Why appeals to common design re:homology are not a cop out.

Why Similarities Do Not Prove the Absence of Design
Granville Sewell 

The idea that the "survival of the fittest" could produce all the magnificent species on Earth, and human brains and human consciousness, is so unreasonable -- how did such an idea ever become so widely accepted in the scientific world? There are two reasons.

First, science has been so successful explaining other phenomena in Nature that -- understandably -- today's scientist has come to expect that nothing can escape the explanatory power of his science. And Darwinism, as far-fetched as it is, is the best "scientific" theory he can come up with for evolution. As microbiologist René Dubos puts it in The Torch of Life, "[Darwinism's] real strength is that however implausible it may appear to its opponents, they do not have a more plausible one to offer in its place." But we have already seen why evolution is a very different and much more difficult problem than others solved by science, and why it requires a very different type of explanation.

Second, for most modern minds, the similarities between species not only prove common descent, they prove that evolution was the result of entirely natural causes, even in the absence of any evidence that natural selection can explain the major steps of evolution. The argument is basically, "This doesn't look like the way God would have created things," an argument used frequently by Darwin in the Origin of Species. But if the history of life does not give the appearance of creation by magic wand, it does look very much like the way we humans create things, through testing and improvements.

In fact, the fossil record does not even support the idea that new organs and new systems of organs arose gradually. Instead, new orders, classes, and phyla consistently appear suddenly. For example, Harvard paleontologist George Gaylord Simpson writes:

It is a feature of the known fossil record that most taxa appear abruptly. They are not, as a rule, led up to by a sequence of almost imperceptibly changing forerunners such as Darwin believed should be usual in evolution.... This phenomenon becomes more universal and more intense as the hierarchy of categories is ascended. Gaps among known species are sporadic and often small. Gaps among known orders, classes and phyla are systematic and almost always large. These peculiarities of the record pose one of the most important theoretical problems in the whole history of life: Is the sudden appearance of higher categories a phenomenon of evolution or of the record only, due to sampling bias and other inadequacies?
Actually, if we did see the gradual development of new orders, classes and phyla, that would be as difficult to explain using natural selection as their sudden appearance. How could natural selection guide the development of the new organs and entire new systems of interdependent organs which gave rise to new orders, classes, and phyla, through their initial useless stages, during which they provide no selective advantage? French biologist Jean Rostand, in A Biologist's View, wrote:

It does not seem strictly impossible that mutations should have introduced into the animal kingdom the differences which exist between one species and the next... [H]ence it is very tempting to lay also at their door the differences between classes, families and orders, and, in short, the whole of evolution. But it is obvious that such an extrapolation involves the gratuitous attribution to the mutations of the past of a magnitude and power of innovation much greater than is shown by those of today.
Rostand says, nevertheless, "However obscure the causes of evolution appear to me to be, I do not doubt for a moment that they are entirely natural."

We see this same pattern, of large gaps where major new features appear, in the history of human technology. (And in software development, as discussed in my Mathematical Intelligencer article "A Mathematician's View of Evolution.") For example, if some future paleontologist were to unearth two species of Volkswagens, he might find it plausible that one evolved gradually from the other. He might find the lack of gradual transitions between automobile families more problematic, for example, in the transition from mechanical to hydraulic brake systems, or from manual to automatic transmissions, or from steam engines to internal combustion engines. But if he thought about what gradual transitions would look like, he would understand why they didn't exist: There is no way to transition gradually from a steam engine to an internal combustion engine, for example, without the development of new, but not yet useful, features. He would be even more puzzled by the huge differences between the bicycle and motor vehicle phyla, or between the boat and airplane phyla. But heaven help us when he uncovers motorcycles and hovercraft, the discovery of these "missing links" would be hailed in all our newspapers as final proof that all forms of transportation arose gradually from a common ancestor, without design.

The similarities between the history of life and the history of technology go even deeper. Although the similarities between species in the same branch of the evolutionary "tree" may suggest common descent, similarities (even genetic similarities) also frequently arise independently in distant branches, where they cannot be explained by common descent. For example, in their Nature Encyclopedia of Life Sciences article on carnivorous plants, Wolf-Ekkehard Lönnig and Heinz-Albert Becker note that

...carnivory in plants must have arisen several times independently of each other... the pitchers might have arisen seven times separately, adhesive traps at least four times, snap traps two times and suction traps possibly also two times.... The independent origin of complex synorganized structures, which are often anatomically and physiologically very similar to each other, appears to be intrinsically unlikely to many authors so that they have tried to avoid the hypothesis of convergence as far as possible.
"Convergence" suggests common design rather than common descent: the probability of similar designs arising independently through random processes is very small, but a designer could, of course, take a good design and apply it several times in different places, to unrelated species. Convergence is a phenomenon often seen in the development of human technology. For example, Ford automobiles and Boeing jets may simultaneously evolve similar new GPS systems.

So if the history of life looks like the way humans, the only other known intelligent beings in the universe, design things -- through careful planning, testing, and improvements -- why is that an argument against design? Somehow we got the idea that nature's designer shouldn't need to get involved in the details, and so should be able to create anything from scratch, using a magic wand. But no matter how intelligent a designer is, he still has to get involved in the details -- that's what design is!

Some people counter by saying that of course cars cannot evolve like animals, because they cannot reproduce, so there are no "variations" for natural selection to work with. But the main point here is not about natural selection -- it is only that similarities between "species" (of cars or animals) do not prove the absence of design.


However, even though it is irrelevant to my main point here, let's look at the argument that evolution is easier to explain if there is reproduction. Is that really so? If cars were able to reproduce themselves almost perfectly (the copies even retaining the ability to reproduce themselves!), with occasional minor errors, would that make the evolution of cars easier to explain without design, than if individual cars experienced slight changes or improvements directly, though rust or crashes or other natural causes? We are so used to seeing animals make nearly perfect copies of themselves that we dismiss this as just another "natural" process; but if we saw cars giving birth to cars, maybe we would realize that this would actually make automobile evolution even more amazing and more difficult to explain without design.

Darwinism Vs. the real world XXX

The Neuromuscular System: Your Body's Balancing Act
Howard Glicksman 

Editor's note: Physicians have a special place among the thinkers who have elaborated the argument for intelligent design. Perhaps that's because, more than evolutionary biologists, they are familiar with the challenges of maintaining a functioning complex system, the human body. With that in mind, Evolution News is delighted to offer this series, "The Designed Body." For the complete series, see here. Dr. Glicksman practices palliative medicine for a hospice organization.

The nerves and muscles of our body allow us not only to breathe, but also to move around and manipulate things. But how do they do it? In my last I article showed that nerve cells (neurons) and muscle cells (myocytes) are excitable. This means that when adequately stimulated, they depolarize. By letting large amounts of Na+ ions enter, they cause the plasma membrane to go from being negatively charged to positively charged. Depolarization triggers large amounts of Ca++ ions to enter the cell, causing the neuron to release its neurotransmitter and the myocyte to contract.

The nervous system is set up like a military operation. Reconnaissance from sensory neurons within the peripheral nerves is sent to and organized by the spinal cord and transmitted to the brain. The brain, acting as headquarters, analyzes the sensory information, makes decisions, and sends out orders. The orders travel to and are organized by the spinal cord and sent through the motor neurons within the peripheral nerves. The messages tell the muscles to contract, which results in controlled and purposeful movement. The success of a military operation is dependent on having good information about the enemy and one's own troops. Let's look at some of the ways the body acquires the information it needs about its external and internal environment so it can know what to do and act accordingly.

Everyone knows that an odometer measures distance and a speedometer measures velocity. Each device is essentially a sensory transducer with a mechanism in place that enables it to sense a physical phenomenon and convert it into useful information. We have seen that the body has a whole host of sensory transducers, which provide the information necessary to maintain its internal environment. They are divided into three different categories: chemoreceptors, which respond to chemicals, like oxygen, glucose and calcium; mechanoreceptors, which respond to motion and stretch, like the baroreceptors in the walls of the arteries leading to the brain that monitor blood pressure; and physical sensors, which respond to natural phenomena, like the thermoreceptors in the hypothalamus that detect core temperature.

The skin not only protects the body from infection and injury. It also provides sensory information about its immediate surroundings. The skin has different sensory receptors that can detect light touch, pressure, motion, vibration, and temperature. It has pain receptors that react to chemicals related to nearby cell injury. They also react to too much pressure or motion and extreme temperatures. Adequate stimulation of any one of these sensory receptors causes the associated neuron to depolarize and release its neurotransmitter. The neurotransmitter then depolarizes a nearby connecting neuron in a cascade that transmits the message all the way to the brain, usually in the sensory region of the cerebral cortex.

In addition to the skin, which provides sensory information about the body's external environment, there are pain and mechanoreceptors in and around the joints, ligaments, and deep soft tissues. These, in addition to chemoreceptors within the major organs, provide sensory information about the body's internal environment. Although we are aware of many of the sensations caused by our external and internal environment, one set, the proprioceptors, acts unconsciously and without them life would be impossible.

Proprioception involves joint position awareness and kinesthesia, or the awareness of joint and limb movement through muscular effort. The proprioceptors tell the central nervous system about muscle length, joint position, and limb movement. If the body had no way of knowing what its muscles and joints were doing and where its bones were located in space, then how could it control its position and movements? In addition to the mechanoreceptors in and around the joints, the two main proprioceptors are the muscle spindles and the Golgi tendon organs, which provide sensory information on joint position and muscle movement.

The Golgi tendon organ joins the muscle to the tendon as it is attached on one end to the muscle fibers and on the other end to the tendon. Because it is directly connected, in series, to the muscle and the tendon, the Golgi tendon organ is sensitive to the degree of tension applied by muscle contraction.

An increase in tension causes the Golgi tendon organs to increase their impulses to the spinal cord, causing an immediate reflex inhibition of muscle contraction and a reduction in tension. This explains one of the important functions of the Golgi tendon organs: preventing muscle injury and tendon rupture by causing automatic muscle relaxation in the presence of dangerously high levels of tension.

Conversely, a decrease in tension causes the Golgi tendon organs to decrease their impulses to the spinal cord, which results in an immediate reflex reduction in inhibition causing an increase in muscle contraction. This explains another important function of the Golgi tendon organs, which is to help the body maintain its posture while performing goal directed activities.

Muscle fatigue, with its resulting diminished contraction, can lead to inadvertent falling or unexpected changes in position. But the information sent by the Golgi tendon organs to the spinal cord reflexively makes the flagging muscles contract more to allow the body to maintain its posture. Clearly, without the Golgi tendon organs to tell the central nervous system what's going on at the level of where the muscle attaches to the tendon, our ability to move around would be impossible.

Muscle spindles are sensory organs consisting of modified muscle fibers positioned in between and parallel to the skeletal muscle fibers, allowing them to compare their respective lengths. Since each skeletal muscle is usually attached to two different bones across a joint, its length also determines the angle of the joint and its position.

For example, when the elbow is fully extended to zero degrees, the biceps are at their greatest length and the triceps are at their shortest. In contrast, when the elbow is fully flexed at about 160 degrees, the biceps are at their shortest length and the triceps are at their greatest. When the angle of the elbow is in between, at 80 degrees, so too are the lengths of the biceps and the triceps. This demonstrates one of the functions of the muscle spindles, which is to provide the central nervous system with information about the length of each skeletal muscle and the angle and position of its associated joint.

If the skeletal muscle fibers are longer than the muscle spindles (an indication of being stretched) the muscle spindles react by sending more impulses to the spinal cord, reflexively causing muscle contraction. Conversely, if the skeletal muscle fibers are shorter than the muscle spindles (an indication of muscle contraction) the muscle spindles react by sending less impulses to the spinal cord which reflexively results in muscle relaxation. This demonstrates another important function of the muscle spindles. Like the Golgi tendon organs, they help the body maintain its posture and position in space while performing purposeful movements.

In a static situation, such as carrying a load in front of the body, it is easy to understand how the muscle spindles maintain position through changes in muscle function. In this setting, the elbows must be maintained at about ninety degrees by the combined actions of the biceps and triceps. During this activity, stretching (lengthening) of the biceps, due to muscle fatigue, will at the same time cause a shortening (contraction) of the triceps. If this is not corrected quickly the angle of the elbow will decrease and allow gravity to take more effect which may cause the load to be dropped.

To prevent this from happening, the muscle spindles in the biceps detect the lengthening and send more messages to the spinal cord, reflexively causing an increase in the contraction of the biceps. This maintains the angle of the elbow at ninety degrees so as to not drop the load. At the same time, the muscle spindles in the triceps detect the shortening of its muscle fibers and send out fewer messages to the spinal cord, reflexively resulting in relaxation of the triceps so that the ninety-degree elbow angle is maintained.

Clinical experience with diabetics and others who suffer from sensory nerve malfunction indicates that without any one of the above-mentioned sensory devices, it would have been impossible for our earliest ancestors to survive. Evolutionary biologists must explain how each of them came about and their presence in the precise locations where they are needed in addition to how intermediate life forms could have survived throughout this developmental process.


Next time we will look at the special sense of vision and see what it requires.

Yellow journalism will be the death of Britain?:Pros and cons.

Demythifying peer review II

The Hoax on Us
Drivel, Fraud & Gibberish in Scientific Papers
by Denyse O'Leary

An entertaining but revealing development in science culture in recent years has been the intentionally nonsensical academic paper. Earlier this year, political scientist Peter Dreier admitted at Prospect that his abstract for a panel of six years ago, "On the Absence of Absences," was "academic drivel":

I tried, as best I could within the limits of my own vocabulary, to write something that had many big words but which made no sense whatsoever. I not only wanted to see if I could fool the panel organizers and get my paper accepted. . . .1

Well, not only was it accepted, but he was also invited to join fellow academics in Tokyo at the annual international conference of the Society for Social Studies of Science.


Sokal & His Imitators

The hoax journal paper genre was started, as Dreier explains, by New York University physicist Alan Sokal in 1996. Sokal aimed to skewer the postmodern dogma that facts, even in mathematics and physics, are merely a social construct. He submitted an article to Social Text, a postmodern cultural studies journal, that, "shorn of its intentionally outrageous jargon, essentially made the claim that gravity was in the mind of the beholder." The paper, "Transgressing the Boundaries: Towards a Transformative Hermeneutics of Quantum Gravity," was published in the Spring/Summer 1996 issue of the journal. Writes Dreier:

As soon as it was published, Sokal fessed up in another journal (Lingua Franca, May 1996), revealing that his article was a sham, describing it as "a pastiche of Left-wing cant, fawning references, grandiose quotations, and outright nonsense . . . structured around the silliest quotations [by postmodernist academics] he could find about mathematics and physics."2

Sokal has had many imitators since, a disquieting number of whom have been successful. One entertaining 2015 hoax purportedly showed that boo-boo kisses from mommy did not help heal children's scrapes and recommended "a moratorium on the practice." Other entries don't sound quite so cute, however.

For example, in 2005, MIT researchers developed software they called SCIgen, which "randomly combines strings of words to produce fake computer-science papers." Their aim was to demonstrate that "conferences would accept meaningless papers."3 That was no idle concern. In 2014, computer scientist Cyril Labbé catalogued 120 computer-generated "gibberish" papers that had been published as conference proceedings in the five years between 2008 and 2013 alone. Sixteen papers had appeared in publications of the well-regarded science publisher Springer, and more than 100 were published by the Institute of Electrical and Electronic Engineers. All the papers had to be removed from the relevant databases.

Once discovered, hoax papers can sometimes be retracted with little fuss, but other times the matter doesn't end well. In a very recent case, the authors of a hoax paper about death-camp guard dogs had intended to satirize postmodern attempts to "interpret historical events through the perspective of affected animals." Unfortunately, the authors failed to let the journal or their readers in on the joke. The paper was retracted with some pointed criticism.4

Along with hoax papers, there has been an increase in fraudulent journal papers as well,5 but here we should recognize a distinction: frauds are not the same thing as hoaxes. Piltdown Man and the feathered dinosaur ("Piltdown Chicken"), to cite two concrete examples, were frauds. The fraudster needs the world to believe—and go on believing—the fraud. The hoaxer, by contrast, delights in the moment he can reveal the truth, for that is the point of the exercise.

Left-Wing Bias Paints the Target

Both fraudulent and hoax papers riff off the needless complexity of today's academic prose. Granted, lay readers are often going to be baffled by forbidding but essential technical terms in a research paper. But papers that baffle everyone—even those in the field—while sounding profound are a different matter. Such papers can be seen as resulting from the postmodern invasion of the sciences by nihilist philosophies. Indeed, wags now offer tongue-in-cheek directions for perpetrating a science hoax, and explain how to construct a gibberish paper that gets accepted by journals.5 Perhaps many journals find it easier just to accept a few such papers than to confront the troubling reality they represent: that words don't need to mean anything to be accepted in their discipline.

Social science is especially hard-hit these days; one psychologist described it as "riddled with flaky research and questionable theories."6 There is a surprisingly broad consensus about the cause—that is, everyone from Michael Shermer to Uncommon Descent agrees on it—namely, that the field's overwhelmingly progressive-left bias makes it an easy mark for both hoaxes and frauds.7

It also makes it an easy target for a third category of problem paper that is neither a hoax nor a fraud exactly: the nonsense paper that may well be believed by its authors. Examples of these include the widely cited "positivity ratio" in psychology, which was assessed as "entirely unfounded" in 2013,8 and the recent, apparently serious attempt to "feminize" melting glaciers.9

This sort of thing should come as no surprise. Monochromatic bias exposes a community to greater risk because few of its members even notice a hoax, fraud, or nonsense thesis that passes their bias filter. Usually, the person to whom it doesn't sound right has different commitments and life experiences, and he or she is the one motivated to investigate.

Ironically, many defenders of the status quo in recent years have claimed to be "scared to death of the anti-science lobby."10 Their worries are misplaced. It's actually science that is coming to get them. Soon. •

Notes
1. Peter Dreier, "Academic Drivel Report," Prospect (Feb. 22, 2016): http://bit.ly/1QeFT8Q.
2. Ibid.
3. Nature News (Feb. 24, 2014): nature.com/news/publishers-withdraw-more-than-120-gibberish-papers-1.14763.
3. "Death camp dog satire retracted when German journal wasn't in on joke," Retraction Watch (Mar. 1, 2016): http://bit.ly/1Tt5vEU.
4. Ibid.
5. Adam Ruben, "Forging a Head," Science (Apr. 22, 2011): http://bit.ly/21ZSNCF; Rob Sheldon, "How, exactly, to construct a gibberish paper that gets accepted by journals," Uncommon Descent (Mar. 6, 2014): http://bit.ly/1XcVycU.
6. Claire Lehmann, "How a rebellious scientist uncovered the surprising truth about stereotypes," Quillette (Dec. 4, 2015): http://bit.ly/1SExNbD.
7. Michael Shermer, "Is Social Science Politically Biased? Political bias troubles the academy," Scientific American (Mar. 1, 2016): scientificamerican.com/article/is-social-science-politically-biased.
8. The Scientist (Aug. 7, 2013): the-scientist.com/?articles.view/articleNo/36910/title/-Positivity-Ratio--Debunked.
9. "As glaciers melt, more voices in research are needed," Around the O (Feb. 25, 2016): http://bit.ly/1QW7efz.
10. Robin McKie, "Attacks paid for by big business are 'driving science into a dark era,'" The Guardian (Feb. 19, 2012): http://bit.ly/1nwMgfE.

Birds in the dock for Design

How Hummingbirds Avoid Collisions
Evolution News & Views

Who doesn't enjoy watching hummingbirds through the window at their backyard feeder? These amazing birds, zipping to and fro in all directions at stunning velocity, never seem to crash. Intrigued by their flight prowess, Canadian scientists decided to look into how they do it. They learned something new and unique about the tiny birds' strategy for collision-free navigation.


To make controlled observations of hummingbird paths, the team from the University of British Columbia built a flight simulator consisting of a long box 5.5 meters long, lined with eight cameras. On the side walls, they could project images of vertical and horizontal lines of various widths, and control their motions. Then they caught 18 wild hummingbirds, kept them separate from one another, and trained them to fly the tunnel toward a feeder. While projecting a wide variety of patterns on the walls, they filmed 3,100 flights by the birds.



The results are published in the Proceedings of the National Academy of Sciences (PNAS). New Scientist says:

Hummingbirds have a unique collision avoidance system built into their brains that allows them to perform high-speed aerobatics in safety.
The super-agile birds, whose wings beat up to 70 times a second, can hover, fly backwards, and whizz through dense vegetation at more than 50 kilometres per hour.

How they manage to avoid potentially fatal crashes has remained a mystery until now. Researchers in Canada conducted a series of experiments which showed that the birds process visual information differently from other animals. [Emphasis added.]

Here's what the team expected. Based on earlier studies with insects, they thought that birds would respond to moving stripes on the side walls. The paper states:

Information about self-motion and obstacles in the environment is encoded by optic flow, the movement of images on the eye. Decades of research have revealed that flying insects control speed, altitude, and trajectory by a simple strategy of maintaining or balancing the translational velocity of images on the eyes, known as pattern velocity. It has been proposed that birds may use a similar algorithm but this hypothesis has not been tested directly.
To their surprise, the scientists found that hummingbirds use a different strategy. They don't seem to be affected by pattern velocity, at least when seeing vertical stripes pass by along the walls (known as "nasal-to-temporal pattern velocity"). One would think that the speed of moving bars in their peripheral vision (i.e., the optic flow), would make them speed up or slow down as they approached the feeder; this is known as the "telegraph pole effect," familiar to drivers who can gauge their speed by the passing of telephone poles. But no matter how they varied the speed of the vertical stripes, it didn't seem to matter to the birds. New Scientist explains:

When the scientists simulated the "telegraph poles effect" with vertical moving stripes, the hummingbirds did not react. Instead, they appeared to rely on the size of objects to determine distance, steering away from the stripes as they grew larger.
"When objects grow in size, it can indicate how much time there is until they collide even without knowing the actual size of the object," says Dakin. "Perhaps this strategy allows birds to more precisely avoid collisions over the very wide range of flight speeds they use."

It's not that the birds were incapable of responding to the speed of the moving bars. When horizontal bars were projected moving up or down, the birds did respond by varying their altitude, probably using the information to gauge their risk of hitting the ground. But for preventing collision with the feeder, they appeared to rely mainly on the increasing vertical size of the target.

Further tests confirmed their findings. Instead of stripes, they tried projecting moving dots. They tested many combinations of dots, stripes, stripe orientations and stripe motions. The secret became clear: expansion of an object in any part of the field of view was the bird's cue to respond. They would slow down or steer away from anything that grew in size vertically.

Collectively, our findings suggest that birds control forward flight by monitoring changes in the vertical axis: specifically, the height of features and vertical pattern velocity. This finding is consistent with other laboratory studies showing that flying birds rapidly stabilize key features in their visual field. In nature, collisions may be avoided by monitoring changes in the apparent size of features, such as trees and branches, as well as changes in the vertical position of those features. Although our experiments focused on manipulating a limited number of cues, we do not suggest that these represent the only visual guidance strategies used by birds.
Now apply this to a confusing, dynamic tangle of branches, leaves, flowers, and objects that hummingbirds must face in their natural environments. The strategy allows them to quickly zero in on the pertinent optic flow information to avoid collisions. Moving at 50 km/hour, hummingbirds must be quick! This programmed strategy avoids TMI (too much information), giving them only what they need at the moment, even though their brains are perfectly capable of gathering and processing all the information in the visual field.

It makes sense that birds, being much larger than insects, would use a different strategy for collision avoidance. It appears that the strategy is common to birds. Previous tests with budgerigars (the pet parakeets) showed similar responses. Now see what a large goshawk has to deal with in its flight through a tangled forest!





The scientists realize that the behaviors must relate somehow to actual nerve impulses:

Neurons that compute expansion have been identified in the nucleus rotundus of the pigeon brain, part of the tectofugal pathway.... These cues can inform an animal about the nearness in time of an impending collision, triggering an appropriately timed response without knowledge of the true size or distance of the approaching object. It was recently discovered that the zebra finch nucleus rotundus also contains cells that respond during simulated flight if an approaching feature is located at the point of expansion, suggesting that the tectofugal pathway may also be involved in flight control.
Flight control. That's design. Understandably, the scientists did not speculate about how flight control systems might have evolved. Spinning a "narrative gloss" on the findings would have dubious value.

On the contrary, you can certainly appreciate that the knowledge gained by investigation of "flight control" in hummingbirds might improve the design of drones, now that "drone racing" is becoming one of the hottest new sports. Look at this:




As you watch the man-made racing drones suffer "spectacular crashes" in their "daring aerial maneuvers," then realize that hummingbirds already had collision avoidance figured out, you can't help but remember Paul Nelson's quip in Flight: The Genius of Birds, "If something works, it's not happening by accident."

The undeniable logic of the case for design II

If You Could Get a Critic to Read Just One Book about Intelligent Design, It Might be Undeniable
David Klinghoffer

Following the evolution debate for me has been a revelation about human nature, among other things, showing as it does how fiercely resistant the mind is to considering other intellectual frameworks. The library of books that make the argument for ID is rich and multifaceted. Yet one of the perennial laments of the ID proponent is that we have a hard time getting our critics, whether in the science or media world, to read any of this literature.

They are much more likely to content themselves with a quick skim of the woefully misleading Wikipedia page, followed by the one word dismissal, "creationist." Sometimes, then, you can't help daydreaming: If you could give a critic just one book on ID with the assurance that he or she would actually read it, what would that book be?

It's a tough question. Certainly Doug Axe's new book, Undeniable:  Undeniable: How Biology Confirms Our Intuition That Life Is Designed, would be a contender for its concision, accessibility, rigor, and passion. I've already shared with you what some open-minded scientists have said about the book (see here  and  here). Here's more from a diverse and distinguished readership.

Undeniable speaks to everyone, and who would know better about that than a New York Times bestselling novelist like Dean Koontz? Says Mr. Koontz:

Great scientists are as much artists as scientists. Enchanted by the beauty of the world, they see through ideologies to facts. In this engaging book, with facts and humility and humor and reason, Axe uses "common science" to consider the biggest mystery: To what or to whom do we owe our existence? I greatly enjoyed it.

It speaks to ultimate questions of origins, from the perspective of science. And who would know better about that than physicist Gerald Schroeder, author of The Science of God:

So often we read secondary accounts of the intelligence that lurks behind the wonders of life. In Undeniable we are privy to a first-hand account of the evidence for intelligence, and also the painful professional cost of swimming against the flow of an accepted, but un-proven, truth. A must-read.

Yes, though newly published, it's already on its way to being recognized as an ID classic. And who would know better about that than an icon and founder of the intelligent design movement, Phillip E. Johnson, Professor Emeritus of Law at U.C. Berkeley and author of Darwin on Trial? Says M. Johnson:

Douglas Axe's Undeniable is bold, insightful and world-changing. It's also a joy to read. I recommend it highly!

Finally, in case you missed it already, Dr. Axe explains the science behind our intuition of design in nature. Not all intuitions are reliable, but this one reflects what Axe calls "common science." Here, then, is still another scientist, biologist Donald Ewert, Director of Research at the Hough Ear Institute and former Wistar Institute Research Scientist. Says Dr. Ewert:

Life begs for an explanation. Written from point of view of a molecular biologist Undeniable makes a compelling case based on current research and human reasoning that living organisms were designed by an intelligent agent. Axe delivers a decisive blow to the foundations of materialistic explanations of the origin and diversity of life's forms, explanations that have dominated biology for the past two hundred years years. He demonstrates an informed grasp of the current scientific and philosophical information that he communicates in an interesting style that can be understood by most laymen. Undeniable will change the way you think about the living world.


That's some very impressive praise. Surely Undeniable belongs in your ID library.

RNA first theory on the rocks

A Chilling Origin of Life Scenario
Evolution News & Views

The most popular of the Origin of Life (OOL) models is the RNA-first world. RNA can have catalytic properties similar to proteins (enzymes) and are thus called ribozymes. RNA or some form of pre-RNA is an attractive early earth molecule and possible progenitor to early life because, unlike the chicken-and-egg problem with proteins and DNA, theoretically, RNA replication can be completely self-contained. In fact, in January 2009 Nature reported on the synthesis of a self-replicating RNA molecule capable of catalyzing its own replication. See Casey Luskin's report here.
There are several problems with the RNA-first model (See here for a short discussion on some problems with RNA, and see Chapter 14 in Signature in the Cell) not the least of which is how difficult RNA is to synthesize. However, two of the major problems that OOL researchers face are the inherent instability of RNA (a much less stable molecule than DNA) and the dilute reaction conditions that were likely on the early earth. A recent Nature Communications proposes a hypothesis that addresses these problems. The authors propose that perhaps these early earth RNA reactions occurred in ice.

The authors began with 18R RNA polymerase ribozyme because of its similarity to probable early earth RNA and brought their reaction solution to the eutectic phase (a specific temperature range for a particular solution) to see whether RNA replication occurs. Although the authors admit that the reaction is slowed down considerably, the sub-zero temperature stabilizes the products, and the formation of ice crystals concentrates the reactants. Overall, they obtained products in the range of 32 to 41 nucleotides, a longer RNA strand than when this reaction is conducted at room temperature.
There are several important points and assumptions made in this article:
Points:

• The temperature was brought to the eutectic phase, which is a specific temperature range for a given solution of solvent and solutes. The eutectic phase is colder than the freezing point of the solvent itself, so in this reaction the solution of solute particles and water is brought to below the freezing point of water.


• Bringing the solution to the eutectic point forms an ice-lattice structure that allows for diffusion and compartmentalization of RNA products and side products.


• Ice causes substrate and solute concentration and prevents replicase degradation. It allows for compartmentalization, and certain microstructures of the ice permit diffusion, helping the overall reaction yield. These are very specific results from a specific set of conditions.

Assumptions:

• The authors state that R18 RNA polymerase ribozyme is "the best available modern day analogue of a primordial replicase," which is based on some presuppositions on what the primordial replicase would be. Furthermore, this starting material was purified before use. One of the biggest problems with the RNA-first world is the problem of synthesizing RNA in the first place. The reactions to produce the nucleotides would inhibit the reactions to produce the ribose rings, making the synthesis complicated.


• The cold temperature slows down the reaction, but stabilizes and reduces degradation of replicase product. The authors assume that the slower kinetics is off-set by the stability of the product.


• The authors assume a cold early Earth, or at least cold portions of an early earth. The authors provide references that suggest perhaps the early earth was cold rather than hot; however, this is a contentious issue.


• An assumption that is common in OOL scenarios, from the article: "Our results imply a potentially wider role for ice, promoting all the steps from prebiotic oligomer synthesis to the emergence of RNA self-replication and Darwinian evolution." Thus far, there is no mechanism describing how to move from RNA to a nucleus-like organelle to a protocell to cellular life. This is taken for granted in origin of life scenarios.

While this is a proof-of-concept experiment, some of these assumptions are too specific or troublesome to be ignored.
For example, slowing down an already slow process when the geological clock is ticking is glossed over in this article, but needs to be considered. In these types of reactions, heating speeds the reaction up but risks destroying the products while cooling protects the products, but slows a reaction down (See also Levy and Miller, "The stability of the RNA bases: Implications for the origin of life" Proc. Natl. Acad. Sci USA vol 95:7933(1998).). OOL of life scenarios presume that even though it is highly improbable that some chemicals will randomly come together and form something functional, given enough time, there will be plenty of opportunities (probabilistic chances) for this to happen. If a reaction is slowed down, then there are fewer opportunities for chemicals to meet.
Time is taken for granted, but many scientists content that the opportunity for an origin of life scenario to occur may be in the range of 200-500 million years, short in a geological sense. The actual date of the emergence of life is a contentious issue, but many findings have pushed the date back to the earliest bacteria living 3.5 billion years ago. Furthermore, the early earth's environment was inhospitable for any kind of life or organic chemistry for the first 500 million years (For one example of reports in this field, see Schopf, J. William "The First Billion Years: When Did Life Emerge?" Elements vol 2:229( 2006).). Given the very specific conditions reported in the article and the slower reaction time, there is not enough time (probabilistic chances) for this to be a plausible origin of life scenario.
Finally, this quote from the article gives one pause if one is trying to model a naturalistic origin of life scenario:

Although ice thus more than doubles the primer extension capability of the R18 RNA polymerase ribozyme, significant further improvements are required to bring self-replication of the 195 nucleotide ribozyme within reach. While in-ice RNA replication activity may be enhanced further by continued fine-tuning of solute concentrations and identity, there is no denying that R18, in its current form, is maladapted to the ice phase.

There are many assumptions (too many) that are granted to origin of life scenarios, but the one assumption that should not be granted is "continued fine-tuning," as that negates the entire point of trying to find a naturalistic process that could have produced the earliest protocells and subsequently the earliest forms of life that would continue to evolve. Even given the author's statement that R18 was maladapted to ice, they were using a substance that they had purified, and one that earlier in the article was assumed to be as close to the early earth molecules as possible. The experimental section for this reaction is not a simple mechanism. It has very specific details on how the authors brought the reaction to the right temperature and maintained that temperature, their buffer solution, the effect of particular solute anions on the ice structure, and their work up of the reaction. With every instance of a chemist's intervention (or fine-tuning) to a reaction, one decreases one's probabilistic chances of this reaction occurring by chance.
In any origin of life scenario the problem of the chemists' presence is difficult to ignore. There comes a point when so much tweaking and fine-tuning should tell the experimenter that this reaction is too sensitive to the reaction conditions to be a viable contender in the search for the first reactions that produced life.

 

Darwinism Vs. the real world XXIX

Muscles and Nervous System: Keeping the Body Moving
Howard Glicksman

Editor's note: Physicians have a special place among the thinkers who have elaborated the argument for intelligent design. Perhaps that's because, more than evolutionary biologists, they are familiar with the challenges of maintaining a functioning complex system, the human body. With that in mind, Evolution News is delighted to offer this series, "The Designed Body." For the complete series, see here. Dr. Glicksman practices palliative medicine for a hospice organization.


To be able to sit and read this paragraph, your body must perform several actions all at once. Sitting upright requires continuous coordination of the spinal muscles and limbs to maintain your body's position in space. Scanning these words involves not only the neck and eye muscles, but also the vestibular apparatus to keep the picture in proper position as you move your head and your eyes track along the page. Your eyes must process the light reflecting off the screen and convert it into something called vision. To understand what you are reading, your brain must recognize the small dark figures it sees, identify them as words to be interpreted, and transform them into ideas.
So how does your body do it? The simple answer is that your nerves and muscles, working together, let you read and reflect on this paragraph and do much more besides. But that only answers the what, and not how. In my next several articles, I will explain how neuromuscular function allows the body to deal with the laws of nature. To begin with, we will briefly explore how nerve and muscle cells work at the molecular level and are organized within the body.
At rest, all human cells carry a negative charge inside and a positive charge outside the plasma membrane, creating what is called the resting membrane potential. Nerve cells (neurons) and muscle cells (myocytes) are excitable, meaning that when adequately stimulated, they can reverse this resting membrane polarity. By allowing sodium ions (Na⁺) to rapidly enter through specific channels, they make the inside positive relative to the outside. This process is called depolarization.
When depolarization of the neuron takes place, the electrical message moves along the cell and causes calcium ions (Ca⁺⁺) to enter as well. The sudden increase of Ca⁺⁺ ions in the cytosol of the neuron signals it to release its neurotransmitter. The neurotransmitter passes out of the neuron and affects either another neuron or a myocyte, which may be stimulated or inhibited.
When a muscle cell is adequately stimulated and Na⁺ ions suddenly enter to cause depolarization of its membrane, it releases Ca⁺⁺ ions from a reservoir called the sarcoplasmic reticulum. The sudden increase in Ca⁺⁺ ions within the cytosol of the myocyte enables the contractile proteins, actin and myosin, to interact. This interaction causes muscle contraction. This is relatively short-lived, because the Ca⁺⁺ ions are soon after pumped back into the sarcoplasmic reticulum, causing actin and myosin to disengage and contraction to cease.
Each skeletal muscle is made up of many individual myocytes that run parallel to each other and are grouped in bundles. At each end of these bundled muscle fibers there is fibrous tissue called the tendons that attach the muscle, usually to two different bones, across a joint. The end of the muscle attached to the bone that stays still during contraction is called the origin and the one that moves one bone toward the other is called the insertion.
Most joints have complementary pairs of muscles that allow it to be moved back and forth along a particular plane. This is how the body uses its muscles. For example, the origin of the biceps in the upper arm is attached to shoulder blade (scapula) just above the shoulder joint, while the insertion is attached to the inner aspect of the forearm. When the biceps contracts, this makes the forearm move toward the shoulder, flexing the elbow and bringing the fist up in the muscle-man pose. Try it and see: with the palm of your hand turned toward your face, maximally flex your elbow and put your other hand on your biceps to feel it contract.
In contrast, the origin of the triceps is located on the scapula just below the shoulder joint and its insertion is attached to the back of the elbow. When the triceps contracts this makes the forearm move away from the upper arm, straightening (extending) the elbow and moving the fist away from the shoulder. Try it and see: while maximally extending your elbow put your hand on your triceps and feel it contract.
The musculoskeletal system consists of over two hundred bones with about six hundred muscles attached to them, usually across a joint consisting of two or more bones. The bones that make up each joint can usually be moved in two or more directions by pairs of complementary muscles, like the biceps and triceps flex and extend the elbow. It is through controlled contraction and relaxation of the muscles that the bones can move to allow the body to breathe, move around, and manipulate things.
The nervous system is organized like a military operation in that a general and his staff must receive information from the reconnaissance team about where the enemy is located and what it is doing. This information is used by headquarters to help make decisions about strategy and to formulate the orders being sent out to the troops. But things don't end there. Headquarters has to constantly be kept informed of what is going on in the field so it can adjust to an ever-changing situation.
Similarly, the body's nervous system is divided into the central and peripheral nervous systems. The peripheral nerves have sensory neurons bundled within them that send information about what is going on inside and outside the body to headquarters. They also have motor neurons bundled within them, which take the orders from headquarters and tell the muscles what to do. The central nervous system, consisting of the brain and the spinal cord, is the headquarters where the sensory information is received, analyzed, and compared with other information. Then orders are sent out to perform coordinated actions that are purposeful and goal directed.
In general, the spinal cord organizes the sensory messages that it receives from the peripheral nerves and sends them to the brain. It also organizes the motor messages from the brain and sends them to the various regions of the body by way of the peripheral nerves. But since the laws of nature (like gravity) wait for no man, the central nervous system uses specific, quick-acting reflexes that work through the spinal cord and the brainstem to prevent injury or to maintain the body's posture while performing goal directed activities. This is how the body protects itself from the forces of nature so it can survive.
Now you understand how the nerve and muscle cells work at a molecular level and how they are organized within the body. Next time we will look at some of the sensory devices used to monitor the goings on both inside and outside the body.
Keep in mind that evolutionary biologists would have us believe that the multiple bones making up the numerous joints that can be moved in many different directions by complementary sets of muscles all under nervous control came into being by the forces of nature alone. As an experienced pediatrician has expressed to me in writing, "Dismissing a Creative Intelligence in favor of Darwinism defies any sense of reason, genuine intelligence, or just plain everyday common sense." I couldn't have said it better myself.  

On decanonising scientists.

Scientists Aren't Exempt from Feelings, Any More Than the Public Is
David Klinghoffer

Amanda Freise makes a fine point in a post for Scientific American, "It's Time for Scientists to Stop Explaining So Much." She's a PhD student in molecular and medical pharmacology at UCLA and has evidently made a study of research on science communication. She concludes that scientists shouldn't be shocked if loading more technical information on the public doesn't dissuade them from skeptical views on certain controversial issues.
She doesn't mention evolution, but she could have done so. Freise explains that many of her colleagues still hold a "widely discredited" idea, the "deficit model," which says that if only people could be supplied with enough of the right information, they would come around and believe what they are supposed to. It's not so, however.

[T]he reluctance of some scientists to accept the failure of the deficit model approach indicates that pure information isn't enough to convince them, either -- otherwise, they would acknowledge the research and look for new ways to talk to the public.
I do not place the blame solely on my stubborn colleagues. The science of science communication is rarely, if ever, discussed among academic researchers in many fields of "hard" science. They may not even be aware that the concept of the information deficit exists, much less that it's not an accepted model of science communication. Training in public communication for researchers is also rare -- so when they operate by the deficit model and share information directly, they're just doing what they know from speaking with colleagues. And although a majority of researchers agree that scientists should be actively engaged in public policymaking about science and technology, they may not want to do it themselves.
There are other approaches to communication which provide alternative methods to opening dialogue with skeptical audiences. For instance, contextualization suggests that science must be presented in the context of a person's values, beliefs, and personal experience. Scientists accustomed to making decisions purely based on evidence, without the influence of feelings or personal values, may find this to be an onerous task.

I don't expect that Amanda Freise will be sympathetic to this -- after all, she seems more interested in redirecting skepticism toward an embrace of orthodoxy -- but engaging with "personal experience" is exactly what some of the best evolutionary skeptics do.

Advocates of intelligent design appeal to the daily observation that only intelligent agents generate information of the kind we find in computer code, magazine articles, and the like, the very same kind of information we find in DNA. Douglas Axe in his new book, Undeniable: How Biology Confirms Our Intuition That Life Is Designed, shows that the intuition of design in nature is valid, being based on our "personal experience" of how expertise is brought to bear in invention. As he points out, a bed is not made, an omelet is not made, unless someone makes them. It's no different with organisms: with the design of an orca, a spider, or a crane. I love his example of the origami crane and the living crane. It defies not only science but personal experience to imagine that only one of the two came about through purposeful application of knowhow.
Again, this is not, I'm pretty certain, what Ms. Freise had in mind. I'm also not sure I can go along with her on this -- more of that precious overestimation of scientists, by the media and by scientists themselves:

We [scientists] place extraordinarily high value in data, with as little emotion involved as possible. Even a strong "gut feeling" about a scientific finding will be pushed aside when we see enough rigorously obtained evidence to the contrary. In contrast to many members of the public, a skeptical scientist can be convinced by giving them enough information. At least that's true when it comes to questions about our personal fields of research.

This seems to exempt scientists from the all too human tendency to be led by one's community, often to the exclusion of your own critical faculties. This tribalism -- which is what it really is -- applies not least when the context is your "personal field of research." You want to be thought well of especially by your colleagues. Another great lesson of Dr. Axe's book is that this applies to scientists too, no less than to the rest of us. You see this all the time in other areas of life -- political debates going on at the moment, for example. Why not in science, too? Why are scientists magically immune from a slavish regard for how others see you?
In the evolution controversy, the context we know best, here's how the dynamic works. So much hinges on the dread of "creationism." No one should ever forget the power of that scare word, "creationist," with all it implies by way of not only scientific but social opprobrium. Though ID is emphatically not creationism, being called "creationists" is something ID proponents face every day. This is the major way in which the orthodox, including scientists, confuse the public in order to tamp down dissent and skepticism.
In the minds of many, in science and in the media, merely to question the evidence that Darwinian processes explain life is to shame and taint yourself through association with "creationism." Of course this would make even Alfred Russel Wallace, co-discoverer with Darwin of the theory of evolution by natural selection, a "creationist."
However absurd, the term "creationist" is an effective prophylactic against thought, which is why, if I had my way, it would be retired from all discussion. Language should clarify and distinguish, not muddy and blur. Any lower standard is a hallmark of propaganda.
But propaganda is effective even with scientists. No, they are hardly more exempt from the "influence of feelings" than the public is. Recognizing that, and its flipside -- that intuition can sometimes be valid, cutting through reams of obscure technical data -- would help advance the conversation about evolution. Maybe about some other controversies in science, too.

Darwinism Vs. the real world. XXVIII

In Female Sexual Function, Irreducible Complexity and Natural Survival Capacity
Howard Glicksman


Editor's note: Physicians have a special place among the thinkers who have elaborated the argument for intelligent design. Perhaps that's because, more than evolutionary biologists, they are familiar with the challenges of maintaining a functioning complex system, the human body. With that in mind, Evolution News is delighted to offer this series, "The Designed Body." For the complete series, see here. Dr. Glicksman practices palliative medicine for a hospice organization.


In previous articles I've explained that the human embryo is destined to become female by default unless several chemicals swing into action to make it become a normal male. But that's only part of the story, because for the first several years of life, humans, whether male or female, cannot reproduce. Puberty involves an as yet unexplained reduction in the feedback inhibition of the hypothalamus and pituitary so they can increase their output of their respective hormones. This leads to the testes being able to produce sperm and more testosterone and the ovaries being able to develop and release an egg and produce more estrogen and also the pregnancy hormone, progesterone.
Once the sexual organs have matured so the male can produce sperm and the female can release an egg into the fallopian tube, all that is needed for new human life to come about is for them to join together to form a zygote. The natural way that human reproduction occurs is by the male and female physically coming together in sexual intercourse. This very intimate physical union requires the man to deposit semen containing sperm near the cervical opening of the woman's uterus. Over the next several hours, aided by the cervical mucus, the sperm use their flagella to swim through the body of the uterus toward the fallopian tubes. If one of the woman's ovaries has released an egg around that time then one of the sperm may be able to penetrate its outer shell to form a zygote in a process called fertilization. Over the next several hours the zygote develops into an embryo which over the next several days moves into the body of the uterus and implants in its endometrial lining. Once implantation takes place the embryo continues to develop and grow into the fetus in a process called gestation. It then exits the mother's body about nine months later as a newborn baby.
In my last article we looked at the two tasks the male must perform to reproduce and what can go wrong to prevent it. The male must produce enough healthy active sperm which is dependent on having, not only properly working testes, but the right amount of hormones and properly working receptors and he must have enough pelvic blood flow and nervous function to penetrate deep into the vagina and ejaculate his semen. Now let's look at what it takes for a woman to reproduce and what can go wrong to prevent it.
From the above it is evident that the female's fertility is mainly dependent on three tasks: developing and releasing an egg from the ovary, getting the egg to enter the fallopian tube while assisting the sperm to reach it for fertilization, and providing nutritional support for the developing new human life once it implants in the endometrial lining of the uterus.
All women have their full complement of immature eggs (ova) in their ovaries at birth. These are contained in sacs, with surrounding support tissue that are called follicles. The first task of the female, developing and releasing an egg from the ovary, is dependent on producing enough of the gonadotropins, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), enough estrogen and having enough properly functioning specific receptors.
At the beginning of a woman's menstrual cycle the blood level of estrogen is low. This tells the hypothalamus to send out more Gonadotropin Releasing Hormone (GnRH) and the pituitary more FSH and LH. In particular, by attaching to specific receptors the rise in FSH stimulates some of the follicles in the ovaries to mature and make estrogen as well. At this point the ovary is said to be in the follicular phase. Throughout this phase the cells in the maturing follicles form more receptors for both FSH and estrogen which results in a positive feedback that makes the follicles even more sensitive to FSH and estrogen. This increased sensitivity enables them to produce more estrogen and causes the eggs to mature further. The dominant follicle that will ultimately release an egg (ovum) is the one that has been able to produce the most FSH and estrogen receptors and therefore has received the most hormonal stimulation.
However, during the follicular phase as the estrogen level rises higher and each of the developing follicles vies for the right to release their egg, something very surprising takes place in the pituitary. Remember that prior to puberty the release of FSH and LH is normally inhibited by a rising estrogen level. This in fact is how the body is able to keep control of its estrogen level. However, as the ovary nears the end of the follicular phase, when the level of estrogen is rising higher, this actually stimulates the pituitary to suddenly release more LH (and to a lesser degree FSH as well) in what is called the LH surge. This actually represents a positive feedback which as yet is still poorly understood. Clinical experience teaches that the LH surge is absolutely necessary for the dominant follicle to release the egg from the ovary so it can migrate toward the fallopian tube and have a chance of meeting up with a sperm in a process called ovulation.
There are several conditions that can result in anovulation, where the ovaries are not able to send out an egg toward the fallopian tube. One category involves inborn errors which results in the ovaries not developing and maturing properly. The vast majority however are acquired disorders which usually are intermittent and with medical intervention can be resolved. Consistent monthly ovulation is dependent on the delicate and complex interplay of the hypothalamus, the pituitary and the ovaries. Disruption of this hormonal balance by chronic emotional stress, malnutrition, significant fluctuations in weight, serious or recurrent illness and excessive physical exercise are some of the commoner reasons for anovulation.
Another not uncommon condition is polycystic ovary syndrome (PCOS). PCOS involves inappropriate negative feedback of the sex hormones on the pituitary gland. This causes a relatively low level of FSH which limits the cyclical development of the follicles in the ovaries so that a dominant one is not able to be released in ovulation. Also, there are numerous different glandular disorders, such as ones that affect the thyroid, the adrenals or the pituitary, which can lead to anovulation as well. Finally, it must be remembered that each woman begins her life with a full complement of egg follicles in her ovaries. Since, after puberty, during each month several follicles mature and vie for ovulation, this means there are that many less follicles available for ovulation and estrogen production in the future. A woman's fertility therefore eventually runs out and with it she no longer ovulates or has menstrual periods and has very low levels of estrogen. This is called menopause and usually takes place after thirty to forty years of menstruating.
If the female has had sexual intercourse around the time she has ovulated then her second task of getting the egg to enter the fallopian tube while assisting the sperm to reach it for fertilization comes into play. By attaching to specific receptors, the high levels of estrogen prior to ovulation makes the cells in the cervical opening of the uterus secrete lots of watery mucus. This watery mucus assists the sperm as they swim up through the body of the uterus to the fallopian tubes. At the same time the high levels of estrogen also causes the fallopian tubes to increase the movement of their cilia (small hair-like projections) and muscle contraction in an effort to try to coax the egg to enter. Once inside the fallopian tube the egg is swept along toward the body of the uterus by ciliary action and muscle contraction. It is here, within the relatively confined space of the fallopian tube, that the sperm usually meet up with the egg and fertilization takes place. The resulting zygote is then also swept along the fallopian tube into the body of the uterus on its way to implantation.
Some of the commoner causes of female infertility involve disorders of the fallopian tubes. Sexually transmitted diseases, like gonorrhea and chlamydia, cause pelvic infections which results in damage to the fallopian tubes and abnormal function. This causes them to either not be able to capture the egg, let the egg and sperm meet, or let the zygote pass through to the body of the uterus. Another not uncommon cause of fallopian tube malfunction, resulting in female infertility is a condition called endometriosis. This disorder involves the growth of tissue from the lining of the uterus (endometrium) in abnormal places, such as around the fallopian tubes and the ovaries. The presence of this abnormally placed endometrial tissue causes obstruction and damage of the fallopian tubes resulting in malfunction.
Recall, the second task of the female involves not only the fallopian tubes but also the cervical opening of the uterus where the sperm enter on their way to trying to fertilize the egg. Sexually transmitted diseases, like gonorrhea and chlamydia, can also cause inflammation and scarring of the cervix. This can lead to narrowing of the cervical canal and abnormal mucus production both of which can prevent the sperm from moving up into the uterus. In addition, certain hormone problems can cause the cervix to not produce the right amount or kind of mucus to adequately help the sperm move into the uterus.
If a sperm is able to fertilize an egg in the fallopian tube and the resulting zygote is able to move into the body of the uterus, then the third task of providing nutritional support for the developing new human life once it implants in the endometrial lining of the uterus becomes necessary. The increasing amounts of estrogen the ovary releases prior to ovulation attaches to specific receptors in the endometrial lining of the uterus and signals it to proliferate. This causes the endometrial lining to grow and develop resulting in it secreting large amounts of clear mucus which aids the sperm in their struggle to reach the fallopian tubes.
After ovulation the remaining cells of the dominant follicle become the corpus luteum (yellow body) and begin to form more LH receptors on their plasma membranes. The predominance of LH receptors on these cells results in the production of mostly progesterone, and to a lesser extent, estrogen as well, from continued FSH stimulation. Progesterone attaches to specific receptors on the endometrial lining and signals them to proliferate further and to secrete thicker and more nutrient-rich mucus in preparation for the implantation of the embryo. The corpus luteum normally has a lifespan of only about 10 to 14 days at which time a precipitous drop in the production of estrogen and progesterone takes place. This sudden drop in the levels of sex hormones results in the endometrial lining no longer being supported and it degenerates and dies. The endometrial tissue is then shed, with blood, out of the uterus and into the vagina and from there out of the woman's body in a menstrual period.
However, if pregnancy does take place the embryo produces a hormone called human Chorionic Gonadotropin (hCG) which acts like LH and is able to keep the corpus luteum alive and functioning until the placenta forms and takes over. From here on gestation takes place whereby the embryo develops into a fetus and continues to grow and develop within the uterus until it comes out into the world as newborn baby several months later.
For a healthy pregnancy to continue the embryo must implant in the lush endometrial lining of the uterus. The presence of uterine defects, such as abnormal shape, a dividing wall (septum), benign muscle tumors (fibroids), and abnormal mucosal growths (polyps) can interfere with either implantation or continued gestation resulting in infertility. If the corpus luteum does not secrete enough progesterone for an adequate amount of time the endometrial lining will not be prepared to properly nurture the embryo. Finally, one other rare cause of luteal phase insufficiency is the complete absence of progesterone receptors on the gland cells of the endometrium. Without these receptors the progesterone secreted by the corpus luteum cannot stimulate the endometrium, it cannot grow and develop properly and the uterine lining will be unable to perform the third task of female fertility.
In summary, human reproduction involves not only having the right tissues and organs in place, but also having them working together in a well-coordinated fashion. The female cannot be fertile unless at least one of her ovaries can release an egg, her fallopian tube can capture it and move it towards the sperm that have been assisted by the cervical mucus to swim toward it, and then provide a supportive haven for the implantation and gestation of new human life. These all require not only having the right tissues and organs in place, but also having the right amount of hormones and receptors that respond in the right way and at the right time. Any one permanent abnormality that leads to any one chronic malfunction is likely to make human reproduction impossible.
Of course, it goes without saying that all of the parts working together in a coordinated fashion, as directed by specific hormones and their receptors, to enable either the male or female to reproduce demonstrates not only irreducible complexity but natural survival capacity as well. However, the word sex comes from the Latin secare which means to separate or divide. This means that for every life form that reproduces sexually not only must all of its organ systems that allow for metabolic control but also its male and female components must have developed simultaneously. As for human life, whether it came about by the more plausible explanation of intelligent design or whether one believes the Darwinian narrative, it all had to start with just one male and just one female. 

A dose of humility re:junk DNA?

On Junk DNA Claim, Francis Collins Walks It Back, Admitting "Hubris"

David Klinghoffer

Count on Marvin Olasky at World Magazine not to miss something like this. In The Language of God, theistic evolutionary icon Francis Collins used so-called Junk DNA as homerun evidence against intelligent design. He has since backed down on that, honorably, admitting "hubris" in the process. Olasky:

Collins claimed on page 136 that huge chunks of our genome are "littered" with ancient repetitive elements (AREs), so that "roughly 45 percent of the human genome [is] made up of such genetic flotsam and jetsam." In his talk he claimed the existence of "junk DNA" was proof that man and mice had a common ancestor, because God would not have created man with useless genes.

Last year, though, speaking at the J.P. Morgan Healthcare Conference in San Francisco, Collins threw in the towel: "In terms of junk DNA, we don't use that term anymore because I think it was pretty much a case of hubris to imagine that we could dispense with any part of the genome, as if we knew enough to say it wasn't functional. ... Most of the genome that we used to think was there for spacer turns out to be doing stuff."

Good for Collins -- and maybe he'll go on to deal with other times scientists feel sorry for God as they look at His purportedly poor design. For example, evolutionists use the retina of the eye as evidence against creation, because nerve endings are at the front rather than at the back, which at first glance seems better placement. Yet, as Lee Spetner explains in The Evolution Revolution (Judaica Press, 2014), physicists now see front placement as the best one for "ingeniously designed light collectors."

The list of needed retractions should include what you probably learned in high school about apparently purposeless human vestigial organs. Robert Wiedersheim's 1895 list of 86 has shrunk, as almost all of them have proved to have functions. For example, the most famous vestigial organ -- the vermiform appendix -- is a crucial storage place for benign bacteria that repopulate the gut when diarrhea strikes. The appendix can be a life-saver.

By "hubris" perhaps he means the overweening tendency to assume that scientific opinion as constituted at the moment has got everything all figured out. The repeated need to retract and walk back previous certainties should be a lesson to all, a warning that we can't simply hand over our intellects to "science."

In briefest form, that's the message of Doug Axe's book Undeniable. When it comes to big-ticket science questions like evolution, not only do you get to think for yourself. You have a positive obligation to do so.