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Sunday, 5 November 2023
Phillipians chapter 3 verses 1 through 9 New international Version.
1Further, my brothers and sisters, rejoice in the Lord! It is no trouble for me to write the same things to you again, and it is a safeguard for you. 2Watch out for those dogs, those evildoers, those mutilators of the flesh. 3For it is we who are the circumcision, we who serve GOD by his Spirit, who boast in Christ Jesus, and who put no confidence in the flesh— 4though I myself have reasons for such confidence.
If someone else thinks they have reasons to put confidence in the flesh, I have more: 5circumcised on the eighth day, of the people of Israel, of the tribe of Benjamin, a Hebrew of Hebrews; in regard to the law, a Pharisee; 6as for zeal, persecuting the church; as for righteousness based on the law, faultless.
7But whatever were gains to me I now consider loss for the sake of Christ. 8What is more, I consider everything a loss because of the surpassing worth of knowing Christ Jesus my Lord, for whose sake I have lost all things. I consider them garbage, that I may gain Christ 9and be found in him, not having a righteousness of my own that comes from the law, but that which is through faith in a Christ—the righteousness that comes from GOD on the basis of faith.
The idolising of necessity and chance is the real science stopper?
The Best and Worst Heuristics for Biological Discovery
The bad news first. What’s the worst possible heuristic for making biological discoveries?
We don’t know what this structure does, so it probably does nothing. Remember, evolution produces a lot of non-functional debris.
What’s the best heuristic?
We don’t know what this does. Let’s find out.
Here’s a case in point at Cell. It’s open access and incredibly cool and interesting:
“Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices”
According to the Summary section:
Mammalian oocytes are filled with poorly understood structures called cytoplasmic lattices. First discovered in the 1960s and speculated to correspond to mammalian yolk, ribosomal arrays, or intermediate filaments, their function has remained enigmatic to date. Here, we show that cytoplasmic lattices are sites where oocytes store essential proteins for early embryonic development. Using super-resolution light microscopy and cryoelectron tomography, we show that cytoplasmic lattices are composed of filaments with a high surface area, which contain PADI6 and subcortical maternal complex proteins. The lattices associate with many proteins critical for embryonic development, including proteins that control epigenetic reprogramming of the preimplantation embryo. Loss of cytoplasmic lattices by knocking out PADI6 or the subcortical maternal complex prevents the accumulation of these proteins and results in early embryonic arrest. Our work suggests that cytoplasmic lattices enrich maternally provided proteins to prevent their premature degradation and cellular activity, thereby enabling early mammalian development.
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