Sunday 5 August 2018
I.D is already mainstream?
Research Showcases Intelligent Design Principles
Evolution News
One of our responses to critics of ID is that scientists use it every day. If intelligent design were not scientific, we would have to throw out forensics, archaeology, cryptology, informatics, optimization theory, engineering and SETI Here are some instances of ID in action that recently showed up in the journals. The principles for inferring design are similar. If some of these examples seem weak for inferring design, it makes our favorite cases stronger when we argue for design in the genetic code, molecular machines or the fine-tuning of the universe.
The Jungle Book
What is etched in the landscape of Amazonia? Something strange and unexpected has come to light. For decades, the rainforests of Brazil exemplified wild, untamed nature. Its few human inhabitants, portrayed romantically as noble savages, carried on their simple lives in harmony with nature as a rebuke to us European-American polluters and ravagers of the planet. This was Darwin’s world, a land of competition and cooperation producing ecological systems by unguided natural law (especially the “law” of natural selection).
Under the forest canopy, though, bizarre structures have now betrayed different forces also at work: intelligent forces. Natural laws don’t usually create concentric circles and squares. Since 1980, earthworks called geoglyphs [“earth messages”] have come to light over a vast area between Amazon’s river systems. A new picture of this region reveals evidence of purpose, intent, and plan: i.e., intelligent design. A dramatic paper by researchers from the University of São Paulo and the University of Exeter, published last month in the Proceedings of the National Academy of Sciences,overthrows the paradigm of untamed wilderness.
Over 450 pre-Columbian (pre-AD 1492) geometric ditched enclosures (“geoglyphs”) occupy ∼13,000 km2 of Acre state, Brazil, representing a key discovery of Amazonian archaeology. These huge earthworks were concealed for centuries under terra firme (upland interfluvial) rainforest, directly challenging the “pristine” status of this ecosystem and its perceived vulnerability to human impacts.…
The notion of Amazonia as a pristine wilderness has now been overturned by increasing evidence for large, diverse, and socially complex pre-Columbian societies in many regions of the basin. The discovery of numerous, vast terra preta (anthropogenic dark earth) sites bordering the floodplains of major rivers, and extensive earthwork complexes in the seasonally flooded savannas of the Llanos de Mojos (northeast Bolivia), Marajó Island (northeast Brazil), and coastal French Guiana, are seen to represent examples of major human impacts carried out in these environments. [Emphasis added.]
— carried out, that is, by intelligent design. This vast region has been “extensively transformed by humans over the course of millennia,” they say In news from the University of Exeter, lead author Jennifer Watling expresses how dramatic this change of thinking is:
Dr Watling said: “The fact that these sites lay hidden for centuries beneath mature rainforest really challenges the idea that Amazonian forests are ‘pristine ecosystems’.
“We immediately wanted to know whether the region was already forested when the geoglyphs were built, and to what extent people impacted the landscape to build these earthworks.”
The team used multiple methods to infer design — important for making a robust design inference. Most obvious are the geoglyphs themselves. Additional inferences about their functions can be adduced by close examination of the structural details:
With ditches up to 11 m wide, 4 m deep, and 100–300 m in diameter, and with some sites having up to six enclosures, the geoglyphs of western Amazonia rival the most impressive examples of pre-Columbian monumental architecture anywhere in the Americas. Excavations of the geoglyphs have shown that they were built and used sporadically as ceremonial and public gathering sites between 2000 and 650 calibrated years before present (BP), but that some may have been constructed as early as 3500–3000 BP. Evidence for their ceremonial function is based on an almost complete absence of cultural material found within the enclosed areas, which suggests they were kept ritually “clean,” alongside their highly formalized architectural forms (mainly circles and squares) — features that distinguish the geoglyphs from similar ditched enclosures in northeast Bolivia.
Is it necessary to know who the designers were? Does ID require knowing their motives?
Surprisingly, little is known about who the geoglyph builders were and how and where they lived, as contemporary settlement sites have not yet been found in the region. It is thought that the geoglyph builders were a complex network of local, relatively autonomous groups connected by a shared and highly developed ideological system. Although some have proposed a connection between the geoglyphs and Arawak-speaking societies, the ceramics uncovered from these sites defy a close connection with Saladoid–Barrancoid styles normally associated with this language family, and instead present a complex mixture of distinct local traditions. Furthermore, it is likely that the geoglyphs were used and reused by different culture groups throughout their life spans.
Here’s where it gets even more interesting. Additional clues reveal that the ecology was intentionally modified by these unknown people. By studying charcoal, plant fossils and carbon isotopes, and by following patterns between geoglyph sites, the researchers inferred that the inhabitants transformed the rainforest to enhance the production of fruits, nuts and other plants they found useful. The team was also able to infer which species were modified and which were ‘natural’ for the climate, and even to determine how the people used fire for controlled land clearing. Not only that, they inferred that “the geoglyphs were used on a sporadic basis rather than continually inhabited.”
Rather than being built within largely “untouched” bamboo forest, our phytolith data suggest that the geoglyphs were constructed within anthropogenic forests that had already been fundamentally altered by human activities over thousands of years.
How can they be sure? “No natural explanation exists” for the patterns they found. Bamboo, they figure, is in its natural abundance, but fruit and nut trees show patterns of “agroforestry,” as if the inhabitants intentionally created “a kind of ’prehistoric supermarket’ of useful forest products.” The team even went so far as to estimate when the geoglyph sites were abandoned, and to tell whether the ecosystem had recovered or not since they left. From the phytolith data (silica deposits from plant remains) alone, they conclude that “legacies of pre-Columbian agroforestry still exist today within Acre’s remaining forests.” That’s a lot of design inference from silent remains!
Similar conclusions were reached by Levis et al. in Science Magazine. From plant patterns alone in the Amazon Basin, a large team of archaeologists concluded that “The marks of prehistoric human societies on tropical forests can still be detected today.” Erin Ross at Nature News concurs, “Amazon rainforest was shaped by an ancient hunger for fruits and nuts.” Scientists can tell that the rainforest is not in a natural state. Rather, “The trees that live in these populated areas may be relics of a vibrant past.”
Lest one argue that these marks of design are no different in kind than bird nests, termite mounds, beaver dams or any other animal structure that modifies the ecology, just turn the argument back on the researchers. Would it make any sense to state that a scientific paper in a journal is the work of unguided natural causes? Of course not. We all recognize the marks of intelligence. Humans are exceptional in that regard, forming unnatural structures for creative purposes that go beyond mere survival and reproduction. Whether beavers and birds obtained their abilities from a programming intelligence is a good question, but humans are under no obligation to build geoglyphs or automobiles, or to think up “ideological systems” that leave their marks centuries later. If humans are just animals, why did they shape the whole forest? Why not develop an appetite for bamboo, like pandas?
Mineral Clues to Design
Let’s expand the above reasoning to a case that is global in scale. Geologists and anthropologists are currently debating whether to name our time the “Anthropocene Epoch.” We’ve heard about the Eocene, Paleocene and other “natural” epochs, but the Anthropocene idea would be characterized by something unnatural. Defined in New Scientist as “a new geological time interval distinguished by the impact of human activities,” the Anthropocene differs from all previous epochs. Watch reporter Chelsea Whyte apply ID reasoning:
Think of large gem collections in museums. Those mineral samples wouldn’t occur naturally in close proximity, but they are likely to get be buried together and cemented in the record as neighbors.
Picture also places like Arlington National Cemetery in Virginia. That ordered array of headstones isn’t likely to occur naturally, without human influence. The mineral record will reveal not only our technological processes, but also our culture.
What gets really interesting is how at least one ardent evolutionist uses the same reasoning to infer human intelligent causes from the mere existence of certain rare minerals:
The evidence of humans changing the planet is solid as rock. A new catalogue of minerals counts 208 that result solely or primarily from human activity, says Robert Hazen of the Carnegie Institution for Science in the US, who led the study.
Most minerals can be accounted for naturally, he says, but one can tell something unnatural has happened from observational evidence. Hazen has identified 208 minerals — about 4 percent of the 5200 some minerals catalogued — that are unusual. They had to be man-made. And that’s not the only evidence for human design.
It’s not just that these new minerals exist, but how they are distributed and how they will persist. Our activity has led to large scale movement of rocks, sediments, and minerals, thanks to mining, transport and infrastructure, as well as global redistribution of highly valued natural minerals such as diamonds and gold. And there are substances in things like cement and bricks that are rare in nature but are now widespread across the globe.
“These are mineral-like and they will form a marker layer for all geologic time,” Hazen says.
Unwarranted Design Inference
In contrast to these examples of legitimate design inference, let’s look at one that’s a bit on the loony side. The UK’s tabloid The Express posted a video clip by some unknown conspiracy theorist pointing to a “bizarre” object under the Pacific Ocean. He points to a straight pathway 41 miles long that he alleges was left by a circular object 2.5 miles in diameter that appears next to it. He claims it “looks man-made rather than natural” — maybe even made by space aliens!
It’s reminiscent of the Face-on-Mars craze that dominated late-night talk shows before spacecraft got a closer look. This just goes to show that design inferences require a minimum level of rigor. It doesn’t appear that these wishful thinkers ruled out chance or natural law as causes. If the object had flashing lights and carved out “Hello, world!” in English, we might be impressed.
Actually, the evidence for design in DNA and cosmic fine-tuning is far stronger than the evidence presented in the two prior citations about geoglyphs and Anthropocene minerals. They illustrate that common-sense reasoning about intelligent causes is alive and well in the sciences, published readily in leading journals — except when the implications might favor a certain world view.
Evolution News
One of our responses to critics of ID is that scientists use it every day. If intelligent design were not scientific, we would have to throw out forensics, archaeology, cryptology, informatics, optimization theory, engineering and SETI Here are some instances of ID in action that recently showed up in the journals. The principles for inferring design are similar. If some of these examples seem weak for inferring design, it makes our favorite cases stronger when we argue for design in the genetic code, molecular machines or the fine-tuning of the universe.
The Jungle Book
What is etched in the landscape of Amazonia? Something strange and unexpected has come to light. For decades, the rainforests of Brazil exemplified wild, untamed nature. Its few human inhabitants, portrayed romantically as noble savages, carried on their simple lives in harmony with nature as a rebuke to us European-American polluters and ravagers of the planet. This was Darwin’s world, a land of competition and cooperation producing ecological systems by unguided natural law (especially the “law” of natural selection).
Under the forest canopy, though, bizarre structures have now betrayed different forces also at work: intelligent forces. Natural laws don’t usually create concentric circles and squares. Since 1980, earthworks called geoglyphs [“earth messages”] have come to light over a vast area between Amazon’s river systems. A new picture of this region reveals evidence of purpose, intent, and plan: i.e., intelligent design. A dramatic paper by researchers from the University of São Paulo and the University of Exeter, published last month in the Proceedings of the National Academy of Sciences,overthrows the paradigm of untamed wilderness.
Over 450 pre-Columbian (pre-AD 1492) geometric ditched enclosures (“geoglyphs”) occupy ∼13,000 km2 of Acre state, Brazil, representing a key discovery of Amazonian archaeology. These huge earthworks were concealed for centuries under terra firme (upland interfluvial) rainforest, directly challenging the “pristine” status of this ecosystem and its perceived vulnerability to human impacts.…
The notion of Amazonia as a pristine wilderness has now been overturned by increasing evidence for large, diverse, and socially complex pre-Columbian societies in many regions of the basin. The discovery of numerous, vast terra preta (anthropogenic dark earth) sites bordering the floodplains of major rivers, and extensive earthwork complexes in the seasonally flooded savannas of the Llanos de Mojos (northeast Bolivia), Marajó Island (northeast Brazil), and coastal French Guiana, are seen to represent examples of major human impacts carried out in these environments. [Emphasis added.]
— carried out, that is, by intelligent design. This vast region has been “extensively transformed by humans over the course of millennia,” they say In news from the University of Exeter, lead author Jennifer Watling expresses how dramatic this change of thinking is:
Dr Watling said: “The fact that these sites lay hidden for centuries beneath mature rainforest really challenges the idea that Amazonian forests are ‘pristine ecosystems’.
“We immediately wanted to know whether the region was already forested when the geoglyphs were built, and to what extent people impacted the landscape to build these earthworks.”
The team used multiple methods to infer design — important for making a robust design inference. Most obvious are the geoglyphs themselves. Additional inferences about their functions can be adduced by close examination of the structural details:
With ditches up to 11 m wide, 4 m deep, and 100–300 m in diameter, and with some sites having up to six enclosures, the geoglyphs of western Amazonia rival the most impressive examples of pre-Columbian monumental architecture anywhere in the Americas. Excavations of the geoglyphs have shown that they were built and used sporadically as ceremonial and public gathering sites between 2000 and 650 calibrated years before present (BP), but that some may have been constructed as early as 3500–3000 BP. Evidence for their ceremonial function is based on an almost complete absence of cultural material found within the enclosed areas, which suggests they were kept ritually “clean,” alongside their highly formalized architectural forms (mainly circles and squares) — features that distinguish the geoglyphs from similar ditched enclosures in northeast Bolivia.
Is it necessary to know who the designers were? Does ID require knowing their motives?
Surprisingly, little is known about who the geoglyph builders were and how and where they lived, as contemporary settlement sites have not yet been found in the region. It is thought that the geoglyph builders were a complex network of local, relatively autonomous groups connected by a shared and highly developed ideological system. Although some have proposed a connection between the geoglyphs and Arawak-speaking societies, the ceramics uncovered from these sites defy a close connection with Saladoid–Barrancoid styles normally associated with this language family, and instead present a complex mixture of distinct local traditions. Furthermore, it is likely that the geoglyphs were used and reused by different culture groups throughout their life spans.
Here’s where it gets even more interesting. Additional clues reveal that the ecology was intentionally modified by these unknown people. By studying charcoal, plant fossils and carbon isotopes, and by following patterns between geoglyph sites, the researchers inferred that the inhabitants transformed the rainforest to enhance the production of fruits, nuts and other plants they found useful. The team was also able to infer which species were modified and which were ‘natural’ for the climate, and even to determine how the people used fire for controlled land clearing. Not only that, they inferred that “the geoglyphs were used on a sporadic basis rather than continually inhabited.”
Rather than being built within largely “untouched” bamboo forest, our phytolith data suggest that the geoglyphs were constructed within anthropogenic forests that had already been fundamentally altered by human activities over thousands of years.
How can they be sure? “No natural explanation exists” for the patterns they found. Bamboo, they figure, is in its natural abundance, but fruit and nut trees show patterns of “agroforestry,” as if the inhabitants intentionally created “a kind of ’prehistoric supermarket’ of useful forest products.” The team even went so far as to estimate when the geoglyph sites were abandoned, and to tell whether the ecosystem had recovered or not since they left. From the phytolith data (silica deposits from plant remains) alone, they conclude that “legacies of pre-Columbian agroforestry still exist today within Acre’s remaining forests.” That’s a lot of design inference from silent remains!
Similar conclusions were reached by Levis et al. in Science Magazine. From plant patterns alone in the Amazon Basin, a large team of archaeologists concluded that “The marks of prehistoric human societies on tropical forests can still be detected today.” Erin Ross at Nature News concurs, “Amazon rainforest was shaped by an ancient hunger for fruits and nuts.” Scientists can tell that the rainforest is not in a natural state. Rather, “The trees that live in these populated areas may be relics of a vibrant past.”
Lest one argue that these marks of design are no different in kind than bird nests, termite mounds, beaver dams or any other animal structure that modifies the ecology, just turn the argument back on the researchers. Would it make any sense to state that a scientific paper in a journal is the work of unguided natural causes? Of course not. We all recognize the marks of intelligence. Humans are exceptional in that regard, forming unnatural structures for creative purposes that go beyond mere survival and reproduction. Whether beavers and birds obtained their abilities from a programming intelligence is a good question, but humans are under no obligation to build geoglyphs or automobiles, or to think up “ideological systems” that leave their marks centuries later. If humans are just animals, why did they shape the whole forest? Why not develop an appetite for bamboo, like pandas?
Mineral Clues to Design
Let’s expand the above reasoning to a case that is global in scale. Geologists and anthropologists are currently debating whether to name our time the “Anthropocene Epoch.” We’ve heard about the Eocene, Paleocene and other “natural” epochs, but the Anthropocene idea would be characterized by something unnatural. Defined in New Scientist as “a new geological time interval distinguished by the impact of human activities,” the Anthropocene differs from all previous epochs. Watch reporter Chelsea Whyte apply ID reasoning:
Think of large gem collections in museums. Those mineral samples wouldn’t occur naturally in close proximity, but they are likely to get be buried together and cemented in the record as neighbors.
Picture also places like Arlington National Cemetery in Virginia. That ordered array of headstones isn’t likely to occur naturally, without human influence. The mineral record will reveal not only our technological processes, but also our culture.
What gets really interesting is how at least one ardent evolutionist uses the same reasoning to infer human intelligent causes from the mere existence of certain rare minerals:
The evidence of humans changing the planet is solid as rock. A new catalogue of minerals counts 208 that result solely or primarily from human activity, says Robert Hazen of the Carnegie Institution for Science in the US, who led the study.
Most minerals can be accounted for naturally, he says, but one can tell something unnatural has happened from observational evidence. Hazen has identified 208 minerals — about 4 percent of the 5200 some minerals catalogued — that are unusual. They had to be man-made. And that’s not the only evidence for human design.
It’s not just that these new minerals exist, but how they are distributed and how they will persist. Our activity has led to large scale movement of rocks, sediments, and minerals, thanks to mining, transport and infrastructure, as well as global redistribution of highly valued natural minerals such as diamonds and gold. And there are substances in things like cement and bricks that are rare in nature but are now widespread across the globe.
“These are mineral-like and they will form a marker layer for all geologic time,” Hazen says.
Unwarranted Design Inference
In contrast to these examples of legitimate design inference, let’s look at one that’s a bit on the loony side. The UK’s tabloid The Express posted a video clip by some unknown conspiracy theorist pointing to a “bizarre” object under the Pacific Ocean. He points to a straight pathway 41 miles long that he alleges was left by a circular object 2.5 miles in diameter that appears next to it. He claims it “looks man-made rather than natural” — maybe even made by space aliens!
It’s reminiscent of the Face-on-Mars craze that dominated late-night talk shows before spacecraft got a closer look. This just goes to show that design inferences require a minimum level of rigor. It doesn’t appear that these wishful thinkers ruled out chance or natural law as causes. If the object had flashing lights and carved out “Hello, world!” in English, we might be impressed.
Actually, the evidence for design in DNA and cosmic fine-tuning is far stronger than the evidence presented in the two prior citations about geoglyphs and Anthropocene minerals. They illustrate that common-sense reasoning about intelligent causes is alive and well in the sciences, published readily in leading journals — except when the implications might favor a certain world view.
Saturday 4 August 2018
The tree v. the graph.
Of Species and Software: What Is a Dependency Graph?
Cornelius Hunter
Cornelius Hunter
A recent paper in the journal BIO-Complexity, authored by Winston Ewert, uses a dependency graph approach to model the relationships between the species. This idea is inspired by computer science which makes great use of dependency graphs for packaging of software and optimization of software architecture.
Complicated software applications typically use a wealth of lower level software routines. These routines have been developed, tested, and stored in modules for use by higher level applications. When this happens the application inherits the lower-level software and has a dependency on those modules.
A Design Diagram
Such applications are written in human-readable languages such as Java. They then need to be translated into machine language. The compiler tool performs the translation, and the build tool assembles the result, along with the lower level routines, into an executable program. These tools use dependency graphs to model the software, essentially building a design diagram, or blueprint which shows the dependencies, specifying the different software modules that will be needed, and how they are connected together.
Dependency graphs also help with software design. Because they provide a blueprint of the software architecture, they are helpful in designing decoupled architectures and promoting software reuse.
Dependency graphs are also used by so-called “DevOps” teams to assist at deployment time in sequencing and installing the correct modules for enterprise applications.
A Failed Model
What Ewert has developed is a model to explain the pattern of similarities in different organisms that mimics how computer applications inherit software from a diverse range of lower-level modules. Species seem likewise to use lower-level modules that perform a diverse range of biological applications. Ewert specifically studied how genomes incorporate various gene families which group into a wide range of genetic modules and how genetic modules feed into a diverse range of genomes.
Superficially, from a distance, the pattern of module use may appear similar to the traditional evolutionary tree. But that model has failed repeatedly as scientists have studied the characters of species more closely. Ewert’s initial research suggests that dependency graphs, on the other hand, could provide a far superior model of the relationships between the species, and their genetic information flow.
And still yet more primeval tech v. Darwin.
Inside the Machine Room of the Nucleus
Evolution News | @DiscoveryCSC
One paper could never do justice to all that the spliceosome does, but in their examination of a couple of protein parts, they could not help but stand in awe at the majesty of this huge molecular machine. They didn’t have much to say about evolution, except pointing out that one “intricate RNA-based active site has been extraordinarily conserved across evolution from bacteria to humans.” News from SISSA via Phys.org recaps the awe by showing the precision the team found in this machine’s operation:
To have a molecule able to transport information usefully, precisely and effectively, the introns must be eliminated by the spliceosome to transform it into mature mRNA.” It is an extremely precise snip-and-stitch process, explains the researcher, because any tiny error can alter the information with serious effects on cell activity and the health of the entire organism.
Topoisomerase the Great
“Supercoil me!” begins the headline of another article from SISSA about “the art of knotted DNA maintenance”(see Science Daily).Is it any surprise that long strands of DNA have knotty problems? Like those old phone cords that would knot up with coils upon coils, DNA can develop messy knots. Specialized enzymes must untangle them; otherwise, important genes might become inaccessible. Like Alexander the Great cutting the Gordian knot, they say, the topoisomerase family of nuclear machines is up to the challenge. They get some help, though, by a physical property of DNA that works to the advantage of the cutting machines: “Supercoiling can keep DNA knots locked in place for long enough that they can be untied by specialised enzymes,” the new study shows.
“We know that living cells routinely deal with DNA knots, and we also know that these forms of entanglement are usually detrimental to biological functionality; for instance they can prevent the genetic information from being read and translated into protein products. Specific enzymes of the topoisomerase family are responsible for disentangling DNA. Their modus operandi recalls the efficient, if not drastic, way in which Alexander the Great untied the proverbial Gordian knot with a cut of his sword. Similarly, these enzymes untie DNA filaments by a sophisticated cutting and sealing action.”
The machines have another problem not faced by Alexander: DNA strands are constantly wiggling. Using computer simulations, the team found that free knots would slide relatively fast along the filaments. This should make it more difficult for the topoisomerases to get to them and repair them. The team then noticed that accidental knots are often associated with supercoiled regions, which are more stable. This led to an “Aha!” moment:
Our study suggests that DNA supercoiling can favour the action of topoisomerases by keeping knots in a stable configuration for a time span that is much longer than other molecular rearrangements. In this way, the enzymes could have sufficient time to recognise the target sites and, in turn, their cut-and-paste action would be simpler, more reliable and efficient.
Their hypothesis will require further testing, but suggests an additional purpose for supercoiling inside the nucleus. It was already known that supercoiling is involved in “exposing or hiding genetic information” for transcription, but now another possibility presents itself: supercoils hold an accidental knot in place long enough for Topoisomerase the Great to arrive with his sword.
“We studied the DNA filament and noted that without supercoils, the knotted region would move relatively fast along the filament. Likewise, supercoiled regions can rapidly change in knot-free DNA. However, when knots and supercoiling are simultaneously present, then the crucial contact points in DNA knots become locked in place, persistently. And this unexpected effect is particularly interesting because it could be key to a specific and unexpected biological functionality.”
It will be interesting to find out if other machines notice the knots and induce supercoiling at those locations. Sounds like a good plan at least.
Scalpel in a Sheath
For our last example of nuclear machines today, consider 53BP1. This enzyme has a critical job: repairing double-stranded breaks, when both strands of DNA are broken. It’s a catastrophic condition leading to cell death. Fortunately, cells come equipped with machinery that can stitch them back together. One of them is 53BP1. But just as you don’t want open knives floating around, you only want this machine activated when it is needed. Fortunately again, this machine comes with a sheath named TIFF. News from the Mayo Clinic explains (you can ignore the evolutionary claim in the first sentence):
Evolution News | @DiscoveryCSC
We’re living in exciting times. It was only a little over 65 years ago that we began to realize that life is information-based, with coded genetic information embedded in alphabet-like molecules. In the years that followed, biochemists also began to discover that the chemical reactions carried on by life were unlike the valence-based reactions we learned about in chemistry class, but were machine-like, with moving parts that function mechanically like rotors and engines. More recently, these machines have been found to interact in large networks of integrated systems, like factories. Is it any wonder that intelligent design rose as a movement in the late 20th century?
The wonders continue at a rapid pace into the 21st century. With increasing resolution thanks to techniques like cryo-electron microscopy, biochemists are focusing on the molecular machines at nearly nanometer scale and determining their modes of action. Let’s look at news about a few of the major players inside the nucleus of cells.
The Majestic Spliceosome
Researchers at the International School of Advanced Studies (SISSA) in Italy use a rare word in a scientific paper: “majestic.” It’s an appropriate adjective for what they saw by examining, for the first time, the spliceosome at near-atomic detail. Their paper in PNAS begins:
The spliceosome (SPL) is a majestic macromolecular machinery composed of five small nuclear RNAs and hundreds of proteins. SPL removes noncoding introns from precursor messenger RNAs (pre-mRNAs) and ligates coding exons, giving rise to functional mRNAs. Building on the first SPL structure solved at near–atomic-level resolution, here we elucidate the functional dynamics of the intron lariat spliceosome (ILS) complex through multi-microsecond-long molecular-dynamics simulations of ∼1,000,000 atoms models. The ILS essential dynamics unveils (i) the leading role of the Spp42 protein, which heads the gene maturation by tuning the motions of distinct SPL components, and (ii) the critical participation of the Cwf19 protein in displacing the intron lariat/U2 branch helix. These findings provide unprecedented details on the SPL functional dynamics, thus contributing to move a step forward toward a thorough understanding of eukaryotic pre-mRNA splicing.
One paper could never do justice to all that the spliceosome does, but in their examination of a couple of protein parts, they could not help but stand in awe at the majesty of this huge molecular machine. They didn’t have much to say about evolution, except pointing out that one “intricate RNA-based active site has been extraordinarily conserved across evolution from bacteria to humans.” News from SISSA via Phys.org recaps the awe by showing the precision the team found in this machine’s operation:
To have a molecule able to transport information usefully, precisely and effectively, the introns must be eliminated by the spliceosome to transform it into mature mRNA.” It is an extremely precise snip-and-stitch process, explains the researcher, because any tiny error can alter the information with serious effects on cell activity and the health of the entire organism.
Topoisomerase the Great
“Supercoil me!” begins the headline of another article from SISSA about “the art of knotted DNA maintenance”(see Science Daily).Is it any surprise that long strands of DNA have knotty problems? Like those old phone cords that would knot up with coils upon coils, DNA can develop messy knots. Specialized enzymes must untangle them; otherwise, important genes might become inaccessible. Like Alexander the Great cutting the Gordian knot, they say, the topoisomerase family of nuclear machines is up to the challenge. They get some help, though, by a physical property of DNA that works to the advantage of the cutting machines: “Supercoiling can keep DNA knots locked in place for long enough that they can be untied by specialised enzymes,” the new study shows.
“We know that living cells routinely deal with DNA knots, and we also know that these forms of entanglement are usually detrimental to biological functionality; for instance they can prevent the genetic information from being read and translated into protein products. Specific enzymes of the topoisomerase family are responsible for disentangling DNA. Their modus operandi recalls the efficient, if not drastic, way in which Alexander the Great untied the proverbial Gordian knot with a cut of his sword. Similarly, these enzymes untie DNA filaments by a sophisticated cutting and sealing action.”
The machines have another problem not faced by Alexander: DNA strands are constantly wiggling. Using computer simulations, the team found that free knots would slide relatively fast along the filaments. This should make it more difficult for the topoisomerases to get to them and repair them. The team then noticed that accidental knots are often associated with supercoiled regions, which are more stable. This led to an “Aha!” moment:
Our study suggests that DNA supercoiling can favour the action of topoisomerases by keeping knots in a stable configuration for a time span that is much longer than other molecular rearrangements. In this way, the enzymes could have sufficient time to recognise the target sites and, in turn, their cut-and-paste action would be simpler, more reliable and efficient.
Their hypothesis will require further testing, but suggests an additional purpose for supercoiling inside the nucleus. It was already known that supercoiling is involved in “exposing or hiding genetic information” for transcription, but now another possibility presents itself: supercoils hold an accidental knot in place long enough for Topoisomerase the Great to arrive with his sword.
“We studied the DNA filament and noted that without supercoils, the knotted region would move relatively fast along the filament. Likewise, supercoiled regions can rapidly change in knot-free DNA. However, when knots and supercoiling are simultaneously present, then the crucial contact points in DNA knots become locked in place, persistently. And this unexpected effect is particularly interesting because it could be key to a specific and unexpected biological functionality.”
It will be interesting to find out if other machines notice the knots and induce supercoiling at those locations. Sounds like a good plan at least.
Scalpel in a Sheath
For our last example of nuclear machines today, consider 53BP1. This enzyme has a critical job: repairing double-stranded breaks, when both strands of DNA are broken. It’s a catastrophic condition leading to cell death. Fortunately, cells come equipped with machinery that can stitch them back together. One of them is 53BP1. But just as you don’t want open knives floating around, you only want this machine activated when it is needed. Fortunately again, this machine comes with a sheath named TIFF. News from the Mayo Clinic explains (you can ignore the evolutionary claim in the first sentence):
Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage….
While the human genome is constantly damaged, cells have proteins that detect and repair the damage. One of those proteins is called 53BP1. It is involved in the repair of DNA when both strands break.
Dr. Georges Mer and team found that TIFF normally binds to 53BP1, rendering it harmless like a sword in its sheath.
The authors report that when DNA damage occurs, RNA molecules produced at that time can bind to TIRR, displacing it from 53BP1 and allowing 53BP1 to swing into action.
Presumably the binding is reversible after the repairs are made, and the Swiss army knife goes back into the pocket till next time. Pretty cool, heh? Read more about the machine in Nature Reviews Molecular Cell Biology (2014).These are brief looks at the amazing machines and processes that keep us going without our conscious awareness. When you ponder the fact that until our day nobody knew about these wonders, our reasons for feeling like a Privileged Species in the 21st century take on historic significance.
Wednesday 1 August 2018
Time to decanonise Darwin?
For This Physicist, “Overthrowing” Darwinism Is on the Table
David Klinghoffer | @d_klinghoffer
than Siegel is a physicist who writes a pretty consistently interesting regular blog for Forbes. Yesterday he offered thoughts on “How To Overthrow A Scientific Theory In Three Easy Steps.” He concedes, “Even our best theories of today may be superseded with tomorrow’s science.”
And no one, except perhaps some ultra-Darwinists, would disagree. He notes that theories have limits:
Any theory, no matter how successful, has a finite range of validity. Stay within that range and your theory works very well to describe reality; go outside of it, and its predictions no longer match observations or experiments. This is true for any theory you pick. Newtonian mechanics breaks down at small (quantum) scales and high (relativistic) speeds; Einstein’s General Relativity breaks down at a singularity; Darwin’s evolution breaks down at the origin of life.
That last point is the theme of Stephen Meyer’s first book, Signature in the Cell. Siegel’s three steps are actually four:
Step 0: recognizing successes and failures of the leading theory.
Step 1: reproducing all the successes of the leading theory.
Step 2: succeeding where the prior theory did not.
Step 3: you must make new, testable predictions that differ from the original theory’s.
Whether proponents of intelligent design have succeeded in any of those is a question you could debate. But it’s beyond doubt that they are trying, in a rigorous manner, to advance through each of those steps. It is striking that Darwin defenders typically refuse to acknowledge that or to address the science of ID. They are mostly content with name-calling.
The Hunt Is On
The ID research community isn’t alone, of course, as as Sarah Chaffee mentioned here. The hunt is on for a successor to Darwinism:
Scientific controversy over evolution exists, quite apart from proponents of intelligent design. Think of the researchers associated with the Third Way of Evolution and the 2016 Royal Society Conference and its subsequently published journal Problems with conventional scientific explanations for the origin of life and of biological diversity are widely acknowledged — and scientists around the world tackle these issues.
This means, in any event, that ID is a rival theory, a scientific theory, doing the normal work that scientific ideas must do to supplant a currently dominant idea. That’s not to say that ID will succeed. But to brand it is as a “religious” rather than “scientific” idea is plainly false.
The Right Stuff
Siegel addresses what it would take to succeed:
Want to go beyond Darwin’s evolution? You still need to explain the emergence of biological diversity, the response to selection pressures, and how inheritance works, among others.
That, again, is something that no ID advocate would disagree with. “[E]xplain[ing] the emergence of biological diversity,” the theme of Meyer’s second book, Darwin’s Doubt , is precisely where the ID argument tackles Darwinism most forcefully. It’s a way of thinking that led Alfred Russel Wallace to his break with Charles Darwin, as Michael Flannery tells in his new book.
Don’t get me wrong. I don’t see any indication that Ethan Siegel has a drop of sympathy for design theory. But recognizing how and where the “overthrow” of Darwinian evolution could happen, if it were to happen, is a step in the right direction. It puts our question on the table.
David Klinghoffer | @d_klinghoffer
than Siegel is a physicist who writes a pretty consistently interesting regular blog for Forbes. Yesterday he offered thoughts on “How To Overthrow A Scientific Theory In Three Easy Steps.” He concedes, “Even our best theories of today may be superseded with tomorrow’s science.”
And no one, except perhaps some ultra-Darwinists, would disagree. He notes that theories have limits:
Any theory, no matter how successful, has a finite range of validity. Stay within that range and your theory works very well to describe reality; go outside of it, and its predictions no longer match observations or experiments. This is true for any theory you pick. Newtonian mechanics breaks down at small (quantum) scales and high (relativistic) speeds; Einstein’s General Relativity breaks down at a singularity; Darwin’s evolution breaks down at the origin of life.
That last point is the theme of Stephen Meyer’s first book, Signature in the Cell. Siegel’s three steps are actually four:
Step 0: recognizing successes and failures of the leading theory.
Step 1: reproducing all the successes of the leading theory.
Step 2: succeeding where the prior theory did not.
Step 3: you must make new, testable predictions that differ from the original theory’s.
Whether proponents of intelligent design have succeeded in any of those is a question you could debate. But it’s beyond doubt that they are trying, in a rigorous manner, to advance through each of those steps. It is striking that Darwin defenders typically refuse to acknowledge that or to address the science of ID. They are mostly content with name-calling.
The Hunt Is On
The ID research community isn’t alone, of course, as as Sarah Chaffee mentioned here. The hunt is on for a successor to Darwinism:
Scientific controversy over evolution exists, quite apart from proponents of intelligent design. Think of the researchers associated with the Third Way of Evolution and the 2016 Royal Society Conference and its subsequently published journal Problems with conventional scientific explanations for the origin of life and of biological diversity are widely acknowledged — and scientists around the world tackle these issues.
This means, in any event, that ID is a rival theory, a scientific theory, doing the normal work that scientific ideas must do to supplant a currently dominant idea. That’s not to say that ID will succeed. But to brand it is as a “religious” rather than “scientific” idea is plainly false.
The Right Stuff
Siegel addresses what it would take to succeed:
Want to go beyond Darwin’s evolution? You still need to explain the emergence of biological diversity, the response to selection pressures, and how inheritance works, among others.
That, again, is something that no ID advocate would disagree with. “[E]xplain[ing] the emergence of biological diversity,” the theme of Meyer’s second book, Darwin’s Doubt , is precisely where the ID argument tackles Darwinism most forcefully. It’s a way of thinking that led Alfred Russel Wallace to his break with Charles Darwin, as Michael Flannery tells in his new book.
Don’t get me wrong. I don’t see any indication that Ethan Siegel has a drop of sympathy for design theory. But recognizing how and where the “overthrow” of Darwinian evolution could happen, if it were to happen, is a step in the right direction. It puts our question on the table.
Sunday 29 July 2018
Yet more on JEHOVAH'S folly v. man's genius.
Oral Cavity’s Supposedly “Lousy” Design Is a Key to Human Speech
Evolution News | @DiscoveryCSC
It’s a staple for Darwinists who compile lists of human anatomical features supposedly demonstrating “unintelligent” or “botched” design. We’re constantly told that the design of the human larynx, trachea, and oral cavity is poor because it allows for choking on food.
At birth, the human tongue is flat in the mouth, as is the case for other mammals. The larynx, which rests atop the trachea, is anchored to the root of the tongue. As infants suckle, they raise the larynx to form a sealed passage from the nose to the lungs, allowing them to breathe while liquid flows around the larynx. Most mammalian species retain this morphology throughout life, which explains why cats or dogs can lap up water while breathing. In humans, however, a developmental process that spans the first 8 to 10 years of life forms the adult version of the SVT [supra-laryngeal vocal tract]. First, the skull is reshaped, shortening the relative length of the oral cavity. The tongue begins to descend down into the pharynx, while the neck increases in length and becomes rounded in the back. Following these changes, half the tongue is positioned horizontally in the oral cavity (and thus called the SVTh), while the other half (SVTv) is positioned vertically in the pharynx. The two halves meet at an approximate right angle at the back of the throat. The tongue’s extrinsic muscles, anchored in various bones of the head, can move the tongue to create an abrupt 10-fold change in the SVT’s cross-sectional area….
As it turns out, the configuration of the adult human tongue’s oral and pharyngeal proportions and shape allow mature human vocal tracts to produce the vowels [i], [u], and [a] (as in the word ma). These quantal vowels produce frequency peaks analogous to saturated colors, are more distinct than other vowels, and are resistant to small errors in tongue placement. Thus, while not required for language, these vowel sounds buffer speech against misinterpretation. This may explain why all human languages use these vowels.
o Darwin and his latter-day followers may complain about the design of the oral cavity but they’d have a harder time doing so (and being understood) if it weren’t for this instance of “poor design.” Note that “all human languages use these vowels,” an indication that this is no negligible feature for clear communication. And speech, of course, is arguably the keystone of humanity’s exceptional status in the world of life.
None of which, of course, is to make light of the peril of choking. But to put things in perspective, according to the National Safety Council, “5,051 people…died from choking in 2015,” which works out to 0.0018 percent of all deaths in the United States, and of those “2,848 were older than 74.” (See here and here.) There is no doubt some relationship to the prevalence of age-related conditions like Alzheimer’s disease. As an article for The Conversation points out, “The result is that millions of brain disease patients are at risk for inhaling food and saliva into the lungs, leading to death by pneumonia or even choking.”
That having been said, the design of the human oral cavity looks more like a trade-off than a botch. As Evolution News has put it, “Trade-offs are compromises made to optimize the highest design goal.” They are not errors but necessary features of design in a material world.
Evolution News | @DiscoveryCSC
It’s a staple for Darwinists who compile lists of human anatomical features supposedly demonstrating “unintelligent” or “botched” design. We’re constantly told that the design of the human larynx, trachea, and oral cavity is poor because it allows for choking on food.
The point is made by the snarky Centre for Unintelligent Design, which lists “The ease with which we can choke” as an example of “unintelligent design,” and by Wikipedia. On the “Argument for poor design“ page they include this under “Fatal flaws” in human anatomy:
The existence of the pharynx, a passage used for both ingestion and respiration ,with the consequent drastic increase in the risk of choking.
In a conversation with Edge on “Unintelligent Design,” anthropologist Scott Atran complains, “Humans are more liable than other animals to choke, as they attempt to simultaneously coordinate eating, breathing and speaking.” RationalWiki adds, “Drinking and laughing at the same time — makes the drink come out of the person’s nose. Or potentially choke the victim of such a lousy design.” And so on.
The design does come with an increased chance of choking, but it’s also something that allows us to speak as we do. An interesting new article at The Scientist goes into some detail. From “Why Human Speech Is Special,” by Philip Lieberman:
In On the Origin of Species, Darwin noted “the strange fact that every particle of food and drink which we swallow has to pass over the orifice of the trachea, with some risk of falling into the lungs.” Because of this odd anatomy, which differs from that of all other mammals, choking on food remains the fourth leading cause of accidental death in the United States. This species-specific problem is a consequence of the mutations that crafted the human face, pharynx, and tongue so as to make it easier to speak and to correctly interpret the acoustic speech signals that we hear.
At birth, the human tongue is flat in the mouth, as is the case for other mammals. The larynx, which rests atop the trachea, is anchored to the root of the tongue. As infants suckle, they raise the larynx to form a sealed passage from the nose to the lungs, allowing them to breathe while liquid flows around the larynx. Most mammalian species retain this morphology throughout life, which explains why cats or dogs can lap up water while breathing. In humans, however, a developmental process that spans the first 8 to 10 years of life forms the adult version of the SVT [supra-laryngeal vocal tract]. First, the skull is reshaped, shortening the relative length of the oral cavity. The tongue begins to descend down into the pharynx, while the neck increases in length and becomes rounded in the back. Following these changes, half the tongue is positioned horizontally in the oral cavity (and thus called the SVTh), while the other half (SVTv) is positioned vertically in the pharynx. The two halves meet at an approximate right angle at the back of the throat. The tongue’s extrinsic muscles, anchored in various bones of the head, can move the tongue to create an abrupt 10-fold change in the SVT’s cross-sectional area….
As it turns out, the configuration of the adult human tongue’s oral and pharyngeal proportions and shape allow mature human vocal tracts to produce the vowels [i], [u], and [a] (as in the word ma). These quantal vowels produce frequency peaks analogous to saturated colors, are more distinct than other vowels, and are resistant to small errors in tongue placement. Thus, while not required for language, these vowel sounds buffer speech against misinterpretation. This may explain why all human languages use these vowels.
o Darwin and his latter-day followers may complain about the design of the oral cavity but they’d have a harder time doing so (and being understood) if it weren’t for this instance of “poor design.” Note that “all human languages use these vowels,” an indication that this is no negligible feature for clear communication. And speech, of course, is arguably the keystone of humanity’s exceptional status in the world of life.
None of which, of course, is to make light of the peril of choking. But to put things in perspective, according to the National Safety Council, “5,051 people…died from choking in 2015,” which works out to 0.0018 percent of all deaths in the United States, and of those “2,848 were older than 74.” (See here and here.) There is no doubt some relationship to the prevalence of age-related conditions like Alzheimer’s disease. As an article for The Conversation points out, “The result is that millions of brain disease patients are at risk for inhaling food and saliva into the lungs, leading to death by pneumonia or even choking.”
That having been said, the design of the human oral cavity looks more like a trade-off than a botch. As Evolution News has put it, “Trade-offs are compromises made to optimize the highest design goal.” They are not errors but necessary features of design in a material world.
God continues to make fools of the 'wise'.
Ecclesiastes8:17ESV"then I saw all the work of God, that man cannot find out the work that is done under the sun. However much man may toil in seeking, he will not find it out. Even though a wise man claims to know, he cannot find it out."
Why Does Biology Still Have the Ability to Surprise Us?
Ann Gauger
About forty years ago, a biochemistry professor told my class that now that the genetic code had been worked out and the lac operon discovered, the only thing left for us students was to work out the details. Boy, was he wrong!
If there's one thing I've learned over the last forty years, it is that every ten years or so the biological apple cart is upset, and a long-established "fact," an assumption based on incomplete knowledge, is proven to be wrong.
I am sure you can find textbooks that still include some of these old "facts." Below is a partial list of those assumptions that have had to be revised, and some that are still under discussion.
1. Old fact: DNA is stable and genes don't hop around.
New discovery: Mobile genetic elements can hop from place to place in the DNA, duplicating themselves and changing gene expression. Sometimes they carry surrounding genes with them.
2. New "old" fact: Mobile genetic elements are selfish DNA that replicate themselves without benefit to the organism, thus cluttering the genome with garbage.
New discovery: Mobile genetic elements appear to be involved in the regulation of many important genes, and their distribution in the genome is nonrandom.
3. Old fact: A gene is an uninterrupted stretch of DNA that encodes a single protein. Genes are arranged like beads on a string.
New discovery: Genes in eukaryotes are interrupted, sometimes multiple times, by non-coding sequences called introns. The introns get spliced out of the messenger RNA before the message is translated. Because of splicing, one gene can produce many different but related proteins.
New discovery: Genes can overlap one another on the same stretch of DNA, on the same strand or on opposite strands. Thus one piece of DNA can produce multiple different proteins.
Take home message: 1 stretch of DNA ≠ 1 gene ≠ 1 protein
4. Old fact: There are only 3 forms of RNA: messenger RNA, transfer RNA, and ribosomal RNA.
New discovery: New classes of short and long RNA transcripts serve to regulate gene expression.
5. Old fact: Pseudogenes are useless broken remnants of former genes.
New discovery: Not all pseudogenes are useless. Pseudogenes can be transcribed, and their products can be used to regulate the expression of their full-length sister genes. Related to #4.
6. Old fact: The genome is full of junk, the remnants of wasteful evolutionary processes and selfish DNA (see #1, #2 and #5 above).
New discovery: "Junk" DNA isn't junk after all. It has many important regulatory functions in the cell.
Revolutionary discoveries like these often happen when someone tries something new, stumbles across some contrary evidence, and begins to question the validity of an established "fact." The results have been astonishing -- and have even won the Nobel Prize. Because of these discoveries we have gained a new and better, though still imperfect understanding of biology.
Why should we still have the "facts" wrong? After all, we've been studying biology for sixty years after the discovery of DNA's structure, and 50 years after the code was worked out.
Perhaps a better question would be, "Why does biology have the ability to surprise us?" It's because life is much more sophisticated than anything we can imagine. We look at biology from our very limited perspective, and at almost every turn we are puzzled or amazed. You can even read it in the understated, carefully couched language of published articles, where words like "surprising" or "unexpected" appear often.
Remember that biochemistry professor who claimed that all the important work in biology was done? He also said we'd never find gears or wheels in biology. Poor guy!
You'd think that scientists would be more cautious about our pronouncements if we can be so wrong. But we are only human, like everyone else, and our accepted "facts" are often deeply entrenched in our thinking. In truth, though, only one rock solid "fact" exists -- that some time in the not too distant future a strongly held "fact" will be proven mistaken.
Like Darwinian evolution, perhaps?
Saturday 28 July 2018
Their own facts?
The Eye Evolution Simulation That Failed
Evolution News | @DiscoveryCSC
Evolution News | @DiscoveryCSC
On a new episode of ID the Future, Discovery Institute biologists Jonathan Wells and Ray Bohlin talk about a conversation that Dr. Wells imagined between evolutionists Richard Dawkins and Dan-Eric Nilsson, and published recently here at Evolution News. Download the podcast or listen to it here.
Dawkins had lectured (in real life) on Nilsson’s computer simulation work, showing the human eye could have evolved easily and quickly. What would the two of them have said when Nilsson contacted Dawkins and told him, “I’m sorry, Richard, but I didn’t do that simulation?”
Wells pictures them talking about rushing the work on that simulation. But then, what about the next conversation when the simulation failed?
Rights for machines=Wrongs for humans?
European Parliament Committee Wants Robot Rights
Wesley J. Smith
Every time I warn that transhumanists and other assorted futurists want to destroy human exceptionalism by granting personhood and citizenship to sophisticated computers, some readers mock me with the "It will never happen here" complacency. (Anyone who says that has been in a coma for the last fifty years.)
Yes, it could "happen here." In fact, a committee of the European Parliament has voted in favor of robot rights:
The draft report, approved by 17 votes to two and two abstentions by the European Parliament Committee on Legal Affairs, proposes that "The most sophisticated autonomous robots could be established as having the status of electronic persons with specific rights and obligations, including that of making good any damage they may cause."
Specifically, the committee calls for AI robot rights. From the draft report (my emphasis):
...creating a specific legal status for robots, so that at least the most sophisticated autonomous robots could be established as having the status of electronic persons with specific rights and obligations, including that of making good any damage they may cause, and applying electronic personality to cases where robots make smart autonomous decisions or otherwise interact with third parties independently;
No! If robots have rights, the concept of human rights will cease to be objective, inherent, and inalienable, but rather, would become subjective and based on perceived individual capacities and capabilities.
Machines are not -- and could never be -- moral agents. They are mere things. Even the most sophisticated AI computer would merely be the totality of its programming, no matter how sophisticated and regardless of whether it was self-teaching.
Think about it. Would owning, buying, and selling these so-called "electronic person" machines amount to slavery? Would machines be allowed to own property, vote, be protected by anti-discrimination laws as the report seems to state?
If a robot were turned off without consent, would it amount to murder? Would it be entitled to due process of law before decommissioning? The whole thing is ludicrous.
The push to conjure non-human rights for non-human and undeserving entities, whether machine, animal, nature, etc., is a serious symptom of societal decadence that should be mocked and rejected out of hand.
Wesley J. Smith
Every time I warn that transhumanists and other assorted futurists want to destroy human exceptionalism by granting personhood and citizenship to sophisticated computers, some readers mock me with the "It will never happen here" complacency. (Anyone who says that has been in a coma for the last fifty years.)
Yes, it could "happen here." In fact, a committee of the European Parliament has voted in favor of robot rights:
The draft report, approved by 17 votes to two and two abstentions by the European Parliament Committee on Legal Affairs, proposes that "The most sophisticated autonomous robots could be established as having the status of electronic persons with specific rights and obligations, including that of making good any damage they may cause."
Specifically, the committee calls for AI robot rights. From the draft report (my emphasis):
...creating a specific legal status for robots, so that at least the most sophisticated autonomous robots could be established as having the status of electronic persons with specific rights and obligations, including that of making good any damage they may cause, and applying electronic personality to cases where robots make smart autonomous decisions or otherwise interact with third parties independently;
No! If robots have rights, the concept of human rights will cease to be objective, inherent, and inalienable, but rather, would become subjective and based on perceived individual capacities and capabilities.
Machines are not -- and could never be -- moral agents. They are mere things. Even the most sophisticated AI computer would merely be the totality of its programming, no matter how sophisticated and regardless of whether it was self-teaching.
Think about it. Would owning, buying, and selling these so-called "electronic person" machines amount to slavery? Would machines be allowed to own property, vote, be protected by anti-discrimination laws as the report seems to state?
If a robot were turned off without consent, would it amount to murder? Would it be entitled to due process of law before decommissioning? The whole thing is ludicrous.
The push to conjure non-human rights for non-human and undeserving entities, whether machine, animal, nature, etc., is a serious symptom of societal decadence that should be mocked and rejected out of hand.
Sunday 22 July 2018
Who wants to be a millionaire?
The downsides of being rich
Unless you were born rich, at some point in your life you’ve probably dreamed about becoming wealthy.
You know, ridiculous wealth, winning-the-lottery kind of money, with visions of lifestyles of the rich and famous, mansions with manicured lawns and massive swimming pools, personal islands, expensive sports cars, private jets and, well, loads of extra money just to do whatever you’d like whenever you’d like to.
What happens to those lucky few people for whom dream becomes a reality? We turned to question-and-answer-site Quora for some advice on whether getting rich is worth it.
True colours
New money brings change — sometimes for the better, sometimes for the worse.
Carol Philo watched her poverty-stricken parents become millionaires when a printing company they owned and ran out of the family’s spare bedroom took off. With the profit, came an obsession for more and more.
“My mom became addicted to the money….Nothing was ever enough,” Philo said, and over the years, family relations eventually dissolved. “Having seen the entire gauntlet, I would say that getting comfortable is worth it. Getting rich is not.”
Murat Morrison couldn’t agree more. He made a mint when he sold his trucking company in the late 1990s. One thing he learned will stay with him forever, he said. “Money buys comfort,” Morrison said. “Comfort is not happiness or satisfaction. I felt as empty as a drum for the next few years. While it is good to be comfortable it is more satisfying to be happy.”
Wealth also tends to bring out people’s true colours, added Paul Buchheit. “In general, it makes people more of whatever they already were,” he said. “If you're an a------, getting more money will probably make you more of an a------. However, if you have purpose and meaning in your life that goes beyond chasing the golden carrot, money can give you the freedom to focus on the things that truly matter to you.”
For Stu Sjouwerman, that purpose was continuing to work. “I worked hard for 15 years and sold my software company. Walked out with an eight-figure number, and was retired for a… whopping five days. You need to have a GAME TO PLAY,” he wrote. “I started my new company immediately and felt a whole lot happier.”
Living with the downsides
The downsides of being rich can outweigh the benefits. “The first thing you are thinking reading that, is, ‘cry me a river.’ You are not allowed to complain about anything, ever,” when you’re wealthy, wrote oneanonymous respondent. “Since most people imagine being rich as nirvana, you are no longer allowed to have any human needs or frustrations in the public eye. Yet, you are still a human being, but most people don't treat you like one.”
Other downsides stretch to new parameters with friends and family. “Most people now want something out of you, and it can be harder to figure out whether someone is being nice to you because they like you, or they are being nice to you because of your money,” the anonymous respondent continued. “If you aren't married yet, good luck trying to figure out (and/or always having self-doubt) about whether a partner is into you or your money.”
Still, money brings perks
Despite the downsides, there are benefits to having more money, most respondents said.
“Being rich is better than not being rich, but it's not nearly as good as you imagine it is,” said the anonymous respondent, who reported having $15m after selling a tech start up. “First, one of the only real things being rich gives you is that you don't have to worry about money as much anymore. There will still be some expenses that you cannot afford (and you will wish you could), but most expenses can be made without thinking about what it costs. This is definitely better, without a doubt.”
And Christopher Angus, who said he made his money on the sale of four small start-ups, said “I’d rather have money than not, as the last seven years as someone with money have allowed me freedoms and experiences that many people won't see and do in their lifetimes. For example, one year I took 25 vacations and at other times I’d spend $20,000 on a Saturday night out.”
Higher expectations
With the added wealth also comes reset expectations. “Everything is relative…The first month you drive the Audi, or eat in a fancy restaurant, you really enjoy it,” the anonymous respondent also wrote. “But then you sort of get used to it. And then you are looking towards the next thing, the next level up. And the problem is that you have reset your expectations, and everything below that level doesn't get you quite as excited anymore.”
Angus, who said he has had more money than he’s known what to do with since his mid-20s, said boredom quickly ensued. “I found that having enough money [where] nearly any material object or status symbol is attainable has removed the excitement and desire for things I always wanted but couldn't afford before I became successful. One Porsche and everything else wasn't nearly enough and over the next three years I bought another five Porsches as well as other Supercars,” Angus said. “I became addicted to buying these symbols to attract attention and get people to want to spend time with me because of what I had and what I could give them.”
A sense of isolation
Another self-made individual, worth more than $20m, said wealth has been a real burden. “I made it big in my mid-30s,” the anonymous tech entrepreneur wrote. “I wanted to get rich and I did it. But I actually feel maybe it's not worth it. A slower path to wealth might be a lot healthier to my career and to my life in general.”
The catch? “It's impossible to give up the money,” the tech entrepreneur wrote. “Being wealthy is probably not worth it. But once you get there, you want to stay there forever.”
Would you want to be rich? Share your thoughts and experiences on BBC Capital's Facebook page or message us on Twitter @BBC_Capital
Quora respondents are required to use their true names under the site’sReal Names policy. To help ensure legitimacy and quality, Quora asks some individuals, such as doctors and lawyers, to confirm their expertise.
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