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Monday 2 November 2015

Exaptation:Darwinian code for spin?

Darwinism's tree of life examined

It's Design all the way down VIII

It's design all the way down VII

UT Southwestern physiologists uncover a new code at the heart of biology
UT SOUTHWESTERN MEDICAL CENTER

DALLAS - Sept. 23, 2015 - UT Southwestern physiologists trying to understand the genetic code have found a previously unknown code that helps explain which protein should be created to form a particular type of cell.

The human body is made up of tens of trillions of cells. Each cell contains thousands of proteins, which determine how the cell should form and what functions it needs to perform. Proteins, in turn, are made up of hundreds of amino acids. The blueprint for each protein is specified by genetic codons, which are triplets of nucleotides that can make 20 different types of amino acids. The way in which amino acids are linked together then determines which proteins are eventually produced, and in turn, what functions the cell will have.

What researchers found was that not only does the sequence of the amino acids matter, but so does the speed of the process in which the amino acids are put together into a functional protein.

"Our results uncovered a new 'code' within the genetic code. We feel this is quite important, as the finding uncovers an important regulatory process that impacts all biology," said Dr. Yi Liu, Professor of Physiology.

It was long known that almost every amino acid can be encoded by multiple synonymous codons and that every organism, from humans to fungi, has a preference for certain codons. The researchers found that more frequently used codons ? the "preferred codons" ? speed up the process of producing an amino acid chain, while less frequently produced codons slow the process. The use of either preferred or non-preferred codons is like having speed signs on the protein production highway: some segments need to be made fast and others slow.

 "The genetic code of nucleic acids is central to life, as it specifies the amino acid sequences of proteins," said Dr. Liu, the Louise W. Kahn Scholar in Biomedical Research. "By influencing the speed with which a protein is assembled from amino acid building blocks, the use of "fast" and "slow" codons can affect protein folding, which is the process that allows a protein to form the right shape to perform a specific function. This speed control mechanism makes sure that proteins are assembled and folded properly in different cells. Therefore, the genetic code not only specifies the sequence of amino acids but also the shape of the protein."

The researchers found that proteins with identical amino acid sequences can have different functions if they are assembled at different speeds. This can have important implications for identifying human disease-causing mutations because this study indicates that a mutation does not have to change amino acid identity to cause a disease. In fact, most mutations in human DNA do not result in amino acid change.

"Therefore, our study indicates that the new "code" ? the speed limit of assembly ? within the genetic code can dictate the ultimate function of a given protein," said Dr. Liu.

The findings appear as the cover story of the journal Molecular Cell, one of the top molecular biology, biophysics, and biochemistry journals.

The latest findings extend prior research published by Dr. Liu and colleagues in Nature in 2013 that broke new ground by demonstrating that synonymous codons of a circadian clock protein are not the same in making functional proteins, despite the fact that they encode the same amino acids.  Genes can adapt to different environmental changes by choosing the most optimal codon, which is counterintuitive to natural selection.

Dr. Liu and his team are able to study these systems using a type of bread mold fungus called Neurospora crassa. The use of the mold allows for easy manipulation of its genes and codons in the laboratory that are more difficult to do in animals. Dr. Liu's lab is also trying to unravel the secrets of chronobiology and the molecular mechanisms that underlie an organism's daily biological clock, called the circadian clock. Biological clocks have been described in almost all organisms ranging in complexity from single cell organisms to mammals, and to function in the control of daily rhythms such as sleep-wake and activity cycles, body temperature cycles, endocrine functions, and gene expression.

###

Other UT Southwestern researchers involved include postdoctoral researchers Chien-Hung Yu, Yunkun Dang, Zhipeng Zhou, first co-authors, and graduate student researcher Fangzhou Zhao. They collaborated with the lab of Dr. Matthew Sachs, Professor of Biology at Texas A&M University.

The work is supported by grants from the National Institutes of Health and the Welch Foundation.

About UT Southwestern Medical Center


UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty includes many distinguished members, including six who have been awarded Nobel Prizes since 1985. The faculty of more than 2,700 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to about 92,000 hospitalized patients and oversee approximately 2.1 million outpatient visits a year.

Sunday 1 November 2015

On the Hubris of Scientism?

Human Cloning Advance: Ban Now or Cry Later
Wesley J. Smith November 1, 2015 4:45 AM 


Human cloning used to make big headlines. But "the scientists" got smart, and just started using the scientific term for cloning -- somatic cell nuclear transfer -- as a way of hiding in plain sight.

Thus, when the first human embryos were successfully manufactured via SCNT, the were few headlines and most people yawned -- if they heard about it at all. Of course, I reacted strongly.

Now, the South Koreans have improved the efficiency of cloning, and again, the scientists are keeping mostly mum in the popular media so as to not alert us rubes that Brave New World is approaching. From the KBS World News Radio story:

A group of medical experts has succeeded at improving the efficiency of human somatic cell nuclear transfer (SCNT) by three times.

A research team at Cha Medical Group said Friday that it found ways to enhance the efficiency of SCNT by discovering a correlation between the quality of female eggs and the success rate of SCNT embryo development.,,

The team said it has made five pilot medicine products using the new findings and plans to seek the government's approval for a large-sized clinical test by the end of this year.


Now, add in the jet-speed advance in genetic engineering known as CRSPR. We are coming closer to the day of manufacturing human beings via cloning, genetically engineered for desired traits.

On non-verbal communication

On those still in chains

Saturday 31 October 2015

On pitching a design inference to a hostile audience.

For SETI Researchers, Here Is a Guide for Handling Fallacious Objections
Casey Luskin October 30, 2015 11:08 AM


A recent story making the rounds, "Space anomaly gets extraterrestrial intelligence experts' attention," claims that the Search for Extra Terrestrial Intelligence (SETI) project has found "a strange star" that "could mean alien life." As David Klinghoffer noted in an earlier post, the raw data entails odd fluctuations in the intensity of light coming from a star. CNN reports:

The Search for Extraterrestrial Intelligence Institute has its eyes -- and soon possibly one of the United States' premier telescopes -- focused on an anomaly that some astronomers can't quite explain.
[...]

"What was unusual about that was the depth of the light dips, up to 20% decrease in light, and the timescales (of light variation) -- a week to a couple of months."

So what's the explanation? Could it be from a swarm of comets? Some sort of intergalactic phenomenon that Earthbound scientists haven't discovered? Or an effect of planet-sized structures built by some sort of alien civilization?

Comparisons between SETI's methodology and the theory of intelligent design (ID) have been made since ID's earliest days. Both SETI and ID seek to detect the signs of intelligence in the world around us. SETI focuses on looking for evidence of extraterrestrial civilizations far away in the universe. ID looks for signs of intelligent agency in the origin of living organisms and the universe itself.
SETI and ID share something else: they both try to be very conservative and cautious, invoking intelligent causation only when it is clearly warranted by the evidence. Here's how one SETI scientist handles this:

Jason Wright, a Penn State astronomy professor, saw Boyajian's data and can't quite explain it. But in a post Thursday to his website, he cautioned against jumping to conclusions -- as some apparently have -- that intelligent beings far away are behind this oddity.
"My philosophy of SETI," Wright wrote, referring to the search for extraterrestrial intelligence, "is that you should reserve your alien hypothesis as a last resort." He also cited "Cochran's Commandment to planet hunters ... Thou shalt not embarrass thyself and they colleagues by claiming false planets.

That's a good philosophy, and ID takes a similar approach. ID proponents only conclude in favor of design when it's clear that known material causes cannot explain the observed phenomena and when the data is best explained by intelligence.
So far, SETI hasn't found a case that is clearly explained by some extraterrestrial civilization. This recent find of a star with flickering light is nowhere near enough evidence to conclude that aliens are the best explanation -- in fact Tech Insider reports that the data could be explained by a "lopsided star" wherein its irregular shape "creates patches of darker and lighter regions within these kinds of stars, so the light curves that make it back to Earth won't look completely uniform."

But suppose SETI were to one day discover strong evidence of some extraterrestrial civilization -- enough to warrant a design inference. They might expect to face some of the same fallacious objections that ID faces. They might like some friendly tips on handling them. Here's a little guide for SETI folks if that day ever comes:

Who Made the Aliens?

As soon as you claim you've detected aliens, skeptics will say "How can you claim there are aliens when you haven't explained who made the aliens?"

The answer to this is very simple: We don't need to be able to explain the origin of the aliens to recognize evidence of them. For example, let's say that Chewbacca, Spock, and ET were standing right in front of you. Would you say to them, "Look, I'm not going to believe any of you actually exist until you tell me where you came from"?

(I should add that it could be very fair to ask where the aliens came from because in an ultimate sense they require an explanation -- but it's not a fair question to ask if your only purpose is to question whether those aliens exist.)

Where's Your "Alien-O'Meter"?

Some critics might reply "You need some kind of an 'alien-o-meter' to show that these aliens really exist before you can claim that you've detected evidence of an extraterrestrial civilization. After all, how do we know that aliens were behind the evidence you've discovered if we don't know the aliens exist?"

The answer to this one is a bit more complicated. But a little explanation shows this objection to be nonsensical and based upon a complete misunderstanding of how we make scientific inferences.

Some ID critics mistakenly think you have to directly witness the designer in action with your own eyes in order to detect design. Sometimes misguided creationists make an analogous critique of evolution, saying that you can never infer evolution if no one was around to see it. Both groups misunderstand the nature of historical sciences.

Historical sciences operate under the principle of uniformitarianism, which assumes that the way the natural world works today is similar to how it worked in the past. In other words, "the present is the key to the past." If we see certain causes at work in the world as we know it and we learn to recognize their known effects, then when we find those same effects in the historical record, we can infer that the same causes were at work. As I have explained before:

Recently an atheist student emailed me to ask how it's reasonable to claim that an "unobserved designer" is responsible for complex features of nature, like high CSI (complex specified information) and irreducibly complex structures. In reply, I explained that first we must ask the question "What does it mean to 'observe' or 'detect' something?" Here's a start:
Our eyes can help us observe objects in nature by seeing light reflected from those objects.
Our ears can help us detect objects in nature by receiving sound emitted from them.
Our nose can help us detect objects in nature by receiving emitted chemicals which we register as a "smell."
Our skin can help us detect objects in nature by receiving signals that tell us about shape, texture, and even temperature.
So when we see a campfire, how do we "observe" it? Our sense organs receive patterns of light, sound, smell, and heat, which our brains recognize and match to fires we've seen in the past. Our brain thinks, in effect, "Okay, as in the past, when the eyes receive a particular pattern of yellow and red light, the ears hear a crackling sound, the nose receives the smell of smoke, and the skin feels heat, that's a campfire." So we recognize and observe something by receiving a pattern of information through our sense organs and then matching it to a pattern we've seen in the past.
Our senses also make another set of observations about a campfire: the morning after a campfire, we observe that there's a bunch of blackened and charred wood, ash and soot, and smoke rising from within a circle of blackened stones. We smell the smoke and ash, and it might be slightly warm from remaining embers from the night before.

So let's say now that we're taking a morning stroll and come upon a circle of blackened stones, charred wood, ash, and soot. There's a little smoke rising from the center, and it's slightly warm. We didn't see a fire directly with our eyes. But our senses tell us that there is evidence that a fire was there. In this case, the most reasonable inference to make is that there was a campfire, even though we can't directly observe it.

Thus, just because something is "unobservable" by our eyes at this exact moment, doesn't mean we can't find compelling evidence that it exists, or that it was present. We must not toss out the word "unobservable" as if it somehow blocks the design inference. We regularly make inferences to unobserved objects and events (like a campfire) by using our senses to detect evidence that reliably indicates that a particular object or event was present (like finding a circle of blackened stones, charred wood, soot, and smoke).

We can use exactly the same method of reasoning to detect design at the heart of biology. In all of our experience, high CSI and irreducible complexity ONLY come from intelligent agents. Thus, based upon our experience of the cause-and-effect structure of the world we observe around us, we are justified in inferring that a mind was at work. ...[W]hen we find high CSI entities like language-based digital codes or irreducibly complex molecular machines, we are justified in inferring that an intelligent agent was at work. Why? Because, in our experience, these things always trace back to a mind. We might not directly see that mind, but we can infer that a mind was present to create the known observed effects.

This is the positive argument for intelligent design, and it is just like inferring that a campfire was present based on remaining physical evidence. One need not directly see the fire, or know who tended it, or why he or she or they did so, to draw a reasonable inference that a fire was present.

So to the critic who asks "Where's the alien-o-meter," SETI's response might go like this: We have an alien-o-meter, but it's not what you think it is. We don't need to Skype with ET to potentially know he's there. If we find in space the kind of evidence that, in our experience, only comes from intelligent beings, then we can infer that ETs exist.
Aliens of the Gaps

A last objection the SETI researcher will face goes like this: You're never allowed to conclude that aliens are responsible for anything because someday we might find a fully material, physical explanation other than ETs for the evidence you claim demonstrates an extraterrestrial civilization. As materialist explanations advance, your "alien" theory will just retreat into the gaps of our knowledge.

Now this objection might have a little more traction than the others. Nobody wants to invoke intelligent aliens only to have them later explained away by some unintelligent material cause. As SETI proponent Jason Wright said, it should be a "last resort." And indeed, in this case that's a good philosophy since the "lopsided star" theory seems to explain the observed data quite well.

But does the fact that some cases aren't best explained by intelligence that mean you can never invoke intelligent causes? Of course not! It just means one needs to be careful and cautious about invoking intelligent design.

What the gaps fallacy really says is, "While your explanation may seem correct today, new evidence may be revealed tomorrow to provide a material explanation and show that intelligent causes aren't the best explanation." That's a fair point, but the reality is that every type of explanation -- material or intelligent -- is subject to the same problem.

Indeed, any explanation could be subject to the "gaps" charge. This is a problem that every kind of explanation in science potentially faces. That's why scientific explanations are always held tentatively and never asserted with complete finality or absolute certainty. Scientific explanations are always subject to revision if newly uncovered data shows they are wrong. This is true whether we're dealing with Darwinian evolution or intelligent design, aliens or standard stellar dynamics.

So at the end of the day, what the "gaps" objection really ought to say is "Today X is the best explanation, but let's hold it tentatively." Nothing wrong with that -- that's how all science ought to work.

What the gaps charge often indicates is that some kind of explanation is assumed to be the default, privileged answer, and that we can only deviate from that default answer under extraordinary circumstances. In the case of intelligent design or SETI, it's material causes that are being privileged. Many who make the "gaps" charge want material causes to have an absolute privilege that precludes making a design inference in all circumstances. But given that we can detect intelligent causation, why should material causes enjoy such an absolute privilege?

Unless we are to privilege material causes on principle and deny our ability to ever infer intelligent causes, the gaps objection fails. But since we know what intelligent causes can do, and because we can reliably detect the prior action of intelligent agents, we can't say that in all cases it's wrong to detect design. We can detect design, and so long as we hold the conclusion of design tentatively, the gaps objection isn't fatal.

Don't Miss the Irony

Now I personally don't object to SETI researchers doing their thing, but I'm highly skeptical that they're ever going to find an extraterrestrial civilization. But my reason for writing this isn't to rant against SETI. It's just to point out the irony. People make a lot of fallacious objections against intelligent causation. We in the ID movement get this all the time. It sounds like, "Who designed the designer?" or "Where's your theo-meter?" or "This is just God of the gaps." If SETI claimed to find some extraterrestrial intelligent civilization, most likely the analagous objections would never come up, at least not with much force.

Why is that? Most materialists would see extraterrestrial life as proof that a naturalistic origin of life is possible, and that perhaps life is therefore common in our universe. After all, what drives many materialists to look for evidence of extraterrestrial life is a misguided assumption that if aliens exist, it would somehow validates their worldview.


But they are mistaken about what SETI means. If we found evidence of an alien civilization, that wouldn't be evidence that life evolves naturally. It would just be evidence for an extraterrestrial civilization. That's it. How it arose would be an entirely different question. And all indications we have so far show that life could not arise naturally, whether on earth or anywhere else. For all we know, finding evidence of extraterrestrial life could end up being yet another piece of evidence pointing to intelligent design.

Friday 30 October 2015

Yet more realism about the Cambrian explosion from Darwinists

The Economist Admits Cambrian Explosion Is a "Mystery"


Thursday 29 October 2015

The design inference defined and refined

Are Hexagons Natural?

Wednesday 28 October 2015

Darwinism Vs. Arithmetic yet again.

Proteins by Accident? Replying to a Critic of The Information Enigma

Monday 26 October 2015

Grabbing some more of that suboptimal design I see.

To convergent evolution be the glory?

Squaring the circle?

Is Evolution Random? Answering a Common Challenge
Ann Gauger October 26, 2015 12:45 PM 

Evolutionists often challenge us for referring to Darwinian evolution as "random." They point to the fact that natural selection, the force that supposedly drives the train, always selects more "fit" organisms, and so is not random. That is only part of the story, though, and to understand why evolution can indeed be called random, the rest needs to be told.

Evolution can be considered to be composed of four parts. The first part, the grist for the mill, is the process by which mutations are generated. Generally this is thought to be a random process, with some qualifications. Single base changes occur more or less randomly, but there is some skewing as to which bases are substituted for which. Other kinds of mutations, like deletions or rearrangements or recombinations (where DNA is exchanged between chromosomes), often occur in hotspots, but not always. The net effect is that mutations occur without regard for what the organism requires, but higgledy-piggledy. In that sense mutation is random

The next part, random drift, is like a roll of the dice that decides which changes are preserved and which are lost. As the name implies, this process is also random, the result of accidental events, and without regard for the benefit of the organism. Most mutations get lost in the mix, especially when newly emerging, just because their host organisms fail to reproduce, or die from causes unrelated to genetics. It can also happen that new mutations are combined with other mutations that are harmful, and so get eliminated.

The random effects of drift are large enough to overwhelm natural selection in organisms with small breeding populations, less than a million, say. New mutations are not born fast enough to escape loss due to drift. There is a fractional threshold in the population that must be crossed before a new mutation can become "fixed," that is, universally present in every individual. A new mutation generally is lost to drift before that population threshold is crossed.

The third part, natural selection, is not random. It acts to preserve beneficial change and eliminate harmful ones. It can be said to be directional. But there are several caveats. Beneficial mutations are rare, and usually only weakly beneficial, so the effects of natural selection are not usually all that strong. Most changes provide only a slight advantage.

In addition, it can happen, and often does, that a "beneficial" mutation involves breaking something, meaning a loss of information, and a loss of potential improvement. This breaking can be irreversible for all intents and purposes. The premiere example in human evolution is that of sickle cell disease. Sickle cell disease is caused by a mutation to the hemoglobin gene that makes red blood cells resistant to the malarial parasite. In one copy the broken gene is beneficial (it increases resistance to malaria), but when two copies are present (both chromosomes carry the mutation), the red blood cells are deformed and cause painful debilitation. The broken gene is actually functionally worse than its normal version, except where malaria is present.

This brings out an important point. Natural selection does not always select the same mutations. The environment determines which mutations are favored. For example, natural selection acts to favor individuals carrying one copy of the sickle cell trait where malaria is present, but acts against the sickle cell gene where malaria is absent. So in this context, selection meanders over a fluctuating landscape of varying criteria for what is beneficial and what is not. Now it is beneficial to carry the sickle cell trait, now it is not. Different populations get favored at different times. In this sense one might say selection has a random component too, because only rarely is selection strong and unidirectional, always favoring the same mutation.

We see this variation in selection with another example, the evolution of finch beaks on the Galápagos Islands. In drought, large beaks are favored, in wet years, small beaks. The weather fluctuates, and so do the beak sizes.

Subpopulations may acquire traits, but because of environmental variation the traits do not become universal. For example, lactose intolerance -- we do not all carry the version of the gene that allows us to digest lactose as adults. Unless suddenly everyone in the world has to eat cheese as a major part of their diet, lactose intolerance won't disappear from our population.

There is a special way evolution can occur -- a sudden bottleneck in the population will tend to fix the traits that predominate in that population. Suppose a nuclear holocaust wiped out everyone except Swedes. The lactose-digesting gene would almost certainly become fixed, as would blond hair, blue eyes, and other Scandinavian traits, provided they ate cheese and lived at high latitudes. Until new mutations in new environments occurred, that would remain the case.

Now you know more about the population genetics of evolution than you imagined could be true. The sum of all these factors is what is responsible for evolution, or change over time. Mutation, drift, selection, and environmental change all play a role. Three out of these four forces are random, without regard for the needs of the organism. Even selection can be random in its direction, depending on the environment.


So tell me. Is evolution random? Most of the processes at work definitely are. Certainly evolution won't make steady progress in one direction without some other factor at work. What that factor might be remains to be seen. I personally do not think a material explanation will be found, because any process to guide evolution in a purposeful way will require a purposeful designer to create it.

Why some just say no to Halloween.:The Watchtower Society's commentary

The Origins of Halloween—What Does the Bible Say About Them?:

The Bible’s answer:

The Bible does not mention Halloween. However, both the ancient origins of Halloween and its modern customs show it to be a celebration based on false beliefs about the dead and invisible spirits, or demons.—See  “Halloween history and customs.”


The Bible warns: “There must never be anyone among you who . . . consults ghosts or spirits, or calls up the dead.” (Deuteronomy 18:10-12, The Jerusalem Bible) While some view Halloween as harmless fun, the Bible indicates that the practices associated with it are not. At 1 Corinthians 10:20, 21, the Bible says: “I do not want you to be participants with demons. You cannot drink the cup of the Lord and the cup of demons too.”—New International Version.

Halloween history and customs:

Samhain: The origin of Halloween can be traced to this “ancient pagan festival celebrated by Celtic people over 2,000 years ago,” states The World Book Encyclopedia. “The Celts believed that the dead could walk among the living at this time. During Samhain, the living could visit with the dead.” However, the Bible clearly teaches that the dead “are conscious of nothing at all.” (Ecclesiastes 9:5) Thus, they cannot contact the living.
Halloween costumes, candy, and trick or treat: According to the book Halloween—An American Holiday, An American History, some of the Celts wore ghoulish costumes so that wandering spirits would mistake them for one of their own and leave them alone. Others offered sweets to the spirits to appease them. In medieval Europe, the Catholic clergy adopted local pagan customs and had their adherents go from house to house wearing costumes and requesting small gifts. The Bible, on the other hand, does not permit merging false religious practices with the worship of God.—2 Corinthians 6:17.
Ghosts, vampires, werewolves, witches, and zombies: These have long been associated with the evil spirit world. (Halloween Trivia) The Bible clearly states that we should oppose wicked spirit forces, not celebrate with them.—Ephesians 6:12.

Halloween pumpkins, or jack-o’-lanterns: In medieval Britain, “supplicants moved from door to door asking for food in return for a prayer for the dead,” and they would carry “hollowed-out turnip lanterns, whose candle connoted a soul trapped in purgatory.” (Halloween—From Pagan Ritual to Party Night) Others say that the lanterns were used to ward off evil spirits. During the 1800’s in North America, pumpkins replaced turnips because they were plentiful as well as easy to hollow out and carve. The beliefs behind this custom—the immortality of the soul, purgatory, and prayers for the dead—are not based on the Bible.—Ezekiel 18:4.