Thursday, 13 July 2023
James Tour vs. Dave Farina: the view from the centre
Origin of Life: Cambridge Astrochemist Paul Rimmer Analyzes the Tour-Farina Debate
Cambridge University astrochemist Paul Rimmer analyzed the debate between James Tour and Dave Farina on the Podcast Capturing Christianity. Rimmer has been recognized as a rising star in the study of the origin of life (OOL). In his charitable and thoughtful demeanor, he represents the antithesis of Farina. He also displays a commitment to describing the science with precision and nuance.
I have many positive thoughts about Rimmer, and I anticipate that many people who watch his post-debate analysis will rightfully come away with a positive view of him. However, the viewer should be aware of a critical caveat: Ultimately, Paul Rimmer is far too credulous about chemical explanations for the origin of life. His stance undoubtedly reflects his membership in the field of mainstream OOL research. To those outside that community, even the research Rimmer lauds as advancing the field only further confirms that life’s originating through natural processes is impossible on scientific grounds.
Analysis of the Debate
Rimmer begins with a helpful tutorial on research into life’s origin. He includes a diagram by John Sutherland on the presumed stages leading to the first self-replicating cell and the current state of the field. Rimmer summarizes the journey toward life as a continuous series of stable systems gradually increasing in complexity until one emerges capable of Darwinian evolution.
Rimmer then expands on specific topics raised by Tour and Farina. He elucidates the research cited by Farina in response to Tour’s question about how the amino acids Asp and Lys could have linked together on the early Earth. Rimmer acknowledges that the articles Farina cited do not directly address Tour’s questions, but he claims they still provide clues as to how amino acid chains could have emerged. He describes how Leman, Orgel, and Ghadiri (2004) linked the amino acids Ala, Phe, Leu, Ser, and Try together with the assistance of carbonyl sulfide. He then describes how Singh et al. (2022) linked aminonitriles (precursors to amino acids) to amino acids by employing catalysts such as thiols.
Rimmer continues by explaining the research referenced by Farina related to the origin of RNA. During the debate, Tour described how nucleotides often join a growing chain with 2’-5’ linkages instead of the standard 3’-5’ linkages — nucleotides connect at the wrong carbon on the ribose molecule. Farina responded to this hurdle by citing Engelhart et al. (2013) who validated that a nucleotide chain known as a hammerhead ribozyme (RNA enzyme) could still break apart an RNA molecule even if the ribozyme possessed some 2’-5’ linkages.
Rimmer states that RNA with the wrong linkages could not have been reliably copied, posing a major hurdle to further progress toward life. A single RNA molecule would almost always break apart before it could migrate to the right local environment where it could facilitate a life-relevant reaction. It would have to be copied numerous times before it could play any role in life’s origin.
Yet Rimmer argues that this challenge is not necessarily insurmountable since Mariani and Sutherland (2017)demonstrated a chemical pathway that replaces 2’-5’ linkages with the correct 3’-5’ linkages. Rimmer acknowledges that this study does not fully solve the problem of building RNA since the correction process is not highly efficient or reliable, but he claims such research provides a “clue” as to how RNA molecules could have emerged. There are additional problems with this research that I will describe below.
Differing Assumptions
The differing perspectives of Tour and Rimmer result from the differences in their starting assumptions. Rimmer’s scientific education trained him to only consider the possibility that life originated from natural processes. Rimmer tacitly acknowledges this fact in his response to a question about the appearance of design in life. He essentially argues that the origin of life requires “mind” only insofar as chemistry or biology or anything else that happens in nature requires mind. This is consistent with what he has written elsewhere predicting that we will one day find a “complete biological explanation … for the question of how life first originated on Earth.” He states that he does not wish to examine the evidence for design beyond the apparent design behind the laws of physics that allow for life to exist. Consequently, he is not concerned if experiments perfectly match what could have occurred on the early Earth or even if the chemistry is prebiotically plausible.He considers progress as simply finding clues as to what might have occurred.
In contrast, Tour considers progress in understanding life’s origin as demonstrating a chemical process that could have occurred naturally and could have produced molecules in sufficient abundance and purity to drive the next step toward life. Tour has convincingly argued that no such research exists (see for example here or here).
From Tour’s perspective, a careful analysis of the procedures used in the research Rimmer references (here and here, ) reveals that the studies only moved chemical systems toward life by starting with carefully chosen molecules in concentrations and purities that could never have arisen naturally. The experiments also employed meticulously designed experimental protocols with only marginal similarity to what could have transpired on the ancient Earth.
If the experiments used more realistic chemical mixtures and environmental conditions, they would not have produced anything biologically relevant. In addition, if the resulting products were deposited in any ancient environment, they would have simply degraded into biologically useless asphalts. Steven Benner describes this tendency as the Asphalt paradox. In other words, this research, while interesting, does not mimic a realistic natural environment, nor does it produce chemical mixtures that could eventually produce life.
Probability Paradox
The hammerhead ribozyme study cited by Farina and Rimmer poses an additional seemingly insurmountable hurdle to the RNA world hypothesis. Ribozymes with 2’-5’ bonds have primarily been shown to break apart RNA, leading to what Benner refers to as the Probability paradox , which he describes as follows:
Experiments show that RNA molecules that catalyze the destruction of RNA are more likely to arise in a pool of random (with respect to fitness) sequences than RNA molecules that catalyze the replication of RNA, with or without imperfections.
If a system of randomly sequenced RNA had emerged on the early Earth, biologically useful ribozymes would have quickly vanished as the system degraded into simpler molecules.
Future Presentations
As I noted, Paul Rimmer is thoughtful, civil, and his voice should be heard. He said nothing wrong in his presentation since he was asked to analyze the debate from the perspective of a scientist working in the field of OOL research. But those not working in the field can find many reasons why the research he cites is not persuasive that the chemical origin of life is possible. Perhaps in future discussions, Rimmer could explore how his philosophical framework shapes his interpretation of the results of OOL studies. Ideally, he would also explain why scientists not operating within the same framework assess the state of the field very differently.
As someone who has also engaged in thoughtful dialogue with OOL researchers, I would be very happy to be part of such a conversation. But I do not want to put Paul Rimmer’s career in any jeopardy: Those working in the field of OOL research would be ill-advised to publicly speak with too much candor about fundamental weaknesses in that field since doing so might jeopardize their career.
Nebuchadnezzar : the Watchtower Society's Commentary.
NEBUCHADNEZZAR
(Neb·u·chad·nezʹzar), Nebuchadrezzar (Neb·u·chad·rezʹzar) [from Akkadian, meaning “O Nebo, Protect the Heir!”].
Second ruler of the Neo-Babylonian Empire; son of Nabopolassar and father of Awil-Marduk (Evil-merodach), who succeeded him to the throne. Nebuchadnezzar ruled as king for 43 years (624-582 B.C.E.), this period including the “seven times” during which he ate vegetation like a bull. (Da 4:31-33) To distinguish this monarch from the Babylonian ruler by the same name but of a much earlier period (the Isin dynasty), historians refer to him as Nebuchadnezzar II.
Historical notices in cuneiform inscriptions presently available about Nebuchadnezzar somewhat supplement the Bible record. They state that it was in the 19th year of Nabopolassar’s reign that he assembled his army, as did his son Nebuchadnezzar, then crown prince. Both armies evidently functioned independently, and after Nabopolassar went back to Babylon within a month’s time, Nebuchadnezzar successfully warred in mountainous territory, later returning to Babylon with much spoil. During the 21st year of Nabopolassar’s reign, Nebuchadnezzar marched with the Babylonian army to Carchemish, there to fight against the Egyptians. He led his forces to victory. This took place in the fourth year of Judean King Jehoiakim (625 B.C.E.).—Jer 46:2.
The inscriptions further show that news of his father’s death brought Nebuchadnezzar back to Babylon, and on the first of Elul (August-September), he ascended the throne. In this his accession year he returned to Hattu, and “in the month Shebat [January-February, 624 B.C.E.] he took the vast booty of Hattu to Babylon.” (Assyrian and Babylonian Chronicles, by A. K. Grayson, 1975, p. 100) In 624 B.C.E., in the first official year of his kingship, Nebuchadnezzar again led his forces through Hattu; he captured and sacked the Philistine city of Ashkelon. (See ASHKELON.) During his second, third, and fourth years as king he conducted additional campaigns in Hattu, and evidently in the fourth year he made Judean King Jehoiakim his vassal. (2Ki 24:1) Also, in the fourth year Nebuchadnezzar led his forces to Egypt, and in the ensuing conflict both sides sustained heavy losses.
Conquest of Jerusalem. Later, the rebellion of Judean King Jehoiakim against Nebuchadnezzar evidently resulted in a siege being laid against Jerusalem by the Babylonians. It appears that during this siege Jehoiakim died and his son Jehoiachin ascended the throne of Judah. But a mere three months and ten days thereafter the reign of the new king ended when Jehoiachin surrendered to Nebuchadnezzar (in the month of Adar [February-March] during Nebuchadnezzar’s seventh regnal year [ending in Nisan 617 B.C.E.], according to the Babylonian Chronicles). A cuneiform inscription (British Museum 21946) states: “The seventh year: In the month Kislev the king of Akkad mustered his army and marched to Hattu. He encamped against the city of Judah and on the second day of the month Adar he captured the city (and) seized (its) king [Jehoiachin]. A king of his own choice [Zedekiah] he appointed in the city (and) taking the vast tribute he brought it into Babylon.” (Assyrian and Babylonian Chronicles, by A. K. Grayson, 1975, p. 102; PICTURE, Vol. 2, p. 326) Along with Jehoiachin, Nebuchadnezzar took other members of the royal household, court officials, craftsmen, and warriors into Babylonian exile. It was Jehoiachin’s uncle Mattaniah that Nebuchadnezzar made king of Judah, and he changed Mattaniah’s name to Zedekiah.—2Ki 24:11-17; 2Ch 36:5-10; see CHRONOLOGY; JEHOIACHIN; JEHOIAKIM.
Sometime later Zedekiah rebelled against Nebuchadnezzar, allying himself with Egypt for military protection. (Eze 17:15; compare Jer 27:11-14.) This brought the Babylonians back to Jerusalem, and on Tebeth (December-January) 10 in the ninth year of Zedekiah’s reign, Nebuchadnezzar besieged Jerusalem. (2Ki 24:20; 25:1; 2Ch 36:13) However, news that a military force of Pharaoh was coming out of Egypt caused the Babylonians to lift the siege temporarily. (Jer 37:5) Subsequently Pharaoh’s troops were forced to go back to Egypt, and the Babylonians resumed the siege against Jerusalem. (Jer 37:7-10) Finally, in 607 B.C.E., on Tammuz (June-July) 9 in the 11th year of Zedekiah’s reign (Nebuchadnezzar’s 19th year if counting from his accession year or his 18th regnal year), a breach was made in Jerusalem’s wall. Zedekiah and his men fled but were overtaken in the desert plains of Jericho. Since Nebuchadnezzar had retired to Riblah “in the land of Hamath,” Zedekiah was brought before him there. Nebuchadnezzar had all of Zedekiah’s sons slaughtered, and then he blinded and bound Zedekiah in order to take him as a prisoner to Babylon. The postconquest details, including the burning of the temple and the houses of Jerusalem, the disposition of temple utensils, and the taking of captives, were handled by Nebuzaradan the chief of the bodyguard. Over those not taken captive, Gedaliah, an appointee of Nebuchadnezzar, served as governor.—2Ki 25:1-22; 2Ch 36:17-20; Jer 52:1-27, 29.
His Dream of an Immense Image. The book of Daniel states that it was in “the second year” of Nebuchadnezzar’s kingship (probably counting from the destruction of Jerusalem in 607 B.C.E. and therefore actually referring to his 20th regnal year) that Nebuchadnezzar had the dream about the golden-headed image. (Da 2:1) Although the magic-practicing priests, conjurers, and Chaldeans were unable to interpret this dream, the Jewish prophet Daniel did so. This moved Nebuchadnezzar to acknowledge Daniel’s God as “a God of gods and a Lord of kings and a Revealer of secrets.” He then constituted Daniel “ruler over all the jurisdictional district of Babylon and the chief prefect over all the wise men of Babylon.” Nebuchadnezzar also appointed Daniel’s three companions, Shadrach, Meshach, and Abednego, to administrative posts.—Da 2.
Later Exiles of Jews. About three years later, in the 23rd year of Nebuchadnezzar’s reign, more Jews were taken into exile. (Jer 52:30) This exile probably involved Jews who had fled to lands that were later conquered by the Babylonians. Lending support to this conclusion is the statement of the historian Josephus: “In the fifth year after the sacking of Jerusalem, which was the twenty-third year of the reign of Nebuchadnezzar, Nebuchadnezzar marched against Coele-Syria and, after occupying it, made war both on the Moabites and the Ammanites. Then, after making these nations subject to him, he invaded Egypt in order to subdue it, and, having killed the king who was then reigning and appointed another, he again took captive the Jews who were in the country and carried them to Babylon.”—Jewish Antiquities, X, 181, 182 (ix, 7).
Takes Tyre. It was also sometime after the fall of Jerusalem in 607 B.C.E. that Nebuchadnezzar began the siege against Tyre. During this siege the heads of his soldiers were “made bald” from the chafing of the helmets and their shoulders were “rubbed bare” from carrying materials used in the construction of siegeworks. As Nebuchadnezzar received no “wages” for serving as Jehovah’s instrument in executing judgment upon Tyre, He promised to give him the wealth of Egypt. (Eze 26:7-11; 29:17-20; see TYRE.) One fragmentary Babylonian text, dated to Nebuchadnezzar’s 37th year (588 B.C.E.), does, in fact, mention a campaign against Egypt. (Ancient Near Eastern Texts, edited by J. Pritchard, 1974, p. 308) But it cannot be established whether it relates to the original conquest or a later military action.
Building Projects. Besides attaining numerous military victories and expanding the Babylonian Empire in fulfillment of prophecy (compare Jer 47-49), Nebuchadnezzar engaged in considerable building activity. To satisfy the homesick longings of his Median queen, Nebuchadnezzar reportedly built the Hanging Gardens, rated as one of the seven wonders of the ancient world. Many of the extant cuneiform inscriptions of Nebuchadnezzar tell of his building projects, including his erection of temples, palaces, and walls. An excerpt from one of these inscriptions reads:
“Nebuchadrezzar, King of Babylon, the restorer of Esagila and Ezida, son of Nabopolassar am I. As a protection to Esagila, that no powerful enemy and destroyer might take Babylon, that the line of battle might not approach Imgur-Bel, the wall of Babylon, that which no former king had done [I did]; at the enclosure of Babylon I made an enclosure of a strong wall on the east side. I dug a moat, I reached the level of the water. I then saw that the wall which my father had prepared was too small in its construction. I built with bitumen and brick a mighty wall which, like a mountain, could not be moved and connected it with the wall of my father; I laid its foundations on the breast of the under-world; its top I raised up like a mountain. Along this wall to strengthen it I constructed a third and as the base of a protecting wall I laid a foundation of bricks and built it on the breast of the under-world and laid its foundation. The fortifications of Esagila and Babylon I strengthened and established the name of my reign forever.”—Archaeology and the Bible, by G. Barton, 1949, pp. 478, 479.
The foregoing harmonizes with Nebuchadnezzar’s boast made just before he lost his sanity: “Is not this Babylon the Great, that I myself have built for the royal house with the strength of my might and for the dignity of my majesty?” (Da 4:30) But when, in fulfillment of his divinely sent dream about the chopped-down tree, his reasoning powers were restored, Nebuchadnezzar had to acknowledge that Jehovah is able to humiliate those walking in pride.—Da 4:37; see MADNESS.
Very Religious. The indications are that Nebuchadnezzar was extremely religious, building and beautifying the temples of numerous Babylonian deities. Particularly was he devoted to the worship of Marduk, the chief god of Babylon. To him Nebuchadnezzar gave credit for his military victories. Trophies of war, including the sacred vessels of Jehovah’s temple, appear to have been deposited in the temple of Marduk (Merodach). (Ezr 1:7; 5:14) Says an inscription of Nebuchadnezzar: “For thy glory, O exalted MERODACH a house have I made. . . . May it receive within itself the abundant tribute of the Kings of nations and of all peoples!”—Records of the Past: Assyrian and Egyptian Monuments, London, 1875, Vol. V, p. 135.
The image of gold set up by Nebuchadnezzar in the Plain of Dura was perhaps dedicated to Marduk and designed to promote religious unity in the empire. Enraged over the refusal of Shadrach, Meshach, and Abednego to worship this image even after being given a second opportunity, Nebuchadnezzar commanded that they be thrown into a fiery furnace heated seven times hotter than usual. However, when these three Hebrews were delivered by Jehovah’s angel, Nebuchadnezzar was forced to say that “there does not exist another god that is able to deliver like this one.”—Da 3.
Nebuchadnezzar also appears to have relied heavily on divination in planning his military moves. Ezekiel’s prophecy, for example, depicts the king of Babylon as employing divination in deciding whether to go against Rabbah of Ammon or against Jerusalem.—Eze 21:18-23.
From following the science to leading the science?
Is There a Boom in Research Dishonesty?
What to make of this news stream?
Distinguished Professor Francesca Gino of Harvard Business School was recently accused by other academics of falsifying data in a number of studies, including one on dishonesty, where she was a co-author:
Professors Joseph Simmons, Uri Simonsohn and Leif Nelson of University of Pennsylvania, Escade Business School in Spain, and University of California, Berkeley, respectively, accused Gino of the fraud on their blog Data Colada.
“Specifically, we wrote a report about four studies for which we accumulated the strongest evidence of fraud,” they wrote, stating they shared their concerns with Harvard Business School.
THERESE JOFFRE, “HARVARD ETHICS PROFESSOR ALLEGEDLY FABRICATED MULTIPLE BEHAVIORAL SCIENCE STUDIES” AT THE COLLEGE FIX, JUNE 28, 2023
Breaking Rules
Gino, currently on administrative leave, is also the author of Rebel Talent: Why It Pays to Break the Rules at Work and in Life (2018). From the blurb: “Award-winning Harvard Business School professor Francesca Gino shows us why the most successful among us break the rules, and how rebellion brings joy and meaning into our lives.” Here are the details at Data Colada.
Another of the authors of the dishonesty paper, the well-known Dan Ariely of Duke University, author of The Honest Truth About Dishonesty: How We Lie to Everyone — Especially Ourselves (Harper 2012), has also been accused by the other authors of Providing fraudulent data:
Behavioral scientists Leif Nelson and Joseph Simmons, who exposed the apparent fraud via their blog Data Colada together with their colleague Uri Simonsohn, say a thorough, transparent investigation is needed. But given other universities’ past reluctance to investigate their own researchers, they are skeptical that Duke will conduct one. That may leave Ariely’s supporters insisting he is innocent and detractors assuming he is guilty, Nelson says. “No one knows. And that’s terrible.”
CATHLEEN O’GRADY, “FRAUDULENT DATA RAISE QUESTIONS ABOUT SUPERSTAR HONESTY RESEARCHER” AT SCIENCE (AUGUST 24, 2021)
Come to think of it, a similar situation arose over a decade ago. Harvard’s Marc Hauser, a principal investigator at the Cognitive Evolution Laboratory, was famous and popular for his research claims that “the foundations of language and morality are hardwired into the brains of humans and our kin.” But he found himself in hot water in 2010 because “lab workers observed huge discrepancies between his descriptions of monkey behavior and the experimental results captured on Video.”
On Aug. 10, the Boston Globe reported the psychology professor was taking a one-year leave of absence after a three-year internal investigation found evidence of scientific misconduct in his lab. Days later, Faculty of Arts and Sciences Dean Michael D. Smith confirmed that a committee found Hauser “solely responsible” for eight instances of misconduct — three of which were published studies that needed to be retracted or corrected to remove unsupported findings.
ERIC P. NEWCOMER AND ELYSSA A. L. SPITZER, “MARC HAUSER’S FALL FROM GRACE” AT THE HARVARD CRIMSON (SEPTEMBER 4, 2010)
Hauser resigned from Harvard in 2011 in the wake.
Dumped by Viking
As it happens, he was working on a book as the story broke: Evilicious. Apparently the book was originally to be published by Viking, with the subtitle Why We Evolved a Taste for Being Bad, but Viking dumped it, post-scandal, in 2012. Hauser later self-published it as Evilicious: Cruelty = Desire + Denial (CreateSpace, 2013). It was endorsed by (among others) some oft-quoted science celebs:
Dumbfounded Harvardites
Many Harvardites found the accusations against Hauser hard to believe:
As Hauser faces federal inquiry, many of his former co-authors, graduate students, and undergraduate advisees struggle to comprehend how the man they knew as a prolific researcher, skilled communicator, and heavyweight in the field of cognitive psychology became enmeshed in scandal.
ERIC P. NEWCOMER AND ELYSSA A. L. SPITZER, “MARC HAUSER’S FALL FROM GRACE” AT THE HARVARD CRIMSON (SEPTEMBER 4, 2010)
But perhaps Ariely and at least some of his colleagues would take a more ambivalent view than theirs, if we are to judge by the abstract of a recent paper:
People like to think of themselves as honest. However, dishonesty pays — and it often pays well. How do people resolve this tension? This research shows that people behave dishonestly enough to profit but honestly enough to delude themselves of their own integrity. A little bit of dishonesty gives a taste of profit without spoiling a positive self-view. Two mechanisms allow for such self-concept maintenance: inattention to moral standards and categorization malleability. Six experiments support the authors’ theory of self-concept maintenance and offer practical applications for curbing dishonesty in everyday life.
MAZAR, N., AMIR, O., & ARIELY, D. (2008). THE DISHONESTY OF HONEST PEOPLE: A THEORY OF SELF-CONCEPT MAINTENANCE. JOURNAL OF MARKETING RESEARCH, 45(6), 633-644
Here’s a Thought
Could seeing morality in purely materialist or naturalist terms, as above, makes it all seem like a game? Then, when dishonesty (or whatever) blows a hole in the system, the researcher finds that colleagues, unlike those human- or monkey-study subjects, are very old-fashioned about cheating… A Bible Belt without the Bible could be a really scary place.
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