do not adopt a single, fixed three-dimensional structure. Instead, they are disorderly structures with a common defined architecture.

By analogy, construction workers at a building project, each with their specialties and skills, have leeway in the exact locations where they hammer nails or string wires, as long as they follow the overarching site plan shown in the blueprint.

Here are additional examples of decision-making by cells to reinforce the point that material cells can only make decisions if specifically structured to follow a blueprint with rules of engagement.

Decisions to Organize: Another “-ome”

paper in Science by Waltz et al. adds to the growing vocabulary of “-omes” (genome, proteome, lipidome, etc.) with the term “respirasome” — a supercomplex that enables respiration in mitochondria. The individual complexes comprising oxidative phosphorylation, culminating in the wondrous rotary engine ATP synthase, are organized in a way that maximizes function. The authors note how precise the arrangement appears under cryo-electron microscopy:

Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, working in concert to transfer electrons and pump protons. The precise organization of these complexes in native cells is debated. We used in situ cryo–electron tomography to visualize the native structures and organization of several major mitochondrial complexes in Chlamydomonas reinhardtii cells. ATP synthases and respiratory complexes segregate into curved and flat crista membrane domains, respectively. Respiratory complexes I, III, and IV assemble into a respirasome supercomplex, from which we determined a native 5-angstrom (Å) resolution structure showing binding of electron carrier cytochrome c. Combined with single-particle cryo–electron microscopy at 2.4-Å resolution, we model how the respiratory complexes organize inside native mitochondria.

The authors advance some hypotheses about why the complexes organize into these supercomplexes, noting that not all respirasomes have identical stoichiometry in different species. They speculate that “evolution appears to have repeatedly selected for respirasomes,” which is the Darwinian way of admitting that the patterns are functionally important (otherwise they wouldn’t exist now, would they?).

As visualized by in situ cryo-ET, this membrane architecture creates a narrow luminal space and lateral heterogeneity with the cristae, thereby enabling proton flux from respirasome source to ATP synthase sink…. In such a manner, respirasomes would enable efficient respiration through the indirect mechanism of establishing crista architecture and molecular organization. The native respirasome structure presented in our study provides a blueprint to specifically disrupt supercomplex formation in vivo and mechanistically dissect the physiological relevance of these enigmatic molecular machines.

The respirasome, therefore, appears as another decision-making structure that solves the problem of how best to organize machines in a factory for efficiency. Solutions like this are not predictable from the laws of nature alone.

Decisions to Prevent Problems

Another kind of decision-making seen in cells involves not just solving puzzles but preventing foreseeable problems. A paper in the EMBO Journal by Fagunloye et al. provides a case in point. The Shu complex is an “evolutionarily conserved” (unevolved) “heterotetramer composed of three Rad51 paralogs, Csm2, Psy3, Shu1, and a SWIM-domain containing protein, Shu2.”

Homologous recombination (HR) is important for DNA damage tolerance during replication. The yeast Shu complex, a conserved homologous recombination factor, prevents replication-associated mutagenesis. Here we examine how yeast cells require the Shu complex for coping with MMS-induced lesions during DNA replication. We find that Csm2, a subunit of the Shu complex, binds to autonomous-replicating sequences (ARS) in yeast…. Lastly, we show interactions between the Shu complex and the replication initiation complexes are essential for resistance to DNA damage, to prevent mutations and aberrant recombination events. In our model, the Shu complex interacts with the replication machinery to enable error-free bypass of DNA damage.

Note the irreducible complexity in this complex that they attribute to evolution. They claim this wonder of the cell evolved on the basis of finding differences between the Shu complexes in yeast and humans. They should instead ask on what basis they could expect material processes to sense, repair, and prevent damage: to go from mindless atoms to decision-making machines.

The Shu complex, they say, can repair “bulky DNA damage” and even bypass lesions, yielding a thousand-fold increase in replication accuracy (see the endnote for the impressive details1). Aren’t mutations thought to be the seed-plot of progress in Darwinism? Without the proofreading accuracy of the Shu complex, a cell would likely suffer error catastrophe long before it could emerge.

Moreover, the Shu complex interacts with other complexes — facts that the authors call “intriguing” and “interesting.”2

Skinner’s Constant

Material entities can make decisions, but only when they are guided to do so by an intelligent cause capable of foresight. Attributing decision-making to matter by invoking a nebulous concept of “selection pressure” — a synonym for Skinner’s Constant, the factor which, “when multiplied by, divided by, added to, or subtracted from the answer you got, gives you the answer you should have gotten” — requires magical thinking under the spell of an overactive imagination. The credibility of the Darwinian mechanism is inversely proportional to the details observed operating in living cells.

Notes

"During DNA replication, DNA damage can be bypassed using a template switching mechanism that is facilitated by the recombinase, Rad51. The yeast Shu complex facilitates the formation of Rad51 filaments in this replicative context where its function is restricted. This is unique to other HR factors that repair direct DSBs [double-stranded breaks] outside of DNA replication. How the Shu complex function is limited to facilitatebypass of replicative DNA damage is enigmatic. However, hints come from its DNA damage sensitivity, where the loss of any Shu complex members results in sensitivity to the alkylating agent, methyl methanesulfonate (MMS). Partially explaining this specificity for replicative repair, the Shu complex DNA binding subunits, the Rad51 paralogs Csm2-Psy3, preferentially bind to double-flap substrates and have increased affinity for a double-flap containing an abasic site, which forms during repair of alkylation damage. Loss of Shu complex function results in translesion synthesis-induced mutations and the mutation rate increases over 1000-fold when abasic sites accumulate.” (External citations omitted.)
“Importantly, these physical interactions with the replication initiation complexes occur independently of other HR machinery, including the recombinase Rad51 and the canonical Rad51 paralog, Rad55. Intriguingly, Csm2 enrichment at ARS sites is largely dependent on its interaction with Rad55. Interestingly, Rad55 is neededfor Csm2 enrichment at ARS sites while being dispensable for Shu complex interaction with Mcm4. These results are consistent with those from the Prado laboratory showing that Mcm4 interaction with Rad51 or Rad52 is also DNA-independent. Furthermore, we show that Csm2 and Psy3 DNA binding is largely dispensable for its interaction with members of the MCM or ORC complexes. Therefore, it is possible that Rad55 helps to stabilize or enrich the Shu complex to ARS sites but that the Shu complex alone is needed to interact with the replisome. Overall, our results delineate a model wherein the Shu complex interacts with the replication machinery to ensure an error-free bypass of DNA damage.”

Tuesday, 15 April 2025

File under "well said" CXVI

"It does not matter how far ahead you can see if you don't understand what you are looking at"

Gary kasparov

Independently recurring design logic vs. Darwin.

 Sporulation: Another Example of a Transcriptional Hierarchy


Previously, I introduced the subject of transcriptional hierarchies in bacteria, which exhibit current design logic across various different systems. We reviewed the control of flagellar assembly in Salmonella and saw that the organization of flagellar genes along the chromosome, and their organization into different operons (collections of genes under control of a common promoter), is crucial to the assembly process. Here, I will discuss another example of a transcriptional hierarchy — the control of sporulation

What Is Sporulation?

Sporulation is a highly regulated process whereby a vegetative cell differentiates into an endospore, a highly resistant, dormant structure that can withstand extreme stress (such as heat, desiccation, and UV radiation). The process is triggered by nutrient starvation. Once sporulation has been initiated, the chromosomes align along the longitudinal axis of the cell — this is known as the axial filament.1 The cell then divides asymmetrically near one of the poles, forming the smaller forespore and the larger mother cell.2,3 The membrane of the mother cell subsequently engulfs the forespore such that it completely envelops it.4 A thick layer of peptidoglycan (known as the cortex) is then deposited between the forespore membranes (this Is crucial for dehydration and dormancy).5 Physical and chemical resistance is conferred by proteinaceous layers known as spore coats, which assemble around the cortex.6 Eventually the mother cell undergoes apoptosis, which releases the mature spore.7

The model system for studying sporulation is Bacillus subtilis (pictured at the top), which I will be focusing on here. 

Regulation of Endospore Formation

Similar to flagellar assembly, which we considered previously, sporulation is under the control of a transcriptional hierarchy, whereby sigma factors promote the expression of specific sets of genes.8

The master regulator of sporulation is Spo0A, which is activated by phosphorylation in response to stress, via a phosphorelay system.9,10 Environmental stress signals are detected by sensor histidine kinases (KinA, KinB, and KinC), which in response undergo autophosphorylation.11 The response regulator for this system is Spo0F, which receives the phosphate group from the histidine kinases. This phosphate group, in turn, is transferred to Spo0A by the phosphotransferase Spo0B. This represents a further example of the recurring design logic exhibited by two-component regulatory systems, which I discussed in a previous article.

Phosphorylated Spo0A deactivates abrB, a repressor of early sporulation genes.12 This facilitates expression of spoIIE, which encodes a phosphatase that dephosphorylates SpoIIAA, which otherwise binds and inhibits SpoIIAB (a protein which inactivates σF).13 σF is thereby released and promotes the transcription of a regulon (i.e., a collection of multiple operons that are transcribed in response to the same regulatory protein).14 These genes are primarily involved in the early stages of endospore formulation — in particular, in the forespore compartment.

Among the genes that are under the regulation of σF is a gene coding for a signaling protein called SpoIIR, which activates SpoIIGA, a protease that cleaves pro-σE into its active form, σE.15 σE, in turn, drives the expression of the genes needed for modification of the mother cell membrane to envelop the forespore.16 σE also drives expression of SpoIVB, which cleaves SpoIVFA, a protein which, along with another molecule called BofA, inhibits a membrane-associated protease called SpoIVFB.17,18 This cleavage releases the inhibitory complex, thereby rendering SpoIVB active. This protease, along with another protein called CtpB, cleaves pro-σK, converting it to active σK.19,20 This, in turn, directs the transcription of the genes that code for coat proteins and lytic enzymes that bring about the death of the mother cell.21

Recurring Design Logic

In my previous article, I surveyed the transcriptional hierarchy responsible for the assembly of bacterial flagella. We saw that the organization of genes into operons relates to the timing of their expression — in particular, whether they are expressed early, midway, or late in flagellar assembly. In the foregoing, we have seen a very similar design logic exhibited by the transcriptional hierarchy that is sporulation. And yet, nobody would argue that these systems are evolutionarily related to one another. Recurring design logic across multiple unrelated systems is surprising in an evolutionary perspective, whereas on the hypothesis of design it is what might be reasonably predicted. Examples like this, therefore, suggest the existence of a master-architect behind biological systems — particularly when we find many different examples of design logic that are found recurrently throughout life.

Notes
Bylund JE, Haines MA, Piggot PJ, Higgins ML. Axial filament formation in Bacillus subtilis: induction of nucleoids of increasing length after addition of chloramphenicol to exponential-phase cultures approaching stationary phase. J Bacteriol. 1993 Apr;175(7):1886-90. doi: 10.1128/jb.175.7.1886-1890.1993. PMID: 7681431; PMCID: PMC204252.
Barák I, Muchová K, Labajová N. Asymmetric cell division during Bacillus subtilis sporulation. Future Microbiol. 2019 Mar;14:353-363. doi: 10.2217/fmb-2018-0338. Epub 2019 Mar 11. PMID: 30855188.
Khanna K, Lopez-Garrido J, Sugie J, Pogliano K, Villa E. Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation. Elife. 2021 May 21;10:e62204. doi: 10.7554/eLife.62204. PMID: 34018921; PMCID: PMC8192124.
Ojkic N, López-Garrido J, Pogliano K, Endres RG. Cell-wall remodeling drives engulfment during Bacillus subtilis sporulation. Elife. 2016 Nov 17;5:e18657. doi: 10.7554/eLife.18657. PMID: 27852437; PMCID: PMC5158138.
Popham DL, Bernhards CB. Spore Peptidoglycan. Microbiol Spectr. 2015 Dec;3(6). doi: 10.1128/microbiolspec.TBS-0005-2012. PMID: 27337277.
McKenney PT, Driks A, Eichenberger P. The Bacillus subtilis endospore: assembly and functions of the multilayered coat. Nat Rev Microbiol. 2013 Jan;11(1):33-44. doi: 10.1038/nrmicro2921. Epub 2012 Dec 3. PMID: 23202530; PMCID: PMC9910062.
Hosoya S, Lu Z, Ozaki Y, Takeuchi M, Sato T. Cytological analysis of the mother cell death process during sporulation in Bacillus subtilis. J Bacteriol. 2007 Mar;189(6):2561-5. doi: 10.1128/JB.01738-06. Epub 2007 Jan 5. PMID: 17209033; PMCID: PMC1899390.
Eichenberger P, Fujita M, Jensen ST, Conlon EM, Rudner DZ, Wang ST, Ferguson C, Haga K, Sato T, Liu JS, Losick R. The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis. PLoS Biol. 2004 Oct;2(10):e328. doi: 10.1371/journal.pbio.0020328. Epub 2004 Sep 21. PMID: 15383836; PMCID: PMC517825.
Chastanet A, Losick R. Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms. J Bacteriol. 2011 Nov;193(22):6366-74. doi: 10.1128/JB.06057-11. Epub 2011 Sep 23. PMID: 21949067; PMCID: PMC3209201.
Hoch JA. Regulation of the phosphorelay and the initiation of sporulation in Bacillus subtilis. Annu Rev Microbiol. 1993;47:441-65. doi: 10.1146/annurev.mi.47.100193.002301. PMID: 8257105.
LeDeaux JR, Yu N, Grossman AD. Different roles for KinA, KinB, and KinC in the initiation of sporulation in Bacillus subtilis. J Bacteriol. 1995 Feb;177(3):861-3. doi: 10.1128/jb.177.3.861-863.1995. PMID: 7836330; PMCID: PMC176674.
Hahn J, Roggiani M, Dubnau D. The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene. J Bacteriol. 1995 Jun;177(12):3601-5. doi: 10.1128/jb.177.12.3601-3605.1995. PMID: 7768874; PMCID: PMC177070Arigoni F, Duncan L, Alper S, Losick R, Stragier P. SpoIIE governs the phosphorylation state of a protein regulating transcription factor sigma F during sporulation in Bacillus subtilis. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3238-42. doi: 10.1073/pnas.93.8.3238. PMID: 8622920; PMCID: PMC39589.
Yeak KYC, Boekhorst J, Wels M, Abee T, Wells-Bennik MHJ. Prediction and validation of novel SigB regulon members in Bacillus subtilis and regulon structure comparison to Bacillales members. BMC Microbiol. 2023 Jan 18;23(1):17. doi: 10.1186/s12866-022-02700-0. PMID: 36653740; PMCID: PMC9847131.
Imamura D, Zhou R, Feig M, Kroos L. Evidence that the Bacillus subtilis SpoIIGA protein is a novel type of signal-transducing aspartic protease. J Biol Chem. 2008 May 30;283(22):15287-99. doi: 10.1074/jbc.M708962200. Epub 2008 Mar 31. PMID: 18378688; PMCID: PMC2397457.
Illing N, Errington J. Genetic regulation of morphogenesis in Bacillus subtilis: roles of sigma E and sigma F in prespore engulfment. J Bacteriol. 1991 May;173(10):3159-69. doi: 10.1128/jb.173.10.3159-3169.1991. PMID: 1902463; PMCID: PMC207910.
Dong TC, Cutting SM. SpoIVB-mediated cleavage of SpoIVFA could provide the intercellular signal to activate processing of Pro-sigmaK in Bacillus subtilis. Mol Microbiol. 2003 Sep;49(5):1425-34. doi: 10.1046/j.1365-2958.2003.03651.x. PMID: 12940997.
Yu YT, Kroos L. Evidence that SpoIVFB is a novel type of membrane metalloprotease governing intercompartmental communication during Bacillus subtilis sporulation. J Bacteriol. 2000 Jun;182(11):3305-9. doi: 10.1128/JB.182.11.3305-3309.2000. PMID: 10809718; PMCID: PMC94525.
Campo N, Rudner DZ. SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2007 Aug;189(16):6021-7. doi: 10.1128/JB.00399-07. Epub 2007 Jun 8. PMID: 17557826; PMCID: PMC1952037.
Resnekov O, Losick R. Negative regulation of the proteolytic activation of a developmental transcription factor in Bacillus subtilis. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3162-7. doi: 10.1073/pnas.95.6.3162. PMID: 9501233; PMCID: PMC19712.
Nugroho FA, Yamamoto H, Kobayashi Y, Sekiguchi J. Characterization of a new sigma-K-dependent peptidoglycan hydrolase gene that plays a role in Bacillus subtilis mother cell lysis. J Bacteriol. 1999 Oct;181(20):6230-7. doi: 10.1128/JB.181.20.6230-6237.1999. PMID: 10515909; PMCID: PMC103754.


Saturday, 12 April 2025

Health risks that corelate with regular gay sex according to GROK

 Anal sex:

Tissue Damage and Injury: The anal tissue is delicate and lacks the natural lubrication of the vagina, making it prone to tearing or abrasions. Repeated trauma can lead to fissures, hemorrhoids, or chronic pain. Over time, this may weaken the anal sphincter, potentially causing incontinence, though evidence on significant sphincter damage from consensual anal sex is mixed and not conclusive for most people.

Increased STI Risk: Anal sex has a higher risk of transmitting sexually transmitted infections (STIs) like HIV, chlamydia, gonorrhea, and HPV due to the thin rectal lining, which is more susceptible to microtears that allow pathogens to enter the bloodstream. Consistent condom use significantly reduces this risk, but it’s not foolproof. HPV, linked to anal cancer, is a particular concern, especially without vaccination.

Infections: Bacterial infections, such as those from E. coli or other fecal bacteria, can occur if hygiene isn’t prioritized. This includes urinary tract infections or, in rare cases, abscesses. Enemas or improper cleaning methods can also disrupt the rectal environment, increasing infection risk.

Anal Cancer: Long-term anal sex, particularly with HPV exposure, correlates with a higher risk of anal cancer, though this is rare. The risk is higher in populations like MSM (men who have sex with men) due to higher HPV prevalence, but it’s not exclusive to them. Regular screening and HPV vaccination can mitigate this.

Discomfort and Pain: Without proper lubrication or relaxation, regular anal sex can cause chronic discomfort or pain, sometimes leading to psychological aversion or sexual dysfunction. Using adequate water-based or silicone-based lubricants and pacing activities reduces this risk.

 STIs: Oral sex can transmit infections such as herpes (HSV), gonorrhea, chlamydia, syphilis, and human papillomavirus (HPV). HIV transmission is less common but possible, especially if there are cuts, sores, or bleeding gums. HPV is notable for its link to throat and mouth cancers, particularly from high-risk strains.


And oral sex:

Bacterial Infections: Less commonly, bacteria like Treponema pallidum (syphilis) or Neisseria gonorrhoeae (gonorrhea) can infect the throat, sometimes without obvious symptoms.

Oral Health Factors: Pre-existing oral wounds, gum disease, or poor hygiene can increase susceptibility to infections during oral sex.

Other Risks: Rare cases of gastrointestinal infections (e.g., from fecal-oral contact in specific practices) or allergic reactions (e.g., to semen or lubricants) have been noted.

Romans ch.1:27NKJV"Likewise also the [j]men, leaving the natural use of the [k]woman, burned in their lust for one another, men with men committing what is shameful, and receiving in themselves the penalty of their error which was due."


The Persian empire : a brief history.

 

Examining Darwinian hagiography

 Darwin’s Sacred Fiction


On a classic episode of ID the Future, historian of science Michael Keas concludes a two-part conversation with science-and-religion scholar Robert Shedinger about his research into the writing and work of Charles Darwin. 

In this segment, Professor Shedinger makes the case that a well-known biography of Charles Darwin, Darwin’s Sacred Cause, is deeply misleading. Specifically, the book by Adrian Desmond and James Moore holds that Darwin was significantly motivated in his scientific work by abolitionist sentiments. Shedinger says not so fast. He saw no evidence of this thesis in Darwin’s correspondence. Shedinger reports on the pattern that emerged when he tracked down the key citations and re-read the book. The sources the authors cite didn’t actually support their thesis. Some were totally irrelevant. Some were cited completely out of context. In other cases, the authors stitched together multiple correspondences to give the illusion Darwin was saying something he wasn’t. This popular biography of Darwin was trying to make Darwin seem like a saintly abolitionist. Instead, argues Shedinger, it’s closer to historical fiction than the truth. 

While Darwin did have anti-slavery sentiments, it didn’t drive his science and he himself was anything but free from racism. In fact, his case for human evolution partly rested on deeply demeaning racist attitudes toward indigenous peoples. For more on this, see historian Richard Weikart’s book Darwinian Racism.

Also in this episode, Shedinger tells host Michael Keas about how he went from a scholar fully persuaded of Darwinian theory to a skeptic of modern evolutionary theory and attracted to the theory of intelligent design. Shedinger lays out his case against Darwinism in his book The Mystery of Evolutionary Mechanisms.

Download the podcast or listen to it here.

Friday, 11 April 2025

Prussia :a brief history.

 

Theistic Darwinism: attempting to keep ones feet on the ground while having ones head in the clouds?

 On the 70th Anniversary of His Death, Anything to Salute in the Thought of Teilhard de Chardin?


Why should advocates of intelligent design care about a French Jesuit priest who died 70 years ago today, on April 10, 1955? Born in 1881, Pierre Teilhard de Chardin along with being a Jesuit priest was also a geologist and paleontologist who made several trips to China to participate in geological and paleontological work (he was part of the team that discovered Piltdown Man, later revealed to be a hoax). But Teilhard is best known for his book The Phenomenon of Man, published in French in the 1930s and in English in 1955. In this book Teilhard lays out a vision for the evolutionary process that is at odds with the established scientific view but is consistent with his own religious convictions.

A Truncated View

Teilhard argued that the science of his time had a truncated view of evolution. Scientists studied the evolutionary process as if it were a movie playing on a screen in front of them with the scientists themselves as mere passive observers. Teilhard thought that evolution needed to be seen from the inside, viewing humans not only as observers of evolution but also as its products. As such, Teilhard conceived evolution as occurring on four levels, only two of which were acknowledged by establishment scientists. 

The first of these levels he called cosmogenesis, the evolution of the physical universe. The second level he labeled biogenesis, the evolution of life in the physical universe. According to Teilhard, this is where evolutionary biologists had traditionally stopped. But a full accounting of the evolutionary process, he believed, required two additional levels: psychogenesis, the evolution of consciousness in biological organisms, and noogenesis, the evolution of reflective thought, a characteristic unique to humans. With the evolution of humans, Teilhard believed evolution had crossed what he called a “threshold of reflection” that would fundamentally alter the very course of evolution. Rather than a billion-fold trial and error, evolution would now proceed more intentionally through the exercise of the human mind. We should remember that Teilhard formulated these ideas in the 1930s, long before anyone had conceived of the possibility of genetic engineering. Teilhard was prescient

His Most Controversial Idea

Having fully accounted for the evolutionary process, Teilhard went on to articulate his most controversial idea. He argued that over time, human minds would eventually form a web of reflective consciousness enveloping the Earth (what would he think of the Internet?!). He called this the noosphere. In time, the noosphere would reach an omega point where consciousness would completely fuse with the God who created it. Teilhard’s view of evolution was thus highly teleological. The evolutionary process existed for the purpose of creating beings with the ability of reflective thought so that they could commune with their Creator. No Darwinian contingency here!

Not surprisingly, most Darwinians howled with derision at Teilhard. In response to The Phenomenon of Man, Nobel Laureate Peter Medawar published one of the most devastating book reviews ever written. Medawar called Teilhard’s book “nonsense, tricked out with a variety of metaphysical conceits, and its author can be excused of dishonesty only on the grounds that before deceiving others he has taken great pains to deceive himself.” For Medawar, reading Phenomenon brought on feelings of “real distress, even despair.” Despite this, many philosophers and theologians found Teilhard’s book of great interest. But according to arch-Darwinian Daniel Dennett, the esteem in which non-scientists held the book is nothing more than a testimony to their “depth of loathing of Darwin’s dangerous idea, a loathing so great that it will excuse any illogicality and tolerate any opacity in what purports to be an argument.” The Darwinian reaction to Teilhard’s explicit evolutionary theology is of course to be expected. What we don’t expect is to find that this disdain was not shared universally within the Darwinian establishment. 

"Nothing in Biology"

Enter Theodosius Dobzhansky, perhaps the most important figure in the history of evolutionary theory after Darwin. In his often-cited essay “Nothing in Biology Makes Sense Except in the Light of Evolution,” Dobzhansky unexpectedly calls Teilhard “one of the great thinkers of our age.” As a man of deep Christian faith himself, Dobzhansky clearly resonated with Teilhard’s attempt to create a synthesis between evolution and religious thought. In fact, Dobzhansky appears to have been so taken with Teilhard’s work that he served for a year as president of the North American Teilhard Society (1969). Of course, we will never learn from the textbooks that a figure as central to the modern evolutionary synthesis as Dobzhansky seemed to embrace an explicitly teleological and even theological understanding of evolution. I suppose Dobzhansky was deceived (according to Medawar) or prone to illogicality (according to Dennett)!

A Logical Dead End

Ofcourse, neither Teilhard nor Dobzhansky appears to have made an explicit design argument. They would be better categorized as theistic evolutionists. For Dobzhansky this is confirmed when in his previously cited essay he states, “There is, of course, nothing conscious or intentional in the action of natural selection.” Here Dobzhansky adheres to the standard Darwinian story. Yet just a few lines later he notes humans’ ability to make conscious, intentional decisions, and concludes, “This is why the species Homo sapiens is the apex of evolution.” The incompatibility between these two statements seems not to have occurred to Dobzhansky. Clearly, a process with no direction or larger purpose by definition has no apex. His attempt to hold to both an orthodox Darwinian viewpoint and an orthodox Christian viewpoint simultaneously dissolves into incoherence. Theistic evolutionary schemes seem to be a logical dead end. 

While Pierre Teilhard de Chardin may not have been a forerunner of intelligent design thinking per se, the significance of his pointing out the incomplete nature of the evolutionary theory of his day should not be underestimated. As Thomas Nagel would argue today, any theory of evolution that excludes the origin of mind and consciousness from consideration is at best half a theory. Teilhard noticed this weakness of Darwinian evolutionary theory nearly a century ago, and at least one very prominent Darwinian may well have agreed, even if he never admitted it in public.

A real life Jurassic park is just as far away as it was yesterday?

 Dire Wolves Are Still Extinct


The  media are such suckers for hyperbolic biotech stories. Colossal Laboratories & Biosciences made headlines for supposedly having genetically engineered a return of dire wolves that disappeared about 12,500 or so years ago, which many stories claimed to now be “de-extinct” after three gene-edited pups were born

Still a Gray Wolf

Uh, no. The company actually engineered gray wolves to have white fur and (if it works) a larger stature. But despite a similar appearance, gray wolves are not actually close relatives of the extinct species. From the New Scientist story:

Grey wolves and dire wolves were thought to be very closely related based on their physical similarities but a 2021 study of ancient DNA revealed that they last shared a common ancestor around 6 million years ago. Jackals, African wild dogs and dholes are all more closely related to grey wolves (Canis lupus) than dire wolves are, despite their similar appearances.

Beth Shapiro of Colossal says her team has sequenced the complete genome of the dire wolf and will soon release it to the public. Shapiro could not tell New Scientist how many differences there are but said the two species share 99.5 per cent of their DNA. Since the grey wolf genome is around 2.4 billion base pairs long, that still leaves room for millions of base-pairs of difference

The company made just 20 gene edits, with five of those having to do with fur color. That’s still a gray wolf any way you look at it.

So, is this a deception? Let’s call it puffery. The company was careful to acknowledge that the dire wolf is not actually back but that the pups are “functional equivalents.” From the Rolling Stone story:

Shapiro says, people should understand an important detail of the project: It is impossible for the DNA of these new cells to be 100 percent identical to their prehistoric ancestors. “There’s probably millions of differences between gray wolves and dire wolves, and the DNA editing technology is not sufficiently robust that we can make all of those changes simultaneously without causing the cell to melt down,” she says. “Until we can synthesize a whole genome from scratch, we can’t make something that’s 100 percent genetically identical, but it’s also not necessary, because what we’re trying to do is create a functional equivalent of that species that used to be there.”

But “functional equivalent” is not a headline grabber, so much of the media went with the exaggerated version that would get bounteous clicks.

Colossal plans to re-create a woolly mammoth. I suspect that if that happens, it will really be an elephant with good hair.

Thursday, 10 April 2025

Real life symbiotes?

 

Intelligent design 101 part II

 

Intelligent Design 101

 Intelligent Design: A Beginner’s Guide with Casey Luskin


How would you explain intelligent design to someone who has just recently begun looking into it? Perhaps you are new to it yourself, or you have a friend or family member who is curious. On a new episode of ID the Future, Dr. Casey Luskin begins a two-part discussion of the basics of intelligent design with Sam Kleckley, host of the Live Life in Motion podcast. Part 1 presents a nice overview of where and when intelligent design began, how it developed, and why it is such a compelling idea for so many. 

After reviewing the history of the idea, Dr. Luskin jumps into some of the key evidence for intelligent design. He first discusses the complexity of living things by highlighting the concept of irreducible complexity, the idea that many biological features require a core number of parts to function, and if their complexity is reduced at all, they stop working. Luskin explains that such systems could not have arisen through the gradual, step-by-step mechanism of natural selection and random mutation required by modern evolutionary theory. 

Luskin then talks about the fine-tuning of the universe. He points to the Big Bang theory as evidence for an abrupt origin of the universe, which aligns with the idea of a creation event. Modern cosmology, according to Luskin, supports the notion that the universe is finite in age and size, originating from an infinitely dense and small point. Luskin explains the fine-tuning of the laws and constants of physics necessary for a universe where life can exist. He also provides examples of the extreme precision required for some of the finely tuned parameters that govern the universe, including the cosmological constant, the gravitational constant, and the initial entropy of the early universe. The conversation sets the stage for a deeper exploration of the evidence supporting ID in a separate episode.

We are grateful to host Sam Kleckley and the Live Life in Motion podcast for permission to share this interview at ID the Future.

We are also grateful for Tom Gilson, author, editor, and longtime sound engineer for the ID the Future podcast, who passed away in November 2024. Tom edited this particular podcast episode before he got sick and we now have the opportunity to share it. We are thankful for his hard work and dedication to ID the Future over the years. 

Download the podcast or listen to it here. This is Part 1 of a two-part conversation. Look for Part 2 next!

Wednesday, 9 April 2025

The trinity doctrine is its own worst enemy?

 Most American Christians don't believe in the Trinity: Survey


An overwhelming majority of Christians reject the basic Christian teaching of the Trinity, prompting new concerns that Americans are living without the influence of “the truths and life principles of God.” The Cultural Research Center at Arizona Christian University released the latest installment of its American Worldview Inventory series which documents Americans’ views on the Trinity. The research is based on responses collected from 2,100 adults in January. 

Overall, just 40% of respondents believe that God exists and affects people’s lives. That figure rises to 53% among self-identified Christians, 60% among theologically-identified born-again Christians, and 100% among Integrated Disciples. The latter term refers to those who have a biblical worldview. While a majority of those surveyed (59%) believe in the existence of Jesus Christ, a significantly smaller share of adults (29%) believe in the Holy Spirit. Slightly more than 1 in 10 respondents (11%) believe in the Trinity, that the God of the Bible is “three distinct but inseparable and equal persons in one infinite Being.” The persons in the Trinity are God the Father, Jesus Christ and the Holy Spirit.

Belief in the Trinity, characterized by the Cultural Research Center as a “fundamental tenet of Christianity,” increases to 16% among self-identified Christians, 24% among theologically-identified born-again Christians and 62% among Integrated Disciples. “These results are further evidence of the limited or lack of trust Americans have in the Bible, the limitations we place on the authority and influence of God, and our refusal to cooperate with God by living in harmony with His ways and purposes,” said CRC Director of Research George Barna in response to the survey results. “Even the statistics for the groups that are most in-tune with biblical teachings, such as belief in the nature and impact of the Trinity, are shockingly low for a nation in which most people claim to be Christian.”Barna identified “these findings about America’s ignorance or rejection of the Trinity” as “simply another in a long list of examples of people living without the truths and life principles of God shaping their life.”

He lamented, “We know from our national worldview tracking studies that most Americans are uninformed about the many essential biblical teachings, ranging from the Ten Commandments and the Trinity, to matters related to repentance, salvation, the chief purpose of life, and divine measures of success.”

“It could be argued that the primary theologians influencing the spiritual views of America these days are figures such as Tucker Carlson, Joe Rogan, Russell Brand, Jordan Peterson, Megyn Kelly, and Bill Maher” — all influential podcasters and not religious figures.Brand and Peterson have expressed interest in Christianity, with Brand recently getting baptized, while Carlson and Kelly are established Christians and Maher is an outspoken atheist. 

“They mix practical and sometimes unbiblical theology and philosophical points of view into their commentary on life and world events,” Barna said of the podcasters. “Meanwhile, many Christian churches are focused on delivering multi-part series that are not effectively developing or bolstering an integrated, biblical worldview that congregants can rely upon to counteract popular, secular takes on reality.”Barna suggested that no influential cultural figure or church is “devoted to obsessively building a solid theological foundation for the masses,” asking a series of rhetorical questions designed to make the point that American culture is missing the elements needed to ensure a biblically literate population: “Who is committed to ensuring that people grasp the basic theological building blocks of a biblical worldview? Where is the concern or anguish over the near universal rejection of numerous central biblical teachings?”

“Is the Church of God devoted to know Him and making Him know, or has it been seduced by the distractions and distortions of our culture?” he inquired

Artificial intelligence will remain forever artificial? II

 A Needed Protest Against “AI Slop” and AI “Word Vomit”


God bless our Center for Science and Culture colleague Peter Biles for a harsh yet at the same time soulful takedown of “AI slop” and artificial intelligence-generated “word vomit.” At Mind Matters News, Peter notes:

“The phrase ‘AI slop’ is circling the headlines daily at this point and is becoming almost a cliché given how much it’s used. But it’s a good way to encapsulate the reality.”
“For some odd but perseverant reason, so many leaders feel it necessary to incorporate AI into their businesses, apparently because it is so ‘innovative,’ and anything innovative and new needs to be embraced. This is a prevailing philosophy among the techno-optimistic. Never mind AI makes mistake, doesn’t understand its own word vomit, and threatens the hard-earned livelihood of real writers everywhere.”
“The easy ability to generate nonsense on command means foregoing the possibility of any meaningful artistic or cultural renaissance.”
“[Ted] Gioia…mentions how real photographs are starting to resemble AI slop. These soulless data-churning machines are spitting out nonsense so pervasively that they’re beginning to shape the way we actually see the world.”
“I recently attended a creative writing festival hosted by the local university where some seventy poets and fiction writers read their work aloud to live audiences. It was a rich time of literature and newfound friendships. And best of all, the work we heard from was written by and for other people.”

East of Java

Sometimes AI errors are amusing. One of my kids in high school tried using ChatGPT to put together a résumé for a summer position and it decided unaccountably to credit him with being “proficient in Javanese,” as in the language of the Indonesian island of Java. (I believe Krakatoa is east of there.) That will be a family in-joke for years to come.

Peter is right that the aesthetics of AI will never match that of humans, nor will the experience of interacting with AI ever do so. There’s a recognizable feel to AI “writing” and a look to AI “art.” They will not age well. There’s no soul in it and there never could be, no matter how sophisticated the algorithm.

Microsoft’s “Copilot”

The other day, I was horrified to listen to a long and very dumb and credulous interview on NPR with the guy behind Microsoft’s “Copilot,” which is supposed to be your AI best friend, life coach, and personal assistant all in one. I would pay not to get anywhere near such a thing.

Two email correspondents recently suggested to me using AI here at the Center for Science and Culture. One thought it could generate podcasts, replacing human podcasters, and he did not see that at all as a nightmare scenario. The other thought it could generate articles and books. I have seen the results of that, and word vomit is exactly the right phrase for it. My inner response was God forbid, and over my dead body.

It’s all another lesson in human exceptionalism, as I trust most of us will come to realize before long about our mindless machines. I believe we will wake up from the AI delusion someday.

I take the opportunity here, by the way, to note that the idea that life, with its biological information, is not a machine is the theme of my upcoming book about the thought of evolutionary biologist Richard Sternberg, Plato’s Revenge: The New Science of the Immaterial Genome. It will be out on April 28 and can be pre-ordered now.

Let God be found true.

 

 When Was Ancient Jerusalem Destroyed?—Part One

Why It Matters; What the Evidence Shows 


This is the first of two articles in consecutive issues of The Watchtower that discuss scholarly questions surrounding the date of the destruction of ancient Jerusalem. This two-part series presents thoroughly researched and Bible-based answers to questions that have puzzled some readers.

“According to historians and archaeologists, 586 or 587 B.C.E. is generally accepted as the year of Jerusalem’s destruction.*Why do Jehovah’s Witnesses say that it was 607 B.C.E.? What is your basis for this date?”

SO WROTE one of our readers. But why be interested in the actual date when Babylonian King Nebuchadnezzar II razed the city of Jerusalem? First, because the event marked an important turning point in the history of God’s people. One historian said that it led to “a catastrophe, indeed the ultimate catastrophe.” The date marked the end of a temple that had been at the heart of the worship of Almighty God for more than 400 years. “O God,” lamented a Bible psalmist, “they have dishonored your holy temple. They have left Jerusalem in ruins.”—Psalm 79:1, God’s Word Bible.*

Second, because knowing the actual year when this “ultimate catastrophe” began and understanding how the restoration of true worship in Jerusalem fulfilled a precise Bible prophecy will build your confidence in the reliability of God’s Word. So why do Jehovah’s Witnesses hold to a date that differs from widely accepted chronology by 20 years? In short, because of evidence within the Bible itself.

“Seventy Years” for Whom?

Years before the destruction, the Jewish prophet Jeremiah provided an essential clue to the time frame given in the Bible. He warned “all those living in Jerusalem,” saying: “This whole country will become a desolate wasteland, and these nations will serve the king of Babylon seventy years.” (Jeremiah 25:1, 2, 11, New International Version) The prophet later added: “This is what Jehovah has said, ‘In accord with the fulfilling of seventy years at Babylon I shall turn my attention to you people, and I will establish toward you my good word in bringing you back to this place.’” (Jeremiah 29:10) What is the significance of the “seventy years”? And how does this time period help us to determine the date of Jerusalem’s destruction?

Instead of saying 70 years “at Babylon,” many translations read “for Babylon.” (NIV) Some historians therefore claim that this 70-year period applies to the Babylonian Empire. According to secular chronology, the Babylonians dominated the land of ancient Judah and Jerusalem for some 70 years, from about 609 B.C.E. until 539 B.C.E. when the capital city of Babylon was captured.

The Bible, however, shows that the 70 years were to be a period of severe punishment from God—aimed specifically at the people of Judah and Jerusalem, who were in a covenant to obey him. (Exodus 19:3-6) When they refused to turn from their bad ways, God said: “I will summon . . . Nebuchadnezzar king of Babylon . . . against this land and its inhabitants and against all the surrounding nations.” (Jeremiah 25:4, 5, 8, 9, NIV) While nearby nations would also suffer Babylon’s wrath, the destruction of Jerusalem and the 70-year exile to follow were called by Jeremiah “the punishment of my people,” for Jerusalem had “sinned greatly.”—Lamentations 1:8; 3:42; 4:6, NIV.

So according to the Bible, the 70 years was a period of bitter punishment for Judah, and God used the Babylonians as the instrument for inflicting this severe chastisement. Yet, God told the Jews: “When seventy years are completed, . . . I will . . . bring you back to this place”—the land of Judah and Jerusalem.—Jeremiah 29:10, NIV.

When Did “the Seventy Years” Start?

The inspired historian Ezra, who lived after the 70 years of Jeremiah’s prophecy were fulfilled, wrote of King Nebuchadnezzar: “He carried into exile to Babylon the remnant, who escaped from the sword, and they became servants to him and his sons until the kingdom of Persia came to power. The land enjoyed its sabbath rests; all the time of its desolation it rested, until the seventy years were completed in fulfillment of the word of the LORD spoken by Jeremiah.”—2 Chronicles 36:20, 21, NIV.

Thus, the 70 years were to be a period when the land of Judah and Jerusalem would enjoy “sabbath rests.” This meant that the land would not be cultivated—there would be no sowing of seed or pruning of vineyards. (Leviticus 25:1-5, NIV) Because of the disobedience of God’s people, whose sins may have included a failure to observe all the Sabbath years, the punishment was that their land would remain unworked and deserted for 70 years.—Leviticus 26:27, 32-35, 42, 43.

When did the land of Judah become desolated and unworked? Actually, the Babylonians under Nebuchadnezzar attacked Jerusalem twice, years apart. When did the 70 years commence? Certainly not following the first time that Nebuchadnezzar laid siege to Jerusalem. Why not? Although at that time Nebuchadnezzar took many captives from Jerusalem to Babylon, he left others behind in the land. He also left the city itself standing. For years after this initial deportation, those left remaining in Judah, “the lowly class of the people,” lived off their land. (2 Kings 24:8-17) But then things drastically changed.

A Jewish revolt brought the Babylonians back to Jerusalem. (2 Kings 24:20; 25:8-10) They razed the city, including its sacred temple, and they took many of its inhabitants captive to Babylon. Within two months, “all the people [who had been left behind in the land] from the least to the greatest, together with the army officers, fled to Egypt for fear of the Babylonians.” (2 Kings 25:25, 26, NIV) Only then, in the seventh Jewish month, Tishri (September/October), of that year could it be said that the land, now desolate and unworked, began to enjoy its Sabbath rest. To the Jewish refugees in Egypt, God said through Jeremiah: “You have seen all the disaster that I brought upon Jerusalem and upon all the cities of Judah. Behold, this day they are a desolation, and no one dwells in them.” (Jeremiah 44:1, 2, English Standard Version) So this event evidently marked the starting point of the 70 years. And what year was that? To answer, we need to see when that period ended.

When Did “the Seventy Years” End?

The prophet Daniel, who lived until “the kingdom of Persia came to power,” was on the scene in Babylon, and he calculated when the 70 years were due to end. He wrote: “I, Daniel, perceived in the books the number of years that, according to the word of the LORD to Jeremiah the prophet, must pass before the end of the desolations of Jerusalem, namely, seventy years.”—Daniel 9:1, 2, ESV.

Ezra reflected on the prophecies of Jeremiah and linked the end of “the seventy years” to the time when “the LORD moved the heart of Cyrus king of Persia to make a proclamation.” (2 Chronicles 36:21, 22, NIV) When were the Jews released? The decree ending their exile was issued in “the first year of Cyrus the king of Persia.” (See the box “A Pivotal Date in History.”) Thus, by the fall of 537 B.C.E., the Jews had returned to Jerusalem to restore true worship.—Ezra 1:1-5; 2:1; 3:1-5.

According to Bible chronology, then, the 70 years was a literal period of time that ended in 537 B.C.E. Counting back 70 years, the start date of the period would be 607 B.C.E.

But if the evidence from the inspired Scriptures clearly points to 607 B.C.E. for Jerusalem’s destruction, why do many authorities hold to the date 587 B.C.E.? They lean on two sources of information—the writings of classical historians and the canon of Ptolemy. Are these sources more reliable than the Scriptures? Let us see.

Classical Historians—How Accurate?

Historians who lived close to the time when Jerusalem was destroyed give mixed information about the Neo-Babylonian kings.* (See the box “Neo-Babylonian Kings.”) The time line based on their chronological information disagrees with that of the Bible. But just how reliable are their writings?

One of the historians who lived closest to the Neo-Babylonian period was Berossus, a Babylonian “priest of Bel.” His original work, the Babyloniaca,written about 281 B.C.E., has been lost, and only fragments are preserved in the works of other historians. Berossus claimed that he used “books which had been preserved with great care at Babylon.”1 Was Berossus really an accurate historian? Consider one example.

Berossus wrote that Assyrian King Sennacherib followed “the reign of [his] brother”; and “after him his son [Esarhaddon ruled for] 8 years; and thereafter Sammuges [Shamash-shuma-ukin] 21 years.” (III, 2.1, 4) However, Babylonian historical documents written long before Berossus’ time say that Sennacherib followed his father, Sargon II, not his brother, to the throne; Esarhaddon ruled for 12 years, not 8; and Shamash-shuma-ukin ruled for 20 years, not 21. Scholar R. J. van der Spek, while acknowledging that Berossus consulted the Babylonian chronicles, wrote: “This did not prevent him from making his own additions and interpretations.”2

How do other scholars view Berossus? “In the past Berossus has usually been viewed as a historian,” states S. M. Burstein, who made a thorough study of Berossus’ works. Yet, he concluded: “Considered as such his performance must be pronounced inadequate. Even in its present fragmentary state the Babyloniaca contains a number of surprising errors of simple fact . . . In a historian such flaws would be damning, but then Berossus’ purpose was not historical.”3

In view of the foregoing, what do you think? Should Berossus’ calculations really be viewed as consistently accurate? And what about the other classical historians who, for the most part, based their chronology on the writings of Berossus? Can their historical conclusions really be called reliable?

The Canon of Ptolemy

The Royal Canon of Claudius Ptolemy, a second-century C.E. astronomer, is also used to support the traditional date 587 B.C.E. Ptolemy’s list of kings is considered the backbone of the chronology of ancient history, including the Neo-Babylonian period.

Ptolemy compiled his list some 600 years after the Neo-Babylonian period ended. So how did he determine the date when the first king on his list began to reign? Ptolemy explained that by using astronomical calculations based in part on eclipses, “we have derived to compute back to the beginning of the reign of Nabonassar,” the first king on his list.4 Thus, Christopher Walker of the British Museum says that Ptolemy’s canon was “an artificial scheme designed to provide astronomers with a consistent chronology” and was “not to provide historians with a precise record of the accession and death of kings.”5

“It has long been known that the Canon is astronomically reliable,” writes Leo Depuydt, one of Ptolemy’s most enthusiastic defenders, “but this does not automatically mean that it is historically dependable.” Regarding this list of kings, Professor Depuydt adds: “As regards the earlier rulers [who included the Neo-Babylonian kings], the Canon would need to be compared with the cuneiform record on a reign by reign basis.”6

What is this “cuneiform record” that enables us to measure the historical accuracy of Ptolemy’s canon? It includes the Babylonian chronicles, lists of kings, and economic tablets—cuneiform documents written by scribes who lived during, or near, Neo-Babylonian times.7

How does Ptolemy’s list compare with that cuneiform record? The box“How Does Ptolemy’s Canon Compare With Ancient Tablets?” (see below) shows a portion of the canon and compares this with an ancient cuneiform document. Notice that Ptolemy lists only four kings between the Babylonian rulers Kandalanu and Nabonidus. However, the Uruk King List—a part of the cuneiform record—reveals that seven kings ruled in between. Were their reigns brief and negligible? One of them, according to cuneiform economic tablets, ruled for seven years.8

There is also strong evidence from cuneiform documents that prior to the reign of Nabopolassar (the first king of the Neo-Babylonian period), another king (Ashur-etel-ilani) ruled for four years in Babylonia. Also, for more than a year, there was no king in the land.9 Yet, all of this is left out of Ptolemy’s canon.

Why did Ptolemy omit some rulers? Evidently, he did not consider them to be legitimate rulers of Babylon.10 For example, he excluded Labashi-Marduk, a Neo-Babylonian king. But according to cuneiform documents, the kings whom Ptolemy omitted actually ruled over Babylonia.

In general, Ptolemy’s canon is regarded as accurate. But in view of its omissions, should it really be used to provide a definite historical chronology?

The Conclusion Based on This Evidence
To sum up: The Bible clearly states that there was an exile of 70 years. There is strong evidence—and most scholars agree—that the Jewish exiles were back in their homeland by 537 B.C.E. Counting back from that year would place Jerusalem’s destruction in 607 B.C.E. Though the classical historians and the canon of Ptolemy disagree with this date, valid questions can be raised about the accuracy of their writings. Really, those two lines of evidence hardly provide enough proof to overturn the Bible’s chronology.

However, further questions remain. Is there really no historical evidence to support the Bible-based date of 607 B.C.E.? What evidence is revealed by datable cuneiform documents, many of which were written by ancient eyewitnesses? We will consider these questions in our next issue.

Footnote 

A PIVOTAL DATE IN HISTORY

The date 539 B.C.E. when Cyrus II conquered Babylon is calculated using the testimony of:

▪ Ancient historical sources and cuneiform tablets: Diodorus of Sicily (c. 80-20 B.C.E.) wrote that Cyrus became king of Persia in “the opening year of the Fifty-fifth Olympiad.” (Historical Library, Book IX, 21) That year was 560 B.C.E. The Greek historian Herodotus (c. 485-425 B.C.E.) stated that Cyrus was killed “after he had reigned twenty-nine years,” which would put his death during his 30th year, in 530 B.C.E. (Histories, Book I, Clio, 214) Cuneiform tablets show that Cyrus ruled Babylon for nine years before his death. Thus, nine years prior to his death in 530 B.C.E. takes us back to 539 B.C.E. as the year Cyrus conquered Babylon.

Confirmation by a cuneiform tablet: A Babylonian astronomical clay tablet (BM 33066) confirms the date of Cyrus’ death in 530 B.C.E. Though this tablet contains some errors regarding the astronomical positions, it contains the descriptions of two lunar eclipses that the tablet says occurred in the seventh year of Cambyses II, the son and successor of Cyrus. These are identified with lunar eclipses visible at Babylon on July 16, 523 B.C.E., and on January 10, 522 B.C.E., thus pointing to the spring of 523 B.C.E. as the beginning of Cambyses’ seventh year. That would make his first regnal year 529 B.C.E. So Cyrus’ last year would have been 530 B.C.E., making 539 B.C.E. his first year of ruling Babylon.