Reading furnishes the mind only with materials of knowledge; it is thinking that makes what we read ours.
John locke.
John locke.
Sunday 7 August 2016
On the supposed solution to the cambrian mystery or "It came from outer space"
To Create Cambrian Animals, Whack the Earth from Space
Evolution News & Views
It's surely not a coincidence that this season in science-journal publishing we've seen a variety of attempts to solve the enigma that Stephen Meyer describes in his new book, Darwin's Doubt. The problem, of course, is how to account for the geologically sudden eruption of complex new life forms in the Cambrian explosion. Meyer argues that the best explanation is intelligent design.
The orthodox materialist camp in mainstream science remains in full denial mode. They can't stomach the proposal of ID, but neither can they for the most part bring themselves to answer Meyer by name, or even admit there's a controversy on the subject. Charles Marshall, reviewing the book in Science, is the honorable exception. So we get what look like stealth responses to Meyer's book that claim to have figured out the Cambrian puzzle without telling you what the urgency for doing so really is, thus evading the task of responding to Meyer directly. (See David Klinghoffer's review of the reviewers of Darwin's Doubt, "A Taxonomy of Evasion.")
Probably the most hopeless solution so far ascribes some of the creative power to a blast in the ocean by a space impact. This supposedly helped "set the stage" for the rapid proliferation of new animal forms. When we examine the complexity of a single Cambrian fossil, though, such a notion, like the others on offer, leaves all the important questions unanswered.
To his credit, Grant M. Young, the author of the proposal, is somewhat modest in the way he formulates his idea. His paper in GSA Today is primarily concerned with looking for evidence of a "very large marine impact" prior to the Ediacaran Period that sent vast quantities of water and oxygen into the atmosphere, changed the obliquity of Earth's spin axis, and altered sea levels. The aftermath of that catastrophe, he speculates, played a role in the Cambrian explosion -- but a "crucial" one.
Attendant unprecedented environmental reorganization may have played a crucial role in the emergence of complex life forms. (Emphasis added.)
That's all Young had to say about it, but the suggestion was enough for NASA's Astrobiology Magazine to jump on it with a breathless headline: "Did a Huge Impact Lead to the Cambrian Explosion?" Author Johnny Bontemps catapulted that tease into the notion that "The ensuing environmental re-organization would have then set the stage for the emergence of complex life." Bontemps is correct about one thing:
These events marked the beginning of another drastic event known as the Cambrian explosion. Animal life on Earth suddenly blossomed, with all of the major groups of animals alive today making their first appearance.
Let's take a look at just one of the Cambrian animals, as seen in an exquisitely preserved new fossil from the Chengjiang strata in China, where so many beautiful fossils have been found (examples are shown in the Illustra film Darwin's Dilemma). The new fossil, Alalcomenaeus, published by Nature, was furnished with multiple claws like other Cambrian arthropods, but was so well preserved its nervous system could be outlined in detail. Even though it is dated from the early Cambrian at 520 million years old, it already had the nerves of modern spiders. Co-author Nick Strausfeld explains:
"We now know that the megacheirans had central nervous systems very similar to today's horseshoe crabs and scorpions," said Strausfeld, the senior author of the study and a Regents' Professor in the UA's Department of Neuroscience. "This means the ancestors of spiders and their kin lived side by side with the ancestors of crustaceans in the Lower Cambrian."'
Though tiny (about an inch long), its nervous system must have been fairly advanced, because the elongated creature was capable of swimming or crawling or both. In addition to about a dozen body segments with jointed appendages, it had a "pair of long, scissor-like appendages attached to the head, most likely for grasping or sensory purposes." It also had two pairs of eyes.
Iron deposits selectively accumulated in the nerve cells, allowing the research team to reconstruct the highly organized brain and nervous system. After processing with CT scans and iron scans, "out popped this beautiful nervous system in startling detail."
Comparing the outline of the fossil nervous system to nervous systems of horseshoe crabs and scorpions left no doubt that 520-million-year-old Alalcomenaeus was a member of the chelicerates.
Specifically, the fossil shows the typical hallmarks of the brains found in scorpions and spiders: Three clusters of nerve cells known as ganglia fused together as a brain also fused with some of the animal's body ganglia. This differs from crustaceans where ganglia are further apart and connected by long nerves, like the rungs of a rope ladder.
Other diagnostic features include the forward position of the gut opening in the brain and the arrangement of optic centers outside and inside the brain supplied by two pairs of eyes, just like in horseshoe crabs.
Horseshoe crabs survive as "living fossils" to this day, as residents near the Great Lakes know from the annual swarms. This fossil resembles modern chelicerates, one of the largest subphyla of arthropods, including horseshoe crabs, scorpions, spiders, mites, harvestmen, and ticks. Live Science adds, "The discovery of a fossilized brain in the preserved remains of an extinct 'mega-clawed' creature has revealed an ancient nervous system that is remarkably similar to that of modern-day spiders and scorpions."
Since crustaceans and chelicerates have both been found in the early Cambrian, Darwinian evolutionists are forced to postulate an unknown ancestor further back in time: "They had to come from somewhere," Strausfeld remarks. "Now the search is on." That sounds like the same challenge Charles Darwin gave fossil hunters 154 years ago to find the ancestors of the Cambrian animals.
The difficulty? It requires many different tissue types and interconnected systems to operate a complex animal like Alalcomenaeus, with its body segments, eyes, claws, mouth parts, gut and nervous system with a brain, to say nothing of coordinating the developmental programs that build these systems from a single cell. That is the major problem that Stephen Meyer emphasizes in Darwin's Doubt: where does the information come from to build complex body plans with hierarchical levels of organization?
Slamming a space rock at the Earth is hardly a plausible source of information. Meyer has been answering in detail the most serious and scholarly critique of his book, by Charles Marshall, refuting Marshall's criticisms point by point. Meanwhile the proposed alternative explanations for the Cambrian event keep coming, bearing increasingly the marks of desperation.
Evolution News & Views
It's surely not a coincidence that this season in science-journal publishing we've seen a variety of attempts to solve the enigma that Stephen Meyer describes in his new book, Darwin's Doubt. The problem, of course, is how to account for the geologically sudden eruption of complex new life forms in the Cambrian explosion. Meyer argues that the best explanation is intelligent design.
The orthodox materialist camp in mainstream science remains in full denial mode. They can't stomach the proposal of ID, but neither can they for the most part bring themselves to answer Meyer by name, or even admit there's a controversy on the subject. Charles Marshall, reviewing the book in Science, is the honorable exception. So we get what look like stealth responses to Meyer's book that claim to have figured out the Cambrian puzzle without telling you what the urgency for doing so really is, thus evading the task of responding to Meyer directly. (See David Klinghoffer's review of the reviewers of Darwin's Doubt, "A Taxonomy of Evasion.")
Probably the most hopeless solution so far ascribes some of the creative power to a blast in the ocean by a space impact. This supposedly helped "set the stage" for the rapid proliferation of new animal forms. When we examine the complexity of a single Cambrian fossil, though, such a notion, like the others on offer, leaves all the important questions unanswered.
To his credit, Grant M. Young, the author of the proposal, is somewhat modest in the way he formulates his idea. His paper in GSA Today is primarily concerned with looking for evidence of a "very large marine impact" prior to the Ediacaran Period that sent vast quantities of water and oxygen into the atmosphere, changed the obliquity of Earth's spin axis, and altered sea levels. The aftermath of that catastrophe, he speculates, played a role in the Cambrian explosion -- but a "crucial" one.
Attendant unprecedented environmental reorganization may have played a crucial role in the emergence of complex life forms. (Emphasis added.)
That's all Young had to say about it, but the suggestion was enough for NASA's Astrobiology Magazine to jump on it with a breathless headline: "Did a Huge Impact Lead to the Cambrian Explosion?" Author Johnny Bontemps catapulted that tease into the notion that "The ensuing environmental re-organization would have then set the stage for the emergence of complex life." Bontemps is correct about one thing:
These events marked the beginning of another drastic event known as the Cambrian explosion. Animal life on Earth suddenly blossomed, with all of the major groups of animals alive today making their first appearance.
Let's take a look at just one of the Cambrian animals, as seen in an exquisitely preserved new fossil from the Chengjiang strata in China, where so many beautiful fossils have been found (examples are shown in the Illustra film Darwin's Dilemma). The new fossil, Alalcomenaeus, published by Nature, was furnished with multiple claws like other Cambrian arthropods, but was so well preserved its nervous system could be outlined in detail. Even though it is dated from the early Cambrian at 520 million years old, it already had the nerves of modern spiders. Co-author Nick Strausfeld explains:
"We now know that the megacheirans had central nervous systems very similar to today's horseshoe crabs and scorpions," said Strausfeld, the senior author of the study and a Regents' Professor in the UA's Department of Neuroscience. "This means the ancestors of spiders and their kin lived side by side with the ancestors of crustaceans in the Lower Cambrian."'
Though tiny (about an inch long), its nervous system must have been fairly advanced, because the elongated creature was capable of swimming or crawling or both. In addition to about a dozen body segments with jointed appendages, it had a "pair of long, scissor-like appendages attached to the head, most likely for grasping or sensory purposes." It also had two pairs of eyes.
Iron deposits selectively accumulated in the nerve cells, allowing the research team to reconstruct the highly organized brain and nervous system. After processing with CT scans and iron scans, "out popped this beautiful nervous system in startling detail."
Comparing the outline of the fossil nervous system to nervous systems of horseshoe crabs and scorpions left no doubt that 520-million-year-old Alalcomenaeus was a member of the chelicerates.
Specifically, the fossil shows the typical hallmarks of the brains found in scorpions and spiders: Three clusters of nerve cells known as ganglia fused together as a brain also fused with some of the animal's body ganglia. This differs from crustaceans where ganglia are further apart and connected by long nerves, like the rungs of a rope ladder.
Other diagnostic features include the forward position of the gut opening in the brain and the arrangement of optic centers outside and inside the brain supplied by two pairs of eyes, just like in horseshoe crabs.
Horseshoe crabs survive as "living fossils" to this day, as residents near the Great Lakes know from the annual swarms. This fossil resembles modern chelicerates, one of the largest subphyla of arthropods, including horseshoe crabs, scorpions, spiders, mites, harvestmen, and ticks. Live Science adds, "The discovery of a fossilized brain in the preserved remains of an extinct 'mega-clawed' creature has revealed an ancient nervous system that is remarkably similar to that of modern-day spiders and scorpions."
Since crustaceans and chelicerates have both been found in the early Cambrian, Darwinian evolutionists are forced to postulate an unknown ancestor further back in time: "They had to come from somewhere," Strausfeld remarks. "Now the search is on." That sounds like the same challenge Charles Darwin gave fossil hunters 154 years ago to find the ancestors of the Cambrian animals.
The difficulty? It requires many different tissue types and interconnected systems to operate a complex animal like Alalcomenaeus, with its body segments, eyes, claws, mouth parts, gut and nervous system with a brain, to say nothing of coordinating the developmental programs that build these systems from a single cell. That is the major problem that Stephen Meyer emphasizes in Darwin's Doubt: where does the information come from to build complex body plans with hierarchical levels of organization?
Slamming a space rock at the Earth is hardly a plausible source of information. Meyer has been answering in detail the most serious and scholarly critique of his book, by Charles Marshall, refuting Marshall's criticisms point by point. Meanwhile the proposed alternative explanations for the Cambrian event keep coming, bearing increasingly the marks of desperation.
When the original technologist holds court.
Intelligent Designs in Nature Make Engineers Envious
Evolution News & Views
We've reported numerous times about the vibrant field of biomimetics: the science of imitating nature. There are whole departments at universities dedicated to this. There are journals like Bioinspiration and Biomimetics, the Journal of Biomimetics, Biomaterials, and Tissue Engineering, and Frontiers in Bioengineering and Biotechnology that regularly report on it. Entrepreneurs have started companies to build products mimicking nature. Biomimetics is on a roll. Here are a few of scientists' latest attempts to copy nature's designs. They wouldn't try so hard if the designs weren't intelligent.
Flight on the Small Scale
A news item from the University of Alabama shows Dr. Amy Lang studiously gazing at a Monarch butterfly on the wing. She has reason to stay focused. She just got a $280,000 grant from the National Science Foundation to study the scales on butterfly wings to find ways to improve flight aerodynamics for MAVs (micro area vehicles).
Butterflies don't require the scales to fly, but Dr. Lang knows they help the insects fly better. "The butterfly scales are beautifully arranged on the wing, and how the scales are arranged is where the aerodynamic benefit comes in," she says. This "unique micro pattern ... reduces drag and likely increases thrust and lift during flapping and glided flight." When the scales are removed, the butterfly has to flap its wings 10 percent more to maintain the same flight.
If you've seen Metamorphosis: The Beauty and Design of Butterflies you may recall the striking electron micrographs of the tiny scales, each less than a tenth of a millimeter in width, arranged like shingles on a roof. According to Dr. Lang, there's a reason: "the scales stick up slightly, trapping a ball of air under the scale and allowing air to flow smoothly over it." Her team wants to understand the physics behind this design before trying to model it on artificial flyers.
The article assumes butterflies happened upon these "evolutionary adaptations" by blind, unguided processes: "The scales covering butterfly and moth wings represent about 190 million years of natural selection for insect flight efficiency." Metamorphosis refutes that notion, but what matters in the story is not evolution, but design -- here is a natural design that the NSF feels is worth at least $280,000 to try to imitate. (Dr. Lang also "works with shark scales" in her "bio-designed engineering" lab.)
It's a Bird; It's a Plane; It's Robo Raven
You met nano-hummingbird in Illustra's film Flight: The Genius of Birds. Now here's Robo Raven, a flying drone built at the University of Maryland -- the first Micro Air Vehicle (MAV) using flapping flight. We've noted this briefly before. A video clip shows how Robo Raven III uses sunlight from solar panels built into its wings to charge batteries.
Nature, as usual, does it better. The Robo Raven III can only gather about 30 watts -- an order of magnitude too low to stay aloft indefinitely, IEEE Spectrum says, pointing out that real ravens get "crazy high power density" from meat. On his blog, Professor S. K. Gupta of the UMass design team compares performance between the two, noting that his invention also mimics another natural technology -- solar energy collection by plants:
However, nature has a significant edge over engineered system in other areas. For example, one gram of meat stores 20 times more energy than one gram of the current battery technology. So in terms of the energy density, we engineers have a lot of catching up to do. In nature, solar energy collection devices (e.g., trees) are not on-board ravens. Hence, ravens ultimately utilize a large collection area to gather energy into highly a dense storage source (e.g., meat), giving them a much longer range and better endurance than Robo Raven III. (Emphasis added.)
While Gupta notes that direct solar energy conversion to mechanical energy would be about an order of magnitude more efficient than an animal's metabolic pathway, "We still need to make significant improvements in solar cell efficiency and battery energy density to replicate the endurance of real ravens in Robo Raven III," he confesses. Real ravens also use that metabolism to perform many functions besides flapping flight -- including reproduction, navigation, and the operation of multiple senses. (Living birds can also fly at night.)
Short Takes
Solar power: "Inspired by nature: To maximise the efficiency of solar cells of the future, physicists are taking a leaf out of nature's book" (Cavendish Laboratory, University of Cambridge).
Robotics: "Amber 2 robot walks with a human gait." Why is that good? "People are able to walk so smoothly because of the seamless interaction between the muscles, bone, ligaments, etc. in the legs, ankles and feet ... Getting a robot to walk like us means not just building legs, ankles or feet like ours, it means programming them all to work together in way that is graceful when the robot walks, and that appears to be where the Amber 2 team is headed" (PhysOrg reporting on work at Texas A&M).
Sonar: An engineer was watching a nature show and wondered why dolphins blew bubbles to trap fish, when it would seemingly mess up their sonar signals. He found that the dolphins use two click frequencies that allow them to distinguish between the bubbles and fish. This "inspired the development of a cheap, coin-sized radar gadget that can sense hidden electronics" (New Scientist, reporting on work at University of Southampton).
Does Darwin-Talk Add Value?
Occasionally, news stories like these attribute the designs in question to natural selection. "Through billions of years of evolution, life on Earth has found intricate solutions to many of the problems scientists are currently grappling with," the item from Cambridge says. But then, most of the story marvels at the intricate design that blind nature supposedly arrived at.
Biology has evolved phenomenally subtle systems to funnel light energy around and channel it to the right places. It has also become incredibly good at building tiny devices that work with high efficiency, and at replicating them millions of times.
Similarly, New Scientist ends its biodesign story with: "Evolution has once again sparked ideas for remarkable innovation."
The Darwin language gets to be as annoying as those pop-up ads on the Internet that have nothing to do with the story. The focus is on design -- "intricate solutions" so good, they occupy the best minds in the world's finest academic institutions; designs so attractive, they are worth six-figure government grants to imitate.
You wouldn't want to insult bioengineers with the suggestion they are mimicking blind, unguided processes in their work. No, from our uniform experience, a good design comes from a good mind.
Evolution News & Views
We've reported numerous times about the vibrant field of biomimetics: the science of imitating nature. There are whole departments at universities dedicated to this. There are journals like Bioinspiration and Biomimetics, the Journal of Biomimetics, Biomaterials, and Tissue Engineering, and Frontiers in Bioengineering and Biotechnology that regularly report on it. Entrepreneurs have started companies to build products mimicking nature. Biomimetics is on a roll. Here are a few of scientists' latest attempts to copy nature's designs. They wouldn't try so hard if the designs weren't intelligent.
Flight on the Small Scale
A news item from the University of Alabama shows Dr. Amy Lang studiously gazing at a Monarch butterfly on the wing. She has reason to stay focused. She just got a $280,000 grant from the National Science Foundation to study the scales on butterfly wings to find ways to improve flight aerodynamics for MAVs (micro area vehicles).
Butterflies don't require the scales to fly, but Dr. Lang knows they help the insects fly better. "The butterfly scales are beautifully arranged on the wing, and how the scales are arranged is where the aerodynamic benefit comes in," she says. This "unique micro pattern ... reduces drag and likely increases thrust and lift during flapping and glided flight." When the scales are removed, the butterfly has to flap its wings 10 percent more to maintain the same flight.
If you've seen Metamorphosis: The Beauty and Design of Butterflies you may recall the striking electron micrographs of the tiny scales, each less than a tenth of a millimeter in width, arranged like shingles on a roof. According to Dr. Lang, there's a reason: "the scales stick up slightly, trapping a ball of air under the scale and allowing air to flow smoothly over it." Her team wants to understand the physics behind this design before trying to model it on artificial flyers.
The article assumes butterflies happened upon these "evolutionary adaptations" by blind, unguided processes: "The scales covering butterfly and moth wings represent about 190 million years of natural selection for insect flight efficiency." Metamorphosis refutes that notion, but what matters in the story is not evolution, but design -- here is a natural design that the NSF feels is worth at least $280,000 to try to imitate. (Dr. Lang also "works with shark scales" in her "bio-designed engineering" lab.)
It's a Bird; It's a Plane; It's Robo Raven
You met nano-hummingbird in Illustra's film Flight: The Genius of Birds. Now here's Robo Raven, a flying drone built at the University of Maryland -- the first Micro Air Vehicle (MAV) using flapping flight. We've noted this briefly before. A video clip shows how Robo Raven III uses sunlight from solar panels built into its wings to charge batteries.
Nature, as usual, does it better. The Robo Raven III can only gather about 30 watts -- an order of magnitude too low to stay aloft indefinitely, IEEE Spectrum says, pointing out that real ravens get "crazy high power density" from meat. On his blog, Professor S. K. Gupta of the UMass design team compares performance between the two, noting that his invention also mimics another natural technology -- solar energy collection by plants:
However, nature has a significant edge over engineered system in other areas. For example, one gram of meat stores 20 times more energy than one gram of the current battery technology. So in terms of the energy density, we engineers have a lot of catching up to do. In nature, solar energy collection devices (e.g., trees) are not on-board ravens. Hence, ravens ultimately utilize a large collection area to gather energy into highly a dense storage source (e.g., meat), giving them a much longer range and better endurance than Robo Raven III. (Emphasis added.)
While Gupta notes that direct solar energy conversion to mechanical energy would be about an order of magnitude more efficient than an animal's metabolic pathway, "We still need to make significant improvements in solar cell efficiency and battery energy density to replicate the endurance of real ravens in Robo Raven III," he confesses. Real ravens also use that metabolism to perform many functions besides flapping flight -- including reproduction, navigation, and the operation of multiple senses. (Living birds can also fly at night.)
Short Takes
Solar power: "Inspired by nature: To maximise the efficiency of solar cells of the future, physicists are taking a leaf out of nature's book" (Cavendish Laboratory, University of Cambridge).
Robotics: "Amber 2 robot walks with a human gait." Why is that good? "People are able to walk so smoothly because of the seamless interaction between the muscles, bone, ligaments, etc. in the legs, ankles and feet ... Getting a robot to walk like us means not just building legs, ankles or feet like ours, it means programming them all to work together in way that is graceful when the robot walks, and that appears to be where the Amber 2 team is headed" (PhysOrg reporting on work at Texas A&M).
Sonar: An engineer was watching a nature show and wondered why dolphins blew bubbles to trap fish, when it would seemingly mess up their sonar signals. He found that the dolphins use two click frequencies that allow them to distinguish between the bubbles and fish. This "inspired the development of a cheap, coin-sized radar gadget that can sense hidden electronics" (New Scientist, reporting on work at University of Southampton).
Does Darwin-Talk Add Value?
Occasionally, news stories like these attribute the designs in question to natural selection. "Through billions of years of evolution, life on Earth has found intricate solutions to many of the problems scientists are currently grappling with," the item from Cambridge says. But then, most of the story marvels at the intricate design that blind nature supposedly arrived at.
Biology has evolved phenomenally subtle systems to funnel light energy around and channel it to the right places. It has also become incredibly good at building tiny devices that work with high efficiency, and at replicating them millions of times.
Similarly, New Scientist ends its biodesign story with: "Evolution has once again sparked ideas for remarkable innovation."
The Darwin language gets to be as annoying as those pop-up ads on the Internet that have nothing to do with the story. The focus is on design -- "intricate solutions" so good, they occupy the best minds in the world's finest academic institutions; designs so attractive, they are worth six-figure government grants to imitate.
You wouldn't want to insult bioengineers with the suggestion they are mimicking blind, unguided processes in their work. No, from our uniform experience, a good design comes from a good mind.
Saturday 6 August 2016
The bumblebee in the dock for design.
Flight of the Bumblebee Reveals Optimization at Multiple Levels
Evolution News & Views
A biological revolution is underway. Technology has allowed field biologists to track individual animals as small as insects, allowing scientists, for the first time, to gain real-time data on their lifetime behaviors. A team using this technology says in PLOS ONE:
Recent advances in animal-tracking technology have brought within reach the goal of tracking every movement of individual animals over their entire lifetimes. The potential of such life-long tracks to advance our understanding of animal behaviour has been compared to that of the advent of DNA sequencing, but the field is still in its infancy. [Emphasis added.]
If you saw Flight: The Genius of Birds you may remember how tiny geolocators allowed Carsten Egevang's team to monitor the pole-to-pole flight paths of Arctic terns from one year to the next. We've also reported on subsequent studies using geolocators on blackpoll warblers, frigate birds, and even giant flower beetles. Now, a team from Queen Mary University of London has attached radar antennas to bumblebees' heads, allowing them to monitor the entire lifetime flight behavior of these important pollinators.
The work adds to previous research that was more limited. Earlier teams used harmonic radar to track initial flights of bees. This is the first time that the technology was used to monitor the lifetime flights of four bumblebees (Bombus terrestris) over 6-15 days until contact was lost.
The studies described above revealed a great deal about the structure of exploratory and foraging flights, but opened up a number of key questions that are unanswered as yet. Does the change in flight structure from inexperienced to experienced bees occur gradually or as a sudden transition? When and how do bees discover the forage sources they go on to exploit? No prior study has been able to track the activity of individual insects throughout their entire life history, or even a significant portion of their life, making it impossible to address these questions.
You can see the headgear worn by the test bees in a summary on PhysOrg. There will always be some doubt about measurements obtained this way. Did the headgear alter the bees' normal behavior? Were they treated differently by other bees because they look weird? The scientists acknowledged other limitations of the study, such as the fact they were conducted sequentially, when different flowers were in bloom, and employed individuals from different colonies in different locations under different weather conditions. Nevertheless, they reached some tentative conclusions based on 15,000 minutes of data from 244 flights covering 180 kilometers.
Woodgate et al. were surprised to find more individuality than expected. "One of the most striking results to emerge from these data is the large degree to which our bees differed from one another," they write. The bees were not like little robots following a predetermined flight strategy. Each one divided its time differently between exploration of new food sources and exploitation of known food sources. One bee was a "lifelong vagabond," never settling down on any favorite patch. Another one, by contrast, quickly devoted most of its energy to patches with a high payoff. Overall, the pollinators seemed to balance their time between exploitation and exploration. It's a smart strategy, Woodgate says in the PhysOrg article:
"This study provided an unprecedented look at where the bees flew, how their behaviour changed as they gained experience and how they balanced the need to explore their surroundings - looking for good patches of flowers -- with the desire to collect as much food as possible from the places they had already discovered."
The bees made from 3 to 15 flights per day, depending on the distance to and quality of the resources. In general, exploratory flights occur within the first few days. That's when they discover most of the goods that they will return to most often. They will, however, make further exploratory flights at any time. The radar maps of their flight paths show extensive exploration of their surroundings in all directions, implying substantial brain power for memory, orientation and strategy to navigate over large areas and still find their way home.
Future work with larger numbers of bees, monitored simultaneously, will undoubtedly add to knowledge about their behaviors. For now, it appears that bumblebee colonies are programmed to use optimization algorithms - an indicator of intelligent design encoded in their brains. These algorithms work at both the individual and collective level. Variability leads some individuals to bring a lot of food back from reliable sources, and some to explore the environment for new and possibly better sources.
Although it is expected that randomly chosen individuals will tend to show variation in behaviour, the extent of the inter-individual differences we observed in flight behaviour is dramatic. These differences appear to persist over the bees' entire foraging career, and are likely to lead to high levels of variation in the contribution different foragers make to provisioning the colony.
An Instrument View of Bee Optimization
We've looked at lifetime flight behavior of these amazing flyers. Another article explores the flight equipment in more detail. The journal eLife reports new findings about how honeybees (Apis mellifera) position their antennae during flight. Antennae are well known as olfactory and tactile sense organs. During flight, they perform additional roles as speedometers and odometers. Experiments in wind tunnels showed that honeybees will position their antennae forward or backward in flight to measure speed, distance and odor sources:
To investigate how honeybees use different types of sensory information to position their antennae during flight, Roy Khurana and Sane first placed freely-flying and tethered bees in a wind tunnel. Flying forward causes air to flow from the front to the back of the bee. The experiments revealed that a bee brings its antennae forward and holds them in a specific position that depends on the rate of airflow. As the bee flies forward more quickly (or airflow increases), the antennae are positioned further forward.
Roy Khurana and Sane then investigated how the movement of images across the insect's eyes causes their antennae to change position. This unexpectedly revealed that moving images across the eye from front to back, which simulates what bees see when flying forward, causes the bees to move their antennae backward. However, exposing the bees to both the frontal airflow and front-to-back image motion as normally experienced during forward flight caused the bees to maintain their antennae in a fixed position. This behaviour results from the opposing responses of the antennae to the two stimuli.
This appears to be another optimization problem solved by the bees, because the mechanosensory input from the antennae can override the visual sense:
When flying in unpredictable conditions, sensory cues from a single modality are often unreliable measures of the ambient environmental parameters. For instance, purely optic flow-based measurements of self-motion can be misleading for insects which experience sideslip while flying in a crosswind. Moreover, reliance on optic flow may be problematic under dimly lit or overcast conditions, or when flying over lakes or deserts which present sparse visual feedback. In such situations, sampling from multiple sensory cues reduces the ambiguity arising from variability in feedback from single modalities (Wehner, 2003; Sherman and Dickinson, 2004; Wasserman et al., 2015). Hence, the integration of multimodal sensory cues is essential for most natural locomotory behaviours, including insect flight manoeuvres (Willis and Arbas, 1991; Frye et al., 2003; Verspui and Gray, 2009).
The researchers found that antenna position is part of this "multimodal sensory integration" that maximizes useful information from multiple -- sometimes antagonistic -- sources. It's like the IFR-trained pilot who learns to trust his instruments instead of his eyes when the sensory data seem to conflict.
Combined with bees' electrical sense, these pollinators of flowers and crops are pretty amazing little creatures. Neither paper explained how these abilities might have evolved. The second one on antenna positioning only mentions the "evolutionary significance of its function" because flight is impaired when it's broken. Blind processes don't achieve such marvels.
Evolution News & Views
A biological revolution is underway. Technology has allowed field biologists to track individual animals as small as insects, allowing scientists, for the first time, to gain real-time data on their lifetime behaviors. A team using this technology says in PLOS ONE:
Recent advances in animal-tracking technology have brought within reach the goal of tracking every movement of individual animals over their entire lifetimes. The potential of such life-long tracks to advance our understanding of animal behaviour has been compared to that of the advent of DNA sequencing, but the field is still in its infancy. [Emphasis added.]
If you saw Flight: The Genius of Birds you may remember how tiny geolocators allowed Carsten Egevang's team to monitor the pole-to-pole flight paths of Arctic terns from one year to the next. We've also reported on subsequent studies using geolocators on blackpoll warblers, frigate birds, and even giant flower beetles. Now, a team from Queen Mary University of London has attached radar antennas to bumblebees' heads, allowing them to monitor the entire lifetime flight behavior of these important pollinators.
The work adds to previous research that was more limited. Earlier teams used harmonic radar to track initial flights of bees. This is the first time that the technology was used to monitor the lifetime flights of four bumblebees (Bombus terrestris) over 6-15 days until contact was lost.
The studies described above revealed a great deal about the structure of exploratory and foraging flights, but opened up a number of key questions that are unanswered as yet. Does the change in flight structure from inexperienced to experienced bees occur gradually or as a sudden transition? When and how do bees discover the forage sources they go on to exploit? No prior study has been able to track the activity of individual insects throughout their entire life history, or even a significant portion of their life, making it impossible to address these questions.
You can see the headgear worn by the test bees in a summary on PhysOrg. There will always be some doubt about measurements obtained this way. Did the headgear alter the bees' normal behavior? Were they treated differently by other bees because they look weird? The scientists acknowledged other limitations of the study, such as the fact they were conducted sequentially, when different flowers were in bloom, and employed individuals from different colonies in different locations under different weather conditions. Nevertheless, they reached some tentative conclusions based on 15,000 minutes of data from 244 flights covering 180 kilometers.
Woodgate et al. were surprised to find more individuality than expected. "One of the most striking results to emerge from these data is the large degree to which our bees differed from one another," they write. The bees were not like little robots following a predetermined flight strategy. Each one divided its time differently between exploration of new food sources and exploitation of known food sources. One bee was a "lifelong vagabond," never settling down on any favorite patch. Another one, by contrast, quickly devoted most of its energy to patches with a high payoff. Overall, the pollinators seemed to balance their time between exploitation and exploration. It's a smart strategy, Woodgate says in the PhysOrg article:
"This study provided an unprecedented look at where the bees flew, how their behaviour changed as they gained experience and how they balanced the need to explore their surroundings - looking for good patches of flowers -- with the desire to collect as much food as possible from the places they had already discovered."
The bees made from 3 to 15 flights per day, depending on the distance to and quality of the resources. In general, exploratory flights occur within the first few days. That's when they discover most of the goods that they will return to most often. They will, however, make further exploratory flights at any time. The radar maps of their flight paths show extensive exploration of their surroundings in all directions, implying substantial brain power for memory, orientation and strategy to navigate over large areas and still find their way home.
Future work with larger numbers of bees, monitored simultaneously, will undoubtedly add to knowledge about their behaviors. For now, it appears that bumblebee colonies are programmed to use optimization algorithms - an indicator of intelligent design encoded in their brains. These algorithms work at both the individual and collective level. Variability leads some individuals to bring a lot of food back from reliable sources, and some to explore the environment for new and possibly better sources.
Although it is expected that randomly chosen individuals will tend to show variation in behaviour, the extent of the inter-individual differences we observed in flight behaviour is dramatic. These differences appear to persist over the bees' entire foraging career, and are likely to lead to high levels of variation in the contribution different foragers make to provisioning the colony.
An Instrument View of Bee Optimization
We've looked at lifetime flight behavior of these amazing flyers. Another article explores the flight equipment in more detail. The journal eLife reports new findings about how honeybees (Apis mellifera) position their antennae during flight. Antennae are well known as olfactory and tactile sense organs. During flight, they perform additional roles as speedometers and odometers. Experiments in wind tunnels showed that honeybees will position their antennae forward or backward in flight to measure speed, distance and odor sources:
To investigate how honeybees use different types of sensory information to position their antennae during flight, Roy Khurana and Sane first placed freely-flying and tethered bees in a wind tunnel. Flying forward causes air to flow from the front to the back of the bee. The experiments revealed that a bee brings its antennae forward and holds them in a specific position that depends on the rate of airflow. As the bee flies forward more quickly (or airflow increases), the antennae are positioned further forward.
Roy Khurana and Sane then investigated how the movement of images across the insect's eyes causes their antennae to change position. This unexpectedly revealed that moving images across the eye from front to back, which simulates what bees see when flying forward, causes the bees to move their antennae backward. However, exposing the bees to both the frontal airflow and front-to-back image motion as normally experienced during forward flight caused the bees to maintain their antennae in a fixed position. This behaviour results from the opposing responses of the antennae to the two stimuli.
This appears to be another optimization problem solved by the bees, because the mechanosensory input from the antennae can override the visual sense:
When flying in unpredictable conditions, sensory cues from a single modality are often unreliable measures of the ambient environmental parameters. For instance, purely optic flow-based measurements of self-motion can be misleading for insects which experience sideslip while flying in a crosswind. Moreover, reliance on optic flow may be problematic under dimly lit or overcast conditions, or when flying over lakes or deserts which present sparse visual feedback. In such situations, sampling from multiple sensory cues reduces the ambiguity arising from variability in feedback from single modalities (Wehner, 2003; Sherman and Dickinson, 2004; Wasserman et al., 2015). Hence, the integration of multimodal sensory cues is essential for most natural locomotory behaviours, including insect flight manoeuvres (Willis and Arbas, 1991; Frye et al., 2003; Verspui and Gray, 2009).
The researchers found that antenna position is part of this "multimodal sensory integration" that maximizes useful information from multiple -- sometimes antagonistic -- sources. It's like the IFR-trained pilot who learns to trust his instruments instead of his eyes when the sensory data seem to conflict.
Combined with bees' electrical sense, these pollinators of flowers and crops are pretty amazing little creatures. Neither paper explained how these abilities might have evolved. The second one on antenna positioning only mentions the "evolutionary significance of its function" because flight is impaired when it's broken. Blind processes don't achieve such marvels.
Darwinism v.the real world.XXXI
The Mystery of Vision
Howard Glicksman
Editor's note: Physicians have a special place among the thinkers who have elaborated the argument for intelligent design. Perhaps that's because, more than evolutionary biologists, they are familiar with the challenges of maintaining a functioning complex system, the human body. With that in mind, Evolution News is delighted to offer this series, "The Designed Body." For the complete series, see here. Dr. Glicksman practices palliative medicine for a hospice organization.
Everyone knows that an odometer measures distance and a speedometer measures velocity. But how do they do it? Each device is essentially a sensory transducer with a mechanism that enables it to sense a physical phenomenon and convert it into useful information. The body has sensory transducers as well that it uses to detect physical phenomena and know what is going on within and without. Vision is the sensation we experience when light, usually reflecting off an object that is within a very narrow range of frequency, enters our eyes.
Common sense teaches that without this special sense our earliest ancestors could never have survived. Evolutionary biologists claim that the presence of different light-sensitive organs in early life forms made it easy for chance and the laws of nature alone to bring about vision. But just like the development of various inventions and technologies, all human experience teaches that intelligent design is a much more plausible explanation. The position of Darwinists not only oversimplifies the development of the irreducibly complex eye, but also does not take into account how our brain converts what it receives from our eyes so that we experience vision.
Nobody, not even evolutionary biologists, truly understands this mystery. The fact that nobody understands it should make any scientist wary of claiming to know how the eye and vision came into being. Yet Darwinists rush in to do just that. Let's look at what makes up the eye, how it works, what the brain receives from it, and how it converts that information into the sensation we call sight.
The human eye is a very complex sensory organ in which many parts work together to focus light on its retina. Although it is in the retina where the nerve impulses for vision begin, the other parts of the eye play important roles that support and protect retinal function. The five different bones that make up the orbital cavity protect about two-thirds of the eyeball and provide the base for the origin tendons of the muscles responsible for eye movement. The eyelids and lashes protect the eye from exposure to too much light or dust, dirt, bacteria, and other foreign objects. A film of tears, consisting of oil, water, and mucus is produced by the oil glands of the eyelids, the lacrimal gland, and the conjunctiva that overlies the sclera (the white outer protective coating of the eyeball). The tear film lubricates the eye, protects it from infection and injury, nourishes the surrounding tissue, and preserves a smooth surface to aid in light transmission.
The cornea is a transparent connective tissue that protects the front of the eye while allowing light to enter. The cornea is transparent because it lacks blood vessels (avascular), instead receiving oxygen, water, and nutrients from two sources. One is the tears that constantly wash across it by the blinking eyelids, and the other is the clear fluid (aqueous humor) within the anterior chamber that sits behind the cornea and in front of the lens. Light rays that reflect from an object more than twenty feet away enter parallel to each other and must be bent (refracted) to focus them on the area in the retina for central (macula) and sharp vision (fovea). The cornea's curvature plays a major role in focusing the light that enters the eye onto the retina.
The lens is a transparent, elastic biconvex structure that is kept in place by suspensory ligaments. Like the cornea, it is avascular and obtains its oxygen, water, and nutrients from the aqueous humor in the anterior chamber. As noted above, light rays from a distance (greater than twenty feet) enter the eye in parallel, whereas those from nearby (generally less than twenty feet away) spread out. To focus the light on the macula and fovea, this diverging light must be further refracted and the biconvex curvature of the lens accomplishes this task. Since what the eye focuses on close-up is always changing, the curvature of the lens can be reflexively adjusted (accommodation) so that the light rays will strike the retina in the area for sharp vision.
The choroid is the layer of tissue located between the sclera and the retina and provides the circulation to the back of the eye. The choroid also contains the retinal pigmented epithelium, which sits behind the retina and absorbs light. This prevents light from reflecting back on the photoreceptors and causing visual blurring. The extension of the choroid in the front of the eye is the colored iris, consisting of two different muscles that control the amount of light that enters through its opening (pupil).
Finally, the thick, transparent, and gelatinous substance that forms and shapes the eyeball is the vitreous. It is able to compress and return to its natural position, allowing the eyeball to withstand most physical stresses without serious injury.
Each eye has about one hundred twenty million rods arranged throughout the retina. The rods contain a photopigment called rhodopsin which is very sensitive to all the wavelengths of the visible light spectrum. In contrast, there are only about six million cones that are mostly concentrated in the macula, primarily in the cone-only fovea. Each cone contains one of three different photosensitive pigments, called photopsins, which tend to react stronger to either the red, green, or blue wavelengths of light. Both rhodopsin and the photopsins are dependent on Vitamin A.
When photons of light strike the retina they interact with the photoreceptor cells and cause an electrical change and the release of a neurotransmitter. Messages are passed through interconnecting neurons within the retina. These retinal interneurons process the information and send the resulting nerve signals along the optic nerve to the brain. About eighty percent of the optic nerve impulses travel to neurons within the brain. These pass on the sensory information to the visual cortex in the occipital lobes. However, the remaining twenty percent veer off and provide sensory data to the neurons in the brainstem that service muscles that help the eye to function better and provide protection.
For example, if you enter a dark room, the dilating muscle of the iris immediately contracts, causing the pupil to enlarge. This lets more light into the eye to help improve vision. But if you shine a bright light into your eye, the contracting muscle of the iris instantly goes into action, causing the pupil to diminish in size to protect the retina from too much light. This is called the pupillary light reflex, which is often used by physicians to determine the presence of brainstem function.
In considering the nature of the sensory data being presented from the eyes to the visual cortex, several points must be kept in mind. First, the use of the cornea and lens to refract and focus light on the retina results in a reversed and upside-down image. This means that what appears in the right upper half of the visual field is detected by the left lower half of the retina and what appears in the left lower half of the visual field is detected by the right upper half of the retina etc. Second, looking through one eye shows that there is an overlap in the nasal visual fields (the right half of the left eye and the left half of the right eye). This overlap provides the visual cortex with two different perspectives and allows for depth perception.
Finally, impulses sent along each optic nerve split-up on their way to the brain. The messages from the nasal half of the retina cross over from right to left and from left to right through what is called the optic chiasm. However the impulses from the temporal half of the retina (the left half of the left eye and the right half of the right eye) stay on the same side. This means that everything seen by the right half of each eye (the nasal field of the left eye and the temporal field of the right eye) goes to the left occipital lobe and everything seen by the left half of each eye (the nasal field of the right eye and the temporal field of the left eye) goes to the right occipital lobe. Our brain then takes this upside down, turned around, split-up and overlapping collection of photon-generated nerve impulses and provides us with what we experience as vision. How it is able to accomplish this feat remains entirely unknown.
If you have ever used a magnifying glass to focus light onto a paper to make it burn, then you know that the refractive power of a lens is dependent on its degree of curvature, which is inversely related to the distance it takes to bring the light together at a focal point. The higher the refractive power, the shorter the focal distance, and vice versa. The eye is dependent on the combined refractive power of the cornea and the lens (58 diopters) to focus light onto the area of the retina for sharp vision. And as luck would have it, the distance from the cornea to the retina (23 mm) is exactly what it should be to get the job done. What do you know?
For our earliest ancestors to have been able to safely find food and water and properly prepare and handle it for ingestion, would have required them having normal distance and near vision. Eye doctors know that about a four percent increase in the combined refractive power of the cornea and lens (or a lengthening of the eye) results in severe myopia (not being able to see the big E on the eye chart clearly). And a twenty five percent decrease in both of these leads to difficulties with distance and near vision.
When evolutionary biologists talk about vision, not only do they leave out how it is irreducibly complex (all of the parts of the eye and the brain are needed for proper function) but also that it demonstrates natural survival capacity, in that the combined refractive power of the cornea and lens and the lens's ability to adjust to close-up objects perfectly matches the diameter of the eyeball. Remember, when it comes to life and the laws of nature, real numbers have real consequences. Without the right refractive power or eyeball diameter our earliest ancestors would have been as blind as bats.
But in that case, as some people mistakenly argue, evolution would have just made them develop sonar instead, because that would have been what they needed to survive. Next time we'll look at hearing.
Howard Glicksman
Editor's note: Physicians have a special place among the thinkers who have elaborated the argument for intelligent design. Perhaps that's because, more than evolutionary biologists, they are familiar with the challenges of maintaining a functioning complex system, the human body. With that in mind, Evolution News is delighted to offer this series, "The Designed Body." For the complete series, see here. Dr. Glicksman practices palliative medicine for a hospice organization.
Everyone knows that an odometer measures distance and a speedometer measures velocity. But how do they do it? Each device is essentially a sensory transducer with a mechanism that enables it to sense a physical phenomenon and convert it into useful information. The body has sensory transducers as well that it uses to detect physical phenomena and know what is going on within and without. Vision is the sensation we experience when light, usually reflecting off an object that is within a very narrow range of frequency, enters our eyes.
Common sense teaches that without this special sense our earliest ancestors could never have survived. Evolutionary biologists claim that the presence of different light-sensitive organs in early life forms made it easy for chance and the laws of nature alone to bring about vision. But just like the development of various inventions and technologies, all human experience teaches that intelligent design is a much more plausible explanation. The position of Darwinists not only oversimplifies the development of the irreducibly complex eye, but also does not take into account how our brain converts what it receives from our eyes so that we experience vision.
Nobody, not even evolutionary biologists, truly understands this mystery. The fact that nobody understands it should make any scientist wary of claiming to know how the eye and vision came into being. Yet Darwinists rush in to do just that. Let's look at what makes up the eye, how it works, what the brain receives from it, and how it converts that information into the sensation we call sight.
The human eye is a very complex sensory organ in which many parts work together to focus light on its retina. Although it is in the retina where the nerve impulses for vision begin, the other parts of the eye play important roles that support and protect retinal function. The five different bones that make up the orbital cavity protect about two-thirds of the eyeball and provide the base for the origin tendons of the muscles responsible for eye movement. The eyelids and lashes protect the eye from exposure to too much light or dust, dirt, bacteria, and other foreign objects. A film of tears, consisting of oil, water, and mucus is produced by the oil glands of the eyelids, the lacrimal gland, and the conjunctiva that overlies the sclera (the white outer protective coating of the eyeball). The tear film lubricates the eye, protects it from infection and injury, nourishes the surrounding tissue, and preserves a smooth surface to aid in light transmission.
The cornea is a transparent connective tissue that protects the front of the eye while allowing light to enter. The cornea is transparent because it lacks blood vessels (avascular), instead receiving oxygen, water, and nutrients from two sources. One is the tears that constantly wash across it by the blinking eyelids, and the other is the clear fluid (aqueous humor) within the anterior chamber that sits behind the cornea and in front of the lens. Light rays that reflect from an object more than twenty feet away enter parallel to each other and must be bent (refracted) to focus them on the area in the retina for central (macula) and sharp vision (fovea). The cornea's curvature plays a major role in focusing the light that enters the eye onto the retina.
The lens is a transparent, elastic biconvex structure that is kept in place by suspensory ligaments. Like the cornea, it is avascular and obtains its oxygen, water, and nutrients from the aqueous humor in the anterior chamber. As noted above, light rays from a distance (greater than twenty feet) enter the eye in parallel, whereas those from nearby (generally less than twenty feet away) spread out. To focus the light on the macula and fovea, this diverging light must be further refracted and the biconvex curvature of the lens accomplishes this task. Since what the eye focuses on close-up is always changing, the curvature of the lens can be reflexively adjusted (accommodation) so that the light rays will strike the retina in the area for sharp vision.
The choroid is the layer of tissue located between the sclera and the retina and provides the circulation to the back of the eye. The choroid also contains the retinal pigmented epithelium, which sits behind the retina and absorbs light. This prevents light from reflecting back on the photoreceptors and causing visual blurring. The extension of the choroid in the front of the eye is the colored iris, consisting of two different muscles that control the amount of light that enters through its opening (pupil).
Finally, the thick, transparent, and gelatinous substance that forms and shapes the eyeball is the vitreous. It is able to compress and return to its natural position, allowing the eyeball to withstand most physical stresses without serious injury.
Each eye has about one hundred twenty million rods arranged throughout the retina. The rods contain a photopigment called rhodopsin which is very sensitive to all the wavelengths of the visible light spectrum. In contrast, there are only about six million cones that are mostly concentrated in the macula, primarily in the cone-only fovea. Each cone contains one of three different photosensitive pigments, called photopsins, which tend to react stronger to either the red, green, or blue wavelengths of light. Both rhodopsin and the photopsins are dependent on Vitamin A.
When photons of light strike the retina they interact with the photoreceptor cells and cause an electrical change and the release of a neurotransmitter. Messages are passed through interconnecting neurons within the retina. These retinal interneurons process the information and send the resulting nerve signals along the optic nerve to the brain. About eighty percent of the optic nerve impulses travel to neurons within the brain. These pass on the sensory information to the visual cortex in the occipital lobes. However, the remaining twenty percent veer off and provide sensory data to the neurons in the brainstem that service muscles that help the eye to function better and provide protection.
For example, if you enter a dark room, the dilating muscle of the iris immediately contracts, causing the pupil to enlarge. This lets more light into the eye to help improve vision. But if you shine a bright light into your eye, the contracting muscle of the iris instantly goes into action, causing the pupil to diminish in size to protect the retina from too much light. This is called the pupillary light reflex, which is often used by physicians to determine the presence of brainstem function.
In considering the nature of the sensory data being presented from the eyes to the visual cortex, several points must be kept in mind. First, the use of the cornea and lens to refract and focus light on the retina results in a reversed and upside-down image. This means that what appears in the right upper half of the visual field is detected by the left lower half of the retina and what appears in the left lower half of the visual field is detected by the right upper half of the retina etc. Second, looking through one eye shows that there is an overlap in the nasal visual fields (the right half of the left eye and the left half of the right eye). This overlap provides the visual cortex with two different perspectives and allows for depth perception.
Finally, impulses sent along each optic nerve split-up on their way to the brain. The messages from the nasal half of the retina cross over from right to left and from left to right through what is called the optic chiasm. However the impulses from the temporal half of the retina (the left half of the left eye and the right half of the right eye) stay on the same side. This means that everything seen by the right half of each eye (the nasal field of the left eye and the temporal field of the right eye) goes to the left occipital lobe and everything seen by the left half of each eye (the nasal field of the right eye and the temporal field of the left eye) goes to the right occipital lobe. Our brain then takes this upside down, turned around, split-up and overlapping collection of photon-generated nerve impulses and provides us with what we experience as vision. How it is able to accomplish this feat remains entirely unknown.
If you have ever used a magnifying glass to focus light onto a paper to make it burn, then you know that the refractive power of a lens is dependent on its degree of curvature, which is inversely related to the distance it takes to bring the light together at a focal point. The higher the refractive power, the shorter the focal distance, and vice versa. The eye is dependent on the combined refractive power of the cornea and the lens (58 diopters) to focus light onto the area of the retina for sharp vision. And as luck would have it, the distance from the cornea to the retina (23 mm) is exactly what it should be to get the job done. What do you know?
For our earliest ancestors to have been able to safely find food and water and properly prepare and handle it for ingestion, would have required them having normal distance and near vision. Eye doctors know that about a four percent increase in the combined refractive power of the cornea and lens (or a lengthening of the eye) results in severe myopia (not being able to see the big E on the eye chart clearly). And a twenty five percent decrease in both of these leads to difficulties with distance and near vision.
When evolutionary biologists talk about vision, not only do they leave out how it is irreducibly complex (all of the parts of the eye and the brain are needed for proper function) but also that it demonstrates natural survival capacity, in that the combined refractive power of the cornea and lens and the lens's ability to adjust to close-up objects perfectly matches the diameter of the eyeball. Remember, when it comes to life and the laws of nature, real numbers have real consequences. Without the right refractive power or eyeball diameter our earliest ancestors would have been as blind as bats.
But in that case, as some people mistakenly argue, evolution would have just made them develop sonar instead, because that would have been what they needed to survive. Next time we'll look at hearing.
Monday 1 August 2016
Dual coding genes in the dock for design
Dual-Coding Genes "Nearly Impossible by Chance" -- How Would Francisco Ayala Respond.
Casey Luskin
We mortals are easily impressed by palindromes -- words or phrases that have the same spelling forwards and backwards. But try writing a sentence which has two different meanings: One meaning is gained when you start with one letter of the first word, and then an entirely different meaning is understood when you start reading with the second letter of the first word. Such a sentence would be most impressive, but what if such "sentences" existed in our DNA?
Leading evolutionary biologist Francisco Ayala recently wrote in Proceedings for the National Academy of Sciences (PNAS) that "Chance is an integral part of the evolutionary process." Ayala then explained why he thinks Darwinian evolution is right and ID is wrong: "Biological evolution differs from a painting or an artifact in that it is not the outcome of preconceived design. The design of organisms is not intelligent but imperfect and, at times, outright dysfunctional." ("Darwin's greatest discovery: Design without designer," PNAS, 104:8567--8573 (May 15, 2007), emphasis added.) This questionable standard and conclusion is Ayala's punchline against ID.
What, then, does Ayala think of organisms whose design is intelligent and highly functional? A recent article in Public Library of Science discussed how dual-coding genes -- genes which overlap and code for multiple proteins when read through different reading frames -- are "hallmarks of fascinating biology" and "nearly impossible by chance" to the extent that evolutionary biologists have held "skepticism surrounding" their very existence. Now it seems they do exist, and they don't quite match Ayala's vision of biology, where "[c]hance is an integral part" of the "design of organisms is "dysfunctional" and "not intelligent." As the article, "A First Look at ARFome: Dual-Coding Genes in Mammalian Genomes," states:
Coding of multiple proteins by overlapping reading frames is not a feature one would associate with eukaryotic genes. Indeed, codependency between codons of overlapping protein-coding regions imposes a unique set of evolutionary constraints, making it a costly arrangement. Yet in cases of tightly coexpressed interacting proteins, dual coding may be advantageous. Here we show that although dual coding is nearly impossible by chance, a number of human transcripts contain overlapping coding regions. Using newly developed statistical techniques, we identified 40 candidate genes with evolutionarily conserved overlapping coding regions. Because our approach is conservative, we expect mammals to possess more dual-coding genes. Our results emphasize that the skepticism surrounding eukaryotic dual coding is unwarranted: rather than being artifacts, overlapping reading frames are often hallmarks of fascinating biology.
(Wen-Yu Chung, Samir Wadhawan, Radek Szklarczyk, Sergei Kosakovsky Pond, Anton Nekrutenko, "A First Look at ARFome: Dual-Coding Genes in Mammalian Genomes," PLOS Computational Biology, Vol. 3(5) (May, 2007), emphasis added.)
Does this sound like a "dysfunctional" process that is "not intelligent" in its design?
Casey Luskin
We mortals are easily impressed by palindromes -- words or phrases that have the same spelling forwards and backwards. But try writing a sentence which has two different meanings: One meaning is gained when you start with one letter of the first word, and then an entirely different meaning is understood when you start reading with the second letter of the first word. Such a sentence would be most impressive, but what if such "sentences" existed in our DNA?
Leading evolutionary biologist Francisco Ayala recently wrote in Proceedings for the National Academy of Sciences (PNAS) that "Chance is an integral part of the evolutionary process." Ayala then explained why he thinks Darwinian evolution is right and ID is wrong: "Biological evolution differs from a painting or an artifact in that it is not the outcome of preconceived design. The design of organisms is not intelligent but imperfect and, at times, outright dysfunctional." ("Darwin's greatest discovery: Design without designer," PNAS, 104:8567--8573 (May 15, 2007), emphasis added.) This questionable standard and conclusion is Ayala's punchline against ID.
What, then, does Ayala think of organisms whose design is intelligent and highly functional? A recent article in Public Library of Science discussed how dual-coding genes -- genes which overlap and code for multiple proteins when read through different reading frames -- are "hallmarks of fascinating biology" and "nearly impossible by chance" to the extent that evolutionary biologists have held "skepticism surrounding" their very existence. Now it seems they do exist, and they don't quite match Ayala's vision of biology, where "[c]hance is an integral part" of the "design of organisms is "dysfunctional" and "not intelligent." As the article, "A First Look at ARFome: Dual-Coding Genes in Mammalian Genomes," states:
Coding of multiple proteins by overlapping reading frames is not a feature one would associate with eukaryotic genes. Indeed, codependency between codons of overlapping protein-coding regions imposes a unique set of evolutionary constraints, making it a costly arrangement. Yet in cases of tightly coexpressed interacting proteins, dual coding may be advantageous. Here we show that although dual coding is nearly impossible by chance, a number of human transcripts contain overlapping coding regions. Using newly developed statistical techniques, we identified 40 candidate genes with evolutionarily conserved overlapping coding regions. Because our approach is conservative, we expect mammals to possess more dual-coding genes. Our results emphasize that the skepticism surrounding eukaryotic dual coding is unwarranted: rather than being artifacts, overlapping reading frames are often hallmarks of fascinating biology.
(Wen-Yu Chung, Samir Wadhawan, Radek Szklarczyk, Sergei Kosakovsky Pond, Anton Nekrutenko, "A First Look at ARFome: Dual-Coding Genes in Mammalian Genomes," PLOS Computational Biology, Vol. 3(5) (May, 2007), emphasis added.)
Does this sound like a "dysfunctional" process that is "not intelligent" in its design?
Predarwinian tech for design.
Rotary Engine Technology in Living Cells
Evolution News & Views
Gone are the days when evolutionists asserted that life would never produce wheels or gears. It was impossible, they thought, for structures like that to arrive by natural selection, because too many coordinated mutations would be required. A wheel without an axle would provide no fitness advantage. One gear could achieve nothing without a matching gear. That was before we learned about the planthopper with its gear-driven jumping feet and the exquisite rotary engines of cells: the bacterial flagellum and the ATP synthase motor, on which all life depends.
Since ATP synthase earned its discoverers a Nobel Prize in 1997, it has remained an object of fascination. New imaging techniques have been steadily improving the focus on these miniature rotary motors that measure a mere 20 x 10 nanometers (billionths of a meter) yet spin at up to 42,000 rpm (see here), generating 3 ATP per revolution. As some years have passed since we discussed these motors in detail, readers may wish to pause to refresh their memories with our video about these amazing machines before learning about some new discoveries:
The Glue-bricator
Even at their tiny scale, molecular motors have to deal with laws of physics that might limit their efficiency. These laws include friction and thermodynamics. A new essential fatty acid, named cardiolipin, has been identified in the membrane right where protons enter to drive rotation in the Fo ring. Cambridge scientists describe it in the Proceedings of the National Academy of Sciences as a molecule that "binds selectively but transiently to conserved lysine residues in the rotor," appearing to function both as a stabilizer (glue) and a lubricant.
It interacts specifically, transiently, and repeatedly with the rotor of the machine, possibly lubricating its rotation or participating directly in the generation of rotation from the transmembrane proton motive force. [Emphasis added.]
The interactions are "highly specific" in location and timing, the authors say:
These highly specific but brief interactions with the rotating c-ring are consistent with functional roles for cardiolipin in stabilizing and lubricating the rotor, and, by interacting with the enzyme at the inlet and exit of the transmembrane proton channel, in participation in proton translocation through the membrane domain of the enzyme.
In a review article in PNAS, two researchers from Max Planck Institute find this remarkable about the already "remarkable proteins that regenerate the molecular fuel for cellular processes in all domains of life." The Cambridge team "found a remarkable interaction pattern" in the glue-lubricator molecule cardiolipin (CL).
The results of Duncan et al. have major implications for our understanding of Fo action. Efficient c-ring rotation demands minimal friction with the surrounding membrane. Tightly bound CL, with the long residence times reported for cytochrome c oxidase and cytochrome bc1, could be unfavorable. Such tight interactions should interfere particularly with the functionally required rotation of the c-ring past the a-subunit. A tightly bound lipid would lock the rotor in a manner similar to some inhibitors. However, selective binding of CL to the c-ring appears to be required for the function and assembly of ATP synthase. The results of Duncan et al. help resolve this paradox: CL binds selectively but, at the same time, intermittently. In complexes III and IV, CL appears to act as a bridging glue; by contrast, it acts here as a lubricant.
This interaction clearly requires careful fine-tuning. Too much glue function would make the motor seize up. Too much lubricant would impair the ability of proton motive force to drive the rotor. High-resolution images of this interaction are eagerly awaited, they say; "Looking forward, we can expect further exciting developments in the CL story." And that story goes beyond just this molecular machine. The Cambridge scientists "point the way for both experimentation and computation to explore one of the most fundamental questions of molecular membrane biology: protein-lipid interactions in ATP synthase and beyond."
Freeze Frame
Freezing the little motors for cryo-electron microscopy has revealed details previously unnoticed. Two Canadian researchers review what is known about ATP synthase and its cousins, the vacuolar ATPases (V-ATPase) we wrote about last year. Now that cryo-EM has reached 6.9 angstrom resolution, the authors, writing in Science Advances, remind us that mutations to V-ATPase can lead to serious disorders, including kidney malfunction, brittle bones, cancer, and even deafness. No wonder the genetic sequences that build these machines are "highly conserved" down to specific amino acids. Here are some tidbits from the review:
More than a third of an organism's genome is devoted to the construction of membrane-embedded proteins.
Some F-type ATP synthases can work in reverse, pumping protons instead of using them to make ATP. Some can also pump sodium ions.
In eukaryotes, vacuolar ATPases can adjust the pH (acidity) inside of organelles. In archaea and some bacteria, they can adjust the pH outside the cell.
Since 10 protons in the Fo domain lead to 3 ATP in the F1 domain, scientists think that intrinsic flexibility of most F-type ATP synthases appears necessary for efficient function.
The most difficult parts to image are two half-channels embedded in the membrane that deliver protons to the rotating c-ring. Specifically placed arginine and glutamate residues appear to be thermodynamically essential for transferring the protons into the c-ring carousel and making it turn.
In some eukaryotes, vacuolar ATPases can dissociate their two primary components, essentially deactivating some of them to regulate their activity.
Within yeast cells, different isoforms of the ATPases can be found. One particular 62-residue loop shows the least sequence conservation. "Although a lack of conservation often indicates a lack of functional importance, evolutionary covariance analysis shows that this sequence varies between different sequences for the a-subunit in a remarkably coordinated way," the authors say. "Consequently, the proximity of this loop to the cytoplasmic half-channel, its net charge, and its isoform-dependent sequence suggest a functional role that differs in different subcellular compartments."
"V-ATPases have many interacting partners in cells, a testament to their importance in cell physiology."
When J.B.S. Haldane argued in a 1949 debate that natural selection would not be expected to produce wheels or magnets, he basically proposed a test: finding such structures would falsify Darwinian evolution. But holding evolutionists to their rules is like trying to win at Calvinball; they can change the rules of the game as they play. In 2003, molecular biologist Robin Holliday pulled a fast one. Knowing about ATP synthase and the bacterial flagellum by that time, he imagined that wheels should be ubiquitous, not limited to a few forms. Wikipedia says that he argued that "the absence of biological wheels argues against creationist or intelligent design accounts of the diversity of life, because an intelligent creator -- free of the limitations imposed by evolution -- would be expected to deploy wheels wherever they would be of use." Uncommon Descent responded:
Wheels need roads. Roads require a lot of exhausting, expensive maintenance and must be defended/policed. The off-road vehicle is a late invention because in former times, its function was performed by life forms who didn't need roads, like horses and camels.
Which the designer of nature did invent.
Holliday used a religious argument. He (and Wikipedia) should stick to science. In our uniform experience, machines and rotary engines are products of intelligent causes. So when we find rotary engines in living things, the inference to the best explanation is that intelligence had a role in their origin. That inference is strengthened by their abrupt appearance, ubiquity, conservation, efficiency, irreducible complexity in both structure and interactions, and indispensable functionality. It also helps to see that they are manufactured from coded instructions. Let the evidence drive the conclusions.
Evolution News & Views
Gone are the days when evolutionists asserted that life would never produce wheels or gears. It was impossible, they thought, for structures like that to arrive by natural selection, because too many coordinated mutations would be required. A wheel without an axle would provide no fitness advantage. One gear could achieve nothing without a matching gear. That was before we learned about the planthopper with its gear-driven jumping feet and the exquisite rotary engines of cells: the bacterial flagellum and the ATP synthase motor, on which all life depends.
Since ATP synthase earned its discoverers a Nobel Prize in 1997, it has remained an object of fascination. New imaging techniques have been steadily improving the focus on these miniature rotary motors that measure a mere 20 x 10 nanometers (billionths of a meter) yet spin at up to 42,000 rpm (see here), generating 3 ATP per revolution. As some years have passed since we discussed these motors in detail, readers may wish to pause to refresh their memories with our video about these amazing machines before learning about some new discoveries:
The Glue-bricator
Even at their tiny scale, molecular motors have to deal with laws of physics that might limit their efficiency. These laws include friction and thermodynamics. A new essential fatty acid, named cardiolipin, has been identified in the membrane right where protons enter to drive rotation in the Fo ring. Cambridge scientists describe it in the Proceedings of the National Academy of Sciences as a molecule that "binds selectively but transiently to conserved lysine residues in the rotor," appearing to function both as a stabilizer (glue) and a lubricant.
It interacts specifically, transiently, and repeatedly with the rotor of the machine, possibly lubricating its rotation or participating directly in the generation of rotation from the transmembrane proton motive force. [Emphasis added.]
The interactions are "highly specific" in location and timing, the authors say:
These highly specific but brief interactions with the rotating c-ring are consistent with functional roles for cardiolipin in stabilizing and lubricating the rotor, and, by interacting with the enzyme at the inlet and exit of the transmembrane proton channel, in participation in proton translocation through the membrane domain of the enzyme.
In a review article in PNAS, two researchers from Max Planck Institute find this remarkable about the already "remarkable proteins that regenerate the molecular fuel for cellular processes in all domains of life." The Cambridge team "found a remarkable interaction pattern" in the glue-lubricator molecule cardiolipin (CL).
The results of Duncan et al. have major implications for our understanding of Fo action. Efficient c-ring rotation demands minimal friction with the surrounding membrane. Tightly bound CL, with the long residence times reported for cytochrome c oxidase and cytochrome bc1, could be unfavorable. Such tight interactions should interfere particularly with the functionally required rotation of the c-ring past the a-subunit. A tightly bound lipid would lock the rotor in a manner similar to some inhibitors. However, selective binding of CL to the c-ring appears to be required for the function and assembly of ATP synthase. The results of Duncan et al. help resolve this paradox: CL binds selectively but, at the same time, intermittently. In complexes III and IV, CL appears to act as a bridging glue; by contrast, it acts here as a lubricant.
This interaction clearly requires careful fine-tuning. Too much glue function would make the motor seize up. Too much lubricant would impair the ability of proton motive force to drive the rotor. High-resolution images of this interaction are eagerly awaited, they say; "Looking forward, we can expect further exciting developments in the CL story." And that story goes beyond just this molecular machine. The Cambridge scientists "point the way for both experimentation and computation to explore one of the most fundamental questions of molecular membrane biology: protein-lipid interactions in ATP synthase and beyond."
Freeze Frame
Freezing the little motors for cryo-electron microscopy has revealed details previously unnoticed. Two Canadian researchers review what is known about ATP synthase and its cousins, the vacuolar ATPases (V-ATPase) we wrote about last year. Now that cryo-EM has reached 6.9 angstrom resolution, the authors, writing in Science Advances, remind us that mutations to V-ATPase can lead to serious disorders, including kidney malfunction, brittle bones, cancer, and even deafness. No wonder the genetic sequences that build these machines are "highly conserved" down to specific amino acids. Here are some tidbits from the review:
More than a third of an organism's genome is devoted to the construction of membrane-embedded proteins.
Some F-type ATP synthases can work in reverse, pumping protons instead of using them to make ATP. Some can also pump sodium ions.
In eukaryotes, vacuolar ATPases can adjust the pH (acidity) inside of organelles. In archaea and some bacteria, they can adjust the pH outside the cell.
Since 10 protons in the Fo domain lead to 3 ATP in the F1 domain, scientists think that intrinsic flexibility of most F-type ATP synthases appears necessary for efficient function.
The most difficult parts to image are two half-channels embedded in the membrane that deliver protons to the rotating c-ring. Specifically placed arginine and glutamate residues appear to be thermodynamically essential for transferring the protons into the c-ring carousel and making it turn.
In some eukaryotes, vacuolar ATPases can dissociate their two primary components, essentially deactivating some of them to regulate their activity.
Within yeast cells, different isoforms of the ATPases can be found. One particular 62-residue loop shows the least sequence conservation. "Although a lack of conservation often indicates a lack of functional importance, evolutionary covariance analysis shows that this sequence varies between different sequences for the a-subunit in a remarkably coordinated way," the authors say. "Consequently, the proximity of this loop to the cytoplasmic half-channel, its net charge, and its isoform-dependent sequence suggest a functional role that differs in different subcellular compartments."
"V-ATPases have many interacting partners in cells, a testament to their importance in cell physiology."
When J.B.S. Haldane argued in a 1949 debate that natural selection would not be expected to produce wheels or magnets, he basically proposed a test: finding such structures would falsify Darwinian evolution. But holding evolutionists to their rules is like trying to win at Calvinball; they can change the rules of the game as they play. In 2003, molecular biologist Robin Holliday pulled a fast one. Knowing about ATP synthase and the bacterial flagellum by that time, he imagined that wheels should be ubiquitous, not limited to a few forms. Wikipedia says that he argued that "the absence of biological wheels argues against creationist or intelligent design accounts of the diversity of life, because an intelligent creator -- free of the limitations imposed by evolution -- would be expected to deploy wheels wherever they would be of use." Uncommon Descent responded:
Wheels need roads. Roads require a lot of exhausting, expensive maintenance and must be defended/policed. The off-road vehicle is a late invention because in former times, its function was performed by life forms who didn't need roads, like horses and camels.
Which the designer of nature did invent.
Holliday used a religious argument. He (and Wikipedia) should stick to science. In our uniform experience, machines and rotary engines are products of intelligent causes. So when we find rotary engines in living things, the inference to the best explanation is that intelligence had a role in their origin. That inference is strengthened by their abrupt appearance, ubiquity, conservation, efficiency, irreducible complexity in both structure and interactions, and indispensable functionality. It also helps to see that they are manufactured from coded instructions. Let the evidence drive the conclusions.
Sunday 31 July 2016
O.O.L requires technology say those who should know.
Scientists Say Intelligent Designer Needed for Origin of Life Chemistry
Casey Luskin
In a recent ENV post, Stephen Meyer critiqued a May 2009 Nature paper co-authored by John D. Sutherland titled, "Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions." The paper claimed to have produced RNA nucleobases under prebiotic conditions, but Meyer observed that it utterly failed to address the most crucial question in the origin of life (OOL): the origin of information, a topic Meyer addresses extensively in his new book Signature in the Cell.
Other scientists agree with Meyer. Organic chemist Dr. Charles Garner recently noted in private correspondence that "while this work helps one imagine how RNA might form, it does nothing to address the information content of RNA. So, yes, there was a lot of guidance by an intelligent chemist."
Sutherland's research produced only 2 of the 4 RNA nucleobases, and Dr. Garner also explained why, as is often the case, the basic chemistry itself also required the hand of an intelligent chemist:
As far as being relevant to OOL, the chemistry has all of the usual problems. The starting materials are "plausibly" obtainable by abiotic means, but need to be kept isolated from one another until the right step, as Sutherland admits. One of the starting materials is a single mirror image for which there is no plausible way to get it that way abiotically. Then Sutherland ran these reactions as any organic chemist would, with pure materials under carefully controlled conditions. In general, he purified the desired products after each step, and adjusted the conditions (pH, temperature, etc.) to maximum advantage along the way. Not at all what one would expect from a lagoon of organic soup. He recognized that making of a lot of biologically problematic side products was inevitable, but found that UV light applied at the right time and for the right duration could destroy much (?) of the junk without too much damage to the desired material. Meaning, of course, that without great care little of the desired chemistry would plausibly occur. But it is more than enough for true believers in OOL to rejoice over, and, predictably, to way overstate in the press.
Another anonymous pro-ID Ph.D. chemist privately wrote me similar criticisms of Sutherland's paper:
They used pH manipulation, phosphate buffers and irradiation all at the correct times and amounts to achieve their goal, which was to produce "activated pyrimidine ribonucleotides." Indeed, they could have shortened their title by chopping off the last four words and sent the paper to the Journal of Organic Synthesis and had a good chance of getting it accepted as a novel synthetic route with full credit to themselves for their clever manipulations. Certainly the fingerprints of several intelligent chemists are all over this pathway if not their rather ham fisted signatures.
Other control they exercised includes careful selection of the precursors, control of competing reactions by pH selection and the phenomenal phosphate concentration they used. Life in the modern ocean is phosphate limited as phosphate is generally about 0.5 micro-molar at the sea surface and only 2-4 micro-molar at depth. But what is a six order of magnitude enrichment among friends if it helps the cause!? Now they could argue that one gets that kind of enrichment in a tide pool but even that is a stretch.
Incidentally, now comes the hard parts: first, selectively hydrolyzing the cyclic 2', 3' phosphates to 3'- only, then getting them to polymerize ONLY at the 5' position. And second, once you have a supply of various RNA molecules, spontaneously developing the required biochemical structure to convert the coded sequences into proteins. Of course, we have to hope that we get lucky and we guess the correct code on the first try. And all of this has to happen in the same tide-pool otherwise, well, you get the picture. It's a bit of a stretch.
It is no wonder that whenever I see the word "plausible" in the title of an article, that I am reminded of the quote attributed to P.T. Barnum, "there is a sucker born every minute."
"Plausible" is in the Eye of the Beholder
There are thus many instances in this research where the conditions they used were anything but, as the paper's title claims, "prebiotically plausible conditions." One such instance may have been the careful addition of the 'just right' quantity of UV light, where even the original Nature paper admits: "Although the issue of temporally separated supplies of glycolaldehyde and glyceraldehyde remains a problem, a number of situations could have arisen that would result in the conditions of heating and progressive dehydration followed by cooling, rehydration and ultraviolet irradiation."
It's no groundbreaking news story that there are potential sources of heat on the early earth. These "number of situations" referred to typically include proposals of heating and drying in intertidal pools or volcanic ridges where repeated cycles of heating and drying can take place. But mundane sources of heat are only a small part of the problem, which largely comes down to the fact that the proper amount of heat has to be carefully applied so as to not wipeout the desired molecular products. It's quite easy to over-cook (or under-cook) the organic molecules, which tend to break down rapidly (i.e. cook) in the presence of heat. This would have to be a fine balancing act that would also require just the right input of organic material, heat, and UV light, so as to avoid destroying the molecules. In other words, it's a finely tuned system, the kind in which a successful scenario is very difficult to imagine without the input of intelligence. And of course, intelligently directed chemistry is exactly what provided the glycolaldehyde and glyceraldehydes in this recent research.
The Nature paper claims that the starting molecules are all "plausible prebiotic feedstock molecules," but as Garner suggests, that claim turns on what we mean by "plausible." In this case, the mechanisms of producing glycolaldehyde and glyceraldehyde are about as "plausible" as saying that if you have a pile of flour, baking powder, salt, butter, and eggs, you can produce a cake, given "the conditions of heating." Any baker knows that the ingredients must be applied in the right quantities and the right order, and that "the conditions of heating" have to be applied at just the right level or you produce nothing worth eating. In the world of creating even the mere precursor molecules to ribonucleotides, it's not just heating that's necessary but also the proper amount and sequence of "the conditions of heating and progressive dehydration followed by cooling, rehydration and ultraviolet irradiation."
As a third chemist put it to me, "The work was very carefully done. The problem is that it was very carefully done." No kidding.
Of course, even some origin of life theorists recognize that this research is not relevant to plausible conditions on the early earth. A news article on the website of the Royal Chemistry Society stated:
However, Robert Shapiro, professor emeritus of chemistry at New York University disagrees. 'Although as an exercise in chemistry this represents some very elegant work, this has nothing to do with the origin of life on Earth whatsoever,' he says. According to Shapiro, it is hard to imagine RNA forming in a prebiotic world along the lines of Sutherland's synthesis.
'The chances that blind, undirected, inanimate chemistry would go out of its way in multiple steps and use of reagents in just the right sequence to form RNA is highly unlikely,' argues Shapiro. Instead, he advocates the metabolism-first argument: that early self-sustaining autocatalytic chemosynthetic systems associated with amino acids predated RNA.
(Robert Shapiro quoted in James Urquhart, Insight into RNA origins, Royal Society of Chemistry (May 13, 2009).)
Of course Shapiro's preferred "metabolism-first argument" has its own problems, but that's a discussion for another day. Perhaps the most generous among the critical comments came from Albert Eschenmoser:
'Of course, it is referring to an event of the past and therefore conclusions will never achieve a level of certainty as in other scientific fields,' says renowned synthetic organic chemist Albert Eschenmoser. 'But Sutherland's work is a fundamental study referring to the problem of the origin of life. It is an exemplary piece of how to do synthetic organic chemistry research under very serious constraints of prebiotic chemistry,' Eschenmoser adds.
(Albert Eschenmoser quoted in James Urquhart, Insight into RNA origins, Royal Society of Chemistry (May 13, 2009).)
Eschenmoser's words are worth remembering next time someone objects to intelligent design on the grounds that it isn't scientific because it pertains to events that took place in the deep past.
Casey Luskin
In a recent ENV post, Stephen Meyer critiqued a May 2009 Nature paper co-authored by John D. Sutherland titled, "Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions." The paper claimed to have produced RNA nucleobases under prebiotic conditions, but Meyer observed that it utterly failed to address the most crucial question in the origin of life (OOL): the origin of information, a topic Meyer addresses extensively in his new book Signature in the Cell.
Other scientists agree with Meyer. Organic chemist Dr. Charles Garner recently noted in private correspondence that "while this work helps one imagine how RNA might form, it does nothing to address the information content of RNA. So, yes, there was a lot of guidance by an intelligent chemist."
Sutherland's research produced only 2 of the 4 RNA nucleobases, and Dr. Garner also explained why, as is often the case, the basic chemistry itself also required the hand of an intelligent chemist:
As far as being relevant to OOL, the chemistry has all of the usual problems. The starting materials are "plausibly" obtainable by abiotic means, but need to be kept isolated from one another until the right step, as Sutherland admits. One of the starting materials is a single mirror image for which there is no plausible way to get it that way abiotically. Then Sutherland ran these reactions as any organic chemist would, with pure materials under carefully controlled conditions. In general, he purified the desired products after each step, and adjusted the conditions (pH, temperature, etc.) to maximum advantage along the way. Not at all what one would expect from a lagoon of organic soup. He recognized that making of a lot of biologically problematic side products was inevitable, but found that UV light applied at the right time and for the right duration could destroy much (?) of the junk without too much damage to the desired material. Meaning, of course, that without great care little of the desired chemistry would plausibly occur. But it is more than enough for true believers in OOL to rejoice over, and, predictably, to way overstate in the press.
Another anonymous pro-ID Ph.D. chemist privately wrote me similar criticisms of Sutherland's paper:
They used pH manipulation, phosphate buffers and irradiation all at the correct times and amounts to achieve their goal, which was to produce "activated pyrimidine ribonucleotides." Indeed, they could have shortened their title by chopping off the last four words and sent the paper to the Journal of Organic Synthesis and had a good chance of getting it accepted as a novel synthetic route with full credit to themselves for their clever manipulations. Certainly the fingerprints of several intelligent chemists are all over this pathway if not their rather ham fisted signatures.
Other control they exercised includes careful selection of the precursors, control of competing reactions by pH selection and the phenomenal phosphate concentration they used. Life in the modern ocean is phosphate limited as phosphate is generally about 0.5 micro-molar at the sea surface and only 2-4 micro-molar at depth. But what is a six order of magnitude enrichment among friends if it helps the cause!? Now they could argue that one gets that kind of enrichment in a tide pool but even that is a stretch.
Incidentally, now comes the hard parts: first, selectively hydrolyzing the cyclic 2', 3' phosphates to 3'- only, then getting them to polymerize ONLY at the 5' position. And second, once you have a supply of various RNA molecules, spontaneously developing the required biochemical structure to convert the coded sequences into proteins. Of course, we have to hope that we get lucky and we guess the correct code on the first try. And all of this has to happen in the same tide-pool otherwise, well, you get the picture. It's a bit of a stretch.
It is no wonder that whenever I see the word "plausible" in the title of an article, that I am reminded of the quote attributed to P.T. Barnum, "there is a sucker born every minute."
"Plausible" is in the Eye of the Beholder
There are thus many instances in this research where the conditions they used were anything but, as the paper's title claims, "prebiotically plausible conditions." One such instance may have been the careful addition of the 'just right' quantity of UV light, where even the original Nature paper admits: "Although the issue of temporally separated supplies of glycolaldehyde and glyceraldehyde remains a problem, a number of situations could have arisen that would result in the conditions of heating and progressive dehydration followed by cooling, rehydration and ultraviolet irradiation."
It's no groundbreaking news story that there are potential sources of heat on the early earth. These "number of situations" referred to typically include proposals of heating and drying in intertidal pools or volcanic ridges where repeated cycles of heating and drying can take place. But mundane sources of heat are only a small part of the problem, which largely comes down to the fact that the proper amount of heat has to be carefully applied so as to not wipeout the desired molecular products. It's quite easy to over-cook (or under-cook) the organic molecules, which tend to break down rapidly (i.e. cook) in the presence of heat. This would have to be a fine balancing act that would also require just the right input of organic material, heat, and UV light, so as to avoid destroying the molecules. In other words, it's a finely tuned system, the kind in which a successful scenario is very difficult to imagine without the input of intelligence. And of course, intelligently directed chemistry is exactly what provided the glycolaldehyde and glyceraldehydes in this recent research.
The Nature paper claims that the starting molecules are all "plausible prebiotic feedstock molecules," but as Garner suggests, that claim turns on what we mean by "plausible." In this case, the mechanisms of producing glycolaldehyde and glyceraldehyde are about as "plausible" as saying that if you have a pile of flour, baking powder, salt, butter, and eggs, you can produce a cake, given "the conditions of heating." Any baker knows that the ingredients must be applied in the right quantities and the right order, and that "the conditions of heating" have to be applied at just the right level or you produce nothing worth eating. In the world of creating even the mere precursor molecules to ribonucleotides, it's not just heating that's necessary but also the proper amount and sequence of "the conditions of heating and progressive dehydration followed by cooling, rehydration and ultraviolet irradiation."
As a third chemist put it to me, "The work was very carefully done. The problem is that it was very carefully done." No kidding.
Of course, even some origin of life theorists recognize that this research is not relevant to plausible conditions on the early earth. A news article on the website of the Royal Chemistry Society stated:
However, Robert Shapiro, professor emeritus of chemistry at New York University disagrees. 'Although as an exercise in chemistry this represents some very elegant work, this has nothing to do with the origin of life on Earth whatsoever,' he says. According to Shapiro, it is hard to imagine RNA forming in a prebiotic world along the lines of Sutherland's synthesis.
'The chances that blind, undirected, inanimate chemistry would go out of its way in multiple steps and use of reagents in just the right sequence to form RNA is highly unlikely,' argues Shapiro. Instead, he advocates the metabolism-first argument: that early self-sustaining autocatalytic chemosynthetic systems associated with amino acids predated RNA.
(Robert Shapiro quoted in James Urquhart, Insight into RNA origins, Royal Society of Chemistry (May 13, 2009).)
Of course Shapiro's preferred "metabolism-first argument" has its own problems, but that's a discussion for another day. Perhaps the most generous among the critical comments came from Albert Eschenmoser:
'Of course, it is referring to an event of the past and therefore conclusions will never achieve a level of certainty as in other scientific fields,' says renowned synthetic organic chemist Albert Eschenmoser. 'But Sutherland's work is a fundamental study referring to the problem of the origin of life. It is an exemplary piece of how to do synthetic organic chemistry research under very serious constraints of prebiotic chemistry,' Eschenmoser adds.
(Albert Eschenmoser quoted in James Urquhart, Insight into RNA origins, Royal Society of Chemistry (May 13, 2009).)
Eschenmoser's words are worth remembering next time someone objects to intelligent design on the grounds that it isn't scientific because it pertains to events that took place in the deep past.
A brother in Christ and a fellow servant of Jehovah.
How do Jehovah's Witnesses view Charles T. Russell?
As Jehovah’s Witnesses today review the work that he did, the things he taught, his reason for teaching them, and the outcome, they have no doubt that Charles Taze Russell was, indeed, used by God in a special way and at a significant time.
This view is not based solely on the firm stand that Brother Russell took with regard to the ransom. It also takes into account the fact that he fearlessly rejected creeds that contained some of the foundation beliefs of Christendom, because these clashed with the inspired Scriptures. These beliefs included the doctrine of the Trinity (which had its roots in ancient Babylon and was not adopted by so-called Christians until long after Bible writing was completed) as well as the teaching that human souls are inherently immortal (which had been adopted by men who were overawed by the philosophy of Plato and which left them open to such ideas as the eternal torment of souls in hellfire). Many of Christendom’s scholars, too, know that these doctrines are not taught in the Bible, but that is not generally what their preachers say from the pulpits. In contrast, Brother Russell undertook an intensive campaign to share what the Bible actually does say with everyone who was willing to hear.
Noteworthy too is what Brother Russell did with other highly significant truths that he learned from God’s Word. He discerned that Christ would return as a glorious spirit person, invisible to human eyes. As early as 1876, he recognized that the year 1914 would mark the end of the Gentile Times. (Luke 21:24, KJ) Other Bible scholars had likewise perceived some of these things and had advocated them. But Brother Russell used all his resources to give them international publicity on a scale then unequaled by any other individual or group.
He urged others to check his writings carefully against God’s inspired Word so that they would be satisfied that what they were learning was in full harmony with it. To one who wrote a letter of inquiry, Brother Russell replied: “If it was proper for the early Christians to prove what they received from the apostles, who were and who claimed to be inspired, how much more important it is that you fully satisfy yourself that these teachings keep closely within their outline instructions and those of our Lord;—since their author claims no inspiration, but merely the guidance of the Lord, as one used of him in feeding his flock.”
Brother Russell claimed no supernatural power, no divine revelations. He did not claim credit for what he taught. He was an outstanding student of the Bible. But he explained that his remarkable understanding of the Scriptures was due to ‘the simple fact that God’s due time had come.’ He said: “If I did not speak, and no other agent could be found, the very stones would cry out.” He referred to himself as being simply like an index finger, pointing to what is stated in God’s Word.
Charles Taze Russell wanted no glory from humans. To readjust the thinking of any who were inclined to give excessive honor to him, Brother Russell wrote, in 1896: “As we have been to some extent, by the grace of God, used in the ministry of the gospel, it may not be out of place to say here what we have frequently said in private, and previously in these columns,—namely, that while we appreciate the love, sympathy, confidence and fellowship of fellow-servants and of the entire household of faith, we want no homage, no reverence, for ourselves or our writings; nor do we wish to be called Reverend or Rabbi. Nor do we wish that any should be called by our name.”
As his death neared, he did not take the view that there was nothing more to be learned, that there was no more work to be done. He had often spoken of preparing a seventh volume of Studies in the Scriptures. When asked about it before he died, he said to Menta Sturgeon, his traveling companion: “Some one else can write that.” In his will he expressed the desire that The Watch Tower continue to be published under the direction of a committee of men fully devoted to the Lord. He stated that those who would thus serve were to be men “thoroughly loyal to the doctrines of the Scriptures—especially so to the doctrine of the Ransom—that there is no acceptance with God and no salvation to eternal life except through faith in Christ and obedience to His Word and its spirit.”
Brother Russell realized that there was much work yet to be done in preaching the good news. At a question-and-answer session in Vancouver, B.C., Canada, in 1915, he was asked when Christ’s spirit-anointed followers then living could expect to receive their heavenly reward. He replied: “I do not know, but there is a great work to be done. And it will take thousands of brethren and millions in money to do it. Where these will come from I don’t know—the Lord knows his own business.” Then, in 1916, a short while before he began the speaking tour on which he died, he called A. H. Macmillan, an administrative assistant, to his office. On that occasion he said: “I am not able to carry on the work any longer, and yet there is a great work to be done.” For three hours he described to Brother Macmillan the extensive preaching work that he saw ahead, on the basis of the Scriptures. To Brother Macmillan’s objections, he replied: “This is not man’s work.”
- Jehovah’s Witnesses—Proclaimers of God’s Kingdom, 1993 WTB&TS
As Jehovah’s Witnesses today review the work that he did, the things he taught, his reason for teaching them, and the outcome, they have no doubt that Charles Taze Russell was, indeed, used by God in a special way and at a significant time.
This view is not based solely on the firm stand that Brother Russell took with regard to the ransom. It also takes into account the fact that he fearlessly rejected creeds that contained some of the foundation beliefs of Christendom, because these clashed with the inspired Scriptures. These beliefs included the doctrine of the Trinity (which had its roots in ancient Babylon and was not adopted by so-called Christians until long after Bible writing was completed) as well as the teaching that human souls are inherently immortal (which had been adopted by men who were overawed by the philosophy of Plato and which left them open to such ideas as the eternal torment of souls in hellfire). Many of Christendom’s scholars, too, know that these doctrines are not taught in the Bible, but that is not generally what their preachers say from the pulpits. In contrast, Brother Russell undertook an intensive campaign to share what the Bible actually does say with everyone who was willing to hear.
Noteworthy too is what Brother Russell did with other highly significant truths that he learned from God’s Word. He discerned that Christ would return as a glorious spirit person, invisible to human eyes. As early as 1876, he recognized that the year 1914 would mark the end of the Gentile Times. (Luke 21:24, KJ) Other Bible scholars had likewise perceived some of these things and had advocated them. But Brother Russell used all his resources to give them international publicity on a scale then unequaled by any other individual or group.
He urged others to check his writings carefully against God’s inspired Word so that they would be satisfied that what they were learning was in full harmony with it. To one who wrote a letter of inquiry, Brother Russell replied: “If it was proper for the early Christians to prove what they received from the apostles, who were and who claimed to be inspired, how much more important it is that you fully satisfy yourself that these teachings keep closely within their outline instructions and those of our Lord;—since their author claims no inspiration, but merely the guidance of the Lord, as one used of him in feeding his flock.”
Brother Russell claimed no supernatural power, no divine revelations. He did not claim credit for what he taught. He was an outstanding student of the Bible. But he explained that his remarkable understanding of the Scriptures was due to ‘the simple fact that God’s due time had come.’ He said: “If I did not speak, and no other agent could be found, the very stones would cry out.” He referred to himself as being simply like an index finger, pointing to what is stated in God’s Word.
Charles Taze Russell wanted no glory from humans. To readjust the thinking of any who were inclined to give excessive honor to him, Brother Russell wrote, in 1896: “As we have been to some extent, by the grace of God, used in the ministry of the gospel, it may not be out of place to say here what we have frequently said in private, and previously in these columns,—namely, that while we appreciate the love, sympathy, confidence and fellowship of fellow-servants and of the entire household of faith, we want no homage, no reverence, for ourselves or our writings; nor do we wish to be called Reverend or Rabbi. Nor do we wish that any should be called by our name.”
As his death neared, he did not take the view that there was nothing more to be learned, that there was no more work to be done. He had often spoken of preparing a seventh volume of Studies in the Scriptures. When asked about it before he died, he said to Menta Sturgeon, his traveling companion: “Some one else can write that.” In his will he expressed the desire that The Watch Tower continue to be published under the direction of a committee of men fully devoted to the Lord. He stated that those who would thus serve were to be men “thoroughly loyal to the doctrines of the Scriptures—especially so to the doctrine of the Ransom—that there is no acceptance with God and no salvation to eternal life except through faith in Christ and obedience to His Word and its spirit.”
Brother Russell realized that there was much work yet to be done in preaching the good news. At a question-and-answer session in Vancouver, B.C., Canada, in 1915, he was asked when Christ’s spirit-anointed followers then living could expect to receive their heavenly reward. He replied: “I do not know, but there is a great work to be done. And it will take thousands of brethren and millions in money to do it. Where these will come from I don’t know—the Lord knows his own business.” Then, in 1916, a short while before he began the speaking tour on which he died, he called A. H. Macmillan, an administrative assistant, to his office. On that occasion he said: “I am not able to carry on the work any longer, and yet there is a great work to be done.” For three hours he described to Brother Macmillan the extensive preaching work that he saw ahead, on the basis of the Scriptures. To Brother Macmillan’s objections, he replied: “This is not man’s work.”
- Jehovah’s Witnesses—Proclaimers of God’s Kingdom, 1993 WTB&TS
Saturday 30 July 2016
David Berlinski on becoming David Berlinski.
How David Berlinski Came to Doubt Darwin
David Berlinski
ENV: When did you start thinking, as a critic, about Darwinian evolution? Did anythingIt was the fall of 1965. My graduate school roommate Daniel Messenger and I were ambling along Nassau Street in Princeton. We were munching the kind of wonderful Winesap apples that seem to have disappeared as a variety. I wonder why that is? Daniel's girlfriend, Sandra Petersen, was there too. Daniel was a fine philosopher and Sandra was doing a degree in classical philosophy. We walked over to Darwin's theory of evolution, living at the time in one of Princeton's back alleys.
A back alley was the right place to look for Darwin. No one in the philosophy department at Princeton had ever introduced his name into a seminar, or thought to argue that his theory was relevant to our concerns.
At Columbia College I had been given a ten minute introduction to the theory of evolution in a class otherwise devoted to comparative anatomy. The impression conveyed was that Darwin's theory was far less interesting than the details embedded in the anatomy of the Dogfish.
-- Now if you will turn to your specimens, Gentlemen...
If I had had those ten minutes to count on, Daniel had more. At Brown, he had once read Darwin's On the Origin of Species. This made him a considerable expert in my eyes. He knew what it was all about. I asked the obvious question: So is that it?
Apparently it was.
Daniel shrugged his rounded shoulders. Someone, he said, had figured it all out.
As she always did, Sandra kept her counsel. She was fond of Daniel; she thought me an idiot.
A year later, I found myself promoted from east coast snow to west coast sunshine. And promoted to more, far more. I was an assistant professor at Stanford: That was more. And I had been given access to the splendor of northern California: That was far more. What is that wonderful line by Robert Lowell? All of life's grandeur is something with a girl in summer.
One night I was having dinner with my great friend, Daniel Gallin. At the time, he lived in San Francisco, his Delmar Street apartment high above the city. We could see the fog roll in, Nassau Street Daniel emerging briefly to offer Delmar Street Daniel the same reprise of Darwin's theory that he had once offered me. Delmar Street Daniel was doing a PhD at Berkeley with Dana Scott; he was an excellent mathematician, and an even better logician. He reserved his approval for mathematical model theory, and his admiration for Alfred Tarski.
"Can you imagine?" he would ask on reading something absurd.
And Darwin?
Can you imagine!
*******************************************
At some time in the early 1970s, I came across the papers that Murray Eden and M.P. Schutzenberger had delivered to the 1966 Wistar Symposium, Mathematical Objections to Neo-Darwinism. I read them closely; I was impressed; and I discussed them at Columbia with Josh Kornberg, a molecular biologist, and George Pieczenik, a biochemist. Pieczenik had just finished his PhD, writing a thesis on the grammatical constraints embedded in the nucleic acids. Sympathetic to Murray's position, he had discovered two facts: The first, that the nucleic acids contain internal terminator codons and the second, that they often express very long palindromes. Josh Kornberg, on the other hand, had no intellectual capital to invest in either Murray or Marco. Not a dime, he said.
Who cares, he added?
For a while, I thought I might find a way to represent an evolutionary process in automata-theoretic terms. And for obvious reasons. The construction of a complex system demands some scheme of anticipation and deferral -- anticipation to determine where things are going, deferral to keep intermediates in reserve for later use. Finite state automata will not do; push-down storage automata are needed.
Sidney Morgenbesser accepted my paper for the Journal of Philosophy without asking for revisions. That my paper had very little to do with philosophy, he regarded as nothing more than an inconvenience. "Stick the word 'philosophy' in the title somewhere," he said. So I called my paper, "Philosophical Aspects of Molecular Biological Systems." Everyone was well satisfied, the philosophers because I was writing about biology, and the biologists because I was writing about philosophy.
It was my introduction to irrelevance, the writer's natural state.
Somewhat later, Noam Chomsky gave me a letter of introduction that allowed me to meet Marco Schutzenberger in Paris.
I've written about Chomsky and Marco in Black Mischief: Language, Life, Logic & Luck.
But this is the way it was. Darwin and I go back. He has long since moved from that scruffy back alley to something grand -- near Lake Cuomo, I believe. Still, it is lucky that we met. I might have encountered Marx instead of Darwin on Nassau Street, another one of the back-alley boys, the fall of the Berlin Wall leaving me, like Roger Kimball, dancing with ghosts. in your biography incline you to freethinking in that area?
David Berlinski
ENV: When did you start thinking, as a critic, about Darwinian evolution? Did anythingIt was the fall of 1965. My graduate school roommate Daniel Messenger and I were ambling along Nassau Street in Princeton. We were munching the kind of wonderful Winesap apples that seem to have disappeared as a variety. I wonder why that is? Daniel's girlfriend, Sandra Petersen, was there too. Daniel was a fine philosopher and Sandra was doing a degree in classical philosophy. We walked over to Darwin's theory of evolution, living at the time in one of Princeton's back alleys.
A back alley was the right place to look for Darwin. No one in the philosophy department at Princeton had ever introduced his name into a seminar, or thought to argue that his theory was relevant to our concerns.
At Columbia College I had been given a ten minute introduction to the theory of evolution in a class otherwise devoted to comparative anatomy. The impression conveyed was that Darwin's theory was far less interesting than the details embedded in the anatomy of the Dogfish.
-- Now if you will turn to your specimens, Gentlemen...
If I had had those ten minutes to count on, Daniel had more. At Brown, he had once read Darwin's On the Origin of Species. This made him a considerable expert in my eyes. He knew what it was all about. I asked the obvious question: So is that it?
Apparently it was.
Daniel shrugged his rounded shoulders. Someone, he said, had figured it all out.
As she always did, Sandra kept her counsel. She was fond of Daniel; she thought me an idiot.
A year later, I found myself promoted from east coast snow to west coast sunshine. And promoted to more, far more. I was an assistant professor at Stanford: That was more. And I had been given access to the splendor of northern California: That was far more. What is that wonderful line by Robert Lowell? All of life's grandeur is something with a girl in summer.
One night I was having dinner with my great friend, Daniel Gallin. At the time, he lived in San Francisco, his Delmar Street apartment high above the city. We could see the fog roll in, Nassau Street Daniel emerging briefly to offer Delmar Street Daniel the same reprise of Darwin's theory that he had once offered me. Delmar Street Daniel was doing a PhD at Berkeley with Dana Scott; he was an excellent mathematician, and an even better logician. He reserved his approval for mathematical model theory, and his admiration for Alfred Tarski.
"Can you imagine?" he would ask on reading something absurd.
And Darwin?
Can you imagine!
*******************************************
At some time in the early 1970s, I came across the papers that Murray Eden and M.P. Schutzenberger had delivered to the 1966 Wistar Symposium, Mathematical Objections to Neo-Darwinism. I read them closely; I was impressed; and I discussed them at Columbia with Josh Kornberg, a molecular biologist, and George Pieczenik, a biochemist. Pieczenik had just finished his PhD, writing a thesis on the grammatical constraints embedded in the nucleic acids. Sympathetic to Murray's position, he had discovered two facts: The first, that the nucleic acids contain internal terminator codons and the second, that they often express very long palindromes. Josh Kornberg, on the other hand, had no intellectual capital to invest in either Murray or Marco. Not a dime, he said.
Who cares, he added?
For a while, I thought I might find a way to represent an evolutionary process in automata-theoretic terms. And for obvious reasons. The construction of a complex system demands some scheme of anticipation and deferral -- anticipation to determine where things are going, deferral to keep intermediates in reserve for later use. Finite state automata will not do; push-down storage automata are needed.
Sidney Morgenbesser accepted my paper for the Journal of Philosophy without asking for revisions. That my paper had very little to do with philosophy, he regarded as nothing more than an inconvenience. "Stick the word 'philosophy' in the title somewhere," he said. So I called my paper, "Philosophical Aspects of Molecular Biological Systems." Everyone was well satisfied, the philosophers because I was writing about biology, and the biologists because I was writing about philosophy.
It was my introduction to irrelevance, the writer's natural state.
Somewhat later, Noam Chomsky gave me a letter of introduction that allowed me to meet Marco Schutzenberger in Paris.
I've written about Chomsky and Marco in Black Mischief: Language, Life, Logic & Luck.
But this is the way it was. Darwin and I go back. He has long since moved from that scruffy back alley to something grand -- near Lake Cuomo, I believe. Still, it is lucky that we met. I might have encountered Marx instead of Darwin on Nassau Street, another one of the back-alley boys, the fall of the Berlin Wall leaving me, like Roger Kimball, dancing with ghosts. in your biography incline you to freethinking in that area?
On human cloning:looks like the fun is just getting started.
Dolly Clones Pave the Way for Human Cloning
Wesley J. Smith
Apparently clones of the same dead sheep from which Dolly was manufactured are in good health and aging normally. From the Live Science story:
Four cloned sheep that are genetically identical to Dolly, the first cloned mammal, are still healthy even in old age, a new study found. The four sheep, which were derived from the same batch of cells as Dolly and could be considered her clone "sisters," have just reached their 9th birthday, which is equivalent to age 70 in human years, researchers who have been studying the sheep said.
A detailed study of these four sheep and nine other cloned sheep that are not related to "the Dollies" found that the animals were healthy. All of the sheep were free from many diseases commonly found in older sheep, such as diabetes and high blood pressure, the study showed.
What does this mean for the future of human cloning?
The technique, known as somatic cell nuclear transfer (SCNT) can be refined so as to permit normal mammals made in such a manner.
Human SCNT has already been done, creating embryos that were developed to the blastocyst stage (the time when stem cells can be derived).
SCNT is cloning. The result is an embryo. The question after that is how will that embryo be used.
Some human cloning apologists say that "therapeutic cloning" is different from "reproductive cloning." That's false. Those terms merely reflect different uses of the cloned embryo, the former being destroyed for research, the latter implanted in a uterus and -- as with Dolly -- brought to birth.
Bioethicists and Big Biotech support have said that human reproductive cloning should be banned until it is "safe."
Animal cloning moves that process forward as does therapeutic human cloning, since the point is to perfect the still faulty techniques needed to do in humans what is currently done in sheep.
The goals of human cloning include, but are not limited to research, learning how to genetically engineer, fetal farming, and reproductive outcomes.
Banning "reproductive cloning" is not banning cloning, but a use of a cloned embryo, in other words, a phony ban intended to fool people.
The time to outlaw human cloning is now -- meaning all human SCNT, regardless of the use to which the embryo will be put. If we wait until the sector perfects its techniques, it will be too late.
Will we? Not a chance. The media are asleep and/or active boosters of Big Biotech and Congress is safely in their campaign donation-paid special interest pockets.
There will be consequences.
Wesley J. Smith
Apparently clones of the same dead sheep from which Dolly was manufactured are in good health and aging normally. From the Live Science story:
Four cloned sheep that are genetically identical to Dolly, the first cloned mammal, are still healthy even in old age, a new study found. The four sheep, which were derived from the same batch of cells as Dolly and could be considered her clone "sisters," have just reached their 9th birthday, which is equivalent to age 70 in human years, researchers who have been studying the sheep said.
A detailed study of these four sheep and nine other cloned sheep that are not related to "the Dollies" found that the animals were healthy. All of the sheep were free from many diseases commonly found in older sheep, such as diabetes and high blood pressure, the study showed.
What does this mean for the future of human cloning?
The technique, known as somatic cell nuclear transfer (SCNT) can be refined so as to permit normal mammals made in such a manner.
Human SCNT has already been done, creating embryos that were developed to the blastocyst stage (the time when stem cells can be derived).
SCNT is cloning. The result is an embryo. The question after that is how will that embryo be used.
Some human cloning apologists say that "therapeutic cloning" is different from "reproductive cloning." That's false. Those terms merely reflect different uses of the cloned embryo, the former being destroyed for research, the latter implanted in a uterus and -- as with Dolly -- brought to birth.
Bioethicists and Big Biotech support have said that human reproductive cloning should be banned until it is "safe."
Animal cloning moves that process forward as does therapeutic human cloning, since the point is to perfect the still faulty techniques needed to do in humans what is currently done in sheep.
The goals of human cloning include, but are not limited to research, learning how to genetically engineer, fetal farming, and reproductive outcomes.
Banning "reproductive cloning" is not banning cloning, but a use of a cloned embryo, in other words, a phony ban intended to fool people.
The time to outlaw human cloning is now -- meaning all human SCNT, regardless of the use to which the embryo will be put. If we wait until the sector perfects its techniques, it will be too late.
Will we? Not a chance. The media are asleep and/or active boosters of Big Biotech and Congress is safely in their campaign donation-paid special interest pockets.
There will be consequences.
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