Why random mutations leave precious little for nature to select.

 

Fin-To-Limb” Paper Shows Destructive Nature of “Evo-Devo” Mutations

Casey Luskin

Yesterday I wrote a post with critiques of a 2021 Cell paper, “Latent developmental potential to form limb-like skeletal structures in zebrafish.” That was in the context of responses from Brian Miller and myself (here, here, here, and here) to a review of Return of the God Hypothesis, for BioLogos. The research purported to produce extra bones in a fish fin by mutating developmental genes. The reviewer, biologist Darrel Falk, argued that these bones are “likely the equivalent of the radius and ulna” from a tetrapod limb. Yet the paper itself stated, “[W]e cannot assign a homology relationship between intermediate radials and any specific element of the limb.” 

A Friend Notes

A reader of Evolution News makes another noteworthy point about why this paper does not demonstrate the evolution of fins into limbs:

Dr. Falk thinks that showing how fins can become limbs is enough to show that new body plans can appear by analogy. He cites the study you discussed to show that mutations in developmental genes can produce new patterns in short steps, but in fact, that study shows exactly what you and Meyer and a lot of ID proponents have been saying long time ago: these kinds of mutations will be catastrophic on the organisms as a whole and the systems they occur in them in particular! 

The mutations that produced the two extra bones are a very good example. They were so destructive (see Figure S2 of the paper) that the authors chose not to study these fishes in a homozygotic form but in heterozygotic form. They say:

“The overall pattern and size of the fin rays are not dramatically altered. We named this mutant rephaim (reph). The mutant phenotype exhibits varied expressivity and dose sensi- tivity, as homozygous fish are highly dysmorphic (Figure S2). Due to the severity of the homozygous condition, we have focused our analysis on heterozygous reph mutants (reph/+).” (Emphasis added.)

This point refutes Falk’s claim and it reinforces our position that mutations to developmental genes are no good solution to the novelty problem.

Not Functional in Nature

The reader makes some good points. Looking at Figure S2 from the paper (below), it is clear that homozygous mutants for the two genes they mutated — the wan gene (wan/wan genotype) and reph gene (reph/reph genotype) — lead to “dysmorphic” pectoral fins. That is, they are highly deformed and would be unlikely to perform as a functional fin or a functional limb or a functional intermediate in nature. That’s for the pectoral fin. The images also show what appear to be deleterious effects for the dorsal fin:

Figure S2 of “Latent developmental potential to form limb-like skeletal structures in zebrafish,” Cell, 184: 1-13, by M. Brent Hawkins, Katrin Henke, Matthew P. Harris (February 18, 2021), with permission from Elsevier. 

Because of the “dysmorphic” phenotype from a homozygous genotype, these mutant genes would be highly unlikely to become fixed in a population as an advantageous trait. That is because individuals having the two mutant alleles would likely not survive. Perhaps some types of compensatory mutations could arise. But at the moment the data illustrate exactly what our friend has highlighted — the destructive and deleterious nature of mutations in “evo-devo” experiments

Why Darwinism's 'simple beginning just keeps receding.

 

Zip It: How Cells Repair Leaking Membranes

Evolution News @DiscoveryCSC

Membrane repair would have been necessary with the first cell. If by a most fantastic miracle scenario — against all probability — a protocell emerged from the primordial soup, it would be all over quickly if the membrane sprang a leak. 

Origin-of-life theorists often assume that membranes would spontaneously form naturally around protocells by the properties of lipid self-organization. That, however, is only the beginning of their challenges. Membranes need channels for active transport to control what goes in and out. They also need repair mechanisms if they break. If by inconceivable chance miracles those properties also emerged along with the lucky contents for life inside the membrane, they would never be inherited if they were not preserved in the genetic code. But even that is not enough. Along with code, machinery must be present to translate the code into other machines that know what to do when a membrane breaks. Unwatched membranes are vulnerable to leaks, and they don’t care. Without foresight and oversight, protocells would be like bubbles that pop in due time. Too bad for those hard-won living ingredients inside.

Fixing a Hole

A paper in the EMBO Journal by Yan Zhen et al., “Sealing holes in cellular membranes,” describes how cells actively monitor and repair leaks. The four authors identify multiple mechanisms for membrane repair. The resemblance to Michael Behe’s irreducibly complex blood clotting cascade (Darwin’s Black Box, Chapter 4) is uncanny, yet this is a leak-patching system an order of magnitude smaller!

The bilayered membranes of eukaryotic cells are vital to their very existence, with the plasma membrane separating the cells from their surroundings, and the endomembranes enclosing the various organelles. It is crucial that these membranes are intact so that only gated transport of molecules and ions across them can occur. Defective membrane sealing is indeed associated with a large number of diseases, including myopathies, central and peripheral neurological disorders, and coronary diseases (Cooper & McNeil, 2015). Sealing of holes in membranes is therefore of great importance in biology, both during biogenesis of double‐membrane organelles and as response to membrane damage…. The molecular and cellular mechanisms that have evolved to seal such holes will be discussed in this review.  [Emphasis added.]

Ah, yes, they “have evolved.” It was so simple. A chance miracle here, another one there; what’s the issue? And yet the diagrams and descriptions of actual mechanisms for maintaining membrane integrity are mind-boggling in their efficiency and complexity. 

Membrane sealing is an ongoing issue for a cell. The authors state that 20-30 percent of muscle cells and 6 percent of skin cells present transient leaks in their membranes that must be sealed promptly, or else serious diseases can occur.

Self-Sealing and Vesicles

For a hole only a few nanometers in size, the properties of lipid attraction allow for spontaneous sealing. Anything larger requires help, though, because membranes are under tension. A hole can quickly rip a stretched cell apart. The cell has at least three ways to reduce membrane tension, the authors say, allowing spontaneous sealing to proceed. Larger holes can be patched by vesicles, which are small lipid-surrounded sacks. A vesicle from outside can cover the hole and merge its lipids with the plasma membrane. Or the membrane can bud outward to bring the intact portions together. Some scientists think that “fusion causes release of an enzyme that promotes membrane sealing.” Imagine a bandage that could merge with your skin!

The cell must have ways to know that a leak has begun. A rapid influx of Ca2+ ions triggers a “simple yet powerful mechanism for detection of membrane integrity.” This, however, requires the presence of proteins that bind to the calcium ions so that they can trigger mechanisms that “promote membrane sealing by membrane fusion, fission or tension reduction.”

What happens to the vesicles after repair has been accomplished? Outside the cell, macrophages can engulf them. Inside, lysomes (the cell’s trash collectors) can engulf them. 

Even though membrane repair has mostly been described as a cell autonomous mechanism, muscle cells, which are particularly prone to damage of their plasma membrane, can also engage neighbouring macrophages to pinch off damaged portions of the muscle cell plasma membrane (Middel et al, 2016) (Fig 1F). How macrophage‐mediated removal of the damaged plasma membrane can proceed in a way that preserves membrane integrity still remains to be resolved.

Enzyme Army

Table 1 in the paper lists at least 16 proteins and protein families that promote membrane sealing in four categories of damage. Annexins, for instance, gather at the site of damage and “assemble into multimeric structures that physically cap the hole in the membrane.” Another protein, named Dysferlin, “Accumulates phosphatidylserine at the site of membrane damage, as an ‘eat‐me’ signal for macrophages.” Dysferlin also “interacts with some annexins” indicating that membrane repair proteins are not superheroes acting alone, but form networks of players that work together. Cooperation between proteins that can solve problems multiplies exponentially the improbability of their spontaneous emergence by unguided natural processes. Here’s another example to show the complexity involved:

Synaptotagmins are integral membrane proteins that function as Ca2+‐sensors that mediate membrane fusion. Among these, Synaptotagmin‐7 (SYT7) has been found to be particularly important for membrane repair. The cytosolic part of SYT7 contains two Ca2+ ‐ and phospholipid‐binding C2 domains that sense cytosolic Ca2+and mediate interactions with membranes. Like other members of the Synaptotagmin family, SYT7 regulates formation of SNARE complexes that drive membrane fusion and thus transduces Ca2+ sensing into membrane fusion ….

The authors go on to describe other proteins that can sense the damage and take appropriate actions. For instance, PDCD6 is a small calcium-binding sensor with big friends.

One of the interacting partners of PDCD6 is ALIX (PDCD6IP), a scaffolding protein involved in diverse cellular functions. ALIX also binds Ca2+, albeit with lower affinity than PDCD6. Injury‐triggered influx of Ca2+ causes accumulation of PDCD6 at the site of injury, and PDCD6 in turn recruits ALIX. ALIX then recruits components of the ESCRT machinery that mediates membrane repair by outward budding and fission of the damaged membrane area….

Not Small Players

Uniprot shows that PDCD6 has 865 amino acids. These are not small players! A whole squadron of machines takes part in healing membrane holes, just like an army of players is required in the blood clotting cascade to repair breaks in blood vessels. There are additional machines involved in repairing internal membranes surrounding organelles and the nucleus. Space forbids discussion here of the ESCRT and SNARE proteins and other players; those interested can read more in the open-access paper or just look at the tables and diagrams to be impressed. But why so many players? The authors refer to backup plans and redundancy: 

There is strong evidence that multiple mechanisms have evolved to seal holes in membranes, and there may be good reasons why separate mechanisms exist. Firstly, because membrane integrity is so crucial for cellular viability and functions, the existence of multiple sealing mechanisms could ensure successful sealing even if one mechanism fails. Secondly, the different mechanisms are optimized for sealing of different types of holes …. It is also plausible that additional mechanisms of membrane sealing exist, which have not been characterized yet.

“It Evolved”

Membrane repair is a key emergency operation for a cell. Just like countries with different military branches for external threats and police agencies for internal threats, cells come well equipped to handle breaches to their security. Saying these systems “have evolved” explains nothing. Something had the foresight to know these systems would be necessary for life and health. Something has the oversight to ensure their successful operation. The irreducible complexity touched on with this brief look at membrane repair provides additional and powerful evidence for intelligent design

From trash to treasure?

Noncoding “Junk” DNA Is Important for Limb Formation

Casey Luskin

A 2021 article in Nature, “Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator,” reports important new functions for non-coding or “junk” DNA that underlie limb formation. Before we get to the paper itself, consider a description of it on the Proceedings of the National Academy of Sciences “Journal Club” blog. The latter describes the research in terms that sound like they could have come directly from an intelligent design source: 

Genes that code for proteins make up only about 2% of the human genome. Many researchers once dismissed the other 98% of the genome as “junk DNA,” but geneticists now know these noncoding regions help to regulate the activity of the 20,000 or so protein-coding genes identified.

A new study in Nature underscores just how important noncoding DNA can be for human development. The authors show that deletions in a noncoding region of DNA on chromosome 2 cause severe congenital limb abnormalities. This is the first time a human disease has been definitively linked to mutations in noncoding DNA, says lead author Stefan Mundlos, head of the development and disease research group at the Max Planck Institute for Molecular Genetics in Berlin, Germany.

“Severe Congenital Limb Malformation” 

The technical paper in Nature describes the research. The investigators examined the chromosomes of people who had naturally occurring limb malformation, and found that these people had deletions of DNA encoding long non-coding RNA sequences (lncRNAs) from human chromosome 2. They deleted corresponding DNA sequences in mice and found similar “severe congenital limb malformation,” suggesting these lncRNA sequences are functionally important:

Here we show that genetic ablation of a lncRNA locus on human chromosome 2 causes a severe congenital limb malformation. We identified homozygous 27–63-kilobase deletions located 300 kilobases upstream of the engrailed-1 gene (EN1) in patients with a complex limb malformation featuring mesomelic shortening, syndactyly and ventral nails (dorsal dimelia). Re-engineering of the human deletions in mice resulted in a complete loss of En1expression in the limb and a double dorsal-limb phenotype that recapitulates the human disease phenotype. Genome-wide transcriptome analysis in the developing mouse limb revealed a four-exon-long non-coding transcript within the deleted region, which we named Maenli. Functional dissection of the Maenli locus showed that its transcriptional activity is required for limb-specific En1 activation in cis, thereby fine-tuning the gene-regulatory networks controlling dorso-ventral polarity in the developing limb bud. 

In the discussion, the article explains how important it is that we seek to understand the key functions of non-coding DNA sequences that encode lncRNAs:

In the era of whole-genome sequencing, the findings described here underscore the need for a systematic annotation and functional characterization of lncRNA loci to interpret and classify non-coding genetic variants. They highlight the importance of elucidating the complex diversity of lncRNA modes of action to assess their role in organ development and disease.

Over 130,000 Functional “Junk DNA” Elements!

So just how are we progressing in the task of determining the functions of non-coding DNA elements? Some defenders of evolutionary orthodoxy would have us believe that we’ve only found a handful of non-coding DNA sequences that have function — exceptions to the rule that non-coding DNA is usually useless junk. Another 2021 article in Nature shows why it’s no longer tenable for evolutionists to hide behind such an argument from ignorance. The article explains that over 130,000 functional “genomic elements, previously called junk DNA” have now been discovered, highlighting how important these “junk” segments have turned out to be:

[I]t is now appreciated that the majority of functional sequences in the human genome do not encode proteins. Rather, elements such as long non-coding RNAs, promoters, enhancers and countless gene-regulatory motifs work together to bring the genome to life. Variation in these regions does not alter proteins, but it can perturb the networks governing protein expression With the HGP draft in hand, the discovery of non-protein-coding elements exploded. So far, that growth has outstripped the discovery of protein-coding genes by a factor of five, and shows no signs of slowing. Likewise, the number of publications about such elements also grew in the period covered by our data set. For example, there are thousands of papers on non-coding RNAs, which regulate gene expression.

The article also observes that prior to the Human Genome Project, which was completed in 2003, there was “great debate” over whether it was “worth mapping the vast non-coding regions of genome that were called junk DNA, or the dark matter of the genome.” Under a paradigm informed by intelligent design, debates over whether to investigate junk DNA would have ended much sooner with an emphatic Yes!, furthering our knowledge of genetics and medicine. How much sooner would these 130,000+ “genomic elements, previously called junk DNA” have been uncovered if an ID paradigm had been governing biology research? 

Yet more on the sacred name in the N.T

YHWH in the New Testament:

This article is a English version of a Italian article published on the catholic magazine, edited from Dehonian friars, "Rivista Biblica", year XLV, n. 2, April-June 1997, p. 183-186. Bologna, Italy.


 

For a long time it was thought that the divine Tetragrammaton YHWH, in Hebrew written with the letters YHWH (which recurs over 6800 times in the Hebrew text of the Old Testament) did not appear in the original writings of the New Testament. In its place it was thought that the writers of the New Testament had used the Greek word for LORD, KYRIOS. However, it seems that such an opinion is wrong. Here below are some factors to consider:

1) The Tetragrammaton in the Greek Version of Old Testament, the Septuagint (LXX).

One of the reasons produced to support the above mentioned opinion was that the LXX substituted YHWH (YHWH) with the term KYRIOS, (kurios) which was the equivalent Greek of the Hebrew word ADONAY used by some Hebrews when they met the Tetragrammaton during the Bible reading.

However, recent discoveries have shown that the practice of substituted in the LXX YHWH with KYRIOS started in a much later period in comparison with the beginning of that version. As a matter of fact, the older copies of the LXX keep the Tetragrammaton written in Hebrew characters in the Greek text. (See App. 1)

Girolamo, the translator of the Latin Vulgate confirms this fact. In the prologue of the books of Samuel and Kings he wrote: "In certain Greek volumes we still find the Tetragrammaton of God's name expressed in ancient characters". And in a letter written in Rome in the year 384 it says: "God's name is made up of four letters; it was thought ineffable, and it is written with these letters: iod, he, vau, he (YHWH). But some have not been able to decipher it because of the resemblance of the Greek letters and when they found it in Greek books they usually read it PIPI (pipi)". S. Girolamo, Le Lettere, Rome, 1961, vol.1, pp.237, 238; compare J.P.Migne, Patrologia Latina, vol.22, coll.429, 430.

Around 245 C.E., the noted scholar Origen produced his Hexapla, a six-column reproduction of the inspired Hebrew Scriptures: (1) in their original Hebrew and Aramaic, accompanied by (2) a transliteration into Greek, and by the Greek versions of (3) Aquila, (4) Symmachus, (5) the Septuagint, and (6) Theodotion. On the evidence of the fragmentary copies now known, Professor W. G. Waddell says: "In Origen's Hexapla . . . the Greek versions of Aquila, Symmachus, and LXX all represented JHWH by PIPI; in the second column of the Hexapla the Tetragrammaton was written in Hebrew characters." - The Journal of Theological Studies, Oxford, Vol. XLV, 1944, pp. 158, 159. Others believe the original text of Origen's Hexapla used Hebrew characters for the Tetragrammaton in all its columns. Origen himself stated that "in the most accurate manuscripts THE NAME occurs in Hebrew characters, yet not in today's Hebrew [characters], but in the most ancient ones".

A biblical magazine declare: "In pre-Christian Greek [manuscripts] of the OT, the divine name was not rendered by 'kyrios' as has often been thought. Usually the Tetragram was written out in Aramaic or in paleo-Hebrew letters. . . . At a later time, surrogates such as 'theos' [God] and 'kyrios' replaced the Tetragram . . . There is good reason to believe that a similar pattern evolved in the NT, i.e. the divine name was originally written in the NT quotations of and allusions to the OT, but in the course of time it was replaced by surrogates". - New Testament Abstracts, March 1977, p. 306.

Wolfgang Feneberg comments in the Jesuit magazine Entschluss/Offen (April 1985): "He [Jesus] did not withhold his father's name YHWH from us, but he entrusted us with it. It is otherwise inexplicable why the first petition of the Lord's Prayer should read: 'May your name be sanctified!'" Feneberg further notes that "in pre-Christian manuscripts for Greek-speaking Jews, God's name was not paraphrased with kýrios [Lord], but was written in the tetragram form in Hebrew or archaic Hebrew characters. . . . We find recollections of the name in the writings of the Church Fathers".

Dr. P.Kahle says: "We now know that the Greek Bible text [the Septuagint] as far as it was written by Jews for Jews did not translate the Divine name by kyrios, but the Tetragrammaton written with Hebrew or Greek letters was retained in such MSS [manuscripts]. It was the Christians who replaced the Tetragrammaton by kyrios, when the divine name written in Hebrew letters was not understood any more". - The Cairo Geniza, Oxford, 1959, p. 222.

Further confirmation comes from The New International Dictionary of New Testament Theology, that says: "Recently discovered texts doubt the idea that the translators of the LXX have rendered the Tetragrammaton JHWH with KYRIOS. The most ancient mss (manuscripts) of the LXX today available have the Tetragrammaton written in Hebrew letters in the Greek text. This was custom preserved by the later Hebrew translator of the Old Testament in the first centuries (after Christ)". Vol.2, pag.512.

Consequently, we can easily deduce that if the writers of NT in their quotations of the OT used the LXX they would surely have left the Tetragrammaton in their writings the way it recurred in the Greek version of the OT. To confirm the correctness of this conclusion it is interesting to note the following declaration made before the finding of the manuscripts proving that the LXX originaly continued the Tetragrammaton:

"If that version (LXX) would have kept the term (YHWH), or had used the Greek term for JEHOVAH and another for ADONAY, such a use would have surely been followed in the discourses and in the reasonings of the NT. Therefore our Lord, in quoting the 110th Psalms, insteand of saying: 'The LORD has said to my LORD' could have said: "JEHOVA has said to ADONI". Supposing that a Christian student was translating in Hebrew the Greek Testament: every time that he met the word KYRIOS, he should have had to consider if in the context there was something that indicated the true Hebrew correspondent; and this is the difficulty that would have arisen in translating the NT in whatever language if the name JEHOVAH would have been left in the Old Testament (LXX). The Hebrew scriptures would have constituted a standard for many passages: every time that the expression "the LORD's angel" recurs, we know that the term LORD represents JEHOVA; we could come to a similar conclusion for the expression "the LORD's word", according to the precedent established in the OT; and so it is in the case of the name "the LORD of armies". On the contrary, when the expression "my LORD" or "our LORD" recurs, we should know that the term JEHOVA would be inadmissible, when instead the words ADONAY or ADONI should be used". R.B.Girdlestone, Synonyms of the Old Testament, 1897, p.43.

For a stronger support of this argument there are the words of the professor George Howard, of the University of Georgia (U.S.A.) who observes: "When the Septuagint Version that the New Testament Church used and quoted, contained the Divine Name in Hebrew characters, the writers of the New Testament included without doubt the Tetragrammaton in their quotations". Biblical Archeology Review, March 1978, p.14.

Consequently several translators of the NT have left the Divine Name in the quotations from the OT made by the New Testament writers. It can be noted, for example the versions of Benjamin Wilson, of Andrè Chouraqui, of Johann Jakob Stolz, of Hermann Heinfetter,in Efik, Ewe, Malgascio and Alghonchin languages.

2)The Tetragrammaton in Hebrew version of the NT.

As many know, the first book of the NT, the gospel of Matthew was written in Hebrew. The proof of this is found in the work of Girolamo De viris inlustribus, chap. 3, where he writes:

"Matthew, that is also Levi, that became an apostle after having been a tax collector, was the first to write a Gospel of Christ in Judea in the Hebrew language and Hebrew characters, for the benefit of those who where circumcised that had believed. It's not know with enough certainly who had then translated it in Greek. However the Hebrew one it self is preserved till this day in the Library at Cesarea, that the martyr Pamphilus collected so accurately. The Nazarenes of the Syrian city of Berea that use this copy have also allowed me to copy it". From the Latin text edited by E.C.Richardson, published in the series Texte und Untersuchungen zur Geschicte der altchristlichen Literatur, vol.14, Lipsia, 1986, pp.8,9.

External evidence to the effect that Matthew originally wrote this Gospel in Hebrew reaches as far back as Papias of Hierapolis, of the second century a.C. Eusebius quoted Papias as stating: "Matthew collected the oracles in the Hebrew language". - The Ecclesiastical History, III, XXXIX, 16. Early in the third century, Origen made reference to Matthew's account and, in discussing the four Gospels, is quoted by Eusebius as saying that the "first was written . . . according to Matthew, who was once a tax-collector but afterwards an apostle of Jesus Christ, . . . in the Hebrew language". - The Ecclesiastical History, VI, XXV, 3-6.

Was this really Aramaic? Not according to documents mentioned by George Howard. He wrote: "This supposition was due primarily to the belief that Hebrew in the days of Jesus was no longer in use in Palestine but had been replaced by Aramaic. The subsequent discovery of the Dead Sea Scrolls, many of which are Hebrew compositions, as well as of other Hebrew documents from Palestine from the general time period of Jesus, now show Hebrew to have been alive and well in the first century".

It is therefore natural to conclude that when Matthew quoted passages from the OT in which the Tetragrammaton appeared (thing that occurred both in the Hebrew OT and in the Greek one then available) he would have surely left YHWH in his gospel as no Jew ever dared to take away the Tetragrammaton from the Hebrew text of the Holy Scriptures.

To confirm this there are at least 27 Hebrew versions of the NT that present the Tetragrammaton in the quotations of the OT or where the text requires it. (see app.2) Three of these are the versions of F.Delitzsch, of I.Salkinson & C.D.Ginsburg , of the United Bible Societies, ed.1991 and of Elias Hutter.

3) The Tetragrammaton in the Christian Scriptures according to the Babylonian Talmud.

The first part of this Jewish work is called Shabbath (Sabbath) and it contains an immense code of rules that establishes what could have been done of a Sabbath. Part of it deals with if on the Sabbath day Biblical manuscripts could be saved from the fire, and after it reads:

"The text declares: 'The white spaces ("gilyohnim") and the books of the Minim, can't be saved from the fire'. Rabbi Jose said: 'On working days one must cut out the Divine Names that are contained in the text, hide them and burn the rest'. Rabbi Tarfon said: 'May I bury my son if I don't burn them together with the Divine Names that they contain if I come across them". -From the English translation of Dr. H.Freedman.

The word "Minim" means "sectarians" and according to Dr. Freedman it's very probable that in this passage it indicates the Jewish-Christians. The expression "the white spaces" translates the original "gilyohnim" and could have meant, using the word ironically, that the writings of the "Minim where as worthy as a blank scroll, namely nothing. In some dictionaries this word is given as "Gospels". In harmony with this, the sentence that appears in the Talmud before the above mentioned passage says: "The books of the Minim are like white spaces (gilyohnim)."

So in the book Who was a Jew?, of L.H.Schiffman, the above mentioned passage of the Talmud is translated: "We don't save the Gospels or the books of Minim from the fire. They are burnt where they are, together with their Tetragrammatons. Rabbi Yose Ha-Gelili says: "During the week one should take the Tetragrammatons from them, hide them and burn the rest". Rabbi Tarfon said: 'May I bury my children! If I would have them in my hands, I would burn them with all their Tetragrammatons'". Dr. Schiffman continues reasoning that here "Minim" is referred to Hebrew Christians.

And it's very probable that here the Talmud refers to the Hebrew Christians. It is a supposition that finds agreement among the studious people, and in the Talmud seems to be well supported by the context. In Shabbath the passage that follows the above mentioned quotations relates a story, regarding Gamaliel and Christian judge in which there is an allusion to parts of the Sermon on the Mount. Therefore, this passage of the Talmud is a clear indication that the Christians included the Tetragrammaton in their Gospel and their writings.

Because of all we have said there are valid reasons to assert that the writers of the New Testament reported the Tetragrammaton in their divinely inspired work.

Matteo Pierro Salita S. Giovanni 5, 84135 Salerno, ITALY. e-mail cdb@supereva.it 

On the divine name in ancient copies of the Greek Septuagint.

 

Historic discovery’ of ancient Biblical fragments made in Israel

Archaeologists have unearthed fragments of a 1,900-year-old Biblical scroll in Israel, in what experts are calling the most important discovery in the last 60 years.

By Devin Watkins

The Israel Antiquities Authority (IAA) has unveiled an historic discovery of Biblical proportions in several desert caves.

In a dig that began in 2017, archaeologists discovered around 80 new parchment fragments of Old Testament texts.

They contain verses written in Greek—with the name of God appearing in Hebrew—from the books of Zechariah and Nahum, which are part of the Book of the Twelve Minor Prophets.

The fragments form part of a scroll which experts believe belonged to Jewish rebels, led by Simon Bar Kokhba, who hid in the caves after a failed revolt against Roman rule between 132 and 136 AD.

Israeli archaeologists began the operation in the Judean desert to prevent caves from being looted. They also unearthed a cache of rare coins from the same period, a 6,000-year-old skeleton of a child, and a large woven basket dating from around 10,500 years ago, the oldest intact in the world. Read article Here

File under" Well said." LXXIII

 

"Without education, we are in a horrible and deadly danger of taking educated people seriously."

G.K. Chesterton

On tithing.:The Watchtower Society's commentary.

 TITHE

A tenth part, or 10 percent, given or paid as a tribute, especially for religious purposes.

The Bible tells of two instances prior to the setting up of the Law covenant in which a tenth part of possessions was paid to God or to his representative. The first of these was on the occasion when Abraham gave Melchizedek one tenth of the spoils of his victory over Chedorlaomer and his allies. (Ge 14:18-20) The apostle Paul cites this incident as proof that Christ’s priesthood according to the manner of Melchizedek is superior to that of Levi, since Levi, being in the loins of Abraham, paid tithes, in effect, to Melchizedek. (Heb 7:4-10) The second case concerned Jacob, who vowed at Bethel to give one tenth of his substance to God.—Ge 28:20-22.

These two accounts, however, are merely instances of voluntarily giving one tenth. There is no record to the effect that Abraham or Jacob commanded their descendants to follow such examples, thereby establishing a religious practice, custom, or law. It would have been superfluous for Jacob, if already under a compulsory obligation to pay tithes, to vow to do so, as he did. It is therefore evident that the tithing arrangement was not a custom or a law among the early Hebrews. It was instituted with the inauguration of the Law covenant, not before.

Mosaic Tithing Laws. Jehovah gave Israel tithing laws for definite purposes, apparently involving the use of two tenths of their annual income, except during the Sabbath years, when no tithe was paid, since no income was anticipated. (Le 25:1-12) However, some scholars believe there was only one tithe. Such tithes were in addition to the firstfruits they were under obligation to offer to Jehovah.—Ex 23:19; 34:26.

The first tithe, consisting of one tenth of the produce of the land and fruit trees and (evidently of the increase) of the herds and flocks, was brought to the sanctuary and given to the Levites, since they had no inheritance in the land but were devoted to the service of the sanctuary. (Le 27:30-32; Nu 18:21, 24) The Levites, in turn, gave a tenth of what they received to the Aaronic priesthood for their support.—Nu 18:25-29.

Evidently the grain was threshed and the fruit of the vine and of the olive tree was converted into wine and oil before tithing. (Nu 18:27, 30; Ne 10:37) If an Israelite wished to give money instead of this produce, he could do so, provided he added an additional fifth to the valuation. (Le 27:31) But it was different with the flock and the herd. As the animals came out of the pen one by one through a gate, the owner stood by the gate with a rod and marked every tenth one as the tithe, without examination or selection.—Le 27:32, 33.

It seems there was an additional tithe, a second tenth, set aside each year for purposes other than the direct support of the Levitical priesthood, though the Levites shared in it. Normally it was used and enjoyed in large measure by the Israelite family when assembling together at the national festivals. In cases where the distance to Jerusalem was too great for the convenient transport of this tithe, then the produce was converted into money and this, in turn, was used in Jerusalem for the household’s sustenance and enjoyment during the holy convention there. (De 12:4-7, 11, 17, 18; 14:22-27) Then, at the end of every third and sixth years of the seven-year sabbatical cycle, this tithe, instead of being used to defray expenses at the national assemblies, was set aside for the Levites, alien residents, widows, and fatherless boys in the local community.—De 14:28, 29; 26:12.

These tithing laws binding on Israel were not excessive. Nor should it be overlooked that God promised to prosper Israel by opening “the floodgates of the heavens” if his tithing laws were obeyed. (Mal 3:10; De 28:1, 2, 11-14) When the people became negligent as to tithing, the priesthood suffered, for the priests and Levites were forced to spend their time in secular work and consequently neglected their ministerial services. (Ne 13:10) Such unfaithfulness tended to bring about a decline in true worship. Sadly, when the ten tribes fell away to calf worship, they used the tithe to support that false religion. (Am 4:4, 5) On the other hand, when Israel was faithful to Jehovah and was under the rule of righteous administrators, tithing for the Levites was restored, and true to Jehovah’s promise, there were no shortages.—2Ch 31:4-12; Ne 10:37, 38; 12:44; 13:11-13.

Under the Law there was no stated penalty to be applied to a person failing to tithe. Jehovah placed all under a strong moral obligation to provide the tithe; at the end of the three-year tithing cycle, they were required to confess before him that the tithe had been paid in full. (De 26:12-15) Anything wrongfully withheld was viewed as something stolen from God.—Mal 3:7-9.

By the first century C.E., the Jewish religious leaders, particularly among the scribes and Pharisees, were making a sanctimonious show of tithing and other outward works, in a form of worship, but their hearts were far removed from God. (Mt 15:1-9) Jesus reproved them for their selfish, hypocritical attitude, calling attention to their being meticulous to give a tenth even of “the mint and the dill and the cumin”—something they should have done—yet at the same time disregarding “the weightier matters of the Law, namely, justice and mercy and faithfulness.” (Mt 23:23; Lu 11:42) By way of illustration, Jesus contrasted the Pharisee who boastfully felt self-righteous because of his own works of fasting and tithing, with the tax collector who, though considered as nothing by the Pharisee, humbled himself, confessed his sins to God, and begged for divine mercy.—Lu 18:9-14.

No Tithing for Christians. At no time were first-century Christians commanded to pay tithes. The primary purpose of the tithing arrangement under the Law had been to support Israel’s temple and priesthood; consequently the obligation to pay tithes would cease when that Mosaic Law covenant came to an end as fulfilled, through Christ’s death on the torture stake. (Eph 2:15; Col 2:13, 14) It is true that Levitical priests continued serving at the temple in Jerusalem until it was destroyed in 70 C.E., but Christians from and after 33 C.E. became part of a new spiritual priesthood that was not supported by tithes.—Ro 6:14; Heb 7:12; 1Pe 2:9.

As Christians, they were encouraged to give support to the Christian ministry both by their own ministerial activity and by material contributions. Instead of giving fixed, specified amounts to defray congregational expenses, they were to contribute “according to what a person has,” giving “as he has resolved in his heart, not grudgingly or under compulsion, for God loves a cheerful giver.” (2Co 8:12; 9:7) They were encouraged to follow the principle: “Let the older men who preside in a fine way be reckoned worthy of double honor, especially those who work hard in speaking and teaching. For the scripture says: ‘You must not muzzle a bull when it threshes out the grain’; also: ‘The workman is worthy of his wages.’” (1Ti 5:17, 18) However, the apostle Paul set an example in seeking to avoid bringing an undue financial burden on the congregation.—Ac 18:3; 1Th 2:9.

File under "Well said" LXII

"Politics is the art of looking for trouble,finding it everywhere,diagnosing it incorrectly and applying the wrong remedies."

Groucho Marx.

The Divided States of America?

 Time for red America and blue America to part ways?

How to split the USA into two countries: Red and Blue

Progressive America would be half as big, but twice as populated as its conservative twin.

FRANK JACOBS

14 November, 2018

Image: Dicken Schrader

• America's two political tribes have consolidated into 'red' and 'blue' nations, with seemingly irreconcilable differences.
• Perhaps the best way to stop the infighting is to go for a divorce and give the two nations a country each
• Based on the UN's partition plan for Israel/Palestine, this proposal provides territorial contiguity and sea access to both 'red' and 'blue' America

If more proof were needed that the U.S. is two nations in one, it was offered by the recent mid-term elections. Democrats swept the House, but Republicans managed to increase their Senate majority. There is less middle ground, and less appetite for compromise, than ever.

To oversimplify America's electoral divide: Democrats win votes in urban, coastal areas; Republicans gain seats in the rural middle of the country. Those opposing blocs have consolidated into 'red' and 'blue' states decades ago.

Occasionally, and often after tight-run presidential elections, that divide is translated into a cartographic meme that reflects the state of the nation.

Jesusland vs. the U.S. of Canada

Canada annexes the entire West Coast and borders Mexico.

Image: Strange Maps

In 2004, this cartoon saw the states that had voted for Democratic presidential candidate John F. Kerry join America's northern neighbor to form the United States of Canada. The states re-electing George W. Bush were dubbed Jesusland.

Trumpistan vs. Clintonesia

Trumpistan is a perforated continent, Clintonesia is a disjointed archipelago.

Image: The New York Times.

In 2016, these two maps disassembled the U.S. into Trumpistan, a vast, largely empty and severely punctuated land mass; and Clintonesia, a much smaller but more densely populated archipelago whose biggest bits of dry land were at the edges, with a huge, empty sea in the middle.

Soyland vs. the FSA

Following state borders, a line separates 'red' America (in the south) from the 'blue' half of the country.

Image: Jesse Kelly

Writing in The Federalist, Jesse Kelly in April this year likened America to a couple that can't stop fighting and should get a divorce. Literally. His proposal was to split the country into two new ones: a 'red' state and a 'blue' state.

On a map accompanying the article, he proposed a division of the U.S. into the People's Republic of Soyland and the Federalist States of America (no prizes for guessing Mr Kelly's politics).

It's a fairly crude map. For example, it includes Republican-leaning states such as Montana and the Dakotas in the 'blue' state for seemingly no other reason than to provide a corridor between the blue zones in the west and east of the country.

Mr Kelly admitted that his demarcational talents left some room for improvement: "We can and will draw the map and argue over it a million different ways for a million different reasons but draw it we must," he wrote. "I suspect the final draft would look similar (to mine)."

Partition, Palestine-style

A county-level division between red and blue, with contiguous territories for both.

Image: Dicken Schrader.

"No, this map won't do," comments reader Dicken Schrader. "It's too crude and would leave too many members of the 'blue' tribe in the 'red' nation, and too much 'red' in the 'blue' state."

Agreeing with the basic premise behind Mr Kelly's map but not with its crude execution, Mr Schrader took it upon himself to propose a better border between red and blue.

Analyzing election maps from the past 12 years, he devised his own map of America's two nations, "inspired by the original UN partition map for Israel and Palestine from 1947." Some notes on the map:

• To avoid the distortions of gerrymandering, it is based on electoral majorities in counties, rather than electoral districts.
• As with the UN partition plan for Israel/Palestine, all territories of both states are contiguous. There are no enclaves. Citizens of either state can travel around their nation without having to cross a border.
• The intersections between both nations are placed at actual interstate overpasses, so both states have frictionless access to their own territory.
• In order to avoid enclaves, some 'blue' islands had to be transferred to 'red', and some 'red' zones were granted to the 'blue' nation. "This exchange is fair to both sides, in terms of area and population".
• Both nations have access to the East, West and Gulf Coasts, and each has a portion of Alaska.

​Red vs. blue

Washington DC would remain part of 'blue' America, and its capital.

Image: Dicken Schrader

Some interesting stats on these two new nations:

Progressive America (blue)

• Area: 1.44 million sq. mi (3.74 million km2), 38% of the total U.S.
• Population: 210 million, 64.5% of the total U.S.
• Pop. Density: 146 inhabitants/sq mi (56/km2), similar to Mexico
• Capital: Washington DC
• Ten Largest Cities: New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, San Jose, Jacksonville

Conservative America (red)

• Area: 2.35 million sq. mi (6.08 million km2), 62% of the total
• Population: 115.4 million, 35.5% of the total
• Pop. Density: 49 inhabitants/sq mi (19/km2), similar to Sudan
• Capital: Dallas
• Ten Largest Cities: Dallas, Austin, Fort Worth, Charlotte, Nashville, Oklahoma City, Louisville, Kansas City, Omaha, Colorado Springs.

What about the nukes?

The partition would not create enclaves, but allow citizens of either nation frictionless access to the entire territory of their state.

Image: Dicken Schrader

'Blue' America would be roughly half the size of 'red' America but have almost double the population.

In terms of area, 'blue' America would be the 13th-largest country in the world, larger than Mexico but smaller than Saudi Arabia. 'Red' America would be the 6th-largest country in the world, larger than India but smaller than Australia.

In terms of population, 'blue' America would now be the 5th-most populous county in the world, with more population than Brazil but less than Indonesia. 'Red' America would be the 12th, with more population than Ethiopia but less than Japan.

For those who think this divorce would end the argument between both tribes, consider that both countries would still have to live next to each other. And then there's the question of the kids. Or, in Mr Schrader's translation to geopolitics: "Who gets the nukes?"

--

Many thanks to Mr Schrader for sending in this map.

Strange Maps #948

Got a strange map? Let me know at strangemaps@gmail.com.

FROM YOUR SITE ARTICLES

• 5 Reasons Why America Will Not Collapse Like the Roman Empire ›
• Why Is the United States So Divided? Simple, It Was Never United at ... ›
• Map: Should America split into two countries? ›
• unusual borders - Big Think ›
• unusual borders - Big Think ›

RELATED ARTICLES AROUND THE WEB

• Former Google CEO predicts the internet will split in two — and one ›
• Imagine the US was split in two countries, and Republicans were ... ›

government Politics Society United States state-building meme Maps

  

Six disastrous encounters with the world’s most hostile uncontacted tribe

From questionable shipwrecks to outright attacks, they clearly don't want to be bothered.

Matt Davis

 

23 September, 2018

c2.staticflickr.com

• Many have tried to contact the Sentinelese, to write about them, or otherwise.
• But the inhabitants of the 23 square mile island in the Bay of Bengal don't want anything to do with the outside world.
• Their numbers are unknown, but either 40 or 500 remain.

 Keep reading

  

Yes, more and more young adults are living with their parents – but is that necessarily bad?

Having grown kids still at home is not likely to do you, or them, any permanent harm.

Jeffrey Arnett

 

16 November, 2020

Photo by Parker Gibbons on Unsplash

When the Pew Research Center recently reported that the proportion of 18-to-29-year-old Americans who live with their parents has increased during the COVID-19 pandemic, perhaps you saw some of the breathless headlines hyping how it's higher than at any time since the Great Depression.

 Keep reading

youth children mobility money parenting family

  

What ended the Black Death, history's worst pandemic

The bubonic plague ravaged the world for centuries, killing up to 200 million people.

Paul Ratner

 

16 November, 2020

A man dresses as a plague doctor at the Bannockburn Live event on June 28, 2014 in Stirling, Scotland.

Photo by Peter Macdiarmid/Getty Images

The Plague was the worst pandemic in history, killing up to 200 million people.

The disease spread through air, rats and fleas, and decimated Europe for several centuries.

The pandemic eased with better sanitation, hygiene, and medical advancements but never completely disappeared.

 Keep reading

medicine history coronavirus plague public health medical research

  

VIDEOS

Is your company innovating? A Whole Foods case study.

JOHN MACKEY

The "lone genius" often gets the credit for big ideas, but real-world innovation is a team sport.

  

SURPRISING SCIENCE

Astrophysicists reconstruct the Milky Way's family tree

MIND & BRAIN

Why schools should not teach general critical-thinking skills

TECHNOLOGY & INNOVATION

"What to Expect When You’re Expecting Robots"

 

CULTURE & RELIGION

Researchers use CT scans to digitally peek at ancient Egyptian mummies

CULTURE & RELIGION

When Christmas was cancelled: a lesson from history

SURPRISING SCIENCE

9 of the most shocking facts about global extinction - and how to stop it

MIND & BRAIN

Our brains have different 'beauty centers' for art and faces

 

MIND & BRAIN

Are brain teasers and apps a waste of time?

Scroll down to load more…