Whether potter's kiln or the refiner's forge JEHOVAH'S renders us fit for service

 Mark.9:49NIV"Everyone will be salted with fire."

On the body as supersystem

 

ID is already mainstream?

 

Beg JEHOVAH God for a proverbs 31 woman

 

JEHOVAH God provides a hope that will never lead to disappointmentt

 

The synthetic life hype demystified

 

The human miracle vs. Darwinism

 

JEHOVAH'S Word is a treasure

 

Know servant of JEHOVAH that the hairs of your head are numbered.

 

The stones continue to cry out even more.

 Luke.19:40NIV"“I tell you,” he replied, “if they keep quiet, the stones will cry out.”"

The origin of life=The origin of information?

 

Standing firm in JEHOVAH'S Strength

 

Lean on JEHOVAH!

 

JEHOVAH the great engineer

 

JEHOVAH'S promise first a new man then a new world.

 

Why AI will remain artificial

 

Blessed is the people whose God is JEHOVAH

 Psalm.144:15ASV"Happy is the people that is in such a case; Yea , happy is the people whose God is JEHOVAH"

Blowback from Europe's latest war?

 

On the purple triangles

 

The stones cry out once more

 

Walking by the light of JEHOVAH'S Word

 

Again to the perpetual schoolyard

 

Scholars on JEHOVAH'S servants fidelity to JEHOVAH'S Kingdom during the third reich

 

It's time for an extended extended synthesis?

 

In JEHOVAH'S Strength we stood our ground.

 

Yet more primeval tech vs. Darwin

 

Real life devotees of the Machine spirit?

 

Theism as the foundation of reason

More on why the multiverse fails as God substitute

Thank JEHOVAH for your body's flawless design

 

The children of Nimrod

 

The shepherd's companion

 

And still yet more on the business of war.

 

JEHOVAH is our north star

 

JEHOVAH is our grand instructor

 

More on the search for earth 2.0

 

James Tour on why micro RNA Further complicates OoL narratives

 

The cell vs. Darwin

 

On the irreducibility of respiration

 

JEHOVAH takes human engineers to school?

 

JEHOVAH'S loyalty liberates the heart and mind

 

The Math of abiogenesis isn't mathing?

 

In search of Earth 2.0

 

On why intelligence remains the best explanation

 

The body is a modern day burning bush?

 

On the circularity of Darwinian rhetoric

 

He is the way,the truth and the life

 

Our brotherhood is ire

 

JEHOVAH the great physician can give us a new heart

 Ezekiel.11:9NIV"I will give them an undivided heart and put a new spirit in them; I will remove from them their heart of stone and give them a heart of flesh."

More on the metaphysics of Darwinism.

 

James Tour holds court on the failure of OOL Science

 

The skies are still proclaiming JEHOVAH'S Glory?

 

Evolution is different?

 

JEHOVAH enables us to stand our ground.

 

Convergent serendipity?

 

Where recess is forever

 

Missing links remain the rule and not the exception?

 

Three discoveries that rehabilitated the God hypothesis

 

Bloodless medicine is the gold standard

 

The corruption of this system is beyond belief, but the Lord JEHOVAH is girding on his sword

 

AI is making dumb machines and even dumber people?

 

Soon JEHOVAH will bring down the walls again.

 

The business of bees

 

Junk DNA even more fully salvaged?

 More Functions Reported for Repeat “Junk” DNA

Casey Luskin June 11, 2026

A new paper in PNAS, “CTCF directly binds G-quadruplex structures to regulate genome topology and gene expression,” elaborates more functions for supposed “junk DNA” as helping to create functionally relevant structures in DNA. Last year I wrote about non-B DNA (see here and here). It doesn’t necessarily exhibit the typical double-helical DNA structure, but it can form unique shapes that contribute to a variety of important genomic functions. This new paper explores a structure called the G-quadruplex (G4s), a loop shape that often arises in DNA segments rich in guanine. The paper reports that G4s can perform a variety of functions: 

"G4 binding activities in genomic regulators of nucleosome remodeling, paraspeckle assembly, RNA splicing, and three-dimensional genome organization. Among the prominent hits, we identify the genomic architectural protein, CCCTC-binding factor (CTCF), as one of the strongest G4 binders."

The latter function is crucial, as it reflects the ability of G4 structures to regulate large-scale chromosomal structures:

"G-quadruplexes interact with several nuclear protein complexes involved in crucial genomic processes. We found that the genomic architectural protein, CCCTC-binding factor (CTCF), directly binds to G4s and this interaction is important for regulation of genome topology and gene expression. Our work uncovers the architectural roles of G4 structures in the genome and contributes important insights into G4 biology and 3D genome organization."

A Variety of Genomic Functions

Thus, these G4 structures contribute to a variety of genomic functions, and importantly they help form topologically associating domains (TADs) that control the 3D structure of the genome:

"At the scale of tens to hundreds of kilobases, the genome is further assembled into self-interacting regions known as topologically associating domains (TADs), with higher propensity of genomic interactions observed within, rather than between TADs. TADs mediate enhancer–promoter interactions and are important for cell-type specific gene expression programs. Interestingly, G4s are shown to be enriched at TAD boundaries and implicated in regulating insulation strength of TADs"

The paper proposes a model that involves “CTCF–G4 interaction in mediating long-range chromatin looping to define stable chromatin loops or boundaries of topologically associating domains (TADs).”

So Why Does This Matter?

A variety of papers note that repetitive DNA — the precise type of DNA that our junk-DNA-defending friends assure us must be functionless — is vital for forming these G4 structures:

Ambrus et al. (2006): Discusses how telomeric repeats in humans form G-quadruplexes.

Bryan (2020): Reviews how telomeric repeat DNA forms G-quadruplexes

 Waisertreiger et al. (2025):: Discusses how pericentromeric tandem repeat DNA forms G4s.

:Nakagama et al. (2006):  Discusses how guanine-rich short tandem repeat DNA forms G4s.

:Piazza et al. (2017):  Zhou et al. (2014): Discusses how the repetitive DNA sequence “GGGGCC” forms G4s.

:Adrian et al. (2014):  Explains how minisatellite tandem repeat sequences contribute to G-quadruplex formation.

: Shows how a minisatellite repeat sequence forms G4s.

:  Raguseo et al. (2023): Explains how the repeat DNA sequence “GGGGCC” forms G4s.

:Bauer et al. (2011): (2011): Shows that repetitive telomeric sequences form G4s.

:Geng et al. (2024): Shows G4s are formed by repeat DNA.

These papers demonstrate that various types of repetitive DNA, including in telomeres, minisatellites, pericentromeric repeats, and other tandem repeat DNA sequences, help form G4 structures. The point being: repetitive DNA helps form non-B DNA shapes like G4s, and these G4s are crucial for defining TADs which help define the 3D structure of the genome, regulating gene expression and even defining cell types. Far from being junk, this repetitive DNA is crucial for formatting the genome.

The genome is rich in function, and we dare not simply dismiss any of it.

Jesus is good and therefore God?

 

Made new by JEHOVAH.

 

All you broken hearted come to JEHOVAH the great physician

 

In search of a an extended synthesis

 

Glorify his Holy name.

 

The case for design is robust?

 

Know servant of JEHOVAH that you are precious to the true God.

More ancient tech vs. Darwinism

 

On the metaphysics of Darwinism

 

Molecular evolution vs. Darwinism

 

Designed evolution vs. Evolved design

 

Real life Tony Stark's masterplan?

JEHOVAH is my fortress

 

O the pleasantness of King JEHOVAH'S Courtyard

 Psalm.122:1 NWT "I rejoiced when they said to me:

“Let us go to the house of JEHOVAH.”+

JEHOVAH is our cause for rejoicing

 

Why you shouldn't let your babies grow up to be cowboys(and if you're old enough to get that reference congrats!)

 

No more Mr. Nice guy

 

More from the forever schoolyard

 

Keepin' it real re:AI

 

For JEHOVAH so loved mankind..

 

JEHOVAH'S Servants are in it to win it

 

JEHOVAH Makes his servants giant killers

 

Drawing near to God is good for me

 

The Joy of JEHOVAH is our strength

 

JEHOVAH Himself will seek out his lost sheep

Pseudoscience is still on the march?

 

And still yet more on darwinism's Origin of Life issues.

 

What could possiby go wrong?

 

The science of doing science needs to advance?

 

Behind enemy lines

 

OoL science is a study in failure?

 

On Isaac Newton's Arianism

 Yes, Sir Isaac Newton held beliefs aligned with Arian theology, though he kept these views private due to their controversial nature. Arianism, based on the teachings of Arius, denies the full divinity of Jesus Christ, asserting that the Son is a created being, subordinate to God the Father. Newton’s extensive theological writings, including manuscripts like A Historical Account of Two Notable Corruptions of Scripture, reveal his rejection of the traditional doctrine of the Trinity. He argued that the concept of the Trinity was not supported by early Christian texts and was a later corruption of scripture, a position central to Arian thought.

Newton’s studies of early Church history and biblical texts led him to conclude that passages like 1 John 5:7, which supports the Trinity, were later interpolations. He believed the original Christian doctrine was closer to Arianism, emphasizing the unity and supremacy of God the Father. However, as a fellow at Trinity College, Cambridge, and a public figure, Newton was cautious, sharing his views only with close associates to avoid persecution, as Arianism was considered heretical in 17th-century England.

His theological notes, many of which were unpublished during his lifetime, confirm his sympathy for Arian ideas, though he never formally declared himself an Arian. Instead, he framed his beliefs as a return to a purer, original Christianity. For further details, Newton’s manuscripts at the National Library of Israel or the Keynes Collection at Cambridge provide primary source material.

The origin of life vs. Darwin

 

Darwinism's third way problem?

 

The thumb print of JEHOVAH in the cell

 

The king of titans is a human engine?