Stalinism redux? III

Russia’s Supreme Court Ruling Has Negative Impact on Jehovah’s Witnesses

Russia’s Supreme Court decision of April 20, 2017, is having a severe nationwide impact on Jehovah’s Witnesses. Authorities are violating the Witnesses’ fundamental freedoms and criminalizing their religious activities. At the same time, some Russian citizens interpret the decision as a license to discriminate against the Witnesses and even to subject them to hate crimes.

Russian Government Abuses and Restrictions on Human Rights

Criminal Charges Against Ministers of Jehovah’s Witnesses

On May 25, police raided the religious services of the Oryol Congregation of Jehovah’s Witnesses. The police arrested Dennis Christensen, a Danish citizen and an elder of the Oryol Congregation. Mr. Christensen is being held in pretrial detention until July 23 while the prosecutor attempts to build a case against him for “extremist activity.” If convicted, Mr. Christensen could be sentenced to a six-to-ten-year prison term.

Official Warnings Issued to Local Religious Organizations

On May 4, the prosecutor’s office issued a warning to the chairman of the Krymsk Local Religious Organization (LRO). The warning stated that the chairman and the members of the LRO can be subject to administrative and criminal liability for holding religious services.

Since the Supreme Court ruling, at least five other LROs have received similar warnings.

Police Raids on Religious Services

On April 22, police entered the Witnesses’ house of worship in Dzhankoy, Republic of Crimea, as religious services were concluding. The officers insisted that after the Supreme Court decision, the Witnesses had no right to meet together for worship. They searched the building and then sealed it to prevent its use for religious meetings.

Since the Supreme Court decision, there have been at least five other instances where police interrupted religious services of the Witnesses, one of which was held in a private home.

“I’m deeply concerned by this unwarranted criminalization of the peaceful activities of members of the Jehovah’s Witnesses communities in Russia. . . . I urge the Russian authorities to ensure that rights to freedom of religion or belief, freedom of opinion and expression, freedom of peaceful assembly and association of individuals belonging to the Jehovah’s Witnesses community are upheld, in compliance with the obligations of the country under international human rights law and OSCE [Organization for Security and Cooperation in Europe] commitments.”—Michael Georg Link, Director of the OSCE Office for Democratic Institutions and Human Rights.

Witness Schoolchildren Targeted

On April 24, in the village of Bezvodnoye, Kirov Region, a teacher humiliated two young students whose mother is one of Jehovah’s Witnesses. The teacher justified her actions by stating that the Witnesses are banned in Russia.

On May 17, in the Moscow Region, a school principal issued a written warning to the parents of an eight-year-old student who had spoken about God to a classmate. The document referred to the Supreme Court decision and prohibited on school grounds “all actions that do not relate to the educational process.” The principal threatened to report the matter to the police and “to raise the issue of transferring the child to another form of training.”

Witness Men Denied Alternative Civilian Service

On April 28, the Conscription Commission of the Cheboksary and Marposadskiy regions rejected the application of one of Jehovah’s Witnesses for alternative service. The Commission stated that Jehovah’s Witnesses are “extremist” and cannot be granted alternative service.

At least two other male Witnesses similarly had their applications for alternative civilian service denied.

Philip Brumley, general counsel for Jehovah’s Witnesses, noted the contradiction in the government’s stance: “On the one hand, the government refuses alternative civilian service to young Witnesses because they are ‘extremists,’ while on the other hand, it demands that these ‘extremists’ be inducted into the army. Does it make sense that the government would allow ‘extremists’ to be in the army?”

Societal Abuses and Discrimination

Acts of Violence Against Witnesses

On April 30, in Lutsino, Moscow Region, the home of a Witness family was burned to the ground, along with the adjoining home of their elderly parents. The arsonist had first expressed his hatred for the family’s religion and then started the fire.

On May 24, in Zheshart, Komi Republic, arsonists caused significant damage to a building used by Jehovah’s Witnesses for religious services.

Kingdom Hall in Zheshart damaged by arson

At least nine other houses of worship have been vandalized since the Supreme Court decision of April 20, 2017.

On April 26, one of Jehovah’s Witnesses in Belgorod was leaving his home when an attacker yelled, “You have been banned!” and then he beat the Witness.

On May 11, a group of men interrupted the religious services of Jehovah’s Witnesses in Tyumen and, using obscene and insulting language, threatened to harm the attendees.

Witnesses Dismissed From Employment

On May 15, the management of a chemical factory in Dorogobuzh, Smolensk Region, dismissed all of its employees who are Jehovah’s Witnesses. The management explained that they had received an order from the FSB to dismiss all of the Witnesses because “extremists” cannot work at the factory.

In at least three other incidents since the Supreme Court decision, Witness employees have been threatened with dismissal because they belong to an “extremist” religion. In the village of Yashkino, Kemerovo Region, the police pressured one Witness, but she refused to divulge information on other Witnesses. The officers said that it was unlawful to be a member of a banned religion and likened Jehovah’s Witnesses to ISIS terrorists.

Concern for the Welfare of Jehovah’s Witnesses in Russia

In the ten years leading up to the Supreme Court decision, Jehovah’s Witnesses in Russia were  victims of a government-sponsored attack against their religious freedom that subjected them to much harassment. Now in the aftermath of the decision, their security is even less certain. The decision vilifies the Witnesses and has emboldened some individuals and government officials to inflict further harm, as exemplified by these recent incidents. Jehovah’s Witnesses worldwide are greatly concerned about what will happen to their fellow Witnesses in Russia if the Appellate Chamber of the Supreme Court upholds the decision when it considers the case on July 17, 2017.

Mr. Brumley stated: “No one has presented any evidence that even remotely links Jehovah’s Witnesses with extremism. The alleged danger that the Witnesses are accused of posing to society is in no way commensurate with the persecution they have already endured. Russia needs to rethink its actions against Jehovah’s Witnesses in light of its constitution and its international agreements that guarantee religious freedom.”

Ragnarok for the RNA world?

As a Solution to the Origin of Life, RNA World Model Comes Under Attack

According to a recent article at New Scientist, "Why 'RNA world' theory on origin of life may be wrong after all," the RNA world model of the origin of life is under attack:

Life has a chicken-and-egg problem: enzymes are needed to make nucleic acids -- the genetic material -- but to build them you need the genetic information contained in nucleic acids. So most researchers assume that the earliest life, long before the evolution of cells, consisted of RNA molecules. These contain genetic information but can also fold into complex shapes, so could serve as enzymes to help make more RNA in their own image -- enabling Darwinian evolution on a molecular level.

At some point, the idea goes, this RNA world ended when life outsourced enzymatic functions to proteins, which are more versatile. The key step in this switch was the evolution of the ribosome, a structure that builds protein molecules from genetic blueprints held in RNA.

But such a transition would require abandoning the enzymatic functions of RNA and reinventing them in proteins. "That is not a simple model," says Loren Williams, a biochemist at the Georgia Institute of Technology in Atlanta.

That's a reasonable point at the end of the quote: If a self-replicating system has all of the enzymatic functions it needs from RNAs (something that hasn't been demonstrated), then rebuilding that system using an entirely different type of molecule (proteins) would be an extremely difficult task and highly unlikely. Yet this is essentially precisely what the classical RNA world model requires.

But there are many other criticisms of the RNA world model. A 2012 paper inBiology Direct by biochemist Harold S Bernhardt keenly titled, "The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)," notes that "the following objections have been raised to the RNA world hypothesis":

(i) RNA is too complex a molecule to have arisen prebiotically; (ii) RNA is inherently unstable; (iii) catalysis is a relatively rare property of long RNA sequences only; and (iv) the catalytic repertoire of RNA is too limited.

Now the author himself accepts the view that the RNA world is the best materialistic model for the origin of life. But he's very frank about its problems. For example, regarding the objection that "RNA is too complex a molecule to have arisen prebiotically," he writes:

RNA is an extremely complex molecule, with four different nitrogen-containing heterocycles hanging off a back-bone of alternating phosphate and D-ribose groups joined by 3',5' linkages. Although there are a number of problems with its prebiotic synthesis, there are a few indications that these may not be insurmountable. Following on from the earlier work of Sanchez and Orgel, Powner, Sutherland and colleagues have published a pathway for the synthesis of pyrimidine nucleotides utilizing plausibly prebiotic precursor molecules, albeit with the necessity of their timed delivery (this requirement for timed delivery has been criticized by Benner and colleagues, although most origin of life models invoke a succession of changing conditions, dealing as they do with the evolution of chemical systems over time; what is critical is the plausibility of the changes).

We covered the research of Powner and Sutherland here and here, pointing out that it was carefully designed to yield the desired results and noting how the goal-directed nature of the experiment undermines claims of the model's plausibility under unguided natural conditions. Hence the criticism that it has an unlikely "requirement for timed delivery."

Bernhardt then moves on to another criticism:

RNA is often considered too unstable to have accumulated in the prebiotic environment. RNA is particularly labile at moderate to high temperatures, and thus a number of groups have proposed the RNA world may have evolved on ice, possibly in the eutectic phase (a liquid phase within the ice solid).

But there's a major problem with the "cold" origin of life hypothesis: at low temperatures, reactions become so slow that nothing interesting ever happens. That's going to be a problem for many types of organic chemistry necessary for the origin of life. This is an especially significant problem when one considers that life appeared on earth very rapidly after conditions became favorable:

"...we have now what we believe is strong evidence for life on Earth 3,800 thousand million years [ago]. This brings the theory for the Origin of Life on Earth down to a very narrow range ... we are now thinking, in geochemical terms, of instant life..." (C. Ponnamperuma,Evolution from Space 1981.)

"[W]e are left with very little time between the development of suitable conditions for life on the earth's surface and the origin of life. Life is not a complex accident that required immense time to convert the vastly improbable into the nearly certain. Instead, life, for all its intricacy, probably arose rapidly about as soon as it could." (Stephen Jay Gould, "An Early Start," Natural History, February, 1978.)

A cold origin of life makes it much more difficult for life to arise under such a short timescale. Moreover, the notion that the early earth was cold rather than hot flies in the face of everything geologists have ever said about the conditions on the early earth.

Next, Bernhardt notes that "Catalysis is a relatively rare property of long RNA sequences only," and he offers a nice discussion of the gross improbability of randomly producing a long, self-replicating RNA molecule:

The RNA world hypothesis has been criticized because of the belief that long RNA sequences are needed for catalytic activity, and for the enormous numbers of andomized sequences required to isolate catalytic and binding functions using in vitro selection. For example, the best ribozyme replicase created so far -- able to replicate an impressive 95-nucleotide stretch of RNA -- is ~190 nucleotides in length, far too long a sequence to have arisen through any conceivable process of random assembly. And typically 10,000,000,000,000-1,000,000,000,000,000 randomized RNA molecules are required as a starting point for the isolation of ribozymic and/or binding activity in in vitro selection experiments, completely divorced from the probable prebiotic situation. As Charles Carter, in a published review of our recent paper inBiology Direct, puts it:

"I, for one, have never subscribed to this view of the origin of life, and I am by no means alone. The RNA world hypothesis is driven almost entirely by the flow of data from very high technology combinatorial libraries, whose relationship to the prebiotic world is anything but worthy of "unanimous support". There are several serious problems associated with it, and I view it as little more than a popular fantasy" (reviewer's report in [5]).

1014 - 1016 is an awful lot of RNA molecules.

Don't miss what's being said here: the argument directly parallels ID proponents who observe that it's extremely unlikely for an RNA molecule with just the right nucleotide sequence needed for self-replication to arise by chance. In other words, he's making the information sequence challenge to the origin of life.

Now Bernhardt proposes that perhaps the first self-replicating RNA was much shorter, reducing the probabilistic obstacles to randomly generating the right nucleotide sequence. But the evidence that this is actually possible is non-existent. Indeed, one of the reviewers, Eugene Koonin, points out that such a self-replicating RNA -- whether long or short -- has yet to be demonstrated:

I basically agree with Bernhardt. The RNA World scenario is bad as a scientific hypothesis: it is hardly falsifiable and is extremely difficult to verify due to a great number of holes in the most important parts. To wit, no one has achieved bona fide self-replication of RNA which is the cornerstone of the RNA World.

Finally, Bernhardt explains a fourth problem with the RNA world model, namely "The catalytic repertoire of RNA is too limited":

It has been suggested that the probable metabolic requirements of an RNA world would have exceeded the catalytic capacity of RNA. The majority of naturally occurring ribozymes catalyze phosphoryl transfer reactions -- the making and breaking of RNA phosphodiester bonds. Although the most efficient of these ribozymes catalyze the reaction at a comparable rate to protein enzymes -- and in vitro selection has isolated ribozymes with a far wider range of catalytic abilities -- the estimate of proteins being one million times fitter than RNA as catalysts seems reasonable, presumably due to proteins being composed of 22 chemically rather different amino acids as opposed to the 4 very similar nucleotides of RNA.

While Bernhardt discusses the various kinds of reactions that RNA can catalyze, he admits "RNAs are, in most cases, worse catalysts than proteins." That sounds like Bernhardt just conceded the validity of the criticism that he described against the RNA world. Somehow, however, he manages to spin the inferiority of RNA catalysis, turning it into not a knock against the RNA world, but an argument for it: "This [the inferior catalytic abilities of RNA] implies that their [RNA's] presence in modern biological systems can best be explained by their being remnants of an earlier stage of evolution, which were too embedded in biological systems to allow replacement easily."

So RNA is used by living organisms -- despite its inferior catalytic abilities -- only because evolution wasn't able to replace it? But aren't we constantly told how proteins can evolve to accommodate virtually any need of an organism? Doesn't this suggest severe limits to the evolvability of proteins? Now it seems that limits to evolution have become an argument forevolution.

This tortured logic brings us back to the criticism raised in the recent New Scientist article: the RNA world model is unlikely to be correct because it requires that proteins (with superior chemistry-catalyzing abilities) somehow swooped in and replaced what RNA was doing. That seems very unlikely. But Bernhardt again tries to spin this dilemma into an argument for the RNA world -- that difficulties replacing RNA with protein point to the fact that RNA was once a precursor of life. However, if it's so hard to replace RNA with proteins, how do we know that it happened in all the other cases required by the RNA world model?

It seems that whether proteins did or did not replace RNA, we're being told that in either case that's evidence for the RNA world. No wonder Eugene Koonin called the model "unfalsifiable."

So why does anyone prefer the RNA world model, given all its problems? Koonin provides the answer in his reviewer's comments at the end of Bernhardt's article -- it's because he requires some materialistic model, and other materialistic models clearly won't explain the origin of replication:

[T]he RNA World appears to be an outright logical inevitability. 'Something' had to start efficiently replicating to kick off evolution, and proteins do not have this ability.

Koonin's argument thus goes like this: We know that unguided evolution is true, so some evolutionary model must be correct. If other unguided models of life's origins won't work, then the RNA world must be correct, because "something" had to happen to get life started.

But what if the RNA world itself has many problems and so it isn't a viable solution? That's not an option Koonin seems willing to consider. He's right that "something" has to get life started. But there is a third way that Koonin hasn't considered. That third way -- the "something" he won't consider -- is the only known cause that can generate the kind of highly complex and specified digital sequences required at the origin of life: intelligent design.

Tree of the undead ?

Zombie Science: Jonathan Wells on Overselling Darwin’s Tree of Life
David Klinghoffer | @d_klinghoffer

There’s no denying the sly brilliance of the evolutionary Tree of Life, memorialized in Darwin’s Origin by the only illustration in that famous book. In its own origin, of course, the Tree of Life is a sacred and mysterious image from the Book of Genesis. Evolutionary theory takes it and twists into the symbol of an idea, universal common ancestry, that collides heads on with the simplest reading of the Genesis creation account. Take that, creationists!

All of life may be related as Darwin hypothesized, or it may not. Certainly, though, the science behind the evolutionary tree of life has been vastly oversold. Author of  Zombie Science: More Icons of Evolution,  biologist Jonathan Wells explains in a new video conversation why that is so.

With his own sly humor, Dr. Wells points out some scientific problems with regarding Darwin’s Tree as unassailable fact. There can be only one “true tree,” yet fossil, molecular, and other data fail to resolve into any such thing. At the time of the publication of Dr. Wells’s 2000 book, Icons of Evolution, many scientists still hoped that this situation would resolve itself. It hasn’t. Seventeen years later, inferences from available data are even more confusing. There is still no realistic prospect of a “true tree” emerging.

Meanwhile, increasing awareness of orphan genes, genes without parallels from one taxon to another, collide head on with evolutionary expectations. Researchers proposing their own “trees” are compelled to cherry-pick, simply ignoring the inconvenient yet widespread orphans.

It looks more and more like the true tree is an illusion. “The reason we get a tree,” in the first place, says Dr. Wells, “is only because we assume at the outset that it’s there.” Meanwhile, year after year, Darwin’s apologists persuade the public, including school kids, that all is well and scientists are homing in on the one and only tree. This is zombie science in its purest, most staggering, shuffling form.

Ancient nanotech v. Darwin

Cell Machines Maintain the Planet for Life
Evolution News | @DiscoveryCSC

Count the mentions of the word “machines” in this news from the University of Liverpool:

“Nanotechnology reveals hidden depths of bacterial ‘machines’…”

“New research from the University of Liverpool, published in the journal  Nanoscale has probed the structure and material properties of protein machines in bacteria, which have the capacity to convert carbon dioxide into sugar through photosynthesis.”

“Unique internal ‘machines’ in cyanobacteria, called carboxysomes, allow the organisms to convert carbon dioxide to sugar and provide impacts on global biomass production and our environment.”

“So far, little is known about how these ‘machines’ are constructed and maintain their organisation to perform carbon fixation activity.”

“They then used electron microscopy and atomic force microscopy to visualise the morphology and internal protein organization of these bacterial machines.”

“‘We’re now just starting to understand how these bacterial machines are built and work in nature. Our long-term vision is to harness the knowledge to make further steps towards better design and engineering of bio-inspired machines,’ added Dr Liu. ‘The knowledge and techniques can be extended to other biological machines.’” [Emphasis added.]

That’s a lot of machine language for one short article! And it doesn’t even include related words like mechanical, nanotechnology, and structure. They’re talking about an amazing little organelle in cyanobacteria (once considered among the most primitive of cells) called the carboxysome — one of those tiny wonders most people don’t know about but depend on for life.

Cyanobacteria are a phylum of bacteria that produce oxygen and energy during photosynthesis, similar to green plants. They are among the most abundant organisms in oceans and fresh water.

As the article states, the machines in carboxysomes “provide impacts on global biomass production and our environment” by using sunlight to turn carbon dioxide into sugar, releasing oxygen for us to breathe.

Carboxysomes are polyhedral structures resembling a viral capsid, except that these living machine factories are “much softer and structurally flexible, which is correlated to their formation dynamics and regulation in bacteria.” Zooming in, we find higher levels of organization. The paper in Nanoscale says:

The protein shell serves as a physical barrier to protect enzymes from the cytosol and a selectively permeable membrane to mediate transport of enzyme substrates and products.

There’s more. The team found three structural domains inside, “a single-layered icosahedral shell, an inner layer and paracrystalline arrays of interior Rubisco.” Rubisco? Is that some kind of cracker? No — it’s another one of the most important things in nature you may have never heard of, and here it is, laid out in nice orderly rows in a geometric nanofactory.

Short for “Ribulose 1,5-bisphosphate carboxylase/oxygenase” (thank goodness), Rubisco is the most abundant protein on earth. According to PNAS, this machine solves an “abominably perplexing puzzle” of distinguishing between “featureless” molecules of carbon dioxide and oxygen, and it “may be nearly perfectly optimized” to do so. Once it was thought to be a slow, sluggish enzyme that leaks, but the authors find otherwise:

We assert that all Rubiscos may be nearly perfectly adapted to the differing CO2, O2, and thermal conditions in their subcellular environments, optimizing this compromise between CO2/O2 specificity and the maximum rate of catalytic turnover.

Commenting in Nature on that 2006 paper, Howard Griffiths added some amazing facts about Rubisco:

Rubisco has the reputation of being slow and inefficient, but it is one of life’s big successes: globally there is an estimated 5–10 kg Rubisco for every person on Earth, and each year it reacts with 15% of the total pool of atmospheric CO2.

Working alongside Rubisco in those neatly arranged layers inside the carboxysome is another amazing enzyme, carbonic anhydrase. Last year, we learned about how this “fine-tuned” enzyme (one of the few that employs zinc in its active site) helps salmon get an energy boost for their muscles when they leap waterfalls. Here it is again in cyanobacteria, working with Rubisco to regulate the levels of carbon dioxide by converting it to bicarbonate or back again as needed. The Protein Data Bank says, “Carbonic anhydrase is an enzyme that assists rapid inter-conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions.” This ubiquitous enzyme is found in mammals, plants, algae, and bacteria.

The current study in Nanoscale explains why compartmentalization of these machines is important:

Within the cytosol which is a crowded and changing environment, it is important that carboxysomes are sufficiently robust to ensure the proper protein assembly, encapsulation of Rubisco enzymes and functional architecture. On the other hand, they are also flexible and dynamic to allow metabolite passage, turnover of building modules and interactions with other cellular components.

It’s not a prison, in other words, but a lively factory with windows and doors, yet it sequesters the machines safely for their protection. Carboxysomes are examples of bacterial microcompartments (BMCs) we’ve discussed before. These sure look designed: “The protein shell, structurally resembling virus capsids, is made of multiple protein paralogs forming hexagons and pentagons, and acts as a physical barrier that controls the passage of substrates and products of enzymatic reactions.” One can find spontaneous hexagons in nature, but some of them are clearly designed: those that exhibit “functional coherence” to use Doug Axe’s term (Undeniable, p. 160, pp. 178-181).

The authors don’t seem to have much use for evolutionary theory; anyway, they never mention it in the paper. But they did have design on their minds:

The study provides novel insights into the inherent structure and physical elasticity of native β-carboxysomes. It will empower our toolbox for the design and construction of functional metabolic machinery with applications in bioengineering and nanotechnology.

The report from the University of Liverpool amplifies the design theme:

“We’re now just starting to understand how these bacterial machines are built and work in nature. Our long-term vision is to harness the knowledge to make further steps towards better design and engineering of bio-inspired machines,” added Dr Liu, “The knowledge and techniques can be extended to other biological machines.”

Let’s end with some “wow” facts about a tiny cyanobacterium you may not have heard of. It contains these molecular factories (carboxysomes) loaded with Rubisco and carbonic anhydrase, working day and night to cleanse our atmosphere and regulate global carbon. Its name is Prochlorococcus. Sallie W. Chisholm says this about it in her Quick Guide in  Current Biology:

“We now know that there are about 100 million of these tiny powerhouses in each liter of seawater over vast oceanic regions,” and yet “they are 100 body lengths away” from each other.

Prochlorococcus “is the smallest and most abundant photosynthetic cell on Earth.”

“There is an estimated 3 x 10(exp)27 of them in the oceans, collectively weighing twice as much as all humans, and sporting a surface area 100 times that of the Earth.”

“They constitute half of the chlorophyll over vast ocean ecosystems, single-handedly supplying significant amounts of organic carbon to the rest of the microbial food web.”

“…they are extremely efficient photosynthetic machines.”

“…their genomes represent one of the most streamlined blueprints for life.”

“With a lower bound of 1,800 genes, they synthesize biomass using only solar energy, CO2 and inorganic compounds. That’s minimal life. That’s impressive!”

Carboxysomes rule the world. What if there had not been enough magnesium (for the chlorophyll) and zinc (for the carbonic anhydrase) close to the surface to supply the layers of enzymes in the factories of all those trillion quintillion cells? The Earth seems to have set the stage for complex life, a point Michael Denton would no doubt appreciate.