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Friday, 10 March 2017

On the evolution of Darwinism.

Evolution, Then and Now
Guy Coe

Let's set the record straight; things have changed a lot since "then."
When Darwin first ventured to propose an explanation for the origin of species, he didn't really try to address the question of the origin of life. No one, at that point, had any good idea of what even really needed to be explained.
When early optical microscopy gave us our first images of cells, what we saw was puzzling, but not particularly awe-inspiring. As microscopy advanced, in conjunction with advances in physics and chemistry, what came clearer into focus was that cellular structure, function and metabolism, and thus biochemistry as a whole, was a universe awaiting new discoveries of its own.
Who could have guessed that the micro-world would dwarf in complexity and organization the macro-cosmos we had only recently come to more fully appreciate? Or that additional discoveries on all orders of scale would point more cogently to deliberative design than ever?
A parable might help. Two people are walking down the beach; one is a philosopher, the other a geologist. As they walk along, they take in the view, and appreciate the beauty of the scene. The geologist explains the visible coastal rock formations, the action of plate tectonics, erosion and sedimentation, and -- wait; what is that?

Both stare in unbelief. There in the sand, about six foot square, is... well, apparently, a sand painting. Miles from anywhere, on the open beach, is an image of the Mona Lisa.
They study it. It's not perfect, but awfully close. The philosopher begins to form a hypothesis. Perhaps the image we call the "Mona Lisa" is just an archetype of a fundamental pattern recurring in nature. The painting by Leonardo da Vinci was, perhaps, just a particular manifestation of this pattern. A closer study of the grains of sand show that the various pigments each possess are a function of the weight and size of each grain. The areas of lighter sand lay, mysteriously, a little lower than the areas with darker, denser sand.
If swirling coastal winds had selectively removed the lighter sand from some areas, the remaining image could be an accidental production of chance variations in the sedimentary deposition of the underlying sand.
The geologist is not convinced. The odds against a pattern match this good, on this scale, are just too improbable. It looks like a product of deliberate artistry. They decide to come back in a few months, to see what changes, if any, develop in the pattern. Six months later, they return. It seems to have changed, imperceptibly, but the pattern is undeniably the same.
Ten years later, it's a tourist destination. It has still only changed imperceptibly. In a concerted effort to explain it, several forensic scientists have decided to sample various grains of the sand, to see if there are any telltale signs of human manipulation or manufacture. Under powerful microscopes, the individual grains reveal something astonishing -- they're not sand at all! They're three-dimensional crystalline-compound computer chips, complete with micro-circuitry and logic processors.
It turns out the persistence of the pattern derives from pre-programmed electro-chemical affinities, specified individually within each grain, mapping to surrounding grains, with reference to the pattern as a whole, which is also present within each grain. The electrical force each uses derives from tiny solar cells embedded in their structure.
The case for random sedimentary origination becomes untenable, and a whole new generation of scientists sets itself to work on understanding the logic of the programming in these chips.
As a parable of the developments of the last 50 years of biochemical research and discovery, this is not an unreasonable characterization of the situation. The closer we've looked, the more we've understood, the more we've been challenged to be able to hold onto theories of chance or unaided development which used to seem adequate.
Lifelong academic atheist Antony Flew, before his death at age 87, summarized his change of mind about the issue of intelligent design in an October 30th, 2007 interview with Dr. Benjamin Wiker. When asked to explain his reasoning, Flew said:
There were two factors in particular that were decisive. One was my growing empathy with the insight of Einstein and other noted scientists that there had to be an intelligence behind the integrated complexity of the physical universe. The second was my own insight that the integrated complexity of life itself - which is far more complex than the physical universe - can only be explained in terms of an intelligent source. I believe that the origin of life and reproduction simply cannot be explained from a biological standpoint despite numerous efforts to do so. With every passing year, the more that was discovered about the richness and inherent intelligence of life, the less it seemed likely that a chemical soup could magically generate the genetic code. The difference between life and non-life, it became apparent to me, was ontological and not chemical. The best confirmation of this radical gulf is Richard Dawkins' comical effort to argue in The God Delusion that the origin of life can be attributed to a lucky chance. If that's the best argument you have, then the game is over. No, I did not hear a voice. It was the evidence itself that led me to this conclusion.

There is more to explain now than ever before. A half a decade of studied observation has brought us closer to an answer for the origin of life, mostly by virtue of failed research paradigms. And that's the way of science; we gain in knowledge not merely by validating hypotheses, but by rejecting those which fail. The more we've rejected hypotheses involving mere chance, and allowed for a theory of intelligent organization, origination and even perhaps periodic intervention, the more we've come to understand the distinctives of the fossil record, the prospects for rapidity of change, and the subtleties of genetic programming.
Research into "junk DNA," pseudogenes, and other areas of supposedly vestigial code degradation, is yielding avenues of new discovery and practical application, as active functions are discovered for these areas of former confusion. The odds are too long to continue to bet against, much less exclude by definition, the involvement of a designing intelligence.
Despite millions spent in research, a myriad of discoveries made, and many legitimately helpful applications of that knowledge, a strictly naturalist paradigm is becoming vestigial, and it's more necessary now than ever to seek to understand the instrumentalities employed by life's intelligent designer.

Thursday, 9 March 2017

File under "Well said" XLVII

The learned Fool writes his Nonsense in better Language than the unlearned; but still 'tis Nonsense.

BENJAMIN FRANKLIN

Minimum function v. Darwinism.

The Designed Body, Continued: Coherence Wins, Gradualism Fails -
Steve Laufmann

In a post yesterday, I explored seven insights from Dr. Howard Glicksman’s 81-part series, The Designed Body. Glicksman takes us on a remarkable exploration of the ways that the human body works to stay alive in a world that’s essentially trying to kill it. To survive, the human body must control 40 chemical and physiological factors. Failure with any one of these results in death.

Coherence, Interdependencies, and Fine-Tuning

Though Glicksman uses medical rather than engineering terminology, the human body is an engineering marvel — an amalgam of interlocking chemical and engineering solutions, sort of like chainmail armor — with dozens of diverse, interdependent control systems driving hundreds of functional subsystems, composed of tens of thousands of specialized parts, and comprised of ~37 trillion individual cells. Each cell is itself an engineering marvel, comprised of thousands of interdependent parts, precisely arranged and coordinating their actions. To make this work, the human body generates around 200 specialized cell types and well over ten thousand specialized proteins. All this “unfolds” from a single cell at fertilization, in a precisely choreographed process.

This is not gratuitous complexity — the complexity is real and necessary for survival:

Finely tuned control systems to manage each of the 40 chemical and physiological factors.
Functional coherence across multiple levels of systems and subsystems.
Process coherence across systems, and throughout an individual’s lifecycle.
Interdependencies among systems and processes.
Failure prevention systems to detect and defend against threats, correct errors, and keep everything working.
Coherence is a distinctive property in which each piece-part is necessary for function, but none by itself is sufficient. Only when all the parts operate as a coherent whole does the body survive. Coherence is difficult to achieve and maintain under any circumstances. But survival of the human body takes functional coherence at a scope and scale that we can scarcely fathom — so far beyond our experience as human engineers that we have no comparable systems to compare it to.

At the same time, coherence makes change more difficult. In a coherent system, a major change in one component (or subsystem) usually requires corresponding changes in other components (or subsystems). The more interdependencies, the more work is required to change a component, yet retain overall function of the whole. As any systems architect can attest, once a complex, coherent, interdependent system is built, it takes no small effort to adapt it in significant ways (e.g., to meet new functional requirements).

Are other organisms similarly fine-tuned?

Is similar coherence present in other body plans? Given that survival depends on controlling so many factors, it seems likely that every body plan must have its own version of coherence. Though the types of control systems and their tuning parameters may vary, we’d expect all such controls to be similarly fine-tuned.

Asked the other way, are there any body plans, currently active or anywhere in the fossil record, that do not exhibit finely tuned coherence? I’ve not heard much discussion of this subject, suggesting that either the question is not being asked, or the answers are not defensible.

How to generate a fully functioning, coherent system

Coherent interdependent systems, like the human body, are tough to “bootstrap.” This occurs in two different processes that must overcome the same basic problems:

Phylogenesis (How does a functioning body plan come into existence?)

If all 40 factors must be controlled at all times, else the organism dies, how can a complex control system like any of those presented by Glicksman come into existence? How do you control a chemical or physiological factor while the body waits for evolution to generate a complete control system capable of controlling that factor?

For example, how do you supply oxygen to every cell in a large, complex body without every part of each required body subsystem (e.g., for oxygen exchange, carbon dioxide removal, circulation, iron harvesting, hemoglobin manufacture, and many more). Sure, we might theorize a simpler system to perform these functions, but it’s hard to imagine a partial system that still gets the job done.

Regardless of how simple the simplest possible version of a control system might be, it still requires all the basic functionality of a control system, and these are, by definition, irreducibly complex. In the human body, and most (all?) other complex body plans, the control systems are also interdependent, so having just one of them, or even all but one, isn’t enough.

How many generations are required for random causes to generate the dozens or thousands of parts needed for even one control system, with the correct control logic and just the right fine-tuning? No one knows, but it’s a lot — certainly more than could fit into the age of the universe.

How many generations are available in the absence of all the needed control systems? Exactly zero, since no individuals will survive long enough to reproduce, and any gradual steps toward a functional whole disappear from the population.

Ontogenesis (How does an individual of the body plan come into existence?)

Humans have an elegant solution to the body plan assembly problem — one we’re quite familiar with.

At the moment of fertilization, the human body consists of a single cell. As it grows into thousands and then to hundreds of millions of cells, it must bootstrap the control systems for all 40 survival factors. Each of the systems and subsystems (and their component parts, and the specialized cell types, etc.) must be generated, assembled, and activated, in the right places, in the right order, at the right times. It takes about 9 months for that single cell (aka, zygote) to grow into a coherent, independent whole (aka, tax deduction).

As it’s developing its internal controls, this new life is extremely vulnerable to the forces of nature, so must rely on outside help to survive. With humans this occurs in the mother’s womb. In this extraordinary process, the mother and unborn child coordinate their activities, such that the mother’s systems “cover for” the growing child’s inability to control all the necessary survival factors.

Only when all of its internal control systems are assembled and functioning can the child survive on its own. At the right time, through coordinated signaling (!), birthing occurs and the child’s body switches over to its internal systems to perform their survival chores (e.g., respiration).

It’s important to note that this process involves two different individuals, using completely different yet perfectly integrated mechanisms. Not only does this illustrate the survival challenges facing a complex body while it’s generating its systems, it also highlights the extraordinary engineering required to overcome those challenges — precise, interdependent, finely-tuned, coordinated functional and process coherence, in this case between two different individuals at two very different points in their life cycles.

Just because this is common does not mean it’s ordinary. Aside from the wonder of what’s happening in the process, it’s uncommonly nifty engineering.

Gradualism Fails

How could any gradual process generate coherent, finely tuned systems, when a failure in any part of those systems prevents an individual organism from surviving? This is problematic no matter how much time is available.

As an example, suppose I want to build a car that’s capable of getting me from point A to point B. It minimally takes several dozen parts to make a drivable car. I’m allowed to add only two or three parts at a time (gradual changes), but at each step, I can only keep what I’ve got if it meets the minimum functional requirement of getting me from here to there (survival requires a minimally functioning whole).

Based on these rules (which parallel the survival constraints of living systems), it doesn’t matter how I begin, where I begin, or in what order I add parts — if I start with a tire and add only a couple of parts, I will never get to minimal functionality, even if they’re the right parts and I add them in the right places!

When gradualism faces a complex assembly task, it inevitably fails unless (a) only a couple of parts are required, or (b) there are a number of intermediate stages, each of which is capable of minimal function, and each of which can be reached from a previous viable stage by only a couple of changes. Complex control systems fail on both counts, and thus present an insurmountable hurdle to gradualism.

And this is true regardless of whether the process is directed or undirected!

Knowing what, where, and how to bolt the parts together doesn’t get the whole built (when it must be done in discrete, gradual steps). Bolting random stuff together in random configurations is astoundingly unlikely to produce any useful function, much less ones that will enable survival at each discreet step. Random, undirected changes simply make the impossible even less possible.

This is the basic flaw in the various genetic algorithms that purport to show how life can build itself randomly — minimal functionality is needed in every area at each step along the way, or the whole endeavor crashes.

The Burden of Proof Grows

Coherent interdependence is an intriguing property — extremely difficult to achieve, and equally difficult to change. When coherent interdependence is essential to survival, as it seems to be for all living organisms, the systems view tells us to expect new body plans to appear suddenly, in a functionally complete form, and change rarely, generally in functionally minor ways.

The fossil record aligns almost perfectly with this view. Nearly all body plans appear suddenly, with essentially no precursors, and are followed by long periods of stasis (invariance) — in many cases hundreds of millions of years — during which only minor variations occur.

This greatly increases the burden of proof for anyone espousing gradual causation, like neo-Darwinism. It’s incumbent upon gradualist proposals to address two key requirements:

Hypothesize (and eventually find in the fossil record) a viable organism at each and every discrete step from a single-celled critter to a complex body plan like a human being (i.e., the theory must propose an adaptive continuum). Viability must account for all 40 of Glicksman’s survival factors at each step.
Explain how any proposed causal mechanism(s) are sufficient to produce all the necessary changes for that discreet step within a single generation. Random causes, for example, cannot explain more than a couple of coherent changes at any given step, much less at every step.
Efforts to date along these lines have been woefully lacking. Admittedly, this is an enormously hard problem, so perhaps we’re being too hard on the Darwinists. But science offers limited compassion for failed theories, especially when the supporting arguments consist mainly of vague story-telling about happy accidents in large quantities, using cool-sounding made-up words like de novo origination (new stuff that pops into existence out of nothing).

Any gradualist theory that fails to address these most fundamental issues with more than an appeal to authority (we’re smarter than you), or an appeal to faith (trust us, we’ll find the answer), should be viewed with skepticism at best.

Think Different

Of course, doctors like Glicksman, who face the real-world implications of body subsystems that have stopped working, and engineers, who need to build systems that work in the real world, already know these things.

Coherent, finely tuned, interdependent, systems of systems are essential to life. They’re needed at the outset, and at each step along the way. Even single-celled organisms cannot live without coherent, finely tuned internal subsystems.

Coherence is thus a prerequisite for life — not the outcome of life, as Darwin supposed. This simple fact is profoundly problematic for material causation. Gradual changes simply cannot produce such systems. Neither can random causes. For Darwinists, the burden of proof grows, while the explanatory power of neo-Darwinism fizzles. Maybe it’s time to rethink everything.

In the human body, Glicksman exposes a world of coherent complexity that we rarely think about, yet which demands a rational conversation. The questions raised are intriguing. Regardless of personal worldviews, any proposal that aligns with the preponderance of the data deserves less knee-jerk derision and more thoughtful consideration, both in the scientific community and in the public square.

Glicksman’s series, The Designed Body, is worth a read. Think, understand, and be amazed. And also, maybe, be thankful to the designing engineer — the architect of life — who made the human body, and you, possible.


- See more at: http://www.evolutionnews.org/2017/03/designed-body-coherence-wins-gradualism-fails/#sthash.dYZcIjAM.dpuf

Monday, 6 March 2017

Precisely accurate?

The case for design remains undeniable.

The Envelope, Please? Doug Axe and Undeniable Are World Magazine 2016 Science Book of the Year! - 
David Klinghoffer

Update: I see that Doug Axe’s book is in its rightful place at the top of Amazon’s bestseller list under Organic Evolution. In fact, of the top ten books on that list, four are by authors affiliated with Discovery Institute’s Center for Science & Culture — Axe, Meyer, Behe, and Johnson. Nice

Unlike the Oscars, World Magazine and its editor Marvin Olasky don’t employ the accounting firm of PricewaterhouseCoopers  to tell them who won Book of the Year. So we trust there’s been no mix-up with the envelopes. In the category of “Science, math, and worldview,” the Book of the Year for 2016 is Undeniable: How Biology Confirms Our Intuition That Life Is Designed.  by Douglas Axe!

Congratulations to Dr. Axe of Biologic Institute — and to our biologist colleague Michael Denton too, who not only figures prominently in Axe’s book, but also tops World‘s shortlist in the same category with his book from Discovery Institute Press, Evolution: Still a Theory in Crisis. Dr. Denton is followed on the Short List by Tom Wolfe’s The Kingdom of Speech, which tweaks Darwin on the mystery of human language and its evolution.

Mr. Olasky is one journalist who has carefully studied the debate about biological origins. His write-up accompanying the announcement is characteristically well informed. It all starts with Denton:

In 1985 biologist Michael Denton noted — in Evolution: A Theory in Crisis — that Darwinism was cruising for a bruising. Now he’s back with Evolution: Still a Theory in Crisis, which shows — with three decades of new research — that Darwin’s theory needs hip replacements, for “there is now a growing chorus of dissent within mainstream evolutionary biology.”

He’s right. Darwin himself wrote, “If it could be demonstrated that any complex organ existed which could not possibly have been formed by numerous successive slight modifications, my theory would absolutely break down.” It has broken down, as advances in paleontology, genomics, and developmental biology show.

For example, mainstream researchers Douglas Erwin and Eric Davidson have noted that “classic evolutionary theory, based on selection of small incremental changes,” is clearly inadequate. Günter Wagner in Homology, Genes, and Evolutionary Innovation writes, “Adaptive modifications often involve only the modification of existing cis-regulatory elements,” but truly new developments “require large-scale reorganizations of the gene regulatory network.”

Moving on to Doug Axe and his achievement:

Axe’s subtitle offers a shocking suggestion: How Biology Confirms Our Intuition That Life Is Designed. Axe has an elite science education and record of journal publication, but he commits treason to the scientism guild when he writes that “people who will never earn PhDs [can] become full participants in the scientific debates that matter to them.” Undeniable is our science book of the year because it’s a largely nontechnical argument showing the incredible improbability that life has evolved as Darwin theorized. Axe offers example after example to show that “functional coherence makes accidental invention fantastically improbable and therefore physically impossible. Invention can’t happen by accident.” He shows how “the claim that evolution did invent proteins, cell types, organs, and life forms is scientifically legitimate only if we know evolution can invent these things.” He then shows how we have learned that evolution can’t.

On Denton:

When Denton in 1985 wrote Evolution: A Theory in Crisis, he was a lonely PhD holder in biochemistry crying out in the wilderness. Now, just about everyone who doesn’t have a monetary or professional stake in defending Darwinism is seeing the theory’s ability to explain small changes but its incompetence in explaining macroevolution — and the adaptive transitional forms Darwin predicted we’d find are still absent without leave. Denton shows how advances in our knowledge of genetics, paleontology, and developmental biology have threatened the faith that macromutations by chance put together complex structures like a diaphragm, a bat’s wing, a branched bipinnate feather, etc.

The point about “monetary or professional stakes” is spot on. Social prestige, self-esteem, vanity — these figure into it as well, as Tom Wolfe repeatedly underlines in his excellent book.

Undeniably, Darwin’s theory is guarded at the highest level by scientists whose careers and the income and esteem that go with them are inextricably tied up with the defense of orthodox evolutionary theory. Scientists like Doug Axe and Michael Denton are a threat to all that, which is why they earn such venom from the establishment — and admiration from open-minded thinkers like Olasky and his colleagues at World.



Saturday, 4 March 2017

History re:The ides of march.

Human history undersea.

Time to call it a day re:A United States of Europe?

Next to the witness stand for design;whales

More "Design of Life" Evidence: Whales




Is democracy past its prime?:Pros and cons.

The revolution rolls on

Michael Behe's Challenge -- Past, Present, and Future
Evolution News & Views

Twenty years after Darwin's Black Box, the irreducibly complex outboard motors showcased by Michael Behe still confound Darwinism. That's one theme of our upcoming documentary Revolutionary:  Revolutionary: Michael Behe & The Mystery of Molecular Machines, which heads to Texas next month for previews. Behe's challenge is the past, the present, and the future.

Look at this quote from a paper in the  Proceedings of the National Academy of Sciences:

The bacterial flagellar system has been an object of intense study for many years. It has helped to elucidate issues of assembly, motility, and chemotaxis at a molecular level in a relatively simple system, typically containing ∼40 different proteins. It has also been the icon for creationists in the United States who deny evolution. [Emphasis added.]
Ah, the bacterial flagellar system. The paper by scientists from Germany, the Netherlands, Israel, and the U.S. (University of Virginia) purports to show how a simpler flagellum in a species of archaea provides evidence for evolution of the more complex flagellum in bacteria. It's satisfying to reflect that the authors remain irritated by the "creationist" icon. They can't let it rest.

As expected, they refuse to cite Behe directly (or any other ID source), so their only references supporting the "creationist" charge are to 6-to-12-year-old writings by Kenneth Miller, Barbara Forrest, and E.H. Egelmann. Have it your way. What matters is the substance of Behe's argument and evidence, which attracted the attention of researchers in four nations.

Meanwhile, farther east -- particularly in Japan -- scientists don't seem quite so motivated to defend Darwin. Two new papers dealing with molecular motors show their openness to design thinking.

Cilium Mimicry

The first deals with designing a mimic of cilia, another one of Behe's examples of irreducibly complex (IC) systems. Five biomedical engineers from Tokyo, writing in Science Advances, succeeded in making "Artificial cilia as autonomous nanoactuators." They call this "Design of a gradient self-oscillating polymer brush with controlled unidirectional motion."

Here, we have prepared a polymer brush surface similar to a living cilium, exhibiting self-oscillating and unidirectional wave motion of the grafted polymer at the nanometer scale.... This study provides a new concept to design autonomous polymer brush surfaces effective in the nanometer scale as bioinspired dynamic soft materials.
They pay tribute to the design in cilia and other cellular machines that inspired their own work:

Spatiotemporally well-ordered mechanical actuation of biomacromolecules in the nanometer-order scale driven by chemical reactions, such as enzymatic reactions, plays an important role in living organisms. For example, motor proteins bind to a polarized cytoskeletal filaments and use the energy derived from repeated cycles of adenosine 5′-triphosphate hydrolysis to move steadily along them. In addition, many motor proteins carry membrane-enclosed organelles to their appropriate locations in the cell. Cytoskeletal motor proteins move unidirectionally along an oriented polymer track. In this process, they use chemical energy to propel themselves along a linear path, and the direction of sliding is dependent on the structural polarity of the track. Recently, the construction and design of these biomolecular motor systems with well-controlled unidirectional motion have become an area of great focus in advanced sciences.
The word "design" appears ten times in the paper. References to evolution are completely absent.

Another team worked on imitating the cilia in hair cells of the inner ear. Publishing in Nature's journal Scientific Reports, they proudly announce, "Here we present a novel, completely biomimetic flow sensor which attempts to replicate the intricate morphological organization and function of the hair bundles of the hair cells" found in zebrafish. Neither of the cheap imitations, however, contain anything like intraflagellar transport in biological cilia (see our report). As for the origin of these intricate structures, the team treated evolution as magic: "Nature's evolutionary path led to sensors of high functionality and robustness, in terms of material properties, anatomical architecture and energy expenditure." That's all the press Darwin got. They used the word design, though, 15 times.

Flagellum Focus

Back in the 1990s, Behe relied on relatively crude electron micrographs of flagella. Imagine twenty years ago if he had been able to see in detail one protein in the stator of the flagellum. That's what Japanese scientists from Nagoya University revealed with advanced imaging techniques. So has the case for design grown stronger or weaker since Darwin's Black Box was published? A paper in Nature's open-access journal Scientific Reports reveals the answer. You can see their composite image of the stator protein MotA here:



It looks more like a well-designed outboard motor than ever!

Many bacterial species use spiral propellers (flagella) attached to motors to move through a liquid environment. An interaction between the rotor and stator components of the motor generates the rotational force required for movement. The stator converts electrochemical energy into mechanical force after undergoing a structural change caused by a movement of charged particles (ions) through an internal channel. Previous studies investigated the stator and its interaction with the rotor by constructing mutant proteins and analyzing their functions. However, little was known about stator structure.
A team of Japanese researchers led by Homma's laboratory of Nagoya University have now purified the stator protein MotA from a bacterium found in hot springs (Aquifex aeolicus) and analyzed its three-dimensional structure using electron microscopy mainly in cooperation with Namba's laboratory of Osaka University.

The stator protein MotA shows an elegantly crafted channel for ions. These are arranged in groups of four at the base of the stator on the cytoplasmic side. Two slender molecules of MotB extend into the periplasm. Identifying the structure is an important step on the way to figuring out how the flagellum works.

The stator is one of the most important parts for the proper functioning of the bacterial flagellar motor, and is believed to work as an energy-converting unit that transduces electrochemical potential gradient across the cytoplasmic membrane into mechanical force. The interaction surfaces of the stator and the rotor have been well studied by mutational analyses. However, the mechanism governing energy conversion remains unknown because of the lack of structural information on the stator.
How is chemical energy converted into rotational energy (torque)? "It is believed that the ion influx through the channel induces a conformational change in the stator, allowing its interaction with the rotor to generate torque," they say.

A little reflection suggests that the components must be well matched. Imagine for a moment a flow of ping-pong balls trying to turn a large metal turbine. It wouldn't work. Somehow, in ways still to be determined two decades after Behe's book was published, tiny hydrogen ions or sodium ions are able to make particular parts of the stator undergo conformational changes that can get the rotor to turn. How that works is bound to be interesting. We know from the discussion in Unlocking the Mystery of Life that not only must the parts be well matched, they must be assembled in the right order, in the right amounts, at the right place and time -- all directed by instructions in the genetic code.

While these Japanese researchers do not mention Behe or his conclusions, their work underscores the case for irreducible complex molecular machines as prima facie evidence for intelligent design. Nowhere do they credit evolution for the motors of the cell:

Various motor proteins are essential for different biological activities such as cell locomotion, cell morphogenesis, metabolism, and material transport. Motor proteins convert various types of energy, such as ATP hydrolysis or electrochemical potential, into mechanical force for directional motion. Motor proteins are divided into two types: linear motors, such as myosin-actin and kinesin/dynein microtubule motors; and rotary motors, such as ATP synthase and bacterial flagellar motor.
Behe's intuitive first impression of the flagellum, "That's an outboard motor!" has stood the test of time. That's what the Japanese teams still call the cilium and the flagellum in 2016.

Scratching the Itch

Now back to the PNAS paper. Did the Western nations solve Michael Behe's challenge? If so, they have a strange way of claiming success:

The proteins that form the bacterial flagellar system have no known homologs in eukaryotic cells. The eukaryotic flagellar [sic], based on a microtubule-containing axoneme, is vastly more complicated. In fact, the current estimate for the number of different proteins in the axoneme is ∼425. In contrast, the archaeal flagellar system appears simpler than the bacterial one and can contain as few as 13 different proteins. As with the eukaryotic flagellar system, the archaeal one does not have homology with the bacterial one and must have arisen by means of convergent evolution.
Ah yes, convergent evolution again. But think about what they say here. The "vastly more complicated" eukaryotic flagellum has no known commonalities with the bacterial flagellum, and the bacterial flagellum has no homolog in the archaeal flagellum: "In archaeal flagellins, however, no homology has yet been found outside of the N-terminal domain with any bacterial or eukaryotic proteins." Do they show any common ancestry between these motors? None. Are we to believe, then, that blind processes happened upon three naturalistic miracles independently?

Notice that the archaeal flagellar system that "appears simpler" contains as few as 13 different proteins. How many different parts were required for the mousetrap? Behe's pithy illustration of an IC system had only five parts. How much more is an IC system with 13 parts, or with 40 parts, each unrelated to machines with similar functions in other types of cells?

If the best that evolutionists can come up with in response to Behe is "convergent evolution," then his 1996 statement can be seen as prescient: "An irreducibly complex biological system, if there is such a thing, would be a powerful challenge to Darwinian evolution" (p. 39). Only he could reword it now with much more confidence: Irreducibly complex biological systems continue to pose a powerful challenge to Darwinian evolution and are best explained by intelligent design.