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Sunday, 29 September 2024

Still a theory in crisis?

 Theory in Crisis? Redefining Science


Editor’s note: We are saddened by the passing of our friend and colleague, the iconoclastic biologist Jonathan Wells. As a tribute, we are presenting some highlights from his work. The following is the second part in a series, “Is Darwinism a Theory in Crisis?” It is adapted from the book, The Comprehensive Guide to Science and Faith. Look here for the series so far.

In his 1962 book The Structure of Scientific Revolutions, philosopher of science Thomas Kuhn noted that scientific revolutions are often marked by disputes over the “standard that distinguishes a real scientific solution from a mere metaphysical speculation.” Newton’s theory of gravity was resisted because “gravity, interpreted as an innate attraction between every pair of particles of matter, was an occult quality” like the medieval “tendency to fall.” Critics of Newtonianism claimed that it was not science and “its reliance upon innate forces would return science to the Dark Ages.”1

Centuries later, some scientists claimed that the big bang was not science. In 1938, German physicist Carl F. von Weizsäcker gave a lecture in which he referred to the relatively new idea that our universe had originated in a big bang. Renowned physical chemist Walther Nernst, who was in the audience, became very angry. Weizsäcker later wrote: 

He said, the view that there might be an age of the universe was not science. At first I did not understand him. He explained that the infinite duration of time was a basic element of all scientific thought, and to deny this would mean to betray the very foundations of science. I was quite surprised by this idea and I ventured the objection that it was scientific to form hypotheses according to the hints given by experience, and that the idea of an age of the universe was such a hypothesis. He retorted that we could not form a scientific hypothesis which contradicted the very foundations of science.

Weizsäcker concluded that Nernst’s reaction revealed “a deeply irrational” conviction that “the world had taken the place of God, and it was blasphemy to deny it God’s attributes.”2

Is Intelligent Design Science?

Similarly, intelligent design has been criticized for not being science. In 2004, American Society for Cell Biology president Harvey Lodish wrote that intelligent design is “not science” because “the ideas that form the basis” of it “have never been tested by any scientific peer-scrutiny or peer-review.”3 In 2005, the American Astronomical Society declared, “Intelligent Design fails to meet the basic definition of a scientific idea: its proponents do not present testable hypotheses and do not provide evidence for their views.”4 And the Biophysical Society adopted a policy stating, “What distinguishes scientific theories” from intelligent design “is the scientific method, which is driven by observations and deductions.” Since intelligent design is “not based on the scientific method,” it is “not in the realm of science.”5

The claims about evidence and peer review in the statements quoted above are false. Nevertheless, the statements illustrate that critics of intelligent design, like the critics of Newtonianism and the big bang, claim that the new paradigm does not qualify as science.

Some pro-Darwin writers have argued that intelligent design is even anti-science. In 2006, philosopher Niall Shanks wrote that “a culture war is currently being waged in the United States by religious extremists who hope to turn the clock of science back to medieval times.” The “chief weapon in this war is…intelligent design theory.”6 In 2008, biologist and textbook writer Kenneth Miller claimed that “to the ID movement the rationalism of the Age of Enlightenment, which gave rise to science as we know it, is the true enemy.” If intelligent design prevails, he wrote, “the modern age will be brought to an end.” For Miller, what is at stake “is nothing less than America’s scientific soul.”6

A Different Definition of Science

It’s true that intelligent design operates with a definition of science that differs from the definition used by pro-Darwin scientists. For the latter, science is the enterprise of seeking natural explanations for everything. Only material objects and the forces among them are real; entities such as a nonhuman mind (which would have to be the source of any intelligent design in nature) are unreal. In Darwinian science, any evidence that seems to suggest intelligent design is ignored or ruled out. In 1999, a biologist wrote in Nature that “even if all the data point to an intelligent designer, such an hypothesis is excluded from science because it is not naturalistic.”7 But in an intelligent design paradigm, science seeks to follow the evidence wherever it leads. According to Kuhn, disputes such as this over the nature of science are common in scientific revolutions.

Notes

Kuhn, The Structure of Scientific Revolutions, 2d ed., 103-105, 163.
Carl F. von Weizsäcker, The Relevance of Science (New York: Harper & Row, 1964), 151-153.
Letter from Harvey F. Lodish to Ohio Governor Bob Taft (February 24, 2004). https://www.newswise.com/articles/ascb-president-says-creationism-does-not-belong-in-ohios-classrooms (accessed August 22, 2020).
Statement on the Teaching of Evolution, American Astronomical Society (September 20, 2005). https://aas.org/press/aas-supports-teaching-evolution (accessed August 22, 2020).
Statement on Teaching Alternatives to Evolution, Biophysical Society (November 2005). https://www.biophysics.org/policy-advocacy/stay-informed/policy-issues/evolution-1 (accessed August 22, 2020).
Niall Shanks, God, the Devil, and Darwin (New York: Oxford University Press, 2006), xi–xii.
Kenneth R. Miller, Only a Theory: Evolution and the Battle for America’s Soul (New York: Viking Press, 2008), 16, 190-191.
Scott Todd, “A view from Kansas on that evolution debate,” Nature 401 (1999), 423.

Tuesday, 24 September 2024

The throne of JEHOVAH'S Son demystified III

   




(B) Bowman declares, “In Scripture a ‘throne’ is not the source of one’s authority, but the position or place from which one rules.”

Isn’t it terribly strange that famed trinitarian New Testament scholars such as Dr. Westcott, Dr. Moffatt, Dr. Goodspeed (Smith-Goodspeed’s AT), and Dr. William Barclay (The Daily Study Bible Series) all prefer the interpretation “Thy throne is God”? (And highly respected trinitarian Bibles ASV, RSV, and NEB also give this rendering as a proper alternate.) Would these respected trinitarian authorities really render this scripture that way if “throne” could only be interpreted in a literal way? 
The trinitarian New Bible Dictionary tells us that in Scripture “the throne symbolizes dignity and authority” - p. 1196 (2nd ed.), Tyndale House, 1984. (Compare Strong’s Exhaustive Concordance.) 
And the equally trinitarian (and highly respected - by trinitarians) The International Standard Bible Encyclopaedia tells us about “throne”: “Usually the symbol of kingly power and dignity .... It symbolizes: (1) The exalted position of earthly kings, ... their majesty and power .... (2) The majesty and power of JEHOVAH as the true king of Israel; .... (3) The rule of the promised theocratic king (the Messiah), its everlasting glory and righteousness. He, too, is JEHOVAH’S representative [so JEHOVAH is the Messiah’s ‘throne’ (“power,” “authority,” and “glory”)]....” - p. 2976, Vol. IV, Eerdmans, 1984 printing. 
Please examine the implied meanings of “throne” in the following scriptures: Gen. 41:40; 2 Sam. 7:13, 14, 16; 2 Sam. 14:9; 1 Ki. 1:37, 47; Ps. 94:20 (“rulers,” RSVMo; “tribunals,” JBNAB) ; Col. 1:16 (compare the very trinitarian TEV and GNB: “spiritual powers” and the Phillips translation: “power”). These clearly do not exclusively mean just “a place” as Bowman insists. In fact, the very trinitarian Good News Bible (GNB) actually renders the Hebrew “throne” at Gen. 41:40 as ”authority.” Also note that even IF Heb. 1:8 were translated “Your throne, O God, is forever,” it would certainly mean more than “the seat you sit upon is everlasting”! It still speaks of the kingly power and authority which will last forever! Bowman is clearly wrong in saying that ‘throne’ must mean the “position or place from which one rules” and denying many other figurative uses. 
(C) “The writer of Hebrews is quoting Ps 45:6 and applying it to the Son to show that the Son is far greater than any of the angels [see quotes by Barclay and Robertson: HEB 2-3]. However, if all this verse means is that the Son’s authority derives from God, this in no way makes him unique or greater than the angels...” says Bowman. 
However, the complete quote from Ps. 45:6, 7 which begins at Heb. 1:8 includes Heb. 1:9. This verse not only specifies that God is the God of the king (Jesus), but also concludes with “God, thy God, hath anointed thee with the oil of gladness above thy fellows.” Jesus was “anointed” (brought into a position he didn’t originally have) by God and, at that point, came to be above his fellows. This is why Heb. 1:8, 9 was quoted by the writer of Hebrews: to show that Jesus is now (after God appointed [Heb. 1:2, 4] and anointed him) higher than the angels (who had been his “fellows”). 
Corroborating this is respected trinitarian Bible scholar, Dr. E. F. Scott, Emeritus Professor at the Union Theological Seminary, who wrote: “The author of Hebrews ... thinks of [Jesus] as an angel, whom God had exalted above all others, investing him with his own majesty and calling him by the name of Son.” - p. 726, An Encyclopedia of Religion, 1945 ed. 
And, again, the trinitarian The Interpreter’s Dictionary of the Bible tells us that at this time the Jewish expectation was that the Christ was “a pre-existent, heavenly ANGELIC being who, at the end of time, will appear at the side of God as judge of the world [see Acts 7:55-56].” - p. 364, Vol. 3, Abingdon Press, 1962. 
Similarly, that most famous of Jewish scholars and teachers of the first century A. D., Philo (see the LOGOS study), wrote about Hagar erroneously describing her seeing the Angel of God as seeing God:
“For just as those who are unable to see the sun itself see the gleam of the parhelion [a ‘mock sun’ - an optical illusion, not the true sun - RDB] and [erroneously] take it for the sun, ... so some regard the image of God, His angel the Word, as His very self.” - p. 423, Philo, vol. V, “On Flight and Finding,” Harvard University Press, Loeb Classical Library, 1988 printing.
“Angel of the Lord [angel of JEHOVAH] - occurs many times in the Old Testament, where in almost every instance it means a supernatural personage to be distinguished from JEHOVAH .... Some feel the pre-incarnate Christ is meant.” - p. 39, Today’s Dictionary of the Bible (trinitarian), Bethany House Publ., 1982. 
“Angel of the Lord. ... Christ’s visible form before the incarnation.” - p. 40, Smith’s Bible Dictionary (trinitarian), Hendrickson Publ. 
“ANGEL OF THE LORD, ... is represented in Scripture as a heavenly being sent by God to deal with men as his personal agent and spokesman [‘word’] .... In the NT [which trinitarians agree explains and amplifies the OT] there is no possibility of the angel of the LORD being confused with God. .... mostly when appearing to men he is recognized as a divine being, even though in human form, and is [sometimes] addressed as God” - p. 38, New Bible Dictionary, Tyndale House (trinitarian), 1984 printing.
“The Angel of the LORD.... Traditional [from 2nd century A. D. (at least)] Christian interpretation has held that this ‘angel’ was a preincarnate manifestation of Christ as God’s Messenger-Servant. It may be ..., the angel could speak on behalf of (and so be identified with) the One [Jehovah] who sent him” - footnote for Gen. 16:7 in the trinitarian The NIV Study Bible by Zondervan Publishing, 1985.
It is not uncommon for a trusted servant to actually represent his master in dealings with others. “What a servant says or does is [sometimes] ascribed to the master” - Young’s Analytical Concordance to the Bible, “Hints and Helps to Bible Interpretation,” Eerdmans Publishing, 1978 printing.
The angel of JEHOVAH “is a heavenly being given a particular task by YAHWEH [JEHOVAH], behind whom the angel’s personality entirely disappears .... because YAHWEH'S holiness could have destroyed Israel, only his angel was to go with the people.” - [see 1 John 4:12; John 6:46.] - The New International Dictionary of New Testament Theology (trinitarian), Vol. 1, p. 101, Zondervan Publ., 1986.
[Even the person speaking to Moses from the burning bush was an angel! Even though he spoke Jehovah's words and seemed to Moses to be JEHOVAH, we know that it was an angel speaking and acting for JEHOVAH: Acts 7:30.]
Please compare the following scriptures: Gen. 16:10, 11 and 13; Gen. 31:11 and Gen. 31:13; Gen. 32:24-30 and Hosea 12:4; Judges 6:16 and 6:20-23. 
It should be obvious that the Angel of JEHOVAH is NOT JEHOVAH himself! Even many trinitarian scholars admit the obvious here. However, some are unwilling to let any opportunity go by, no matter how poor, (since there is no real evidence for it to begin with) to insist that Jesus is JEHOVAH. So, although admitting that Jesus was (or probably was) the Angel of JEHOVAH in the OT (at least part of the time) they also insist that he was also JEHOVAH! 
Consider, however, if “Angel of JEHOVAH ” really meant that the one who had that title was JEHOVAH (even though the term literally means “messenger OF JEHOVAH ”), no inspired prophet of God or inspired Bible writer would ever use that term for anyone else. And yet Luke used it for the angel Gabriel, and Haggai actually used it for himself! 
Yes, Luke tells us at Lk 1:11, 19 “Then there appeared to him the angel of the LORD [the very same wording as found in the Septuagint at Gen. 16:7] .... The angel replied, ‘I am Gabriel who stands in God’s presence, and I have been sent to you’” - The Jerusalem Bible, also see NJB and NAB (‘91).
And the prophet and inspired Bible writer Haggai writes at Haggai 1:13 “Then Haggai, the messenger of JEHOVAH, spoke JEHOVAH’S message to the people.” The words are identical to both the Greek and Hebrew of Genesis 16:7: “the messenger [or angel] of JEHOVAH ”! And, of course, the NT shows that other angels [in addition to the “pre-incarnate” Jesus] may use the same title “angel of the LORD.” Even though the angel may, at times, actually identify himself as God (or JEHOVAH), it obviously does not mean he is JEHOVAH himself! He is perfectly representing JEHOVAH as his messenger and is speaking JEHOVAH’S very words at times. 
(Let’s not overlook the fact that King David was described as being “like the Angel of God.” - 2 Sam. 19:28, NJB (c.f., 2 Sam. 19:27 in NASB, NEB, NKJV, AT, RSV). If this angel were really God Himself, such a statement would not have been made - or tolerated by David when he heard it. Instead, King David is often compared to the Messiah in Scripture!)
When JEHOVAH (God alone) created his workman, his firstborn, as his first and only direct creation (the highest of angels or servants of God: Jesus, the Word), he became the Father. This is why Jesus may be called the “Firstborn” and the “onlybegotten” (only direct creation by JEHOVAH himself). When Jesus (the Word), at the command and direction of JEHOVAH God (the Father), became the instrument by which the material universe was made, the other angels (his fellows) were present. When he spoke to men in behalf of JEHOVAH (often using JEHOVAH’S very words which his Father spoke through him), he was called “the Angel of JEHOVAH.” When he had finished his sacrifice on earth, he became much superior to his fellow angels by appointment and anointment from JEHOVAH (but even at this time he certainly did not become equal to God). 
- - - - - - - - - - 
3. A. Some translations of Heb. 1:8 by trinitarians:
“God is your throne” - AT (Dr. Goodspeed)
“God is thy throne” - Mo (Dr. Moffatt)
“God is your throne” - Byington
“God is your throne” - Dr. Barclay
“God is thy throne” - Dr. Westcott
“God is thy throne” - A.T. Robertson (Alternate translation)
“God is thy throne” - Dr. Young (Alt.)
“God is thy throne” - RSV (Alt.) 
“God is your throne” - NRSV (Alt.)
“God is thy throne” - NEB (Alt.)
“Thy throne is God” - ASV (Alt.)
B. Some translations of Ps. 45:6 (quoted at Heb. 1:8) by trinitarians:
“Your Divine throne” - RSV
“Your throne is like God’s throne” - NEB
“God is your throne” - Byington
“The kingdom that God has given you” - GNB
“God has enthroned you” - REB
“Your throne is from God” - NJB
“Your throne is a throne of God” - NRSV (Alt.)
“Thy throne is the throne of God” - ASV (Alt.)



- - - - - - - - - - -
4. New Testament texts produced by trinitarians in which Autou (“His”) was chosen as part of the original text ("... the scepter of his [autou] kingdom":
Westcott and Hort
Nestle’s
It has been admitted by respected trinitarian scholars (UBS text writers) that if autou ("his") were in the original writing of Heb. 1:8, the proper rendering earlier in the same verse must be “God is your throne”! – p. 663, A Textual Commentary on the Greek New Testament, United Bible Societies, 1971.

Even the highly respected NASB renders this as "... the scepter of his kingdom." The Jerusalem BibleNew Jerusalem BibleThe New English BibleRevised English BibleAT (Smith and Goodspeed); Rotherham; Byington; C.B. Williams; etc. also render it using "his." 
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The throne of JEHOVAH'S Son demystified II

   




Another consideration is that later Church copyists would often change the wording of a scripture if it seemed to contradict a teaching of the Roman Church.[1] Therefore, if the wording of an ancient manuscript seems to contradict a later teaching of the Roman Church, it is more likely to have the original wording than another ancient manuscript which (at the same verse) seems to agree with that Church teaching.


Using these criteria, the UBS Committee unanimously agreed with all the wording of Heb. 1:8 except for one word. They agreed that the original writing of Heb. 1:8 should read literally (in the NT Greek): “toward but the son the throne of you the god into the age of the age and the staff of the straightness staff of the kingdom [‘of him’ or ‘of you’].”


It was the very last word of Heb. 1:8 that caused a “considerable degree of doubt” among those textual scholars. This very last word was either the NT Greek word sou (translated into English as “of you” or “your”) or autou (translated “of him” or “his”).


Why is it so important? Because these trinitarian scholars agreed that if autou (“his”) were used here by the author of Hebrews 1:8, then the verse “must be” translated “God is thy throne” and not “thy throne, O God”!! If, however, sou (“your”) was the original wording, then it could be translated either way. Obviously, then, a trinitarian would strongly prefer the reading of sou. [See end note 4]


In discussing this problem the UBS Committee noted that all the very oldest and best manuscripts (p46 - circa 200 A.D.; 'Aleph' - 4th century; and B - 4th century) all agree that the original wording was “his (autou) kingdom.” 


They also noted that later manuscripts which read “your (sou) kingdom” are now in agreement with the corresponding passage in the Greek OT Septuagint! (Remember that the UBS Committee recognizes, as do most Bible scholars, that the NT manuscript that differs slightly from the Septuagint is more likely to be correct than another one which perfectly agrees because copyists strongly tended to deliberately “correct” Septuagint quotes they found in the NT .) 


Furthermore, since autou is not repeated near the word in question in this NT manuscript quote of Ps. 45:6, 7, but sou is repeated, before and after, it would have been easy for a copyist to have inadvertently miscopied sou here. Autou, then, is more likely to have been original than sou for more than one reason.


It is also important to realize that all the oldest manuscripts (which were probably written before the full trinity doctrine was officially declared by the Roman Church in 381 A. D. and certainly written well before it was popularly accepted through the efforts of such men as Augustine in the early 5th century) use the word autou which will not properly allow for the trinitarian-preferred interpretation. Whereas many of the later manuscripts now use the word sou which will allow for the trinitarian-preferred interpretation of Heb. 1:8.


Isn’t it significant that the very earliest manuscript to use the trinitarian-preferred sou is Manuscript A from the 5th century which is shortly after the trinity doctrine was fully and officially declared at the Council of Constantinople in 381 A. D. and during the highly successful efforts of Augustine and others to defend and popularize this newly established “truth” of the Roman Church? (Remember the correlation between new church doctrines and changes in later manuscripts.) - See the HIST study paper. 


So even though there is overwhelming evidence that “his” (autou) was in the original manuscript of Hebrews 1:8 (even the trinitarian scholars who developed the Westcott and Hort text and the Nestle text use autou at Heb. 1:8), the UBS Committee finally agreed to choose “your” (sou) and label that choice as “having considerable degree of doubt,” anyway! 


Why did they bend their own rules of evidence? Because (1) they said there were so many later manuscripts that used sou, and (2) they admitted that they didn’t like what that verse actually said if autou had really been used in the original!


Oh, they did soften the arbitrariness of their choice slightly by labeling it as “having considerable degree of doubt,” but if any honest impartial scholar will examine their own comments on the evidence, he must agree that the UBS Committee’s choice is purely an emotional one and the evidence rules otherwise (as other trinitarian texts noted above admit).


Sou not only has “considerable degree of doubt,” it is nearly impossible. The UBS Committee’s own comments on the evidence make autou virtually certain as the original word, and, therefore, in the committee’s own word’s, Hebrews 1:8 “must be” translated “God is thy throne” and not “thy throne, O God.” - (study pp. 662-663 in A Textual Commentary on the Greek New Testament, United Bible Societies, 1971.) 


It might be worthwhile to see that that same UBS textual committee said (p. 522) when discussing Romans 9:5: 


“In fact, on the basis of the general tenor of his theology it was tantamount to impossible that Paul would have expressed Christ’s greatness by calling him God blessed for ever.” And, “Nowhere else in his genuine epistles does Paul ever designate [‘the Christ’] as theos [‘God’ or ‘god’].”


So, for those of us who believe that Paul wrote the Bible book of Hebrews, the UBS committee provides yet another reason why Heb. 1:8 must be translated “God is your throne” not “your throne, O God.” (But don’t forget that some scholars don’t consider Paul to be the author of Hebrews even though they may still consider Hebrews to be inspired scripture.) 


Some trinitarians have objected that “it does not make sense [or even, ‘it’s ridiculous’] to call God a ‘throne.’”[2] However, to any serious Bible student, it is entirely reasonable and appropriate. Calling God “the throne of Jesus” is an excellent figurative way to show that God approves and upholds Christ’s kingly reign (as in Westcott’s comment previously quoted).


Is God ever called “unlikely” things in a figurative sense that are as equally “ridiculous” as calling him “a throne”? Every Bible student of any experience knows that He is, repeatedly!


Many times he is called someone’s “Rock” (e.g., Ps. 78:35). 


He is called a “fortress” (e.g., Ps. 91:2). 


He is called a “lamp” in 2 Samuel 22:29. 


He is called a “crown” (“in that day will Jehovah of hosts become a crown of glory, unto the 

residue of his people” - Is. 28:5, ASV). 


Jehovah is called “our dwelling place” - Ps. 90:1, KJV. 


And “Jehovah is my ... song” - Ps. 118:14. 


Also notice Ps. 60:7, 8 “Ephraim is my helmet, Judah my scepter, Moab is my washbasin”, NIV. And in Is. 22:23 we find Eliakim, whom Jehovah said he would call and commit authority to (Is. 22:20, 21), called a “throne” (“and he will become a throne of honor to his father’s house,” RSV). 


Not only is it made very clear by many trinitarian translators [3] and text writers [4] themselves that Heb. 1:8 may be honestly translated “God is your throne,” but all real evidence shows that it should be so translated!


So we find once more that Jesus cannot possibly be God. Just as we saw in the case of the Israelite king in Ps. 45:6, 7, if God is his throne (the one supporting him - giving him power and authority), then he cannot be that God!


............................................................................



NOTES




1. An example of this is the omission of the words “nor the son” in the majority of manuscripts at Matt. 24:36. However, the two oldest and best manuscripts, Aleph and B (as well as Manuscript A of the 5th century), do have “nor the son” after the word “heaven” (as it is in Mark 13:32). Bible scholars have come to the conclusion that the words were first omitted by a copyist sometime shortly after the development of the trinity doctrine by the Roman Church in the 4th century (see the HIST study) because it seemed to contradict the trinity doctrine: Jesus as equal to the Father. - See A Textual Commentary on the Greek New Testament, p. 62, United Bible Societies, 1971. Also see The Codex Sinaiticus and the Codex Alexandrinus, published by the trustees of the British Museum (quoted in the Feb. 1, 1984 WT, p. 7) or see the Manuscripts at . http://www.codex-sinaiticus.net/en/ and http://www.csntm.org/Manuscript/View/GA_02 and http://www.csntm.org/Manuscript/View/GA_03 




2. Bowman, in his Why You Should Believe in the Trinity, after explaining that Heb. 1:1-6 describes the Son as in essence God, says:


It should come as no surprise, then, that in verse 8 God the Father says “of the Son, ‘Your throne, O God, is forever and ever...’” (translating literally). 


To circumvent this plain statement, the NWT renders verse 8 as “God is your throne forever and ever....” On merely grammatical considerations, this translation is possible, and some biblical scholars have favored this rendering. According to such a reading, the point of the statement is then that God is the source of Jesus’ authority. 


However, this seems to be an unusual, if not completely odd, way of making that point. In Scripture a “throne” is not the source of one’s authority, but the position or place from which one rules. Thus, heaven is called “the throne of God” (Matt. 5:34). Surely God does not derive his authority from heaven, or from anyone or anything! But, even assuming that “God is your throne” would be understood as having that meaning, in context this makes no sense. The writer of Hebrews is quoting Psalm 45:6 and applying it to the Son to show that the Son is far greater than any of the angels. However, if all this verse means is that the Son’s authority derives from God, this in no way makes him unique or greater than the angels, since this could be said of any of God’s obedient angels. - pp. 106-107, Baker Book House, 1991 ed. 


To take things in the order Bowman states them, 


(A) his “literal” translation of Heb. 1:8 is certainly not literal. As we saw at the beginning of this paper, the actual NT Greek literally says “the throne of you the god into the age of the age.” The understood verb “is” may be inserted anywhere in the sentence, but it is not literally in the original manuscript, and to insist that it must be inserted and interpreted as Bowman has done is simply (literally) untrue! In fact it seems much more probable, whether one inserts it before or after “the god,” to mean: ‘the throne of you IS the God into the age of the age.’ (Although it is less likely, it is possible that ho theos could be considered a vocative [‘O God’] - but see trinitarian Dr. Westcott’s quote above). But, at any rate, Bowman is not being truthful when he says he is “translating literally” as ‘your throne, O God, is forever and ever...’! 


Posted by Elijah Daniels 

It's design through and through?

 In Our World, Multiple Levels of Intelligent Design


A few weeks ago, when the start of the fall semester brought to me a classroom full of new students for their first college physics course, I took a few minutes to get to know them by asking them a question. Since I currently teach at a Christian university, I asked the students to write out an example or two of how they see God’s hand in nature.

Reading responses to an open-ended question like this provides a valuable glimpse into what students are thinking and where they are in their understanding of science and faith. It was good for me to be reminded that nature offers poignant testimony to a designer, for those who have eyes to see.

Most students saw “God’s hand in nature” in a general way through order, beauty, and interconnectedness. Examples included seeing a sunrise or sunset and the feelings of peace that come when viewing these. The beauty of plants and flowers that thrive in nature. Autumn leaves changing colors, the first snowfall and other seasonal changes. The awesome beauty of mountains and the Grand Canyon. Animals and birds and the purposes they serve. The ocean and all the life it sustains. Clouds and how they bring the rain. The moon and stars at night. And the intricacy of the human body.

An Admission

I’ll have to admit that when I first read through these responses, the thought came to me that appealing to aesthetics or the calming effect of the ocean waves, the regularity of the seasons, or the awesomeness of a starry night sky as evidence would be quickly discounted by most atheists. And yet I realize that all these examples speak most deeply to my own heart not only of the existence of a designer but of his character. 

Lest we become too focused on scientific evidence, to the seeking heart, a deeper question seeks for an answer. The 19th-century Scottish storyteller and theologian George MacDonald framed it this way in his novel Robert Falconer:

The Most Fundamental Level

Evidence from nature is at the heart of the intelligent design argument. As we examine the natural world, multiple levels of design become apparent. At the most fundamental of these we encounter designs that can be fully explained by the universal laws of nature. We’re all familiar with examples, such as exquisite six-sided snowflakes, rainbows across a misty valley, the rosy hues of a sunrise or sunset, or the rhythmic waves of the ocean washing over a sandy beach. Each of these examples of natural design can be fully explained by reference to the forces and laws of nature discovered.

Does explanation by natural cause negate intelligent design? Only if the existence of these prior causes can also be explained naturally. As it is, however, and despite the best efforts of many scientists to explain otherwise, the laws of nature that bring about beautiful instances of natural design have no other scientific explanation than that they just are the way they are. Postulating a designer for the particular suite of orchestrated natural laws that govern our universe has seemed to many scientists a more reasonable conclusion than simply ascribing everything to “dumb luck.”

Designs of Life

Within our world, we also find higher genres of design that cannot be explained by appealing to the actions of natural forces and laws of nature. In every case, these higher levels of design originate from or within living creatures. I address the evidential power of some of these designs in my book, Canceled Science:

Animals, even insects, can create designs that extend beyond the kinds of design produced by the forces of nature alone. Animal designs typically have the added hallmark of functionality — for example, a beehive, or a bird’s nest, or a spider’s web. However, these designs seem to be pre-programmed or instinctive, and do not originate from the individual creativity of the animal.

A creature’s instinctive ability to create a structure of functional design prompts us to investigate how this ability could have been brought about. Three questions regarding instinctive designs need consideration:  

How did the information required to instantiate the design arise in the first place?
How did the information for the design become coded within the biochemistry of the organism?
How did an effectual, multi-generational information storage, retrieval, and implementation system come to exist within the living creature’s being?
These are profound questions that need more than a bobble-head nod to evolution to answer them. Complex, functional systems do not arise without intelligent guidance and direction. 

A Naturalistic Point of View

The mystery of explaining design from a naturalistic point of view reaches an even higher level when we consider human designs that exponentially exceed anything else in nature. I wrote in Canceled Science:

Humans, in contrast, can and do create beautiful designs with a seemingly inexhaustible fund of creativity. Humans can endow their designs with functionality or whimsy, can express the complex emotions of the artist, or the mood and outlook of a people or culture at a particular time and place — the zeitgeist. 

The fields of painting, sculpture, music, literature, architecture, and engineering all offer proofs in abundance of the human capacity and drive to produce masterful designs. Such work involves matter and a mastery of material forces, but it is more than this. Leonardo da Vinci said, “The painter has it first in his mind, and then in his hands.”1 Human-level designs far exceed anything the laws of physics and chemistry alone could produce. Nowhere do we find such laws producing, from scratch, anything approaching the Taj Mahal, or a racing yacht, or the Space Shuttle, or da Vinci’s Mona Lisa.

The Highest Level

Within the physical universe, the highest level of design we encounter manifests in the functional biochemistry of a living creature, perhaps attaining its pinnacle in the human body. Even a single-celled organism exhibits masterful biochemical design properties that challenge the human ability to comprehend, let alone mimic with our most sophisticated technology. Asking for the origin of such exquisitely complex biological designs — designs that surpass the combined intelligence of the entire human race — surely points us to a designer far beyond nature.

And where we directly witness the creation of a form that is fundamentally new, information rich, and of great depth, there is always behind it an intelligent agent — an artist or poet, an architect or engineer. Based on this uniform and repeated experience, biological designs — themselves novel, information-rich, and of great depth — would appear to be the prerogative of creative intelligence.

Eric Hedin, Canceled Science: What Some Atheists Don’t Want You to See (Seattle: Discovery Institute Press, 2021, pp. 204-5)

Notes

Martin Kemp, ed. Leonardo on Painting: An Anthology of Writings by Leonardo da Vinci with a Selection of Documents Relating to His Career as an Artist, trans. Martin Kemp and Margaret Walker (New Haven: Yale University Press, 1989), 32.

Their kingdom is very much a part of this world.

 "Pope Pius XII, in particular, had failed to condemn the Final Solution, though he knew of it."

Paul Johnson, History of the Jews

"How could the Christian Church, apparently quite willingly, accommodate this weird megalomaniac [Constantine] in it's theocratic system? Was there a conscious bargain? Which side benefited most form this unseemly marriage between church and state? Or, to put it another way, did the empire surrender to Christianity, or did Christianity prostitute itself to the empire? It is characteristic of the complexities of early Christian history that we cannot give a definite answer to this question."

Paul Johnson, A History of Christianity

Tags: christianity, history

"Jesus answered, “My Kingdom is not an earthly kingdom. If it were, my followers would fight to keep me from being handed over to the Jewish leaders. But my Kingdom is not of this world.”"

John chapter 18 verse 36 New Living translation 

File under "Well said" CXI

"The study of history is a powerful antidote to contemporary arrogance. It is humbling to discover how many of our glib assumptions, which seem to us novel and plausible, have been tested before, not once but many times and in innumerable guises; and discovered to be, at great human cost, wholly false."

Paul Johnson

Monday, 23 September 2024

The Joy of examining the thumb print of JEHOVAH.

 

In search of Darwinism in the real world.

 Decade-Long Study of Water Fleas Found No Evidence of Darwinian Evolution


Science programs tell us that natural selection explains the development of all life forms from the origin of life to the present, from amoebas to humans:

Natural selection is the adaptation strategy of living organisms on Earth. It occurs when they acquire and evolve a trait with time that provides them a distinct advantage for their survival and reproduction over other organisms in the population. Darwin called them “survival of the fittest.”’ (ScienceFacts.net)

It seems so simple. Philosopher Daniel Dennett (1942–2024) called it the single greatest idea anyone ever had. It was perfect for the stark materialism he espoused. 

Times Change

Questions accumulate. Research results don’t add up. And dissatisfaction has grown.

Recently, Arizona State University geneticist Michael Lynch headed up a study published in the venerable journal PNAS that comes as close as any to saying the unsayable: Darwinian evolution, as espoused by, say, Dennett and Richard Dawkins, is not on such firm ground. In a world where huge battles have been fought to entrench it in the school systems, findings like that, published in a key journal, may signal a cultural shift.

The study concerns the common water flea (Daphnia pulex):

Daphnia is a good choice for this kind of study because it is very sensitive to changes in its environment. For that reason, it is used to test water purity. It also reproduces quickly, asexually. So if changes in the environment do change Daphnia’s genome, those changes should be detected.

“Little Consistent Selection Pressure”

The researchers analyzed DNA from 1,000 Daphnia over a decade and did not find evidence of Darwin’s natural selection happening as described. Their findings are phrased in careful science news media prose:

The multi-year, genome-wide analysis of nearly 1,000 genetic samples from a Daphnia pulex population shows that most genetic sites experience varying selection, with an average effect close to zero, indicating little consistent selection pressure over different times and selection spread across many genomic regions.

These findings challenge the usual understanding of genetic diversity and divergence as indicators of random genetic drift and selection intensity. 

The study’s Abstract is unusually blunt:

Despite evolutionary biology’s obsession with natural selection, few studies have evaluated multigenerational series of patterns of selection on a genome-wide scale in natural populations. Here, we report on a 10-y population-genomic survey of the microcrustacean Daphnia pulex … These results suggest that interannual fluctuating selection is a major determinant of standing levels of variation in natural populations, challenge the conventional paradigm for interpreting patterns of nucleotide diversity and divergence, and motivate the need for the further development of theoretical expressions for the interpretation of population-genomic data. 

The science media release says something else that is quite interesting:

These findings challenge the traditional belief that measuring genetic diversity (the range of different traits in a population) and genetic divergence (the differences between populations) can easily show how natural selection is consistently operating. Instead, natural selection seems to operate with greater subtlety and complexity than previously thought.

“Greater Subtlety and Complexity”?

The whole point of claims for Darwinian evolution is to eliminate subtlety and complexity. To show that merely random mutations in response to environmental changes can create everything from the organized complexity of the beehive to the nearly unfathomable human mind. And the researchers did not find these random but creative mutations. 

Since we are here anyway, what is the origin of complexity and subtlety? Do they not suggest a mind in or behind the universe?

To say that “natural selection seems to operate with greater subtlety and complexity than previously thought” is a polite way of saying that Darwinian evolution is not a correct interpretation of the history of life. Culturally, that is very interesting. It means that the only theory permissible in U.S. school systems may not be a correct interpretation of nature.

Sunday, 22 September 2024

The fuse of the cambrian explosion?

 Fossil Friday: Update on the Dubious Nature of the Precambrian Gabonionta


In a Fossil Friday article last year (Bechly 2023) I discussed the dubious status of an assemblage of alleged Precambrian macrofossils from West Africa that have been informally called Gabonionta. Meanwhile, two new articles on the subject have been published, so that I here present an updated and expanded version of my article.

“According to conventional thinking, unequivocal evidence for eukaryotic fossils first appeared in the geological record some 1700–1600 million years ago” (Chi Fru et al. 2024). However, in 2008 the Moroccan-French geologist Prof. Abderrazak El Albani from the University Poitiers discovered strange three-dimensionally preserved radial structures in Proterozoic rocks of the Francevillian Formation in the West African country Gabon, which are believed to be about 2.1 billion years old. The ear-shaped structures of up to 6.7 inch size were interpreted as earliest fossil evidence for oxygen-respiring, multicellular eukaryotic life forms and were published two years later in the prestigious journal Nature (El Albani et al. 2010, Maxmen 2010).

Somewhat More Cautious

This original description was somewhat more cautious than the later public presentation of the discovery. The authors said:

We consider it most likely that these structures represent fossilized colonial organisms … it is also possible that they represent colonial eukaryotes. … Although we cannot determine the precise nature and affinities of the 2.1-Gyr macroorganisms from the Francevillian B Formation of Gabon, we interpret these fossils as ancient representatives of multicellular life, which expanded so rapidly 1.5 Gyr later.

In 2014, these findings were first presented to the general public with a special exhibition titled “Experiment Life: The Gabonionta” opened in March 2014 at the Natural History Museum in Vienna (), which also featured a 40-minute documentary film by the University of Poitiers about the discovery. This exhibition was accompanied by a sensationalist media campaign, which included fancy headlines such as: “Gabonionta: sensational discovery in Vienna” (ORF 2014), “Gabonionta, the little revolutionaries of evolution” (Vosatka 2014), or “Gabonionta: How multicellular organism tried to conquer the Earth” (Anonymous 2014).

Remarkable and Highly Unusual

It is remarkable and highly unusual in bioscience that the new taxon Gabonionta was never formally described as scientific name, but only used informally in public presentations and press releases. While El Albani refrained from formally naming the fossils, the new name Gabonionta was first introduced by the head of the paleontology department, Dr. Matthias Harzhauser, on occasion of the mentioned special exhibition at the Natural History Museum of Vienna. Therefore, it is commonly thought that this name Gabonionta, which designates a supposed independent and extinct branch of multicellular life, is not taxonomically valid because it was not properly described according to the international rules of nomenclature. However, this is not true, because these rules do not apply to higher taxa above the family group level. Even if this name was only used in popular science publications, it is as scientifically valid and available just as other higher taxonomic names such as Eukaryota or Metazoa.

Anyway, there are more important issues with this discovery: other experts such as the late great German paleontologist Prof. Adolf Seilacher remained highly sceptical about the interpretation and suggested that the structures rather represent only pseudo-fossils formed by abiotic pyrite crystals during the diagenesis of the rocks. El Albani et al. (2014) responded to this critique and objected that not all of the fossils are pyritized and that the fossils formed at the same time as the sediment and therefore could not have been produced later by metamorphic processes. However, the initial critique was later strongly corroborated by the discovery of very similar structures from 1.1 billion year old sediments of Lake Michigan that were described by the authors as inorganic concretions (Anderson et al. 2016). Therefore, Javaux & Lepot (2018) remarked that “the identity of these macrostructures remains unknown and their biogenicity is questionable”.

Just a year later, El Albani et al. (2019) defended the organic origin and syngenicity of some other alleged fossils from the Francevillian Formation, and boldly suggested that they were analog to “the aggregation of amoeboid cells into a migratory slug phase in cellular slime molds.” This cannot be so easily dismissed, as this publication includes among its co-authors some world renowned experts such as Drs. Stefan Bengtson, Luis Buatois, and Gabriela Mangano. Nevertheless, other experts remained very much unconvinced. More recently, Fakhraee et al. (2023) again came to the devastating finding that these structures could rather represent abiotic concretions and synaeresis cracks. They concluded that “in light of their stratigraphic age, unusual morphology, and the relative rarity of these features, a eukaryote affinity for these features—or affinity with analogously complex multicellular organisms — remains uncertain.” It looks like the dubious name Gabonionta may not even refer to any organism that ever existed. The scientists simply made up a new domain of life, based on nothing but inorganic patterns in ancient rocks.

Nothing But Hype?

Is there any other evidence that this sensational discovery was nothing but hype? Sure there is: after the 2014 media circus nobody ever published any primary research again about these “fossils” and the mysterious Gabonionta, at least until last year (see below). Even in their newer papers about the Francevillian Biota, El Albani and his colleagues only described lenticular structures produced by agglutinated protists (Lekele Baghekema et al. 2017, Reynaud et al. 2017, El Albani et al. 2019, 2023), but no longer promoted the presence of truly multicellular organisms. The silence was deafening!

Even, the mentioned two most recent works on the assumed Francevillian fossils, which appeared after my first article on this subject, again only defended their biogenic origin and eukaryotic nature. Ossa Ossa et al. (2023) did not base their conclusions on a study of the fossil structures but on geochemical evidence from Zinc enrichment, which could be consistent with eukaryotic metabolism. However, they openly admitted that “geochemical evidence presented here also cannot resolve the exact type of eukaryotic organisms that inhabited the Francevillian basin, i.e., colonies of multiple cells or individual, large complex multicellular organisms.” Moreover, there is no independent confirmation yet that the enrichment of Zinc isotopes could not be alternatively better explained with inorganic processes or prokaryotic microbial activity. After all, these structures are pyritized, which is quite typical for bacterial metabolic activity during fossilization (Janssen et al. 2022). Ossa Ossa et al. devote a whole lengthy chapter of their discussion to the question if the Zinc enrichment is based on prokaryotic or eukaryotic metabolic processes, but in the last paragraph they have to admit that:

However, it is important to emphasize here that studies of Zn isotope fractionation by eukaryotes have been focused exclusively on modern photosynthetic eukaryotes. This leaves the uncertainty whether strong enrichment in light Zn isotopes represents a distinct trait of the whole eukaryotic domain and whether the Francevillian Group fossilized structures represent photosynthetic or non-photosynthetic eukaryotes.

Indeed, Ossa Ossa et al. are careful to conclude that their data only “may [my emphasis] point to their eukaryotic rather than prokaryotic affinity” and “once confirmed [my emphasis], this would provide a critical calibration point for eukaryogenesis.”

The Usual Evolutionist Word Salad

The newest study by Chi Fru et al. (2024), which has Dr. El Albani as senior author, did not look at the alleged fossils either, but instead found a correlation of the Francevillian Formation with a “previously unrecognized local pulse in dissolved seawater P concentration, of comparable magnitude to Ediacaran seawater levels”, which seems to have been caused by “an episode of intense submarine hydrothermal alteration of a nutrient-rich seafloor reservoir”. The authors interpret this slim data point as evidence that “hydrothermal seawater eutrophication triggered local macrobiological experimentation in the 2100 Ma Paleoproterozoic Francevillian sub-basin” and “nutrient enrichment initiated localized emergence of large colonial macrofossils in the Franceville sub-basin.” In spite of these weak speculations based on highly circumstantial evidence, the new study was sold to the public in a press release titled “complex life on Earth began around 1.5 billion years earlier than previously thought” (Cardiff University 2024). If you read the original study you will find the usual evolutionist word salad of “may have”, “could have”, “likely have”, “possibly reflects”, and “might explain”. Not exactly the usual vocabulary of hard science.

Here is what I tentatively suggest is more likely what really happened: a surplus of nutrients (such as phosphates) triggered a lot of microbial activity that resulted in different concentrations of elements and the formation of pseudo-fossils. Maybe some of the protists already were eukaryotic and maybe some of them formed colonial aggregations, or maybe not, we have no clue. What we definitely do not find here is any credible evidence for an evolutionary transition to genuine multicellular eukaryotes, as was initially claimed with the overhyped discovery of the Gabonionta.

References

Anderson RP, Tarhan LG, Cummings KE, Planavsky NJ, Bjørnerud M 2016. Macroscopic structures in the 1.1 Ga continental Copper Harbor Formation: Concretions of fossils? Palaios 31(7), 327–338. DOI: https://doi.org/10.2110/palo.2016.013
Anonymous 2014. Gabonionta: Wie Mehrzeller versuchten, die Erde zu erobern. OÖNachrichten March 8, 2014. https://www.nachrichten.at/panorama/weltspiegel/Gabonionta-Wie-Mehrzeller-versuchten-die-Erde-zu-erobern;art17,1323424
Bechly G 2023. Fossil Friday: How an Austrian Scientist Concocted a New Domain of Life called Gabonionta. Evolution News June 2, 2023. https://evolutionnews.org/2023/06/fossil-friday-how-an-austrian-scientist-concocted-a-new-domain-of-life-called-gabonionta/
Cardiff University 2024. Complex life on Earth began around 1.5 billion years earlier than previously thought, new study claims. Phys.org July 29, 2024. https://phys.org/news/2024-07-complex-life-earth-began-billion.html
Chi Fru E, Aubineau J, Bankole O, Ghnahalla M, Soh Tamehe L & El Albani A 2024. Hydrothermal seawater eutrophication triggered local macrobiological experimentation in the 2100 Ma Paleoproterozoic Francevillian sub-basin. Precambrian Research 409: 107453, 1–17. DOI: https://doi.org/10.1016/j.precamres.2024.107453
El Albani A, Bengtson S, Canfield DE et al. 2010. Large colonial organisms with coordinated growth in oxygenated environments 2.1 Gyr ago. Nature 466(7302), 100–104. DOI: https://doi.org/10.1038/nature09166El Albani A, Bengtson S, Canfield DE et al. 2014. The 2.1 Ga Old Francevillian Biota: Biogenicity, Taphonomy and Biodiversity. PLoS ONE 9(6):e99438, 1–18. DOI: https://doi.org/10.1371/journal.pone.0099438
El Albani A, Mangano MG, Buatois LA, Bengtson S, Riboulleau A, Bekker A, Konhauser K, Lyons T, Rollion-Bard C, Bankole O, Lekele Baghekema SG, Meunier A, Trentesaux A, Mazurier A, Aubineau J, Laforest C, Fontaine C, Recourt P, Chi Fru E, Macchiarelli R, Reynaud JY, Gauthier-Lafaye F & Canfield DE 2019. Organism motility in an oxygenated shallow-marine environment 2.1 billion years ago. PNAS 116(9), 3431–3436. DOI: https://doi.org/10.1073/pnas.181572111
El Albani A, Konhauser KO, Somogyi A et al. 2023. A search for life in Palaeoproterozoic marine sediments using Zn isotopes and geochemistry. Earth and Planetary Science Letters 612:118169, 1–13. DOI: https://doi.org/10.1016/j.epsl.2023.118169
Fakhraee M, Tarhan LG, Reinhard CT, Crowe SA, Lyons TW & Planavsky NJ 2023. Earth’s surface oxygenation and the rise of eukaryotic life: Relationships to the Lomagundi positive carbon isotope excursion revisited. Earth-Science Reviews 240: 104398. DOI: https://doi.org/10.1016/j.earscirev.2023.104398
Janssen K, Mähler B, Rust J, Bierbaum G & McCoy VE 2022. The complex role of microbial metabolic activity in fossilization. Biological Reviews 97(2), 449–465. DOI: https://doi.org/10.1111/brv.12806
Javaux EJ & Lepot K 2018. The Paleoproterozoic fossil record: Implications for the evolution of the biosphere during Earth’s middle-age. Earth-Science Reviews 176, 68–86. DOI: https://doi.org/10.1016/j.earscirev.2017.10.001
Lekele Baghekema SG, Lepot K, Riboulleau A, Fadel A, Trentesaux A & El Albani A 2017. Nanoscale analysis of preservation of ca. 2.1 Ga old Francevillian microfossils, Gabon. Precambrian Research 301, 1–18. DOI: https://doi.org/10.1016/j.precamres.2017.0
Maxmen A 2010. Ancient macrofossils unearthed in West Africa. Nature News June 30, 2010. DOI: https://doi.org/10.1038/news.2010.323
NHM 2014. Experiment Life – the Gabonionta. Press release March 7, 2014. ORF 2014. „Gabonionta“: Sensationsfund in Wien. ORF.at March 11, 2014. https://wien.orf.at/v2/news/stories/2635417/
Ossa Ossa F, Pons M-L, Bekker A, Hofmann A, Poulton SW, Andersen MB, Agangi A, Gregory D, Reinke C, Steinhilber B, Marin-Carbonne J & Schoenberg R 2023. Zinc enrichment and isotopic fractionation in a marine habitat of the c. 2.1 Ga Francevillian Group: A signature of zinc utilization by eukaryotes? Earth and Planetary Science Letters 611: 118147, 1–13. DOI: https://doi.org/10.1016/j.epsl.2023.118147
Reynaud J-Y, Trentesaux A, El Albani A et al. 2017. Depositional setting of the 2·1 Ga Francevillian macrobiota (Gabon): Rapid mud settling in a shallow basin swept by high-density sand flows. Sedimentology 65(3), 670–701. DOI: https://doi.org/10.1111/sed.12398
Vosatka M 2014. Gabonionta, die kleinen Revolutionäre der Evolution. DerStandard March 11, 2014. https://www.derstandard.at/story/1392687847479/gabonionta-die-kleinen-revolutionaere-der-evolution

And yet another clash of Titans

 

JEHOVAH's technology vs. Darwinism

 Challenges to the Evolutionary Origins of the Glycolytic Pathway



The purpose of cellular respiration is to convert the energy stored in glucose into adenosine triphosphate (ATP), the primary energy currency of the cell. Cellular respiration occurs in three main stages. Glycolysis involves the breakdown of glucose into pyruvate, producing a small amount of ATP. The citric acid cycle further breaks down pyruvate into carbon dioxide, generating NADH and FADH2. The final step of cellular respiration is the electron transport chain and oxidative phosphorylation, which produce a large amount of ATP, as well as water as a byproduct. In a series of articles, I will discuss features of cellular respiration that provide evidence of intelligent design. In this first installment, I will consider the problem of causal circularity as it pertains to the utilization of ATP in glycolysis.

The first step in cellular representation (glycolysis) is represented by the figure at the top. Glycolysis is ubiquitous across all living organisms. As shown in the figure, glycolysis involves the conversion of glucose, through a series of intermediates, to pyruvate. This pyruvate is then transported into the mitochondria where it is converted into acetyl-CoA by the enzyme pyruvate dehydrogenase. This process also produces NADH and releases one molecule of carbon dioxide (CO2). The acetyl-CoA then feeds into the citric acid cycle, where it is further oxidized, generating more NADH, FADH2, and ATP (or GTP).

Incremental Evolution?

Glycolysis has been proposed to be the first biochemical pathway to arise in evolution. Among the reasons for this are the fact that glycolysis is found ubiquitously across the tree of life (so may be inferred to have been present in the last universal common ancestor). Moreover, glycolysis is an anaerobic reaction sequence, and thus is consistent with the absence of oxygen in the primitive Earth environment.

There are, however, significant challenges to a proposed evolutionary origin of the glycolysis pathway. For example, the conversion of glucose to pyruvate involves as many as ten independent enzymes, typically 300 to 500 amino acids in length. It is extremely implausible that ten enzymes with complementary activities could have arisen at essentially the same time. But could the pathway have evolved incrementally, either forwards or backwards? It is generally rejected that glycolysis arose backwards (i.e., with pyruvate being initially available, then its precursor, etc.) since it was not the oxidized pyruvate, but rather sugar, that would have been present in the early Earth environment. Moreover, every intermediate between glycose and pyruvate is phosphorylated (i.e., has one or two of its hydroxyl groups replaced by phosphate). This involves a condensation reaction (where a water molecule is eliminated). Given the difficulties of this type of reaction, it is questionable whether the various intermediates could have emerged abiotically in high enough quantities to facilitate the origin of glycolysis.

The more popular view is that glycolysis evolved incrementally in the forwards direction. This hypothesis, of course, relies on the presumption that the intermediates could have served their own independent utility. However, since glycolysis is generally thought to have arisen extremely early — before additional utility of the intermediates could have arisen — it seems unlikely that the intermediates could have had independent usages.

Causal Circularity

Notice that the process of glycolysis consumes two ATP molecules — one at the glucose to glucose 6-phosphate step (catalyzed by hexokinase) and one at the fructose 6-phosphate to fructose 1,6-bisphosphate step (catalyzed by phosphofructokinase). The overall ATP yield of glycolysis is four (although many more ATPs will be produced later on), while two are consumed — making the net yield two ATPs. In order for ATP to be produced, ATP must first be consumed. This presents a causal circularity challenge to an evolutionary account of the origins of glycolysis. Strikingly, this causal circularity of ATP being required to manufacture more ATP appears to be ubiquitous across life.1 How could the process of glycolysis be established without an initial supply of ATP? Moreover, after the consumption of the first ATP, there are at least five additional steps (each involving its own enzyme) before any further ATP is produced), and nine before there is a net yield of ATP. Given that natural selection lacks foresight, this renders it extremely implausible that the enzymes early on in the glycolytic pathway could have served any benefit in the absence of the enzymes later in the pathway.

Excluding Water

Of the ten enzymes involved in glycolysis, six catalyze reactions that involve a phosphate group transfer. For a phosphate to react with a hydroxyl group of water to form phosphoric acid is just as energetically favorable as for it to react with the hydroxyl or a sugar or ADP. But this would be of no evolutionary advantage. Thus, water must be excluded from the enzymes’ active sites to prevent hydrolytic reactions from occurring. This is achieved through a mechanism involving conformational changes that resemble a “hinge motion.” Initially, the enzyme’s active site assumes an open conformation, allowing the substrate to enter. When the substrate binds to the active site, it induces a conformational change, causing the enzyme to undergo a “closing” motion, with the domains of the enzyme coming together, effectively shielding the active site. This motion not only secures the substrate but also excludes water from entering the active site.

This phenomenon underscores the engineering sophistication — and the degree of amino acid specificity — of these enzymes. Since the exclusion of water is absolutely critical to the occurrence of the appropriate reactions, there would be no use in having a partly formed enzyme (i.e., one that could catalyze the phosphorylation reaction but failed to exclude water). This casts further doubt on the ability of incremental adaptations to account for the glycolytic pathway.

Relationship Between Enzymes?

A further issue is that, if indeed glycolysis were one of the earliest metabolic pathways to evolve, one might expect that at the time of its origin there existed only a small repertoire of enzymes. Moreover, the compounds on which these enzymes act have similar structures. This might lead us to predict that the enzymes involved in glycolysis are evolutionarily related to one another. However, as Keith Webster notes:

Sequence and crystallographic data favor the divergent evolution of for example monophosphoglycerate mutase and diphosphoglycerate mutase, and possibly glyceraldehyde-3-P dehydrogenase and phosphoglycerate kinase from respective common ancestors, but convergence appears to have played a greater role in the development of all of the other 11 enzymes(Fothergill-Gilmore, 1986; Fothergill-Gilmore and Watson,1989). For example, there is no evidence of a common ancestor for any of the four glycolytic kinases or of the seven enzymes that bind nucleotides, with the exception of those mentioned above. Rather, it seems likely that the pathway resulted from the chance assembly of independently evolving enzymes and genes, probably in association with the co-evolution of other functions and linked pathways.

This seems contrary to what might be predicted on an evolutionary account of the origins of glycolysis.

Intelligent Design

Multiple challenges confront an explanation of the glycolytic pathway in terms of unguided evolutionary mechanisms. The complexity and engineering sophistication comport much better with the hypothesis of design. In particular, the causal circularity of ATP being required to make more ATP is difficult to account for by a stepwise evolutionary process. On the other hand, this sort of phenomenon is totally unsurprising on the supposition of the involvement of an intelligent mind.

Notes

Kun A, Papp B, Szathmáry E. Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks. 

Genome Biol. 2008;9(3): R51.
Webster KA. Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia. J Exp Biol. 2003 Sep; 206(Pt 17):2911-22.

The Origin of Life : the simplified version?

 Is Assembling Life Like Assembling LEGOs?


I recently read Sara Walker’s new book, Life as No One Knows It: The Physics of Life’s Emergence. The book is addressed to a popular audience, and although the term is barely used, it is really about assembly theory in origin of life research. Walker asks questions like, What is Life? (with no definitive answer), and calls the origin of matter and the origin of life two hard problems in science. Walker mostly tackles the latter through her explication of assembly theory, but with questionable success. 

Illustrating with LEGO Blocks

Because the book is aimed at a popular audience, Walker has the difficult task of explaining technical concepts in ways accessible to general readers. Thus, she resorts to the analogy of LEGO blocks to illustrate how complex structures can be assembled by combining simpler structures through a process called selection. Two LEGO blocks can be combined in only a small number of ways. But as a LEGO figure grows larger, the number of ways to attach new blocks quickly inflates. Randomly attaching new blocks to a complex figure will likely not produce a useful or meaningful figure. But a process of selection at each step can cut a path through this inflating combinatorial space toward the creation of a complex and meaningful figure. 

According to Walker, this is how life originated. She writes:

The origin-of-life transition occurs when the combinatorial explosion of possible low assembly molecules gets constrained and funneled to select only a subset of possible molecules. Those are scaffolded to build more assembled objects, where those objects in turn build even more assembled ones. It captures the idea that it is objects building slightly more complex objects all the way down. As Lee [Cronin] sometimes says, to solve the origin of life all we need is to generate a simple machine that can build a slightly more complex machine, and so on. (163)

Unfortunately, Walker provides no clue as to what process does all the “constraining,” “funneling,” and “scaffolding.” And what characteristic marks the non-life-to-life transition if we don’t have a good working definition of life in the first place? Moreover, if Lee Cronin is successful in generating a machine capable of generating more complex machines, it will be Cronin’s intelligence standing at the head of this process. What undirected process would be capable of generating the original machine-generating machine? I came away from Walker’s book with far more questions than answers. 

Refreshingly Transparent

To Walker’s credit, however, she is refreshingly transparent on one crucial point. In a discussion of homochirality in organic molecules, she freely admits, “We do not know the mechanism by which this property first arose for the life we observe on Earth.” (173) She does go on to state her hope that assembly theoretic principles might eventually “shed new light on what has been a stubborn mystery.” (173) I wouldn’t bet the house on it. And without a naturalistic explanation for homochirality, one can never have a naturalistic explanation for the origin of life. 

One other stylistic feature of Walker’s book is worth mentioning. Against all literary convention, she insists on referring to other scientists by their first names after the first reference where she provides the full name. So, we are regularly treated throughout the book to references to conversations Walker has had with people like Paul, or Lee, or Andy, leaving the reader to scramble to remember that these are references to Paul Davies, Lee Cronin, and Andrew Ellington. I don’t know if she is trying to impress the reader by showing that she is on a first-name basis with all these scientists. But this stylistic decision can be confusing and undercuts the professionalism of the book (I’m surprised the publisher allowed it).

In all honesty, I wouldn’t recommend spending time reading Life as No One Knows It. Sara is well-versed in physics and chemistry, yet she is just as clueless on the origin of life as every other scientist trying to explain it in purely naturalistic terms.